Alexandre R Gingras

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail
    Alexandre R Gingras
    Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:23639-49. 2013
  2. pmc Structural basis of the junctional anchorage of the cerebral cavernous malformations complex
    Alexandre R Gingras
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 199:39-48. 2012
  3. doi request reprint Reconstructing integrin activation in vitro
    Alexandre R Gingras
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Methods Mol Biol 1046:1-17. 2013
  4. pmc A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions
    Jian J Liu
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 22:2509-19. 2011

Collaborators

Detail Information

Publications4

  1. pmc The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail
    Alexandre R Gingras
    Department of Medicine, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 288:23639-49. 2013
    ..These data show that HEG1 can recruit the Rap1-KRIT complex to the plasma membrane where Rap1's Switch II region remains accessible and reveals an important determinant of KRIT1's specificity for Rap1. ..
  2. pmc Structural basis of the junctional anchorage of the cerebral cavernous malformations complex
    Alexandre R Gingras
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 199:39-48. 2012
    ..These data establish that this novel FERM-membrane protein interaction anchors CCM1/KRIT1 at EC junctions to support cardiovascular development...
  3. doi request reprint Reconstructing integrin activation in vitro
    Alexandre R Gingras
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Methods Mol Biol 1046:1-17. 2013
    ..It can also serve as the nidus for synthetic assembly of adhesion plaque like complexes from purified proteins. ..
  4. pmc A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions
    Jian J Liu
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 22:2509-19. 2011
    ..These studies establish that the direct physical interaction of Rap1 with KRIT1 enables the translocation of microtubule-sequestered KRIT1 to junctions, thereby supporting junctional integrity and cardiovascular development...