Genomes and Genes
R M Gemmill
Affiliation: University of Colorado Health Sciences Center
- The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8R M Gemmill
Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 95:9572-7. 1998..By analogy to patched, TRC8 might function as a signaling receptor and other pathway members, to be defined, are mutation candidates in malignant diseases involving the kidney and thyroid...
- RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer geneA Brauweiler
Division of Medical Oncology, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 0511, USA
Oncogene 26:2263-71. 2007..These data suggest that TRC8 modulation of SREBP activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway...
- Altered HOX and WNT7A expression in human lung cancerR Calvo
Division of Medical Oncology, and Department of Pathology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 97:12776-81. 2000..Our results suggest that alterations in regulatory circuits involving HOX, WNT, and possibly fibroblast growth factor pathways occur frequently in lung cancer...
- Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinomaR M Gemmill
Division of Medical Oncology, University of Colorado at Denver and Health Sciences and Cancer Centers, Mail Stop 8117, PO Box 6511, Aurora, CO 80045 0511, USA
Br J Cancer 92:2266-77. 2005..We propose that combined EGFR and mTOR inhibitors may be useful in the subset of RCCs with wt-VHL. However, apparent differences between primary tumours and cell lines require further investigation...
- High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancerR M Bremnes
Department of Pathology, Division of Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA
J Clin Oncol 20:2417-28. 2002..We constructed tissue microarrays (TMAs) to investigate the expression of cadherins and catenins and their prognostic significance in NSCLC...
- DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLCH A Drabkin
Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262, USA
Oncogene 18:2589-97. 1999..They are co-deleted in some lung cancers and immunologically distinct from the Hu proteins...
- Assignment of the human slow twitch skeletal muscle/cardiac troponin C gene (TNNC1) to human chromosome 3p21.3-->3p14.3 using somatic cell hybridsW J Song
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650, USA
Cytogenet Cell Genet 75:36-7. 1996
- Report of the sixth international workshop on human chromosome 3 mapping 1995S L Naylor
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
Cytogenet Cell Genet 72:255-70. 1996
- Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpointF L Boldog
University of Colorado Cancer Center, Division of Medical Oncology, Denver 80262
Proc Natl Acad Sci U S A 90:8509-13. 1993..We have identified a gene, referred to as HRCA1 (hereditary renal cancer associated 1), that maps immediately adjacent to the breakpoint. On the basis of its chromosomal position, HRCA1 may be a candidate tumor suppressor gene...
- Mutations of the beta- and gamma-catenin genes are uncommon in human lung, breast, kidney, cervical and ovarian carcinomasM Ueda
Department of Obstetrics and Gynecology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
Br J Cancer 85:64-8. 2001..These results suggest that beta- and gamma-catenins are infrequent mutational targets during development of human lung, breast, kidney, cervical and ovarian carcinomas...
- Minimal residual disease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sortingM Varella-Garcia
Division of Medical Oncology, University of Colorado Health Sciences and Cancer Centers, Denver 80262, USA
Leukemia 15:1408-14. 2001..Thus, FISH can identify MRD in a majority of t(8;21) patients and, combined with CD34+ selection, may provide an indirect assessment of the differentiation state of residual t(8;21) cells...
- Transcription initiation sites of the leucine operons of Salmonella typhimurium and Escherichia coliR M Gemmill
J Mol Biol 170:39-59. 1983..Under such conditions, about 20% of the total soluble protein of strain CV605 is alpha-isopropylmalate synthase and another 20% is beta-isopropylmalate dehydrogenase (leuB product)...
- Molecular cloning of alpha-amylase genes from Drosophila melanogaster. I. Clone isolation by use of a mouse probeR M Gemmill
Genetics 110:299-312. 1985..No RNA homologous to lambda Dm32 was detected. We suggest that the class B clone, lambda Dm65, contains the functional Amy structural gene(s) and that class A clones contain an amylase pseudogene...
- Report of the Second International Workshop on Human Chromosome 3 mappingR M Gemmill
Eleanor Roosevelt Institute for Cancer Research, Denver, CO 80206
Cytogenet Cell Genet 57:162-6. 1991