M Eric Gershwin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The autoimmunity of primary biliary cirrhosis and the clonal selection theory
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Immunol Cell Biol 89:70-80. 2011
  2. pmc Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells
    Hiroto Kita
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    J Exp Med 195:113-23. 2002
  3. pmc Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II
    Weici Zhang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e49413. 2012
  4. pmc Environmental pathways to autoimmune diseases: the cases of primary biliary cirrhosis and multiple sclerosis
    Carlo Selmi
    Department of Medicine and Autoimmunity and Metabolism Unit, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Arch Med Sci 7:368-80. 2011
  5. doi request reprint Abul Abbas: an epitome of scholarship
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA Electronic address
    J Autoimmun 45:1-6. 2013
  6. pmc Response to Dr. Roger's letter: further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of metabolic syndrome in the rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand
    Nutr Metab (Lond) 10:10. 2013
  7. pmc Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Nutr Metab (Lond) 9:50. 2012
  8. doi request reprint The practical understanding and treatment of asthma
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 43:1-2. 2012
  9. pmc Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis
    Andrea T Borchers
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    Semin Immunopathol 31:309-22. 2009
  10. pmc The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Nutr J 9:38. 2010

Research Grants

Collaborators

Detail Information

Publications79

  1. pmc The autoimmunity of primary biliary cirrhosis and the clonal selection theory
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Immunol Cell Biol 89:70-80. 2011
    ..This article will review the current knowledge on PBC etiology and pathogenesis in light of the clonal selection theory developments...
  2. pmc Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells
    Hiroto Kita
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    J Exp Med 195:113-23. 2002
    ....
  3. pmc Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II
    Weici Zhang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e49413. 2012
    ..Further, 2×10(4) isolated lymphoma-like cells transplant disease by adoptive cell transfers. Collectively, our data demonstrate that increased copy number of dnTGFβRII is critical for development of lymphoma-like T cell infiltration...
  4. pmc Environmental pathways to autoimmune diseases: the cases of primary biliary cirrhosis and multiple sclerosis
    Carlo Selmi
    Department of Medicine and Autoimmunity and Metabolism Unit, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Arch Med Sci 7:368-80. 2011
    ....
  5. doi request reprint Abul Abbas: an epitome of scholarship
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA Electronic address
    J Autoimmun 45:1-6. 2013
    ..In this special issue a number of Abul's colleagues have specifically written papers to honor this unique individual. It is an extraordinary honor to be chosen for a special issue of a journal in recognition of one's career. ..
  6. pmc Response to Dr. Roger's letter: further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of metabolic syndrome in the rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand
    Nutr Metab (Lond) 10:10. 2013
    ..See related article: http://www.nutritionandmetabolism.com/content/10/1/14...
  7. pmc Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Nutr Metab (Lond) 9:50. 2012
    ..Epidemiology and animal models suggest that dietary monosodium glutamate (MSG) may contribute to the onset of obesity and the metabolic syndrome...
  8. doi request reprint The practical understanding and treatment of asthma
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 43:1-2. 2012
    ..This issue is dedicated to helping the many sufferers of asthma with the hope that this topic will eventually become a medical anachronism...
  9. pmc Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis
    Andrea T Borchers
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    Semin Immunopathol 31:309-22. 2009
    ..The relative importance of these chemokines in the recruitment or the retention of lymphocytes around the bile ducts remains unclear. The available data remain limited but underscore the importance of recruitment and homing...
  10. pmc The use of a commercial vegetable juice as a practical means to increase vegetable intake: a randomized controlled trial
    Sonia F Shenoy
    Department of Nutrition, University of California Davis, Davis, California 95616, USA
    Nutr J 9:38. 2010
    ..The secondary aim is to assess the effect of a vegetable juice on measures of cardiovascular health...
  11. pmc Genomic variants associated with primary biliary cirrhosis
    Carlo Selmi
    Department of Translational Medicine, Universita degli Studi di Milano, Milan, Italy
    Genome Med 2:5. 2010
    ..The aim of this present work is to critically review the numerous studies dedicated to revealing genetic associations in PBC, and to predict the potential for future studies based on these data...
  12. pmc Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma
    Vincent A Ziboh
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Dermatology, University of California at Davis School of Medicine, TB 192, Davis, CA 95616, USA
    Clin Dev Immunol 11:13-21. 2004
    ..Nonetheless, the study demonstrated dietary fatty acid modulation of endogenous inflammatory mediators without side effects and thus warrant further explorations into the roles of GLA at higher doses, leukotrienes and asthma...
