Sara Gianella

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 90:3944-52. 2016
  2. pmc Genital Epstein Barr Virus is associated with higher prevalence and persistence of anal human papillomavirus in HIV-infected men on antiretroviral therapy
    Sara Gianella
    University of California San Diego, 500 Gilman Drive MC 0679, La Jolla, CA, 92093 0679, USA
    BMC Infect Dis 16:24. 2016
  3. pmc Seminal Shedding of CMV and HIV Transmission among Men Who Have Sex with Men
    Sara Gianella
    Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
    Int J Environ Res Public Health 12:7585-92. 2015
  4. pmc Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 88:7818-27. 2014
  5. pmc Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men
    Sara Gianella
    University of California, San Diego, La Jolla, CA 92093 0679, USA
    Clin Infect Dis 57:441-7. 2013
  6. pmc Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA
    Sara Gianella
    University of California San Diego, 9500 Gilman Dr, MC 0679, La Jolla, CA 92093 0679, USA
    J Infect Dis 207:898-902. 2013
  7. pmc Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract
    Sara Gianella
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0679, USA
    AIDS 27:39-47. 2013
  8. pmc Role of seminal shedding of herpesviruses in HIV Type 1 Transmission
    Sara Gianella
    University of California San Diego, La Jolla 92093 0679, USA
    J Infect Dis 207:257-61. 2013
  9. pmc Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells
    Sara Gianella
    University of California San Diego, La Jolla, CA 92093 0679, USA
    Virology 434:2-4. 2012
  10. pmc Impact of seminal cytomegalovirus replication on HIV-1 dynamics between blood and semen
    Sara Gianella
    University of California San Diego, La Jolla, California 92093 0679, USA
    J Med Virol 84:1703-9. 2012

Collaborators

Detail Information

Publications44

  1. pmc Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 90:3944-52. 2016
    ..001) and increased unspliced cellular HIV RNA transcription (P= 0.010). These observations suggest that replication of HHV may help maintain a larger HIV DNA reservoir, but the underlying mechanisms remain unclear...
  2. pmc Genital Epstein Barr Virus is associated with higher prevalence and persistence of anal human papillomavirus in HIV-infected men on antiretroviral therapy
    Sara Gianella
    University of California San Diego, 500 Gilman Drive MC 0679, La Jolla, CA, 92093 0679, USA
    BMC Infect Dis 16:24. 2016
    ..However, the natural history and factors associated with persistent HPV infection among HIV-infected men who have sex with men (MSM) are unclear...
  3. pmc Seminal Shedding of CMV and HIV Transmission among Men Who Have Sex with Men
    Sara Gianella
    Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA
    Int J Environ Res Public Health 12:7585-92. 2015
    ....
  4. pmc Cytomegalovirus replication in semen is associated with higher levels of proviral HIV DNA and CD4+ T cell activation during antiretroviral treatment
    Sara Gianella
    University of California, San Diego, La Jolla, California, USA
    J Virol 88:7818-27. 2014
    ..These results suggest that CMV reactivation might play a role in the maintenance of the HIV DNA reservoir during suppressive ART and that it could be a target of pharmacologic intervention in future studies...
  5. pmc Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men
    Sara Gianella
    University of California, San Diego, La Jolla, CA 92093 0679, USA
    Clin Infect Dis 57:441-7. 2013
    ..Current antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) in blood to undetectable levels in most infected individuals; however, some men shed HIV in semen despite suppressed levels in blood...
  6. pmc Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA
    Sara Gianella
    University of California San Diego, 9500 Gilman Dr, MC 0679, La Jolla, CA 92093 0679, USA
    J Infect Dis 207:898-902. 2013
    ..These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir...
  7. pmc Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract
    Sara Gianella
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093 0679, USA
    AIDS 27:39-47. 2013
    ..To further understand the role that chronic viral infections of the male genital tract play on HIV-1 dynamics and replication...
  8. pmc Role of seminal shedding of herpesviruses in HIV Type 1 Transmission
    Sara Gianella
    University of California San Diego, La Jolla 92093 0679, USA
    J Infect Dis 207:257-61. 2013
    ....
  9. pmc Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells
    Sara Gianella
    University of California San Diego, La Jolla, CA 92093 0679, USA
    Virology 434:2-4. 2012
    ..Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event...
