Genomes and Genes
B D Gaylinn
Affiliation: University of Virginia
- Growth hormone releasing hormone receptorBruce D Gaylinn
Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Box 801411, Charlottesville, VA 801411, USA
Receptors Channels 8:155-62. 2002..Homology among GHRH-Rs from different species is shown and a map of receptor mutations reported to effect function is presented...
- Molecular and cell biology of the growth hormone-releasing hormone receptorB D Gaylinn
Division of Endocrinology, University of Virginia, Charlottesville 22908, USA
Growth Horm IGF Res 9:37-44. 1999..A better understanding of the GHRH receptor may lead to new therapies for the treatment of GH disorders...
- The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRHB D Gaylinn
Department of Medicine, University of Virginia, Charlottesville 22908, USA
Endocrinology 140:5066-74. 1999....
- Molecular cloning of ovine and bovine growth hormone-releasing hormone receptors: the ovine receptor is C-terminally truncatedR Horikawa
Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Endocrinology 142:2660-8. 2001..This suggests that this C-terminal domain acts to inhibit cAMP signaling possibly through a role in receptor down regulation...
- Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormoneB D Gaylinn
Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908
Mol Endocrinol 7:77-84. 1993..A specific GHRH antagonist blocked both binding and second messenger response. Northern analysis indicated that GHRH-R mRNA was most abundant in extracts of pituitary and was not detected in other tissues...
- Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridizationB D Gaylinn
Department of Internal Medicine, University of Virginia, Charlottesville 22908
Genomics 19:193-5. 1994
- Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous systemD L Rosin
Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
J Comp Neurol 372:135-65. 1996..In general, the pattern of alpha 2C-LI throughout the neuraxis is consistent with previously published reports of the distribution of receptor mRNA detected by hybridization histochemistry...
- Cloning of the chicken pituitary receptor for growth hormone-releasing hormoneAndrew A Toogood
Division of Endocrinology, University of Virginia Health System, Charlottesville, 22903, USA
Endocrinology 147:1838-46. 2006..The chicken GHRH receptor cloned in this study can serve as a tool to identify its ligand and to clarify the evolutionary development of the regulation of GH...
- GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatinIsabel Garcia-Tornadú
Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas CONICET and University of Buenos Aires, V Obligado 2490, 1428 Buenos Aires, Argentina
J Endocrinol 190:611-9. 2006..Our data also reveal that somatotrope cell number is much more sensitive to changes in neonatal GHRH input than their capacity to develop properly regulated GH-secretory function...
- Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistanceJuan Pablo Del Rincon
Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Diabetes 56:1638-46. 2007....
- Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydratesKaren E Foster-Schubert
University of Washington School of Medicine, Seattle, WA 98195, USA
J Clin Endocrinol Metab 93:1971-9. 2008..Its circulating levels increase before meals and are suppressed after food ingestion. Understanding the effects of specific types of ingested macronutrients on ghrelin regulation could facilitate the design of weight-reducing diets...
- Regulation of ghrelin structure and membrane binding by phosphorylationEva Dehlin
Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, United States
Peptides 29:904-11. 2008..These results are consistent with binding of ghrelin and desacylghrelin to acidic lipids via the basic face of an amphipathic helix with Ser-18 phosphorylation disrupting both helical character and membrane binding...
- GROWTH HORMONE RELEASING FACTOR RECEPTORBruce Gaylinn; Fiscal Year: 2001..This suppression will be challenged by either elevating endogenous GHRH with intracerebroventricular injection of GH antagonist or by iv infusion of exogenous GHRH. ..