D Alex Gibson

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil
    D Alex Gibson
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Cooper and University Drives, Lexington, KY 40546 0236, USA
    Brain Res 952:71-7. 2002
  2. ncbi request reprint Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor
    D Alex Gibson
    Department of Pharmacology, University of Kentucky, Tobacco and Health Research Institute, Lexington 40546 0236, USA
    Alcohol Clin Exp Res 27:1099-106. 2003
  3. ncbi request reprint The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546, USA
    Alcohol Clin Exp Res 27:1724-35. 2003
  4. ncbi request reprint Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus
    Sveta Mayer
    Department of Molecular and Biomedial Pharmacology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40546 0236, USA
    Alcohol Clin Exp Res 26:1468-78. 2002
  5. ncbi request reprint Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546 0236, USA
    Alcohol Clin Exp Res 26:1779-93. 2002
  6. ncbi request reprint Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat
    Sveta Mayer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington, USA
    Alcohol Clin Exp Res 26:655-62. 2002

Collaborators

  • Thomas C Foster
  • Barton R Harris
  • Robert C Holley
  • Mark A Prendergast
  • Sveta Mayer
  • John A Blanchard
  • Norman W Pedigo
  • John M Littleton
  • Stewart R Hart
  • John Littleton
  • Rebecca L Scotland
  • Barton Harris
  • May C Fu
  • John Blanchard
  • D Trent Rogers

Detail Information

Publications6

  1. ncbi request reprint Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil
    D Alex Gibson
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Cooper and University Drives, Lexington, KY 40546 0236, USA
    Brain Res 952:71-7. 2002
    ....
  2. ncbi request reprint Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor
    D Alex Gibson
    Department of Pharmacology, University of Kentucky, Tobacco and Health Research Institute, Lexington 40546 0236, USA
    Alcohol Clin Exp Res 27:1099-106. 2003
    ..Therefore, the goal of this investigation was to examine what role, if any, spermidine and spermine have in the generation of ethanol withdrawal-induced neurotoxicity...
  3. ncbi request reprint The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546, USA
    Alcohol Clin Exp Res 27:1724-35. 2003
    ..The following studies use organotypic hippocampal slice cultures at a mature age to investigate the potential for this interplay in the neurotoxicity associated with withdrawal from long-term ethanol exposure...
  4. ncbi request reprint Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus
    Sveta Mayer
    Department of Molecular and Biomedial Pharmacology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40546 0236, USA
    Alcohol Clin Exp Res 26:1468-78. 2002
    ....
  5. ncbi request reprint Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546 0236, USA
    Alcohol Clin Exp Res 26:1779-93. 2002
    ....
  6. ncbi request reprint Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat
    Sveta Mayer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington, USA
    Alcohol Clin Exp Res 26:655-62. 2002
    ..These effects on NMDA receptors imply that the drug may have neurotoxic or neuroprotective actions under different conditions, and these studies were undertaken to evaluate this possibility in hippocampal neuronal cultures...