Joe G N Garcia

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression
    Biji Mathew
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 44:415-22. 2011
  2. pmc Plasma and myocardial visfatin expression changes are associated with therapeutic hypothermia protection during murine hemorrhagic shock/resuscitation
    David G Beiser
    Section of Emergency Medicine, University of Chicago, Chicago, IL 60637, USA
    Resuscitation 81:742-8. 2010
  3. pmc Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis
    Tong Zhou
    Institute for Personalized Respiratory Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e44818. 2012
  4. pmc Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome
    Xiaoguang Sun
    Institute for Personalize Respiratory Medicine, Univ of Illinois at Chicago, 3099 COMRB MC719 909 S Wolcott Ave, Chicago, IL 60612
    Am J Physiol Lung Cell Mol Physiol 305:L467-77. 2013
  5. pmc Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury
    Armand Mekontso Dessap
    INSERM, Unité U, Creteil, France
    Am J Respir Cell Mol Biol 46:541-50. 2012
  6. pmc Genomic investigations into acute inflammatory lung injury
    Joe G N Garcia
    University of Illinois, Chicago, IL 60612, USA
    Proc Am Thorac Soc 8:167-72. 2011
  7. pmc Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium
    Peter V Usatyuk
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 287:9360-75. 2012
  8. pmc Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:34964-75. 2009
  9. pmc Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility
    Xiaoguang Sun
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill, USA
    J Allergy Clin Immunol 126:241-9, 249.e1-3. 2010
  10. pmc Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways
    Ting Wang
    Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 42:442-9. 2010

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. pmc Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression
    Biji Mathew
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 44:415-22. 2011
    ..These studies identify the involvement of specific genes and gene networks in RILI pathobiology, and confirm that statins represent a novel strategy to limit RILI...
  2. pmc Plasma and myocardial visfatin expression changes are associated with therapeutic hypothermia protection during murine hemorrhagic shock/resuscitation
    David G Beiser
    Section of Emergency Medicine, University of Chicago, Chicago, IL 60637, USA
    Resuscitation 81:742-8. 2010
    ..We developed a mouse model of HS to study the effect of therapeutic hypothermia (TH) on hemodynamic outcomes and associated plasma and tissue visfatin content...
  3. pmc Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis
    Tong Zhou
    Institute for Personalized Respiratory Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 7:e44818. 2012
    ..In summary, this validated peripheral blood molecular gene signature appears to be a valuable biomarker in identifying cases with sarcoidoisis and predicting risk for complicated sarcoidosis...
  4. pmc Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome
    Xiaoguang Sun
    Institute for Personalize Respiratory Medicine, Univ of Illinois at Chicago, 3099 COMRB MC719 909 S Wolcott Ave, Chicago, IL 60612
    Am J Physiol Lung Cell Mol Physiol 305:L467-77. 2013
    ..These highly functional studies support S1PR3 as a novel ARDS candidate gene and a potential target for individualized therapy...
  5. pmc Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury
    Armand Mekontso Dessap
    INSERM, Unité U, Creteil, France
    Am J Respir Cell Mol Biol 46:541-50. 2012
    ..These novel insights should be integrated into the clinical assessment of the risk/benefit of recruitment maneuver strategies...
  6. pmc Genomic investigations into acute inflammatory lung injury
    Joe G N Garcia
    University of Illinois, Chicago, IL 60612, USA
    Proc Am Thorac Soc 8:167-72. 2011
    ....
  7. pmc Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium
    Peter V Usatyuk
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 287:9360-75. 2012
    ..These results suggest a novel role for nmMLCK in hyperoxia-induced recruitment of cytoskeletal proteins and NADPH oxidase components to CEM, ROS production, and lung injury...
  8. pmc Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:34964-75. 2009
    ..These results suggest that hyperoxia induces c-Abl-mediated dynamin 2 phosphorylation required for recruitment of p47(phox) to CEMs and subsequent ROS production in lung endothelium...
  9. pmc Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility
    Xiaoguang Sun
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill, USA
    J Allergy Clin Immunol 126:241-9, 249.e1-3. 2010
    ..Increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (S1PR1) is an essential participant regulating lung vascular integrity and responses to lung inflammation...
