Subroto Ghose

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia
    K A Gleason
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Transl Psychiatry 2:e199. 2012
  2. ncbi request reprint Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters
    Subroto Ghose
    Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892, USA
    Synapse 56:100-4. 2005
  3. pmc Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?
    Subroto Ghose
    University of Texas Southwestern Medical Center, NE5 110C, Dallas, TX 75390 9127, USA
    Am J Psychiatry 166:812-20. 2009
  4. pmc Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia
    Subroto Ghose
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9127, USA
    Schizophr Res 111:131-7. 2009
  5. ncbi request reprint Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:100-4. 2006
  6. ncbi request reprint PET [11C]DASB imaging of serotonin transporters in patients with alcoholism
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, One Center Drive, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 31:28-32. 2007
  7. doi request reprint Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex
    Max A Castillo
    Department of Neurology, The University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 67:208-16. 2010
  8. pmc Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ
    Yota Fujimura
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:94-7. 2009
  9. pmc Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T
    Abhishek Banerjee
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 68:325-31. 2012
  10. pmc Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA
    Int J Neurosci 118:1609-27. 2008

Detail Information

Publications22

  1. pmc Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia
    K A Gleason
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Transl Psychiatry 2:e199. 2012
    ..These data suggest that significant cannabis use during adolescence may be a contributory causal factor in the development of certain features of schizophrenia and may offer mGluR5 as a potential therapeutic target...
  2. ncbi request reprint Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters
    Subroto Ghose
    Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland 20892, USA
    Synapse 56:100-4. 2005
    ..3H]MeNER displayed much higher affinity for NET than for SERT or DAT in homogenate binding studies. Each of these features supports the binding specificity of this candidate in vivo NET ligand...
  3. pmc Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?
    Subroto Ghose
    University of Texas Southwestern Medical Center, NE5 110C, Dallas, TX 75390 9127, USA
    Am J Psychiatry 166:812-20. 2009
    ..GCP II is an enzyme that metabolizes N-acetyl-aspartyl-glutamate (NAAG), which is the only known specific endogenous agonist of mGluR3 in the mammalian brain...
  4. pmc Localization of NAAG-related gene expression deficits to the anterior hippocampus in schizophrenia
    Subroto Ghose
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9127, USA
    Schizophr Res 111:131-7. 2009
    ..These data suggest that NAAG-mediated signaling is disrupted in the AH in schizophrenia and localize the defect to the CA1 and CA3 regions...
  5. ncbi request reprint Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans
    Vanessa L Cropley
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 47:100-4. 2006
    ....
  6. ncbi request reprint PET [11C]DASB imaging of serotonin transporters in patients with alcoholism
    Amira K Brown
    Molecular Imaging Branch, National Institute of Mental Health, One Center Drive, Bethesda, MD 20892, USA
    Alcohol Clin Exp Res 31:28-32. 2007
    ..We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics...
  7. doi request reprint Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex
    Max A Castillo
    Department of Neurology, The University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 67:208-16. 2010
    ..This in turn could affect the binding of Stx 1 to its protein partners and result in abnormal neurotransmitter release and synaptic transmission...
  8. pmc Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ
    Yota Fujimura
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:94-7. 2009
    ..We also sought to determine if a drug-induced panic attack releases substance P in brain, as measured by decreased binding of [(18)F]SPA-RQ...
  9. pmc Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T
    Abhishek Banerjee
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 68:325-31. 2012
    ..The Gly concentrations in pure GM and white matter were estimated to be 1.1 and 0.1 mM, with 95% confidence intervals 1.0-1.2 and 0.0-0.2, respectively...
  10. pmc Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA
    Int J Neurosci 118:1609-27. 2008
    ..The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia...
  11. pmc Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 64:1247-51. 2010
    ..13 and 0.28 by difference editing (95% confidence intervals 0.07-0.19 and 0.22-0.34), respectively, assuming identical relaxation effects between the metabolites...
  12. pmc Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling
    Carol A Tamminga
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Schizophr Bull 38:927-35. 2012
    ....
  13. pmc Human postmortem tissue: what quality markers matter?
    Ana D Stan
    University of Texas Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd, NE5 110F, Dallas, TX 75390 9127, USA
    Brain Res 1123:1-11. 2006
    ..g., thawed tissue, surgical tissue), that yielded unexpected quality indicators. These data also suggest that cases whose source was a Medical Examiner's office represent high tissue quality...
  14. pmc AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli
    Vaishnav Krishnan
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 64:691-700. 2008
    ..Recent evidence suggests that dopaminergic neurons of the ventral tegmental area (VTA) play a key role in the manifestation of stress vulnerability...
  15. pmc PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Synapse 61:242-51. 2007
    ..7 in gray matter regions. In conclusion, a two-parameter reference tissue method (MRTM2) provided reproducible and reliable measurements of [(18)F]SPA-RQ brain uptake using 240 min of both regional and voxel-wise data...
  16. pmc Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, I Center Drive, MSC 0135, Bethesda, MD, USA
    Ann Neurol 59:174-7. 2006
    ..Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects...
  17. ncbi request reprint Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 29:117-25. 2004
    ..Our findings support the notion that the hydrolysis of NAAG is disrupted in schizophrenia and that specific anatomical regions may show discrete abnormalities in GCP II synthesis...
  18. pmc The GABAβ receptor as a target for antidepressant drug action
    Subroto Ghose
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Br J Pharmacol 162:1-17. 2011
    ..Together with the earlier preclinical studies, these new data point to a role for the GABA(B) system in major depression and support the antidepressant potential of GABA(B) receptor antagonists...
  19. ncbi request reprint Biodistribution and radiation dosimetry of the serotonin transporter ligand 11C-DASB determined from human whole-body PET
    Jian Qiang Lu
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    J Nucl Med 45:1555-9. 2004
    ..The goal of this study was to provide dosimetry estimates for 11C-DASB based on human whole-body PET...
  20. pmc In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:1042-6. 2009
    ..03-ppm peaks, assuming identical T(1) and T(2) between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 +/- 0.2 (mean +/- SD; N = 6)...
  21. pmc Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder
    Aybala Saricicek
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Am J Psychiatry 169:851-9. 2012
    ..To understand its molecular basis, the authors also studied β2*-nAChR binding in postmortem brain samples from depressed subjects...
  22. doi request reprint Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
    Thomas A Green
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2025-32. 2008
    ....