Richard N Garrison

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Peritoneal resuscitation
    R Neal Garrison
    Department of Surgery, University of Louisville and Veterans Affairs Medical Center, ACB Building, Louisville, KY 40292, USA
    Am J Surg 190:181-5. 2005
  2. pmc Vasoactive components of dialysis solution
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Perit Dial Int 28:283-95. 2008
  3. doi request reprint Direct peritoneal resuscitation augments ileal blood flow in necrotizing enterocolitis via a novel mechanism
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 47:1128-34. 2012
  4. pmc Hypertonic saline resuscitation improves intestinal microcirculation in a rat model of hemorrhagic shock
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA
    Surgery 140:579-87; discussion 587-8. 2006
  5. pmc Chronic infusion of sterile peritoneal dialysis solution abrogates enhanced peritoneal gene expression responses to chronic peritoneal catheter presence
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Adv Perit Dial 24:7-15. 2008
  6. pmc Intraperitoneal resuscitation improves intestinal blood flow following hemorrhagic shock
    El Rasheid Zakaria
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Ann Surg 237:704-11; discussion 711-3. 2003
  7. ncbi request reprint Immune-enhancing diet and cytokine expression during chronic sepsis: an immune-enhancing diet containing L-arginine, fish oil, and RNA fragments promotes intestinal cytokine expression during chronic sepsis in rats
    Ryan T Hurt
    Department of Surgery, University of Louisville, KY 40206, USA
    J Gastrointest Surg 10:46-53. 2006
  8. doi request reprint Obesity, Inflammation, and the Potential Application of Pharmaconutrition
    Matt C Cave
    Departments of Medicine, Physiology and Biophysics, Surgery, and Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky and the Louisville Veterans Affairs Medical Center, Louisville, Kentucky
    Nutr Clin Pract 23:16-34. 2008
  9. pmc Plasma appearance rate of intraperitoneal macromolecular tracer underestimates peritoneal lymph flow
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Adv Perit Dial 24:16-21. 2008
  10. pmc Hemorrhage-induced hepatic injury and hypoperfusion can be prevented by direct peritoneal resuscitation
    Ryan T Hurt
    Department of Internal Medicine, University of Louisville, Louisville, KY 40292, USA
    J Gastrointest Surg 13:587-94. 2009