  10. pmc Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways
    Ting Wang
    Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 42:442-9. 2010
    ..These findings support a novel mechanism for PM-induced lung dysfunction and adverse cardiopulmonary outcomes...
  11. pmc Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells
    Peter V Usatyuk
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:15339-52. 2009
    ..These results demonstrate a role of PLD in hyperoxia-mediated IQGAP1 activation through Rac1 in tyrosine phosphorylation of Src and cortactin, as well as in p47(phox) translocation and ROS formation in human lung endothelial cells...
  12. pmc Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement
    Djanybek M Adyshev
    Institute for Personalized Respiratory Medicine, Department of Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cell Signal 23:2086-96. 2011
    ..These results suggest that ERM activation is an important regulatory event in EC barrier responses to S1P...
  13. pmc Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity
    Yulia Ephstein
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 288:2191-200. 2013
    ..These results support a critical role for S1PR1 and ITGB4 transactivation as rate-limiting events in the transduction of HGF signals via a dynamic c-Met complex resulting in enhanced EC barrier integrity...
  14. pmc Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function
    Steven M Dudek
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Biol Cell 21:4042-56. 2010
    ....
  15. pmc Ezrin/radixin/moesin proteins differentially regulate endothelial hyperpermeability after thrombin
    Djanybek M Adyshev
    Institute for Personalized Respiratory Medicine, Department of Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, COMRB 3154, MC 719, 909 S Wolcott Ave, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 305:L240-55. 2013
    ..These data suggest that ERM proteins play important differential roles in the thrombin-induced modulation of EC permeability, with moesin promoting barrier dysfunction and radixin opposing it. ..
  16. pmc High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness
    Patrick A Singleton
    Dept of Medicine, Univ of Chicago, MC 6076, I 503C, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 299:L639-51. 2010
    ..These data suggest that HMW-HA, via CD44-mediated CEM signaling events, represents a potentially useful therapeutic agent for syndromes of increased vascular permeability...
  17. pmc Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury
    Xiaoguang Sun
    Institute for Personalized Respiratory Medicine, College of Medicine, University of Illinois at Chicago, 914 South Wood St, MC 719, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 47:628-36. 2012
    ..These results suggest that microparticles containing nitrated S1PR3 shed into the circulation during inflammatory lung states, and represent a novel ALI biomarker linked to disease severity and outcome...
  18. pmc Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation
    Ting Wang
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Part Fibre Toxicol 9:35. 2012
    ..The mechanism of PM-mediated pathophysiology remains unknown. However, PM is proinflammatory to the endothelium and increases vascular permeability in vitro and in vivo via ROS generation...
  19. pmc Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids
    Patrick A Singleton
    Department of Medicine, Division of Biomedical Sciences, Section of Pulmonary and Critical Medicine, University of Chicago, Ill 60637, USA
    Circ Res 104:978-86. 2009
    ..Taken together, these results suggest Akt-dependent transactivation of S1P(1) within CEMs is important for OxPAPC-mediated cortical actin rearrangement and EC barrier protection...
  20. pmc Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury
    Viswanathan Natarajan
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Am J Respir Cell Mol Biol 49:6-17. 2013
    ....
  21. pmc A common cortactin gene variation confers differential susceptibility to severe asthma
    Shwu Fan Ma
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Genet Epidemiol 32:757-66. 2008
    ....
  22. pmc Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium
    Mary Brown
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Microvasc Res 80:75-88. 2010
    ....
  23. pmc Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways
    Peter V Usatyuk
    Department of Pharmacology, University of Illinois at Chicago, 60612, USA
    Am J Physiol Lung Cell Mol Physiol 300:L840-50. 2011
    ..These results provide evidence that intracellular S1P modulates signal transduction in lung ECs via signaling pathway(s) independent of S1P receptors...
  24. pmc Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs
    Biji Mathew
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    FASEB J 25:3388-400. 2011
    ..1 and 1 mg/kg i.p., 2×/wk) and to a lesser degree by SEW-2871 (1 mg/kg i.p., 2×/wk), compared with those in controls. These results support the targeting of S1P signaling as a novel therapeutic strategy in RILI...