  10. pmc Impact of seminal cytomegalovirus replication on HIV-1 dynamics between blood and semen
    Sara Gianella
    University of California San Diego, La Jolla, California 92093 0679, USA
    J Med Virol 84:1703-9. 2012
    ..In conclusion, the effects of CMV replication on HIV-1 viral and immunologic dynamics within the male genital tract are not significant enough to perturb evolution or disrupt compartmentalization in the genital tract...
  11. pmc Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants
    Sara Gianella
    niversity of California San Diego, San Diego, California, USA
    J Virol 85:8359-67. 2011
    ..The majority of low-frequency DRM detected using UDS are likely errors inherent to UDS methodology or a consequence of error-prone HIV-1 replication...
  12. pmc Associations between virologic and immunologic dynamics in blood and in the male genital tract
    Sara Gianella
    University of California, San Diego, La Jolla, California
    J Virol 86:1307-15. 2012
    ..These factors likely influence replication dynamics, sexual transmission risk, and disease outcomes for all three viruses...
  13. pmc Virologic correlates of anti-CMV IgG levels in HIV-1-infected men
    Sara Gianella
    University of California San Diego, La Jolla
    J Infect Dis 209:452-6. 2014
    ....
  14. pmc Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART
    Jennifer M Dan
    La Jolla Institute for Allergy and Immunology, La Jolla, CA University of California, San Diego, CA Veterans Affairs San Diego Healthcare System, San Diego, CA Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA and University of Southern California, Keck School of Medicine, Los Angeles, CA
    J Acquir Immune Defic Syndr 72:133-7. 2016
    ....
  15. pmc Circulating HIV DNA Correlates With Neurocognitive Impairment in Older HIV-infected Adults on Suppressive ART
    Michelli Faria de Oliveira
    University of California San Diego, La Jolla, CA, USA
    Sci Rep 5:17094. 2015
    ..Correlates of neurocognitive impairment might differ between younger and older adults, suggesting that future treatment and prevention strategies for HIV-associated neurocognitive disorders likely need to be tailored based on age...
  16. pmc HIV Trafficking Between Blood and Semen During Early Untreated HIV Infection
    Antoine Chaillon
    Department of Medicine, University of California, San Diego, La Jolla, CA Veterans Affairs San Diego Healthcare System, San Diego, CA National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD and National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    J Acquir Immune Defic Syndr 74:95-102. 2017
    ..In this study, we evaluated viral trafficking between blood and semen during primary HIV infection in 6 antiretroviral-naive men who have sex with men...
  17. pmc Using ultradeep pyrosequencing to study HIV-1 coreceptor usage in primary and dual infection
    Gabriel A Wagner
    University of California San Diego, La Jolla, CA 92093, USA
    J Infect Dis 208:271-4. 2013
    ..12), suggesting a weak statistical trend toward occurrence of superinfection and acquiring X4 usage...
  18. pmc (1→3)-β-d-Glucan: A Biomarker for Microbial Translocation in Individuals with Acute or Early HIV Infection?
    Martin Hoenigl
    Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria Department of Internal Medicine, Division of Pulmonology, Medical University of Graz, Graz, Austria
    Front Immunol 7:404. 2016
    ..This study evaluated BDG as a biomarker of gut integrity in adults with acute or early HIV infection (AEH)...
  19. pmc Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy
    Sara Gianella
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Virus Evol 2:vew020. 2016
    ..The most likely source of compartmentalized HIV RNA is a CNS reservoir that would need to be targeted to achieve complete HIV eradication...
  20. pmc Early Antiretroviral Therapy is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations
    Michelli F Oliveira
    University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 13:e1006112. 2017
    ..Such compartmentalized provirus in the CNS needs to be considered for the design of future eradication strategies and might contribute to the neuropathogenesis of HIV...
  21. pmc Highly precise measurement of HIV DNA by droplet digital PCR
    Matthew C Strain
    University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 8:e55943. 2013
    ..The improved sensitivity and precision of measurement of these rare events should facilitate measurements to characterize the latent HIV reservoir and interventions to eradicate it...
  22. pmc Asymptomatic CMV Replication During Early Human Immunodeficiency Virus (HIV) Infection Is Associated With Lower CD4/CD8 Ratio During HIV Treatment
    Davey M Smith
    University of California, San Diego, La Jolla
    Clin Infect Dis 63:1517-1524. 2016
    ....
  23. pmc Rapid HIV Viral Load Suppression in those Initiating Antiretroviral Therapy at First Visit after HIV Diagnosis
    Martin Hoenigl
    Division of Infectious Diseases, Department of Medicine, University of California San Diego, San Diego, California, United States
    Sci Rep 6:32947. 2016
    ..ART initiated at the intake visit led to rapid and reliable viral suppression in acute, early and chronic HIV infection, in particular when integrase inhibitor-based regimens were used. ..