  13. doi request reprint Public safety and dietary supplementation
    M Eric Gershwin
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, California 95616, USA
    Ann N Y Acad Sci 1190:104-17. 2010
    ..More importantly, we provide a working plan for addressing this important issue...
  14. ncbi request reprint The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 47:737-45. 2008
    ..We present these data under the umbrella of convenient truths that support this thesis as well as some inconvenient truths that are not readily accommodated by current theory...
  15. ncbi request reprint Cryptic antigenic determinants on the extracellular pyruvate dehydrogenase complex/mimeotope found in primary biliary cirrhosis. A probe by affinity mass spectrometry
    T T Yip
    Department of Food Science and Technology, Allergy and Clinical Immunology, University of California Davis, School of Medicine, Davis, California 95616, USA
    J Biol Chem 271:32825-33. 1996
    ..We believe AMS may be an important new approach with wide application to the identification of molecules associated with a number of disease states...
  16. pmc Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 42:1194-202. 2005
    ..Exogenous estrogens may also contribute to explain the female predominance of the disease...
  17. doi request reprint Bone marrow transplantation, refractory autoimmunity and the contributions of Susumu Ikehara
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 E Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 30:105-7. 2008
  18. doi request reprint Macrophage activation syndrome in autoimmune disease
    Sean Deane
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Int Arch Allergy Immunol 153:109-20. 2010
    ..This review discusses the major aspects of the pathophysiology, diagnosis, and management of MAS with a focus on the association with autoimmune disease...
  19. doi request reprint Chella David: a lifetime contribution in translational immunology
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 37:59-62. 2011
    ..Chella David, at age 75, is an athlete in immunology and still keeps going with the same enthusiasm as manifest as a young post-doc...
  20. pmc Liver involvement in subjects with rheumatic disease
    Carlo Selmi
    Department of Medicine and Autoimmunity and Metabolism Unit, IRCCS Istituto Clinico Humanitas, University of Milan, Via A Manzoni 56, 20089 Rozzano MI, Italy
    Arthritis Res Ther 13:226. 2011
    ..We review herein the data on the role of the liver in the clinical management of systemic rheumatic diseases...
  21. doi request reprint Cutting-edge issues in organ-specific autoimmunity
    M Eric Gershwin
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis School of Medicine, Davis, USA
    Clin Rev Allergy Immunol 41:123-5. 2011
    ..Common themes on both etiology and effector mechanisms are described throughout these papers with an attempt to provide a cutting-edge overview...
  22. ncbi request reprint Primary biliary cirrhosis and autoimmunity: evaluating the genetic risk
    M E Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California at Davis, Davis, CA, USA
    Isr Med Assoc J 2:7-10. 2000
    ..In this review we place these concepts in perspective and highlight in particular the genetic associations in primary biliary cirrhosis...
  23. ncbi request reprint Phenotypic and functional considerations in the evaluation of immunity in nutritionally compromised hosts
    M E Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    J Infect Dis 182:S108-14. 2000
    ..This review summarizes interactions between nutrition and immunity and focuses on practical aspects for evaluation of the immune function in the field...
  24. ncbi request reprint Primary biliary cirrhosis: an orchestrated immune response against epithelial cells
    M E Gershwin
    Division of Allergy, Rheumatology, and Clinical Immunology, University of California, Davis, School of Medicine, 95616, USA
    Immunol Rev 174:210-25. 2000
    ..The data so far provide suggestive evidence that PBC is a mucosal disease; this thesis provides a basis for discussion of etiology via the enterohepatic circulation of toxins and/or infection...
  25. pmc Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 48:531-40. 2008
    ....
  26. pmc Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis
    Weici Zhang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 52:215-22. 2010
    ..Importantly, however, autoimmune cholangitis in dnTGFbetaRII IL-6(-/-) mice was significantly exacerbated, including elevated inflammatory cytokines, increased numbers of activated T cells, and worsening hepatic pathology...
  27. pmc Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice
    Guo Xiang Yang
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 47:1974-82. 2008
    ..In contrast, B6/Rag(-/-) recipients of CD4(+) T cells from dnTGFbetaRII mice predominantly developed inflammatory bowel disease associated with higher levels of serum interferon gamma and tumor necrosis factor alpha...
  28. pmc Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice
    Katsunori Yoshida
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 50:1494-500. 2009
    ....
  29. ncbi request reprint AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers
    Yuki Moritoki
    Division of Rheumatology, Allergy, and Clinical Immunology and the University of California at Davis, Davis, CA 95616, USA
    Hepatology 45:314-22. 2007
    ..Conclusion: These data suggest that the hyperresponsiveness of B cells in PBC accelerates B cell-mediated autoimmunity...