  25. pmc Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury
    Tamara Mirzapoiazova
    Institute for Personalized and Respiratory Medicine, Department of Medicine, University of Illinois at Chicago, 1705 Polk 305, Chicago, IL 60612, USA
    Am J Respir Cell Mol Biol 44:40-52. 2011
    ..These studies validate nmMLCK as an attractive target for ameliorating the adverse effects of dysregulated lung inflammation...
  26. pmc Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation
    Ting Wang
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Respir Cell Mol Biol 47:491-6. 2012
    ..These data suggest a potentially protective role for H(2)S in PM-induced inflammatory lung injury and vascular hyperpermeability...
  27. pmc FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells
    Evgeny V Berdyshev
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:5467-77. 2009
    ..These findings open a novel direction for therapeutic applications of FTY720 that focuses on inhibition of ceramide biosynthesis, ceramide-dependent signaling, and the up-regulation of DHS1P generation in cells...
  28. pmc Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction
    Peter V Usatyuk
    Institute for Personalized Respiratory Medicine, University of Illinois, Chicago, Illinois, United States of America
    PLoS ONE 8:e63007. 2013
    ..These results demonstrate that S1P activation of PLD2, PKC and Rac1 is part of the signaling cascade that regulates coronin 1B translocation to the cell periphery and the ensuing cell chemotaxis...
  29. ncbi request reprint Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement
    Irina A Kolosova
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 97:115-24. 2005
    ..We conclude that the mechanisms of ATP-induced barrier enhancement are independent of intracellular Ca2+, but involve activation of myosin phosphatase via a novel G-protein-coupled mechanism and PKA...
  30. ncbi request reprint Endothelial cell myosin light chain kinase (MLCK) regulates TNFalpha-induced NFkappaB activity
    Raj Wadgaonkar
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Cell Biochem 94:351-64. 2005
    ..Together, these novel observations indicate that TNFalpha-induced cytoskeletal rearrangement driven by MLCK activity is necessary for TNFalpha-dependent NFkappaB activation and amplification of pro-survival signals...
  31. pmc Differential regulation of sphingosine kinases 1 and 2 in lung injury
    Raj Wadgaonkar
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Am J Physiol Lung Cell Mol Physiol 296:L603-13. 2009
    ..Collectively, our results for the first time demonstrate distinct functional roles of the two SphK isoforms in the regulation of LPS-induced lung injury...
  32. pmc FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury
    Lichun Wang
    1Institute for Personalized Respiratory Medicine, Department of Medicine, University of Illinois, Chicago, IL 2Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY
    Crit Care Med 42:e189-99. 2014
    ..The objective of this study is to characterize the effects of FTY720 (S)-phosphonate, a novel analog of FTY720-phosphate, on variables of pulmonary vascular permeability in vitro and alveolar-capillary permeability in vivo...
  33. pmc Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1
    Irina Gorshkova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:11794-806. 2008
    ..Activation of this pathway is necessary to stimulate the migration of lung endothelial cells, a key component of the angiogenic process...
  34. ncbi request reprint Protective effect of purinergic agonist ATPgammaS against acute lung injury
    Irina A Kolosova
    Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Am J Physiol Lung Cell Mol Physiol 294:L319-24. 2008
    ..These findings suggest that purinergic receptor stimulation exerts a protective role against ALI by preserving integrity of endothelial cell-cell junctions...
  35. pmc Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses
    Weiguo Chen
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biochem 110:718-24. 2010
    ..Upregulation of integrin beta4 may represent an important element of the anti-inflammatory and vascular-protective properties of statins and provides a novel strategy to limit inflammatory vascular syndromes...
  36. ncbi request reprint Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 36:2794-800. 2008
    ..We tested the association of MYLK gene variation in the development of acute lung injury in major trauma patients...
