Gwenn Garden

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death
    Lisa Chakrabarti
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Mol Brain 2:24. 2009
  2. ncbi request reprint Caspase cascades in human immunodeficiency virus-associated neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:4015-24. 2002
  3. ncbi request reprint Microglia biology in health and disease
    Gwenn A Garden
    Department of Neurology and Center for Neurogenetics and Neurotherapeutics, University of Washington, Box 356465, Seattle, WA 98195, USA
    J Neuroimmune Pharmacol 1:127-37. 2006
  4. ncbi request reprint The multiple roles of p53 in the pathogenesis of HIV associated dementia
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, WA, USA
    Biochem Biophys Res Commun 331:799-809. 2005
  5. ncbi request reprint HIV associated neurodegeneration requires p53 in neurons and microglia
    Gwenn A Garden
    Department of Neurology, Box 356465, University of Washington, Seattle, WA 98195, USA
    FASEB J 18:1141-3. 2004
  6. ncbi request reprint Microglia in human immunodeficiency virus-associated neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    Glia 40:240-51. 2002
  7. ncbi request reprint p53-dependent cell death signaling in neurons
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    Neurochem Res 28:15-27. 2003
  8. pmc Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release
    Suman Jayadev
    Department of Neurology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e15743. 2010
  9. ncbi request reprint The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes
    Suman Jayadev
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Neuroimmune Pharmacol 2:359-70. 2007
  10. ncbi request reprint Neuronal survival and cell death signaling pathways
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
    Adv Exp Med Biol 513:41-86. 2002

Research Grants

  1. CASPASE ENZYMES & APOPTOSIS IN HIV INDUCED NEURAL INJURY
    Gwenn Garden; Fiscal Year: 2003
  2. Olympus FV-1000 Confocal Microscope
    Gwenn Garden; Fiscal Year: 2006
  3. Apoptotic Mediators in HIV Associated Dementia
    Gwenn Garden; Fiscal Year: 2006

Collaborators

Detail Information

Publications18

  1. pmc Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death
    Lisa Chakrabarti
    Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
    Mol Brain 2:24. 2009
    ..However, our results support a role for dysregulated autophagy activation in pcd, and suggest that increased or aberrant mitophagy contributes to the Purkinje cell degeneration in pcd mice...
  2. ncbi request reprint Caspase cascades in human immunodeficiency virus-associated neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:4015-24. 2002
    ..These findings suggest that pharmacologic interventions aimed at the caspase enzyme pathways may be beneficial for the prevention or treatment of HAD...
  3. ncbi request reprint Microglia biology in health and disease
    Gwenn A Garden
    Department of Neurology and Center for Neurogenetics and Neurotherapeutics, University of Washington, Box 356465, Seattle, WA 98195, USA
    J Neuroimmune Pharmacol 1:127-37. 2006
    ..In addition, microglia modulate both the activation and down-regulation of the adaptive immune response in the CNS. Evidence that microglia cells play a primary role in regulating CNS immune responses will also be discussed...
  4. ncbi request reprint The multiple roles of p53 in the pathogenesis of HIV associated dementia
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, WA, USA
    Biochem Biophys Res Commun 331:799-809. 2005
    ....
  5. ncbi request reprint HIV associated neurodegeneration requires p53 in neurons and microglia
    Gwenn A Garden
    Department of Neurology, Box 356465, University of Washington, Seattle, WA 98195, USA
    FASEB J 18:1141-3. 2004
    ....
  6. ncbi request reprint Microglia in human immunodeficiency virus-associated neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    Glia 40:240-51. 2002
    ..Several molecular mediators of neuronal injury in HAD that emanate from microglia have been identified, and strategies for altering the impact of these neurotoxins are discussed...
  7. ncbi request reprint p53-dependent cell death signaling in neurons
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    Neurochem Res 28:15-27. 2003
    ....
  8. pmc Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release
    Suman Jayadev
    Department of Neurology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e15743. 2010
    ..We propose PS2 may participate in a negative feedback loop regulating inflammatory behavior in microglia...
  9. ncbi request reprint The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes
    Suman Jayadev
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Neuroimmune Pharmacol 2:359-70. 2007
    ..Activation of p53 mediated pathways in the glia of HAD patients may contribute to the neuroinflammatory processes that promote neurodegeneration by inhibiting glial proliferation and/or promoting glial cell dysfunction...
  10. ncbi request reprint Neuronal survival and cell death signaling pathways
    Richard S Morrison
    Department of Neurological Surgery, University of Washington School of Medicine, Box 356470, Seattle, Washington 98195 6470, USA
    Adv Exp Med Biol 513:41-86. 2002
    ..In this review we examine recent evidence pertaining to the presence and activation of anti- and pro-cell death regulatory pathways in nervous system injury and degeneration...
  11. ncbi request reprint Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis
    Christina Tun
    Department of Neurology, The University of Washington, Seattle, Washington 98195, USA
    J Neurochem 102:1206-19. 2007
    ..These findings suggest that p53 regulates neuronal apoptosis, in part, by suppressing the anti-apoptotic protein XIAP via transcriptional activation of Omi/HtrA2...
  12. pmc Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk
    Jessica E Young
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110, USA
    J Neurosci 29:1987-97. 2009
    ....
  13. pmc Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release
    Heather Klintworth
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195 7234, USA
    Neurosci Lett 462:1-5. 2009
    ....
  14. pmc Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195 7110, USA
    Cerebellum 7:138-49. 2008
    ....
  15. ncbi request reprint Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
    Sara K Custer
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
    Nat Neurosci 9:1302-11. 2006
    ..Our studies indicate that impairment of glutamate transport secondary to glial dysfunction contributes to SCA7 neurodegeneration, and suggest a similar role for glial dysfunction in other polyglutamine diseases and SCAs...
  16. pmc Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders
    Suman Jayadev
    Department of Neurology and Center for Neurogenetics and Neurotherapeutics, University of Washington, Seattle, WA 98195, USA
    J Neuroimmune Pharmacol 4:175-89. 2009
    ....
  17. ncbi request reprint Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice
    Gwenn A Garden
    Department of Neurology, University of Washington Medical Center, Seattle, Washington 98195 7110, USA
    J Neurosci 22:4897-905. 2002
    ..The non-cell-autonomous nature of the Purkinje cell degeneration in our SCA7 mouse model indicates that polyglutamine-induced dysfunction in adjacent or connecting cell types contributes to the neurodegeneration...

Research Grants3

  1. CASPASE ENZYMES & APOPTOSIS IN HIV INDUCED NEURAL INJURY
    Gwenn Garden; Fiscal Year: 2003
    ..abstract_text> ..
  2. Olympus FV-1000 Confocal Microscope
    Gwenn Garden; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  3. Apoptotic Mediators in HIV Associated Dementia
    Gwenn Garden; Fiscal Year: 2006
    ..How p53 may promote neurodegeneration through the modulation of caspase enzyme activity will also be studied. ..