Peter Garlick

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint The nature of human hazards associated with excessive intake of amino acids
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 134:1633S-1639S; discussion 1664S-1666S, 1667S-1672S. 2004
  2. ncbi request reprint The role of leucine in the regulation of protein metabolism
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
    J Nutr 135:1553S-6S. 2005
  3. ncbi request reprint Toxicity of methionine in humans
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 136:1722S-1725S. 2006
  4. ncbi request reprint In vivo urea kinetic studies in conscious mice
    Juan C Marini
    Animal Science Department, University of Illinois, Urbana IL, USA
    J Nutr 136:202-6. 2006
  5. ncbi request reprint Reduced ornithine transcarbamylase activity does not impair ureagenesis in Otc(spf-ash) mice
    Juan C Marini
    Animal Science Department, University of Illinois, Urbana, IL 61801, USA
    J Nutr 136:1017-20. 2006
  6. doi request reprint The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats
    Layne E Norton
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 139:1103-9. 2009
  7. ncbi request reprint Protein and amino acid requirements and the composition of complementary foods
    Peter J Reeds
    Department of Animal Sciences, University of Illinois at Urbana Champaign, IL, USA
    J Nutr 133:2953S-61S. 2003
  8. ncbi request reprint Protein requirements of infants and children
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, IL, USA
    Nestle Nutr Workshop Ser Pediatr Program 58:39-47; discussion 47- 50. 2006
  9. ncbi request reprint Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice
    Juan C Marini
    Molecular and Human Genetics and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutr 136:1834-8. 2006
  10. ncbi request reprint Effect of insulin with concurrent amino acid infusion on protein metabolism in rapidly growing pubertal children with type 1 diabetes
    Mushtaq A Godil
    Department of Pediatrics, State University of New York, Stony Brook, NY 11794, USA
    Pediatr Res 58:229-34. 2005