  37. pmc Endothelial permeability is controlled by spatially defined cytoskeletal mechanics: atomic force microscopy force mapping of pulmonary endothelial monolayer
    Anna A Birukova
    Division of Biomedical Sciences, Department of Medicine, Section of Pulmonary and Critical Care Medicine University of Chicago, Chicago, Illinois 60637, USA
    Nanomedicine 5:30-41. 2009
    ..Attenuation of thrombin-induced permeability correlates well with stiffness changes from the cell center to periphery. These results directly link for the first time the patterns of cell stiffness with specific EC permeability responses...
  38. pmc A sphingosine 1-phosphate 1 receptor agonist modulates brain death-induced neurogenic pulmonary injury
    Saad Sammani
    Section of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, 60612, USA
    Am J Respir Cell Mol Biol 45:1022-7. 2011
    ..We conclude that SEW-2871 significantly attenuates BD-induced lung injury, and may serve as a potential candidate to improve human donor availability...
  39. pmc Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung
    Saad Sammani
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 43:394-402. 2010
    ....
  40. pmc Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury
    Sang Bum Hong
    Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
    Am J Respir Crit Care Med 178:605-17. 2008
    ..We previously demonstrated pre-B-cell colony enhancing factor (PBEF) as a biomarker in sepsis and sepsis-induced acute lung injury (ALI) with genetic variants conferring ALI susceptibility...
  41. pmc Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement
    Eddie T Chiang
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, MC 6092 Chicago, IL 60637 1470, USA
    Microvasc Res 77:174-86. 2009
    ..In summary, PEG joins a number of EC barrier-regulatory agents which rapidly activate barrier-enhancing signal transduction pathways which target the cytoskeleton and provides a potential therapeutic strategy in inflammatory lung injury...
  42. pmc HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption
    Rachel K Wolfson
    University of Chicago, Department of Pediatrics, IL, USA
    Microvasc Res 81:189-97. 2011
    ..These studies add to the understanding of HMGB1-induced inflammatory events and vascular barrier disruption and offer the potential for clinical intervention in sepsis-induced ALI...
  43. pmc Type 2 deiodinase and host responses of sepsis and acute lung injury
    Shwu Fan Ma
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Illinois 60612 7227, USA
    Am J Respir Cell Mol Biol 45:1203-11. 2011
    ..Increased DIO2 expression may dampen the ALI inflammatory response, thereby strengthening the premise that thyroid hormone metabolism is intimately linked to the integrated response to inflammatory injury in critically ill patients...
  44. pmc Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement
    Jing Zhao
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, United States
    Cell Signal 21:1945-60. 2009
    ..These results suggest that S1P induces both the tyrosine phosphorylation and recruitment of key actin cytoskeletal proteins to membrane rafts, resulting in enhanced human EC barrier function...
  45. pmc Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression
    Yutong Zhao
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 45:426-35. 2011
    ..These results identify a novel role for intracellularly generated S1P in protection against ALI and suggest S1PL as a potential therapeutic target...
  46. ncbi request reprint Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
    Rhett Cummings
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 279:41085-94. 2004
    ..These results demonstrate for the first time that LPA is a potent stimulator of IL-8 production in HBEpCs, which involves PKCdelta/NF-kappaB signaling pathways...
  47. ncbi request reprint CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:30643-57. 2007
    ..Taken together, these results suggest that CD44 is an important regulator of HGF/c-Met-mediated in vitro and in vivo barrier enhancement, a process with essential involvement of Tiam1, Rac1, dynamin 2, and cortactin...
  48. pmc Role of growth arrest and DNA damage-inducible α in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury
    Sumegha Mitra
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, 60612, USA
    Am J Respir Crit Care Med 184:1030-40. 2011
    ..However, the functional role of GADD45a in the pathogenesis of VILI is unknown...
  49. pmc Receptor tyrosine kinase inhibitors in rodent pulmonary hypertension
    Liliana Moreno-Vinasco
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL, 60637, USA
    Adv Exp Med Biol 661:419-34. 2010
    ..Our studies suggest the PKI sorafenib as a potentially novel treatment for severe PH with the MAPK cascade a potential canonical target profoundly effecting vascular cytoskeletal -rearrangements and remodeling1...