Research Grants

Detail Information

Publications39

  1. ncbi request reprint Peritoneal resuscitation
    R Neal Garrison
    Department of Surgery, University of Louisville and Veterans Affairs Medical Center, ACB Building, Louisville, KY 40292, USA
    Am J Surg 190:181-5. 2005
    ..This occurs despite restoration of central hemodynamics. We review studies on the use of peritoneal dialysis fluid as an adjunct treatment in amelioration of this gut hypoperfusion...
  2. pmc Vasoactive components of dialysis solution
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Perit Dial Int 28:283-95. 2008
    ..The components causing such vasoactivity are still controversial. This study was conducted to define the vasoactive components of conventional and new PD solutions...
  3. doi request reprint Direct peritoneal resuscitation augments ileal blood flow in necrotizing enterocolitis via a novel mechanism
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 47:1128-34. 2012
    ..We hypothesized that direct peritoneal resuscitation (DPR) dilates the intestinal microvasculature and improves blood flow independent of these mechanisms...
  4. pmc Hypertonic saline resuscitation improves intestinal microcirculation in a rat model of hemorrhagic shock
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA
    Surgery 140:579-87; discussion 587-8. 2006
    ..We propose that intestinal ischemia can be prevented with hypertonic saline resuscitation (HTSR)...
  5. pmc Chronic infusion of sterile peritoneal dialysis solution abrogates enhanced peritoneal gene expression responses to chronic peritoneal catheter presence
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Adv Perit Dial 24:7-15. 2008
    ..Chronic exposure of the nonuremic peritoneum to sterile PD solutions overrides the catheter-related endothelial cell proinflammatory phenotype to restore peritoneal microvascular function...
  6. pmc Intraperitoneal resuscitation improves intestinal blood flow following hemorrhagic shock
    El Rasheid Zakaria
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Ann Surg 237:704-11; discussion 711-3. 2003
    ..To study the effects of peritoneal resuscitation from hemorrhagic shock...
  7. ncbi request reprint Immune-enhancing diet and cytokine expression during chronic sepsis: an immune-enhancing diet containing L-arginine, fish oil, and RNA fragments promotes intestinal cytokine expression during chronic sepsis in rats
    Ryan T Hurt
    Department of Surgery, University of Louisville, KY 40206, USA
    J Gastrointest Surg 10:46-53. 2006
    ....
  8. doi request reprint Obesity, Inflammation, and the Potential Application of Pharmaconutrition
    Matt C Cave
    Departments of Medicine, Physiology and Biophysics, Surgery, and Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky and the Louisville Veterans Affairs Medical Center, Louisville, Kentucky
    Nutr Clin Pract 23:16-34. 2008
    ..A number of dietary agents such as arginine, fish oil, and carnitine may correct these problems at the molecular level. Pharmaconutrition formulas may provide exciting innovations for the nutrition therapy of the obese patient...
  9. pmc Plasma appearance rate of intraperitoneal macromolecular tracer underestimates peritoneal lymph flow
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Adv Perit Dial 24:16-21. 2008
    ....
  10. pmc Hemorrhage-induced hepatic injury and hypoperfusion can be prevented by direct peritoneal resuscitation
    Ryan T Hurt
    Department of Internal Medicine, University of Louisville, Louisville, KY 40292, USA
    J Gastrointest Surg 13:587-94. 2009
    ..We examined HS-mediated hepatic perfusion (galactose clearance), tissue injury (histopathology), and dysfunction (liver enzymes)...
  11. doi request reprint Direct peritoneal resuscitation improves obesity-induced hepatic dysfunction after trauma
    Paul J Matheson
    Robley Rex Veteran s Affairs Medical Center, Louisville, KY, USA
    J Am Coll Surg 214:517-28; discussion 528-30. 2012
    ..We hypothesized that obesity-related liver dysfunction could be mitigated with the novel technique of adjunctive direct peritoneal resuscitation (DPR)...
  12. ncbi request reprint Role of neutrophils on shock/resuscitation-mediated intestinal arteriolar derangements
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Shock 21:248-53. 2004
    ....
  13. ncbi request reprint Direct peritoneal resuscitation as adjunct to conventional resuscitation from hemorrhagic shock: a better outcome
    R Neal Garrison
    Department of Surgery, University of Louisville, KY 40292, USA
    Surgery 136:900-8. 2004
    ..In this study we evaluated the therapeutic potential of DPR on the SIR and fluid sequestration as parameters of treatment outcome...
  14. ncbi request reprint Omega-3 fatty acids in immune-enhancing enteral diets selectively increase blood flow to the ileum by a bile acid dependent mechanism
    Paul J Matheson
    Departments of Surgery, and Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Surgery 132:673-80; discussio 680-1. 2002
    ..We hypothesized that the increase in ileal blood flow with IED might be a result of ileal omega-3 fatty acid absorption in the ileum by a bile-dependent mechanism...