  24. pmc Correlation of (1→3)-β-D-glucan with other inflammation markers in chronically HIV infected persons on suppressive antiretroviral therapy
    Martin Hoenigl
    Division of Infectious Diseases, University of California San Diego, San Diego, California, USA Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    GMS Infect Dis 3:. 2015
    ..Future studies are needed to evaluate whether BDG may be a marker for morbidity in chronic HIV infection...
  25. ncbi request reprint Increased cell-free mitochondrial DNA is a marker of ongoing inflammation and better neurocognitive function in virologically suppressed HIV-infected individuals
    Josué Pérez-Santiago
    University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093 0679, USA
    J Neurovirol . 2016
    ..e. lower NFL). Higher cell-free mtDNA is associated with inflammation during treated HIV infection, but the impact on neurocognitive functioning and neuronal damage remains unclear and may differ in the setting of suppressive ART...
  26. pmc Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy
    Marta Massanella
    University of California San Diego, La Jolla, CA, United States
    Sci Rep 5:13179. 2015
    ..Meth use is also associated with a loss of control of CMV replication, which could be related to loss of immune response to pathogens. Future studies should consider meth use as a potential modulator of T-cell responses. ..
  27. pmc Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men
    Sara Gianella
    University of California, San Diego, La Jolla, California, United States of America
    PLoS ONE 10:e0130410. 2015
    ..While behavioral factors are important in STI acquisition, other biological factors such as immune modulation due to chronic viral infection may further predispose to STI acquisition...
  28. pmc Antibody response to Achromobacter xylosoxidans during HIV infection is associated with lower CD4 levels and increased lymphocyte activation
    Erick T Tatro
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Clin Vaccine Immunol 21:46-50. 2014
    ..01). HIV-positive individuals had higher anti-A. xylosoxidans IgG titers than HIV-uninfected individuals (P = 0.04). The results suggest an abnormal adaptive immune activation to gut microflora during HIV infection. ..
  29. pmc HIV migration between blood and cerebrospinal fluid or semen over time
    Antoine Chaillon
    University of California San Diego, La Jolla
    J Infect Dis 209:1642-52. 2014
    ..These findings imply that viral subpopulations in anatomical sites are an active part of the whole viral population and that compartmental reservoirs could have implications in future eradication studies. ..
  30. pmc Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco VA Medical Center SFVAMC and University of California, San Francisco UCSF, San Francisco, California, USA
    AIDS 24:2451-60. 2010
    ..To determine whether raltegravir-containing antiretroviral therapy (ART) intensification reduces HIV levels in the gut...
  31. pmc Cell-free mitochondrial DNA in CSF is associated with early viral rebound, inflammation, and severity of neurocognitive deficits in HIV infection
    Josué Pérez-Santiago
    University of California San Diego, 9500 Gilman Drive MC 0679, La Jolla, CA, 92093 0679, USA
    J Neurovirol 22:191-200. 2016
    ..Our findings suggest that within a subset of subjects cell-free CSF mtDNA is associated with inflammation and degree of NCI...
  32. pmc Quantification of Total and 2-LTR (Long terminal repeat) HIV DNA, HIV RNA and Herpesvirus DNA in PBMCs
    Marta Massanella
    University of California San Diego, La Jolla, USA
    Bio Protoc 5:. 2015
    ..i>, 2015)...
  33. pmc No evidence of posttreatment control after early initiation of antiretroviral therapy
    Sara Gianella
    aUniversity of California, San Diego, La Jolla bVeterans Affairs San Diego Healthcare System, San Diego, California, USA
    AIDS 29:2093-7. 2015
    ..Median time to HIV-RNA rebound after ART interruption was 0.9 months (range: 0.2-6.4 months). ..
  34. pmc Minority variants of drug-resistant HIV
    Sara Gianella
    Departments of Pathology and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
    J Infect Dis 202:657-66. 2010
    ..In this review, we summarize the attributes and limitations of the currently available detection assays and review the existing information about both acquired and transmitted drug-resistant minority variants...