  50. pmc Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter
    Srikanth Pendyala
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Free Radic Biol Med 50:1749-59. 2011
    ..Collectively, these results demonstrate, for the first time, a novel role for Nrf2 in regulating hyperoxia-induced Nox4 transcription via AREs in lung endothelium...
  51. pmc MicroRNA regulation of nonmuscle myosin light chain kinase expression in human lung endothelium
    Djanybek M Adyshev
    Institute for Personalized Respiratory Medicine, Department of Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Respir Cell Mol Biol 49:58-66. 2013
    ....
  52. ncbi request reprint Role of CPI-17 in the regulation of endothelial cytoskeleton
    Irina A Kolosova
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 287:L970-80. 2004
    ..Together these data suggest the potential importance of PKC/CPI-17-mediated pathway in histamine-triggered cytoskeletal rearrangements leading to lung microvascular barrier compromise...
  53. ncbi request reprint The role of caldesmon in the regulation of endothelial cytoskeleton and migration
    Tamara Mirzapoiazova
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Cell Physiol 203:520-8. 2005
    ..These results suggest that CaD is critically involved in the regulation of the actin cytoskeleton and migration in EC, and that p38 MAPK-mediated CaD phosphorylation may be involved in endothelial cytoskeletal remodeling...
  54. pmc Alternative promoter and GATA5 transcripts in mouse
    Bohao Chen
    Departments of Medicine, Univ of Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1214-22. 2009
    ..These findings extend current understanding of the tissue distribution of GATA5 expression and suggests that GATA5 expression and function are more complex than previously appreciated...
  55. pmc Critical role for integrin-β4 in the attenuation of murine acute lung injury by simvastatin
    Weiguo Chen
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 303:L279-85. 2012
    ..These findings support integrin-β4 as an important mediator of ALI protection by simvastatin and implicate signaling by integrin-β4 as a novel therapeutic target in patients with ALI...
  56. doi request reprint An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform
    Yoo Jeong Han
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Mol Med (Berl) 90:299-308. 2012
    ....
  57. pmc Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase
    Evgeny V Berdyshev
    Department of Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e16571. 2011
    ..As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility...
  58. pmc Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium
    Djanybek M Adyshev
    Institute for Personalized Respiratory Medicine, Department of Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, Illinois
    Am J Respir Cell Mol Biol 50:409-18. 2014
    ..e., excessive mechanical stress, LPS) involves epigenetic regulation with hsa-miR-374a and hsa-miR-568, representing novel therapeutic strategies to reduce inflammatory lung injury. ..
  59. pmc Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity
    Nurbek Mambetsariev
    Department of Medicine, University of Chicago, CIS Bldg W403E, Chicago, IL 60637, USA
    Arterioscler Thromb Vasc Biol 30:483-90. 2010
    ..We evaluated the role of the extracellular serine protease, hyaluronic acid binding protein 2 (HABP2), in vascular barrier regulation...
  60. ncbi request reprint Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium
    Raj Wadgaonkar
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Cell Biochem 95:849-58. 2005
    ..Together these studies suggest that the novel interaction between MIF and MLCK may have important implications for the regulation of both non-muscle cytoskeletal dynamics as well as pathobiologic vascular events that involve MLCK...
  61. pmc Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury
    Carolyn S Calfee
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143 0111, USA
    Crit Care Med 39:711-7. 2011
    ....
  62. pmc Role of type 2 deiodinase in response to acute lung injury (ALI) in mice
    Olga Barca-Mayo
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 108:E1321-9. 2011
    ..We conclude that TH metabolism in the lung is linked to the response to inflammatory injury and speculate that D2 exerts its protective effect by making more TH available to the injured lung tissue...
  63. pmc Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension
    Liliana Moreno-Vinasco
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Physiol Genomics 33:278-91. 2008
    ..In summary, sorafenib represents a novel potential treatment for severe PH with the MAPK cascade a potential canonical target...
  64. doi request reprint IL6 gene-wide haplotype is associated with susceptibility to acute lung injury
    Carlos Flores
    Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Ill 60637, USA
    Transl Res 152:11-7. 2008
    ..These data support the association of the IL6 gene with ALI susceptibility and illustrate the value of haplotype analysis as a robust approach for evaluating IL6 gene effects in association studies...