  15. doi request reprint Association Between MC-2 Peptide and Hepatic Perfusion and Liver Injury Following Resuscitated Hemorrhagic Shock
    Paul J Matheson
    Robley Rex Veteran s Affairs Medical Center, Louisville, Kentucky2Department of Surgery, University of Louisville, Louisville, Kentucky3Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky
    JAMA Surg 151:265-72. 2016
    ..Hemorrhagic shock often progresses to multiple organ failure despite conventional resuscitation (CR) that restores central hemodynamics...
  16. pmc Postresuscitation tissue neutrophil infiltration is time-dependent and organ-specific
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    J Surg Res 143:119-25. 2007
    ..The aim of this study is to determine the effect of adjunctive DPR on neutrophil and fluid sequestration...
  17. pmc Cellular edema regulates tissue capillary perfusion after hemorrhage resuscitation
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    Surgery 142:487-96; discussion 496.e1-2. 2007
    ..Ogden, Ut) enhances capillary filling and gut perfusion by mechanisms that are independent of the Na+/H+ function...
  18. doi request reprint Altered intestinal microcirculation is the critical event in the development of necrotizing enterocolitis
    Cynthia D Downard
    Pediatric Surgery, University of Louisville, Louisville, KY 40202, USA
    J Pediatr Surg 46:1023-8. 2011
    ..We hypothesized that vasoconstriction of the neonatal intestinal microvasculature is the essential mechanistic event in NEC and that these microvascular changes correlate with alterations in mediators of inflammation...
  19. pmc Clinical peritoneal dialysis solutions modulate white blood cell-intestinal vascular endothelium interaction
    James E Campbell
    Department of Physiology, University of Louisville, Louisville, KY, USA
    Am J Surg 192:610-6. 2006
    ..We hypothesize that topical application of clinical peritoneal dialysis solutions (PD) modulates such interaction...
  20. pmc Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock
    El Rasheid Zakaria
    Department of Physiology, Health Sciences Center, University of Louisville, Kentucky 40292, USA
    Shock 27:436-42. 2007
    ..Direct peritoneal resuscitation preserves endothelial dilatory functions, thereby overriding any endothelium-derived constrictor response triggered by hemorrhagic shock and CR...
  21. pmc Direct energy delivery improves tissue perfusion after resuscitated shock
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, KY 40292, USA
    Surgery 138:195-203. 2005
    ..We hypothesize that the direct intravenous delivery of lipid-encapsulated high-energy phosphates to cells improves intestinal perfusion during HS and resuscitation (RES)...
  22. ncbi request reprint Immune-enhancing enteral diet increases blood flow and proinflammatory cytokines in the rat ileum
    Paul J Matheson
    Department of Physiology and Biophysics, University of Louisville, 800 Zorn Avenue, Research Building 19, Louisville, KY 40292, USA
    J Surg Res 110:360-70. 2003
    ..We hypothesize that a mechanism for the gut protective effect of IED is augmentation of blood flow to the gut-associated lymphoid tissue (GALT) in the terminal ileum...
  23. ncbi request reprint A novel method of peritoneal resuscitation improves organ perfusion after hemorrhagic shock
    El Rasheid Zakaria
    Department of Surgery, University of Louisville, Louisville, KY, USA
    Am J Surg 186:443-8. 2003
    ..We hypothesize that initiation of DPR simultaneously with resuscitation from hemorrhagic shock enhance organ blood flow to all tissues surrounding the peritoneal cavity as well as distant organs...
  24. ncbi request reprint Adrenomedullin is increased in the portal circulation during chronic sepsis in rats
    Paul J Matheson
    Department of Surgery, University of Louisville, 800 Zorn Avenue, Research Bldg 19, Louisville, KY 40206, USA
    Am J Surg 186:519-25. 2003
    ..We hypothesize that AM expression is increased in acute Escherichia coli bacteremia and chronic E coli-Bacteroides fragilis sepsis...
  25. ncbi request reprint Optimization of donor management goals yields increased organ use
    Glen A Franklin
    Department of Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Am Surg 76:587-94. 2010
    ..Surprisingly, not all standard goals are necessary for optimal organ use. The most significant parameters were the low use of vasopressor agents and oxygenation. Donor management strategies should strive to optimize these goals...
  26. pmc Direct peritoneal resuscitation accelerates primary abdominal wall closure after damage control surgery
    Jason W Smith
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    J Am Coll Surg 210:658-64, 664-7. 2010
    ....
  27. doi request reprint Obesity-induced hepatic hypoperfusion primes for hepatic dysfunction after resuscitated hemorrhagic shock
    Paul J Matheson
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Surgery 146:739-47; discussion 747-8. 2009
    ..We hypothesized that obesity further aggravates liver dysfunction by reduced hepatic perfusion following resuscitated hemorrhagic shock (HEM)...
  28. ncbi request reprint Incremental increases in organ retrieval after protocol driven change in an organ procurement organization: a 15-year assessment