  30. ncbi request reprint Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California School of Medicine, Davis, CA 95616, USA
    J Immunol 177:1655-60. 2006
    ....
  31. doi request reprint B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis
    Yuki Moritoki
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, California, USA
    Gastroenterology 136:1037-47. 2009
    ..Mice that express a dominant-negative form of transforming growth factor-beta receptor restricted to T cells (dnTGF-betaRII) develop antimitochondrial antibodies and liver inflammation similar to human primary biliary cirrhosis...
  32. pmc Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis
    Kazuhito Kawata
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California, United States of America Hepatology Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    PLoS ONE 8:e74225. 2013
    ..In conclusion, whereas IFN-γ has a pivotal role in the early events involved in the pathogenesis of autoimmune cholangitis induced by 2OA-BSA, the IL-23/Th17 pathway potentiates the effects of IL-12/IFN-γ-mediated immunopathology. ..
  33. ncbi request reprint Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization
    Patrick S C Leung
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    J Immunol 179:2651-7. 2007
    ....
  34. pmc Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Hepatology 52:987-98. 2010
    ..Moreover, MDMphis from PBC patients cultured with BEC apoptotic bodies in the presence of AMAs markedly increase tumor necrosis factor-related apoptosis-inducing ligand expression...
  35. pmc Apotopes and the biliary specificity of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 49:871-9. 2009
    ..The fact that AMA-containing sera reacted with PDC-E2 on apoptotic BECs without a requirement for permeabilization suggests that the autoantigen is accessible to the immune system during apoptosis...
  36. ncbi request reprint Analysis of TCR antagonism and molecular mimicry of an HLA-A0201-restricted CTL epitope in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
    Hepatology 36:918-26. 2002
    ..Our finding also supports the thesis that molecular mimicry may be implicated in the initiation of the autoreactive CD8 T-cell responses and has implications for the use of such peptides for immunotherapy...
  37. ncbi request reprint Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible
    Katsushi Amano
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
    J Immunol 172:6444-52. 2004
    ..e., the primary tolerance-breaking autoantigen. Detailed analysis of this system may provide strategies on how to restore tolerance in patients with autoimmune disease...
  38. ncbi request reprint CD4- plasmacytoid dendritic cells (pDCs) migrate in lymph nodes by CpG inoculation and represent a potent functional subset of pDCs
    Guo Xiang Yang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    J Immunol 174:3197-203. 2005
    ....
  39. pmc Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-β receptor type II mouse
    Yugo Ando
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, School of Medicine, Davis, CA 95616, USA
    J Autoimmun 41:111-9. 2013
    ....
  40. ncbi request reprint Murine thymic plasmacytoid dendritic cells
    Tomoyuki Okada
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis, Davis 95616, USA
    Eur J Immunol 33:1012-9. 2003
    ..The repertoire of this cell lineage to TLR9 ligands demonstrate that such responses are determined not only by the quantity of expression, but also cell lineage...
  41. ncbi request reprint Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis
    Ya Hui Chuang
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis, CA 95616, USA
    Hepatology 47:571-80. 2008
    ....
  42. ncbi request reprint Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis
    Kentaro Kikuchi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Genome and Biomedical Sciences Facility, 451 E Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 24:347-52. 2005
    ..Interestingly, however, despite the functional association, there is no difference in the distribution of TLR9 genotypes between patients and controls. Our data emphasize the importance of dissecting the innate immune response in PBC...
  43. doi request reprint Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis
    Sabine Oertelt-Prigione
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Autoimmunity 41:92-9. 2008
    ..In conclusion, we submit that an impaired IDO induction characterizes PBC and might represent a contributing factor in disease pathogenesis in association with several specific defects in the target tissue...
  44. ncbi request reprint IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Hepatology 44:1240-9. 2006
    ....
  45. ncbi request reprint Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis
    Kerstien A Padgett
    Division of Rheumatology, Allergy and Clinical Immunology, University of California School of Medicine, GBSF, 451 E Health Sciences Drive, Suite 6510, Davis, California 95616, USA
    J Autoimmun 24:209-19. 2005
    ..In conclusion, our data provide a high degree of confidence that N. aromaticivorans may potentiate the breakdown of self tolerance in genetically susceptible individuals...
  46. pmc Hepatic IL-17 responses in human and murine primary biliary cirrhosis
    Ruth Y Z Lan
    Division of Rheumatology, Allergy and Clinical Immunology, Genome and Biomedical Sciences Facility, University of California at Davis, 451 East Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 32:43-51. 2009
    ....