  65. pmc A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age
    Jaideep Moitra
    Department of Medicine, University of Chicago, Chicago, IL 60637 1470, USA
    Transl Res 151:141-53. 2008
    ..These data reveal that nmMLCK2 overexpression in the endothelium exacerbates lung injury in vivo in a sexually dimorphic and age-dependent manner...
  66. ncbi request reprint Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation
    Patrick A Singleton
    Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 37:222-31. 2007
    ..These results indicate that MNTX provides barrier protection against edemagenic agonists via inhibition of S1P(3) receptor activation and represents a potentially useful therapeutic agent for syndromes of increased vascular permeability...
  67. pmc Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease
    Xu Zhang
    Comprehensive Sickle Cell Center, Section of Hematology Oncology X Z, S S, V R G, Section of Cardiology A A D, and Section of Pulmonary, Critical Care, and Sleep Medicine J G N G, R F M, Department of Medicine, Institute of Human Genetics W Z, R K, Department of Pediatrics W Z, and Institute for Personalized Respiratory Medicine A A D, T A, N G C, J G N G, R F M, University of Illinois at Chicago, Chicago, IL Section of Pulmonary Critical Care, Department of Medicine, University of Chicago, Chicago, IL S F M Chuvash Republic Clinical Hospital 2, Cheboksary, Russia G M Cheboksary Children s Hospital, Cheboksary, Russia A S Center for Sickle Cell Disease, Howard University, Washington, DC T A, M X, S N Department of Medicine, Boston University School of Medicine, Boston, MA M H S, C T B Department of Biostatistics, Chile
    Circulation 129:1650-8. 2014
    ..We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality...
  68. doi request reprint Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels
    Ting Wang
    Section of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 46:524-31. 2012
    ..Our results suggest a multiorgan pathobiology inherent to the CHF phenotype that is exaggerated by PM exposure via heightened carotid body sensitivity and cardiac Na(+) channel dysfunction...
  69. pmc Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins
    Srikanth Pendyala
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:841-60. 2009
    ..Future studies on temporal and spatial localization of Nox isoforms will provide new insights into the role of NADPH oxidase-derived ROS in the pathobiology of lung diseases...
  70. pmc Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition
    Weiguo Chen
    Sect of Pulmonary and Critical Care Medicine, Pritzker School of Medicine, Univ of Chicago, Chicago, IL 60637
    Am J Physiol Lung Cell Mol Physiol 295:L575-83. 2008
    ....
  71. pmc Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin
    Fernando Teran Arce
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Biophys J 95:886-94. 2008
    ....
  72. pmc Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis
    Long Shuang Huang
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612 7343, USA
    FASEB J 27:1749-60. 2013
    ..Taken together, these data indicate that SphK1 plays a critical role in the pathology of lung fibrosis and is a novel therapeutic target...
  73. pmc Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model
    Jiwang Chen
    Department of Medicine, Northwestern University, Chicago, Illinois, USA
    PLoS ONE 8:e70176. 2013
    ..Furthermore, at day 3 lungs displayed significantly lower levels of vascular permeability to albumin, compared to day 1. Collectively, this data helps us elucidate the molecular mechanisms of the recovery after MRSA lung infection. ..
  74. pmc Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin
    Weiguo Chen
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, Illinois
    Am J Respir Cell Mol Biol 50:328-36. 2014
    ..These findings implicate a distinct mechanism underlying size-selective endothelial barrier-protective properties of statins, and may ultimately lead to new novel therapeutic targets for patients with acute lung injury. ..
  75. ncbi request reprint Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin
    Peter V Usatyuk
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:23284-95. 2007
    ..These data demonstrate a novel function for cortactin and actin in hyperoxia-induced activation of NADPH oxidase and ROS generation in human lung endothelial cells...
  76. doi request reprint Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells
    Yutong Zhao
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 40:19-30. 2009
    ..In addition, inhibition of COX-2 partly attenuated PM-induced Prostaglandin E2 and IL-6 release...