    Glen A Franklin
    Department of Surgery, 2nd Floor ACB, 550 South Jackson Street, University of Louisville, Louisville, KY 40292, USA
    Am Surg 75:537-43; discussion 543-4. 2009
    ..Family support and intensivist programs enhanced CR and OTPD. Increases in the number of ECD were noted with increasing age after the introduction of the intensivist program and an increase in transplant center use of these organs...
  29. doi request reprint Modulation of mesenteric lymph flow and composition by direct peritoneal resuscitation from hemorrhagic shock
    Paul J Matheson
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Arch Surg 144:625-34. 2009
    ..We examined mesenteric lymph flow and proinflammatory constituents to determine whether DPR-stabilized interstitial compartment function could explain improved outcomes...
  30. doi request reprint Enteral glutamine supplementation impairs intestinal blood flow in rats
    Paul J Matheson
    Department of Surgery, University of Louisville, 800 Zorn Ave, Research Building 19, Louisville, KY 40206, USA
    Am J Surg 196:293-9. 2008
    ..Animal studies suggest IED benefits might include augmented gut blood flow. We hypothesized that enteral glutamine supplementation modulates gastrointestinal blood flow...
  31. pmc Disparity in osmolarity-induced vascular reactivity
    El Rasheid Zakaria
    Department of Physiology and Biophysics, Health Sciences Center A 1115, University of Louisville, Louisville, KY 40292, USA
    J Am Soc Nephrol 16:2931-40. 2005
    ....
  32. pmc Hemorrhagic shock and resuscitation-mediated tissue water distribution is normalized by adjunctive peritoneal resuscitation
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
    J Am Coll Surg 206:970-80; discussion 980-3. 2008
    ..Conventional resuscitation (CR) with crystalloid aggravates water sequestration. We examined the compartment pattern of organ tissue water after HS and CR, and modulation of tissue edema by adjunctive DPR...
  33. ncbi request reprint Sepsis alters vessel contraction by adrenoceptor-induced nitric oxide and prostanoid
    Touichi Kawabe
    Department of Physiology and Biophysics, School of Medicine HSC 1115, University of Louisville, Louisville, KY 40292, USA
    J Surg Res 110:352-9. 2003
    ..Our study examined constrictor prostanoid (cPN) and nitric oxide (NO) as secondary factors which could alter alpha-1 adrenoceptor-mediated contraction during sepsis...
  34. ncbi request reprint Immune-enhancing enteral diet selectively augments ileal blood flow in the rat
    Diane Rhoden
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    J Surg Res 106:25-30. 2002
    ..This suggests that a mechanism for the protective effect of IED might be the preferential augmentation of gut blood flow to gut-associated lymphoid tissue (GALT) or mucosa-associated lymphoid tissue (MALT)...
  35. ncbi request reprint Intravital intestinal videomicroscopy: techniques and experiences
    Paul J Matheson
    Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA
    Microsurgery 25:247-57. 2005
    ..e., the endothelial cell. This review focuses on methods and techniques for studying microvascular function, and concludes with focused reviews of pertinent findings...
  36. ncbi request reprint Microvascular responses to adenosine help explain functional and pathologic differences between intestinal segments
    Na Li
    Department of Physiology and Biophysics, University of Louisville, Louisville, KY, USA
    Am J Surg 188:526-31. 2004
    ..This suggests the possibility that Ado-based microvascular control varies between anatomic intestinal segments and microvascular levels in those intestinal segments...
  37. ncbi request reprint Impairment of endothelium-dependent dilation response after resuscitation from hemorrhagic shock involved postreceptor mechanisms
    El Rasheid Zakaria
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Shock 21:175-81. 2004
    ..Cellular mechanisms that participate in or are part of oxygen free radical formation after resuscitation from hemorrhagic shock such as Ca2+ and leukocytes, appear to have a pivotal role in the mechanism of cellular dysfunction...
  38. ncbi request reprint Obesity, inflammation, and the potential application of pharmaconutrition
    Matt C Cave
    Department of Medicine, University of Louisville School of Medicine, 500 S Jackson Street, University of Louisville, Louisville, KY 40292, USA
    Nutr Clin Pract 23:16-34. 2008
    ..A number of dietary agents such as arginine, fish oil, and carnitine may correct these problems at the molecular level. Pharmaconutrition formulas may provide exciting innovations for the nutrition therapy of the obese patient...
  39. pmc Practicing surgeons lead in quality care, safety, and cost control
    Eugene H Shively
    Department of Surgery, University of Louisville School of Medicine and Quality Surgical Solutions, PLLC, Louisville, KY, USA
    Ann Surg 239:752-60; discussion 760-2. 2004
    ..To report the experiences of 66 surgical specialists from 15 different hospitals who performed 43 CPT-based procedures more than 16,000 times...

Research Grants1

  1. Direct Peritoneal Resuscitation from Hypovolemic Shock
    Richard Garrison; Fiscal Year: 2007
    ..abstract_text> ..