  47. doi request reprint Treatment with PEG-interferon and ribavirin for chronic hepatitis C increases neutrophil and monocyte chemotaxis
    Alessia Giorgini
    Division of Internal Medicine, San Paolo School of Medicine, University of Milan, Milan, Italy
    Ann N Y Acad Sci 1173:847-57. 2009
    ..In conclusion, the innate immune cell activity is enhanced in patients with CHC during antiviral treatment and returns to normal after its discontinuation thus possibly playing a role in their susceptibility to infections...
  48. ncbi request reprint Innate immunity and primary biliary cirrhosis
    Carlo Selmi
    Department of Internal Medicine, IRCCS Istituto Clinico Humanitas, University of Milan, and Division of Internal Medicine and Liver Unit, San Paolo Hospital School of Medicine, Milan, Italy
    Curr Mol Med 9:45-51. 2009
    ..We suggest that future therapeutic efforts in PBC will depend heavily on understanding the nature of this innate immune responses and methodology to blunt their cytotoxicity...
  49. ncbi request reprint Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis
    Shuji Matsumura
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
    Hepatology 36:1125-34. 2002
    ..These data will become important in the development of altered peptide ligands to modulate disease activity...
  50. pmc Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice
    Willy Hsu
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 49:133-40. 2009
    ..In conclusion, on loss of Treg function in mice, CD8 T cells mediate biliary ductular damage whereas CD4 T cells mediate induction of colon-specific autoimmunity...
  51. pmc The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice
    Yugo Ando
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 56:1418-26. 2012
    ..These results affirm that the IL-12/Th1 pathway is critical to biliary pathology in dnTGFβRII mice, whereas colitis is caused by a direct effect of IL-23...
  52. pmc B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice
    Yuki Moritoki
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 50:1893-903. 2009
    ....
  53. ncbi request reprint Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations
    Zhe Xiong Lian
    Division of Rheumatology Allergy Clinical Immunology, University of California, Davis, CA 95616, USA
    J Immunol 170:2323-30. 2003
    ..Our results demonstrate the highly heterogeneous nature of hepatic DC, which is in agreement with the unique requirements for APC in the complex liver environment...
  54. ncbi request reprint Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid
    Katsushi Amano
    Division of Rheumatology, Allergy and Clinical Immunology, Genomic and Biomedical Sciences Facility, University of California, Davis, CA 95616, USA
    J Immunol 174:5874-83. 2005
    ..Not only does 2-octynoic acid have the potential to modify PDC-E2 in vivo but importantly it was/is widely used in the environment including perfumes, lipstick, and many common food flavorings...
  55. pmc Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA
    Patrick S C Leung
    Division of Rheumatology Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    J Autoimmun 41:79-86. 2013
    ..We submit that in genetically susceptible hosts, electrophilic modification of lipoic acid in PDC-E2 by acetaminophen or similar drugs can facilitate loss of tolerance and lead to the development of PBC...
  56. pmc B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis
    Yuki Moritoki
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Cell Immunol 268:16-23. 2011
    ..c3c4 mice, illustrating a critical role of B cells in modulating specific organ pathology and, in particular, in exacerbating both the biliary disease and the sialadenitis...
  57. ncbi request reprint Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis
    Kentaro Kikuchi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Gastroenterology 128:304-12. 2005
    ..We hypothesized that the increase in serum IgM is the result of chronic B-cell activation induced via the Toll-like receptor (TLR) signaling pathway...
  58. ncbi request reprint Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow
    Zhe Xiong Lian
    Division of Rheumatology Allergy and Clinical Immunology, University of California, Davis 95616, USA
    J Immunol 173:5283-9. 2004
    ..These data on the functional characteristics of the IPDC lineages explain in part the mechanism of hyper-IFN-alpha production and help clarify the mechanism for the expansion of NZB BM IPDCs...
  59. ncbi request reprint Proteasome is required for class I-restricted presentation by Fcgamma receptor-mediated endocytosis in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, TB 192, One Shields Avenue, Davis, CA 95616, USA
    J Autoimmun 21:175-82. 2003
    ..This data reflects another layer of interaction between components of the immune system in the development of autoimmunity. Further characterization of autoantigen uptake and processing may lead to potential therapeutic intervention...
  60. ncbi request reprint Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis
    Yasuhiko Kimura
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA, USA
    Hepatology 41:55-63. 2005
    ..In conclusion, genetic polymorphisms of CYP 2D6 and 2E1, PXR, and MDR1 do not appear to play a role in the onset of PBC...