  77. pmc Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement
    Xiaoguang Sun
    Department of Medicine, Division of Biological Sciences, The University of Chicago, 5841 Maryland Ave, Chicago, IL 60637 1470, USA
    Microvasc Res 77:304-13. 2009
    ..These results demonstrate a mechanism of S1P-induced endothelial barrier enhancement via beta-catenin-linked adherens junction and focal adhesion interaction...
  78. pmc Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation
    Biji Mathew
    Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, IL 60612 7227, USA
    Am J Respir Cell Mol Biol 49:269-78. 2013
    ..These findings implicate an important role for MIF in radiation-induced changes in lung-cell antioxidant concentrations via Nrf2, and suggest that MIF may contribute to age-related susceptibility to thoracic radiation. ..
  79. doi request reprint Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor-induced angiogenesis
    Patrick A Singleton
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Mol Cancer Ther 7:1669-79. 2008
    ..Therefore, addition of MNTX could potentially lower the therapeutic doses of 5-FU and bevacizumab, which could improve index...
  80. doi request reprint Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy
    Long Shuang Huang
    Department of Pharmacology, The University of Illinois, Chicago, Illinois, USA
    Thorax 70:1138-48. 2015
    ..Idiopathic pulmonary fibrosis (IPF) is characterised by accumulation of fibroblasts and myofibroblasts and deposition of extracellular matrix proteins. Sphingosine-1-phosphate (S1P) signalling plays a critical role in pulmonary fibrosis...
  81. ncbi request reprint Transactivation of sphingosine 1-phosphate receptors is essential for vascular barrier regulation. Novel role for hyaluronan and CD44 receptor family
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 281:34381-93. 2006
    ..In summary, HA regulates EC barrier function through novel differential CD44 isoform interaction with S1P receptors, S1P receptor transactivation, and RhoA/Rac1 signaling to the EC cytoskeleton...
  82. pmc GADD45a promoter regulation by a functional genetic variant associated with acute lung injury
    Sumegha Mitra
    Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 9:e100169. 2014
    ..The regulation of GADD45a expression by mechanical stress and its relationship with acute lung injury (ALI) susceptibility and severity, however, remains unknown...
  83. ncbi request reprint Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation
    Shui Q Ye
    Department of Medicine, Section of Pulmonary Critical Care, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, MC 6076, Chicago, IL 60637, USA
    Microvasc Res 70:142-51. 2005
    ..Ongoing studies will continue to address the molecular mechanisms by which PBEF contributes to ALI susceptibility...
  84. ncbi request reprint Re-evaluation of Evans Blue dye as a marker of albumin clearance in murine models of acute lung injury
    Jaideep Moitra
    Department of Medicine, University of Chicago, Chicago, IL 60637 1470, USA
    Transl Res 150:253-65. 2007
    ..This factor may be of significant utility in animal models of inflammatory injury...
  85. pmc GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling
    Nuala J Meyer
    Department of Medicine, W604, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Ave, W604 Chicago, IL 60637, USA
    FASEB J 23:1325-37. 2009
    ..These studies validate GADD45a as a novel candidate gene in inflammatory lung injury and a significant participant in vascular barrier regulation via effects on Akt-mediated endothelial signaling...
  86. pmc c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury
    Panfeng Fu
    Department of Pharmacology, University of Illinois, Chicago, Illinois
    Am J Physiol Lung Cell Mol Physiol 308:L1025-38. 2015
    ..Together, these results suggest that c-Abl mediated tyrosine phosphorylation of paxillin at Y31 and Y118 regulates LPS-mediated pulmonary vascular permeability and injury. ..
  87. ncbi request reprint A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans
    Carlos Flores
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Genet Epidemiol 31:296-305. 2007
    ..This finding also offers a possible genetic explanation for some of the more severe asthma phenotype observed in African American asthmatics...
  88. pmc Ethnic differences and functional analysis of MET mutations in lung cancer
    Soundararajan Krishnaswamy
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Clin Cancer Res 15:5714-23. 2009
    ....
  89. pmc Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1
    Yutong Zhao
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 282:14165-77. 2007
    ..This involves the conversion of extracellular S1P to Sph by LPP-1, which facilitates Sph uptake, followed by the intracellular conversion of Sph to S1P by SphK1...