Research Grants

  1. PH CONTROL OF PROTEIN SYNTHESIS
    Peter Garlick; Fiscal Year: 2003

Detail Information

Publications22

  1. ncbi request reprint The nature of human hazards associated with excessive intake of amino acids
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 134:1633S-1639S; discussion 1664S-1666S, 1667S-1672S. 2004
    ..This article is a brief summary of the available evidence regarding the safety of individual amino acids when taken in excess relative to the amounts absorbed from dietary protein...
  2. ncbi request reprint The role of leucine in the regulation of protein metabolism
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
    J Nutr 135:1553S-6S. 2005
    ..It is concluded that the role of leucine in vivo is to provide a signal that amino acids are available, which in combination with the signal of energy availability from insulin, stimulates muscle protein synthesis...
  3. ncbi request reprint Toxicity of methionine in humans
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 136:1722S-1725S. 2006
    ..In infants, methionine intakes of 2-5 times normal resulted in impaired growth and extremely high plasma methionine levels, but no adverse long-term consequences were observed...
  4. ncbi request reprint In vivo urea kinetic studies in conscious mice
    Juan C Marini
    Animal Science Department, University of Illinois, Urbana IL, USA
    J Nutr 136:202-6. 2006
    ..This is especially relevant because mouse targeting technologies will likely facilitate the generation of organ and tissue specific nulls of the various urea cycle enzymes...
  5. ncbi request reprint Reduced ornithine transcarbamylase activity does not impair ureagenesis in Otc(spf-ash) mice
    Juan C Marini
    Animal Science Department, University of Illinois, Urbana, IL 61801, USA
    J Nutr 136:1017-20. 2006
    ..This implies that Otc(spf-ash) mice are able to dispose of ammonia, without apparent adverse effects, when a balance mixture of amino acids is provided, despite reduced enzyme activity...
  6. doi request reprint The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats
    Layne E Norton
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 139:1103-9. 2009
    ..These studies demonstrate that peak activation but not duration of MPS is proportional to the Leu content of a meal...
  7. ncbi request reprint Protein and amino acid requirements and the composition of complementary foods
    Peter J Reeds
    Department of Animal Sciences, University of Illinois at Urbana Champaign, IL, USA
    J Nutr 133:2953S-61S. 2003
    ..The calculations of the dietary requirement for whole protein imply that achieving a minimum protein-energy ratio of 6.3% is desirable. The amount of protein needed from complementary foods for breast-fed children is discussed...
  8. ncbi request reprint Protein requirements of infants and children
    Peter J Garlick
    Department of Animal Sciences, University of Illinois, Urbana, IL, USA
    Nestle Nutr Workshop Ser Pediatr Program 58:39-47; discussion 47- 50. 2006
    ..12 g/kg/day at age 6 months to 0.74 g/kg/day at 10 years, with a small decline towards the adult value thereafter. The corresponding values for the safe level are 1.43 g/kg/day at 6 months and 0.91 g/kg/day at 10 years...
  9. ncbi request reprint Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice
    Juan C Marini
    Molecular and Human Genetics and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutr 136:1834-8. 2006
    ..These data strongly suggest that ornithine has the potential for the biochemical correction of OTCD in Otc(spf-ash) mice...
  10. ncbi request reprint Effect of insulin with concurrent amino acid infusion on protein metabolism in rapidly growing pubertal children with type 1 diabetes
    Mushtaq A Godil
    Department of Pediatrics, State University of New York, Stony Brook, NY 11794, USA
    Pediatr Res 58:229-34. 2005
    ..The data suggest that insulin alone does not increase protein synthesis in pubertal children with type 1 diabetes...
  11. ncbi request reprint Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchanged
    Jonas Nygren
    Centre for Gastrointestinal Disease, Ersta Hospital, Box 4622, Karolinska Institute, 116 91 Stockholm, Sweden
    Clin Sci (Lond) 102:457-64. 2002
    ..The nitrogen retention accompanying GH treatment seems to be due largely to improved nitrogen balance in non-muscle tissue...
  12. ncbi request reprint Aminoacyl-tRNA enrichment after a flood of labeled phenylalanine: insulin effect on muscle protein synthesis
    Giuseppe Caso
    Department of Surgery, State University of New York, Stony Brook, New York 11794 8191, USA
    Am J Physiol Endocrinol Metab 282:E1029-38. 2002
    ..This study confirms that, with a bolus injection of labeled phenylalanine, the enrichment of aminoacyl-tRNA, the true precursor pool for protein synthesis, can be assessed from more readily sampled plasma phenylalanine...
  13. ncbi request reprint Introduction to Protein Summit 2007: exploring the impact of high-quality protein on optimal health
    Nancy R Rodriguez
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269 4017, USA
    Am J Clin Nutr 87:1551S-1553S. 2008
  14. ncbi request reprint Altered protein metabolism following coronary artery bypass graft (CABG) surgery
    Giuseppe Caso
    Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794 8191, USA
    Clin Sci (Lond) 114:339-46. 2008
    ..In conclusion, the results demonstrate that CABG surgery has a profound effect on protein metabolism, with a differential response of protein synthesis in muscle and liver...
  15. ncbi request reprint Skeletal muscle protein synthesis after active or passive ascent to high altitude
    Reinhard Imoberdorf
    Department of Internal Medicine, University of Berne, Inselspital, Berne, Switzerland
    Med Sci Sports Exerc 38:1082-7. 2006
    ..The effects of acute exposure to high altitude on muscle protein synthesis rates in human volunteers were examined after active and passive ascent...
  16. ncbi request reprint Effects on skeletal muscle of intravenous glutamine supplementation to ICU patients
    Inga Tjader
    Department of Anesthesiology and Intensive Care, Clinical Metabolic Research Center, Huddinge University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
    Intensive Care Med 30:266-75. 2004
    ..To evaluate the effect of four doses of intravenous glutamine supplementation on skeletal muscle metabolism...
  17. ncbi request reprint Acute metabolic acidosis inhibits muscle protein synthesis in rats
    Giuseppe Caso
    Dept of Surgery, HSC T19 048, State Univ of New York at Stony Brook, Stony Brook, NY 11794 8191, USA
    Am J Physiol Endocrinol Metab 287:E90-6. 2004
    ..Inhibition of muscle protein synthesis might be another mechanism contributing to the loss of muscle tissue observed in acidosis...
  18. ncbi request reprint The increase in human muscle protein synthesis induced by food intake is similar when assessed with the constant infusion and flooding techniques
    Giuseppe Caso
    Department of Surgery, Stony Brook University, Stony Brook, NY 11794, USA
    J Nutr 136:1504-10. 2006
    ....
  19. ncbi request reprint Tumour cell growth in culture: dependence on arginine
    Giuseppe Caso
    Department of Surgery, State University of New York, Stony Brook, NY 11794 8191, USA
    Clin Sci (Lond) 107:371-9. 2004
    ..Intracellular arginase activity may be the major factor determining the requirement for arginine of all cells in culture...
  20. ncbi request reprint Impact of surgical trauma on human skeletal muscle protein synthesis
    Inga Tjader
    Department of Anaesthesiology and Intensive Care, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Sci (Lond) 107:601-7. 2004
    ..This finding is discussed in relation to confounders, postoperative course and to muscle protein degradation. The shortage of knowledge in this field is emphasized...
  21. ncbi request reprint Control of muscle protein kinetics by acid-base balance
    Giuseppe Caso
    Department of Surgery, State University of New York, Stony Brook, New York, USA
    Curr Opin Clin Nutr Metab Care 8:73-6. 2005
    ..This review aims at outlining the effects of acid-base balance abnormalities on muscle protein metabolism, and will in particular summarize and evaluate the most recent studies on the impact of pH on control of muscle protein metabolism...
  22. ncbi request reprint Response of protein synthesis to hypercapnia in rats: independent effects of acidosis and hypothermia
    Giuseppe Caso
    Department of Surgery, State University of New York, Stony Brook, NY 11794 8191, USA
    Metabolism 54:841-7. 2005
    ....

Research Grants1

  1. PH CONTROL OF PROTEIN SYNTHESIS
    Peter Garlick; Fiscal Year: 2003
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