  61. pmc Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California 95616, USA
    J Clin Invest 109:1231-40. 2002
    ..These data, we believe for the first time, document the enrichment of autoantigen-specific CD8(+) T cells in the PBC liver, suggesting that CD8(+) T cells play a significant role in the immunopathogenesis of PBC...
  62. pmc Etiopathogenesis of primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis, CA 95616, USA
    World J Gastroenterol 14:3328-37. 2008
    ..In this article, we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data, new developments and theories, and nominate directions for future research...
  63. pmc Quality of life and everyday activities in patients with primary biliary cirrhosis
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 46:1836-43. 2007
    ..Nevertheless, patients with PBC suffer significantly more than controls from a variety of symptoms that are beyond the immediate impact of liver failure and affect their lifestyle, personal relationships, and work activities...
  64. ncbi request reprint Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 38:1250-7. 2003
    ..aromaticivorans is a candidate for the induction of PBC...
  65. doi request reprint Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid
    Masanobu Tsuda
    Divisions of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA 95817, USA
    Hepatology 55:512-21. 2012
    ..Notably, serum alkaline phosphatase levels were significantly reduced up to 36 weeks following rituximab treatment...
  66. ncbi request reprint Mitochondrial antigens as targets of cellular and humoral auto-immunity in primary biliary cirrhosis
    Yasunori Ichiki
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, TB192, Davis, CA, USA
    Clin Rev Allergy Immunol 28:83-91. 2005
    ..This article reviews the current reports regarding the auto-immune reaction against mitochondrial auto-antigens in PBC...
  67. pmc Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis
    Patrick S C Leung
    Division of Rheumatology Allergy, University of California, Davis Medical Center, Sacramento, CA, USA
    Hepatology 46:1436-42. 2007
    ..The rapid disappearance of AMAs in these patients provides further support for the contention that PBC pathogenesis requires additional factors, including genetic susceptibility...
  68. ncbi request reprint A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 45:659-65. 2007
    ..CONCLUSION: The development of this assay reflects the potential for automated detection with rapid and reliable assaying and further highlights the diminished number of truly AMA-negative PBC patients...
  69. pmc Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis
    Weici Zhang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 49:545-52. 2009
    ....
  70. pmc Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation
    Zhe Xiong Lian
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 95616, USA
    Dev Immunol 9:35-45. 2002
    ..The decreased frequency of precursor B cells in the Pre-Pro B cell population occurs at the most primitive stage of B cell differentiation...
  71. ncbi request reprint Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis
    Ya Hui Chuang
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis School of Medicine, 95616, USA
    J Autoimmun 26:232-40. 2006
    ..In conclusion, data from this study provide compelling evidence supporting a biologic role of NK cells in the immunopathogenesis of PBC...
  72. pmc Clonality, activated antigen-specific CD8(+) T cells, and development of autoimmune cholangitis in dnTGFβRII mice
    Kazuhito Kawata
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA
    Hepatology 58:1094-104. 2013
    ....
  73. pmc Autophagy: highlighting a novel player in the autoimmunity scenario
    Ana Lleo
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    J Autoimmun 29:61-8. 2007
    ..We review herein the role of autophagy in immune function and its possible contribution to breakdown of tolerance and development of autoimmunity...
  74. ncbi request reprint Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis
    Tin Ky Mao
    Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA 95616, USA
    Hepatology 42:802-8. 2005
    ....
  75. pmc The consequences of apoptosis in autoimmunity
    Ana Lleo
    Division of Rheumatology, University of California, Davis, CA, USA
    J Autoimmun 31:257-62. 2008
    ..We herein review the known mechanisms for regulating the uptake of the products of apoptosis in the development of autoimmunity...
  76. pmc B cell depletion therapy exacerbates murine primary biliary cirrhosis
    Amy Dhirapong
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 53:527-35. 2011
    ..Anti-CD20/CD79-treated mice had increased liver T cell infiltrates and higher levels of proinflammatory cytokines...
  77. ncbi request reprint Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2
    Thomas P Kenny
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
    Exp Biol Med (Maywood) 229:765-71. 2004
    ..If these observations are applicable in vivo, they suggest a beneficial effect for cells overexpressing ErbB2, such as in specific neoplasias..
  78. doi request reprint Definition of human autoimmunity--autoantibodies versus autoimmune disease
    Ana Lleo
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Autoimmun Rev 9:A259-66. 2010
    ..This review discusses the clinical significance of autoantibodies, their pathogenic mechanisms in autoimmune diseases and, finally, illustrates the technology available for appropriate autoantibody detection...

Research Grants2

  1. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  2. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..abstract_text> ..