  90. ncbi request reprint Role of protein phosphatase 2A in the regulation of endothelial cell cytoskeleton structure
    Krisztina Tar
    Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, Illinois, USA
    J Cell Biochem 98:931-53. 2006
    ..PP2A-mediated dephosphorylation of HSP27 and tau correlated with PP2A-induced preservation of EC cytoskeleton and barrier maintenance. Collectively, our observations clearly demonstrate the crucial role of PP2A in EC barrier protection...
  91. pmc The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation
    Biji Mathew
    University of Chicago, Chicago, Illinois, USA
    Anesth Analg 112:558-67. 2011
    ..In this study, we identify a possible mechanism for these epidemiologic findings on the basis of μ opioid receptor (MOR) regulation of Lewis lung carcinoma (LLC) tumorigenicity in cell and animal models...
  92. pmc A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease
    Ankit A Desai
    Institute for Personalized Respiratory Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Respir Crit Care Med 186:359-68. 2012
    ..An increased tricuspid regurgitation jet velocity (TRV > 2.5 m/s) and pulmonary hypertension defined by right heart catheterization both independently confer increased mortality in sickle cell disease (SCD)...
  93. pmc Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness
    Ting Wang
    Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois, USA
    Environ Health Perspect 116:1500-8. 2008
    ..Epidemiologic studies have demonstrated that exposures to environmental factors such as ambient particulate matter (PM), a major air pollutant, contribute to increased asthma prevalence and exacerbations...
  94. pmc TGFβ signaling induces expression of Gadd45b in retinal ganglion cells
    Bin Liu
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois Hospitals and Health Sciences System, 1855 West Taylor Street, MC 648, Chicago, IL 60612, USA
    Invest Ophthalmol Vis Sci 54:1061-9. 2013
    ..This study was performed to elucidate further the induction pathway of Gadd45b expression in RGCs...
  95. pmc Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics
    Patrick Belvitch
    Division of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois Hospital and Health Science System, Chicago, IL, USA
    Microvasc Res 95:94-102. 2014
    ..the wild-type nmMLCK construct. These results provide evidence that critical prolines within nmMLCK (amino acids 973, 976, 1019, 1022) regulate cytoskeletal and membrane events associated with pulmonary endothelial barrier function. ..
  96. pmc Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression
    Irina Gorshkova
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Lipid Res 53:1553-68. 2012
    ..These data demonstrate a novel role for SPT in regulating TGF-β signaling and fibrogenesis that is linked to the regulation of SphK1 expression and S1P-DHS1P formation...
  97. pmc Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch
    Anna A Birukova
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Pathol 168:1749-61. 2006
    ..These results suggest a critical role for the CS amplitude and the balance between Rac and Rho in mechanochemical regulation of lung EC barrier...
  98. ncbi request reprint Caldesmon is a cytoskeletal target for PKC in endothelium
    Natalia V Bogatcheva
    Department of Medicine, Section of Pulmonary and Critical Care, The University of Chicago Center for Integrative Science, 929 E 57th Street, Chicago, IL 60637, USA
    J Cell Biochem 99:1593-605. 2006
    ..Our results suggest that PKC-dependent phosphorylation of caldesmon is involved in PMA-mediated complex cytoskeletal changes leading to the EC barrier compromise...
  99. pmc C5a alters blood-brain barrier integrity in experimental lupus
    Alexander Jacob
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    FASEB J 24:1682-8. 2010
    ..For the first time, a novel role of C5a in the maintenance of BBB integrity is identified and the potential of C5a/C5aR blockade highlighted as a promising therapeutic strategy in SLE and other neurodegenerative diseases...
  100. pmc Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry
    Nadera J Sweiss
    Section of Rheumatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e29126. 2011
    ..We investigated serum levels of these cytokines in a large multi-ancestral sarcoidosis population to determine correlations between cytokine levels and disease phenotypes...
  101. ncbi request reprint Wading into the genomic pool to unravel acute lung injury genetics
    Nuala J Meyer
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Proc Am Thorac Soc 4:69-76. 2007
    ....