  35. pmc (1→3)-β-D-Glucan Levels Correlate With Neurocognitive Functioning in HIV-Infected Persons on Suppressive Antiretroviral Therapy: A Cohort Study
    Martin Hoenigl
    From the Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA MH, MFDO, JP S, SM, SG, Department of Internal Medicine, Section of Infectious Diseases and Tropical Medicine MH, Department of Internal Medicine, Division of Pulmonology, Medical University of Graz, Graz, Austria MH, Research Laboratory, Associates of Cape Cod, Inc, Falmouth, MA YZ, MF, Department of Psychiatry AJM, TDM, and Department of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, CA RJE
    Medicine (Baltimore) 95:e3162. 2016
    ..BDG may be a promising independent biomarker associated with neurocognitive functioning in virologically suppressed HIV-infected individuals...
  36. doi request reprint Standard vaccines increase HIV-1 transcription during antiretroviral therapy
    Christina Yek
    aUniversity of California San Diego, La Jolla, California, USA bInstitut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS cMedical Intensive Care Unit dDepartment of Infectious Diseases, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain eVeterans Affairs Healthcare System, San Diego, California, USA Present address Christina Yek, University of Texas Southwestern Medical Center, Dallas, Texas, USA Present address Konrad Scheffler, Illumina, San Diego, California, USA
    AIDS 30:2289-98. 2016
    ..We investigated whether vaccination against non-HIV pathogens can induce HIV transcription and thereby play a role in future eradication strategies...
  37. ncbi request reprint Longitudinal Viral Dynamics in Semen During Early HIV Infection
    Sheldon R Morris
    University of California, San Diego, La Jolla, CA, USA
    Clin Infect Dis . 2016
    ..Multiple viruses co-infect the male genital tract, influencing each other's replication and perhaps affecting HIV pathogenesis and disease progression...
  38. pmc Comparative Analysis of Cell-Associated HIV DNA Levels in Cerebrospinal Fluid and Peripheral Blood by Droplet Digital PCR
    Michelli Faria de Oliveira
    University of California, San Diego, La Jolla, California, United States of America
    PLoS ONE 10:e0139510. 2015
    ..Measurement of HIV DNA-bearing cells in cerebrospinal fluid (CSF) is challenging because few cells are present. We present a novel application of the sensitive droplet digital (dd)PCR in this context...
  39. pmc The Sordid Affair Between Human Herpesvirus and HIV
    Sara Gianella
    University of California San Diego, La Jolla
    J Infect Dis 212:845-52. 2015
    ..In this review, we discuss how HHVs, and cytomegalovirus in particular, interact with concurrent HIV infection, and we describe the next steps necessary to understand and address these connections. ..
  40. pmc Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
    Steven A Yukl
    San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    J Infect Dis 202:1553-61. 2010
    ..The gut is a major reservoir for human immunodeficiency virus (HIV) in patients receiving antiretroviral therapy (ART). We hypothesized that distinct immune environments within the gut may support varying levels of HIV...
  41. pmc Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy
    Antoine Chaillon
    1 University of California, San Diego, La Jolla, California
    AIDS Res Hum Retroviruses 30:165-9. 2014
    ..We then investigated the potential impact of identified mutations in RT and antiretroviral binding affinity using a novel computational approach...
  42. pmc Cytomegalovirus and HIV: A Dangerous Pas de Deux
    Sara Gianella
    Department of Medicine, Division of Infectious Disease, University of California San Diego, La Jolla
    J Infect Dis 214:S67-74. 2016
    ..Further investigation of the relationships between CMV, immune dysfunction, and unsuccessful aging during chronic HIV infection is warranted. ..
  43. pmc Quantification of HIV RNA and Human Herpesvirus DNA in Seminal Plasma
    Milenka V Vargas-Meneses
    University of California San Diego, La Jolla, USA
    Bio Protoc 5:. 2015
    ..i>, 2014). This protocol was designed to collect and process male genital secretion (GS), and to isolate and further quantify HIV RNA and DNA of seven HHV from seminal plasma using quantitative real time PCR technology...
  44. pmc Estimating the timing of mother-to-child transmission of the human immunodeficiency virus type 1 using a viral molecular evolution model
    Antoine Chaillon
    Universite Francois Rabelais, Institut National de la Santé et de la Recherche Médicale Unité 966 et Laboratoire de Virologie, Centre Hopsitalier Universitaire Bretonneau, Tours, France University of California San Diego, Department of Pathology, San Diego, California, United States of America
    PLoS ONE 9:e90421. 2014
    ..Taking advantage of the constant accumulation of HIV genetic variation over time and using longitudinally sampled viral sequences, we used a coalescent approach to investigate the timing of MTCT...