Jian Gao

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Direct observation of enantioselective synergism at trimetallic centers
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Org Lett 6:2453-5. 2004
  2. ncbi request reprint Novel chiral "calixsalen" macrocycle and chiral robson-type macrocyclic complexes
    Jian Gao
    Department of Radiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Inorg Chem 44:232-41. 2005
  3. ncbi request reprint In vitro anticancer activities and optical imaging of novel intercalative non-cisplatin conjugates
    Jian Gao
    Department of Radiology, School of Medicine, University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    J Med Chem 48:7192-7. 2005
  4. doi request reprint Cytotoxic activities, cellular uptake, gene regulation, and optical imaging of novel platinum(II) complexes
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Chem Res Toxicol 22:1705-12. 2009
  5. doi request reprint Herceptin-platinum(II) binding complexes: novel cancer-cell-specific agents
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, TX 77843 3255, USA
    ChemMedChem 3:954-62. 2008
  6. ncbi request reprint Artificial zinc(II) complexes regulate cell cycle and apoptosis-related genes in tumor cell lines
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Chembiochem 8:332-40. 2007
  7. ncbi request reprint Chiral salicyl diamines: potent anticancer molecules
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, TX 77843 3255, USA
    ChemMedChem 2:1723-9. 2007
  8. ncbi request reprint Synthesis and DNA binding properties of a cationic 2,2':6',2"-terpyridine cobalt(II) complex containing an oligopeptide
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, TX 77842 3012, USA
    J Inorg Biochem 94:272-8. 2003
  9. ncbi request reprint Selective recognition of thymidylylthymidine (TpT) and antitumor effects of a macrocyclic dizinc(II) complex
    Jian Gao
    Department of Chemistry Texas A and M University, College Station, TX 77842 3012, USA
    Org Biomol Chem 1:4242-7. 2003
  10. ncbi request reprint Catalytic asymmetric cyclopropanation at a chiral platform
    Jian Gao
    Department of Radiology, University of Texas Health Science Center San Antonio, Texas 78229 3900, USA
    Org Biomol Chem 3:2126-8. 2005

Collaborators

  • Yikang Wu
  • Sophie Chen
  • Zhi Bin Zhen
  • Zbigniew Darzynkiewicz
  • H Dorota Halicka
  • Frank Traganos
  • Cheng Gang Jiang
  • Tao Wu
  • Hui Mian Xu
  • Fu Rong Liu
  • Xuan Huang

Detail Information

Publications15

  1. ncbi request reprint Direct observation of enantioselective synergism at trimetallic centers
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Org Lett 6:2453-5. 2004
    ..High enantioselective cooperativity in the catalytic asymmetric aldol reactions was directly observed using the conceptually novel chiral multinuclear complex catalysts...
  2. ncbi request reprint Novel chiral "calixsalen" macrocycle and chiral robson-type macrocyclic complexes
    Jian Gao
    Department of Radiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Inorg Chem 44:232-41. 2005
    ..The systematic synthesis, structure, and coordination properties of the [2 + 2] and [3 + 3] Robson-type Schiff base macrocyclic mono-, di-, tri-, and tetranuclear metal complexes were explored...
  3. ncbi request reprint In vitro anticancer activities and optical imaging of novel intercalative non-cisplatin conjugates
    Jian Gao
    Department of Radiology, School of Medicine, University of Texas Health Science Center at San Antonio, Texas 78229 3900, USA
    J Med Chem 48:7192-7. 2005
    ..This paper describes a new class of platinum-based antitumorals differing from cisplatin in several critical aspects with the potential for significantly improving clinical outcomes in cancer patients...
  4. doi request reprint Cytotoxic activities, cellular uptake, gene regulation, and optical imaging of novel platinum(II) complexes
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Chem Res Toxicol 22:1705-12. 2009
    ..Taken together, these new platinum(II)-based antitumor agents are different from marketed platinum drugs in several critical aspects and could have potential in cancer therapy...
  5. doi request reprint Herceptin-platinum(II) binding complexes: novel cancer-cell-specific agents
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, TX 77843 3255, USA
    ChemMedChem 3:954-62. 2008
    ..Also, enhanced regulatory effects were observed in Her-10L1Pt(II). Taken together, this study suggests a new approach for the development of mAb-platinum(II)-based targeting agents for the treatment of human cancers...
  6. ncbi request reprint Artificial zinc(II) complexes regulate cell cycle and apoptosis-related genes in tumor cell lines
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Chembiochem 8:332-40. 2007
    ..This study provides a new insight into the development of zinc(II) complexes as potential drugs...
  7. ncbi request reprint Chiral salicyl diamines: potent anticancer molecules
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, TX 77843 3255, USA
    ChemMedChem 2:1723-9. 2007
    ..This study provides a new insight into the development of novel small molecules in the treatment of human breast cancers...
  8. ncbi request reprint Synthesis and DNA binding properties of a cationic 2,2':6',2"-terpyridine cobalt(II) complex containing an oligopeptide
    Jian Gao
    Department of Chemistry, Texas A and M University, College Station, TX 77842 3012, USA
    J Inorg Biochem 94:272-8. 2003
    ..The stabilities and species distributions of Co(II)-DOTA (1:1) and DOTA-Co(II)-TPY (1:1:1) systems were investigated by potentiometry titration...
  9. ncbi request reprint Selective recognition of thymidylylthymidine (TpT) and antitumor effects of a macrocyclic dizinc(II) complex
    Jian Gao
    Department of Chemistry Texas A and M University, College Station, TX 77842 3012, USA
    Org Biomol Chem 1:4242-7. 2003
    ..In vitro antitumor investigation shows that LZn is a patent inhibitor of tumor cell growth with IC50 values below 10 micromolar...
  10. ncbi request reprint Catalytic asymmetric cyclopropanation at a chiral platform
    Jian Gao
    Department of Radiology, University of Texas Health Science Center San Antonio, Texas 78229 3900, USA
    Org Biomol Chem 3:2126-8. 2005
    ..The dinuclear Co(II) and Co(III) complexes catalyze asymmetric cyclopropanation of styrene with diazoacetate cooperatively and with high enantioselectivity...
  11. ncbi request reprint The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage
    Sophie Chen
    NovaSpes Research Lab, Hawthorne, NY 10532, USA
    Int J Oncol 26:579-88. 2005
    ..The present data suggest that further studies are warranted to assess the potential of oridonin in cancer prevention and/or treatment...
  12. pmc Down-regulation of androgen-receptor and PSA by phytochemicals
    Sophie Chen
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:405-11. 2008
    ..In each case, these compounds have independent activities which may partly contribute to the biological activity of PC-SPES...
  13. doi request reprint Total synthesis of (+)-brefeldin A
    Yikang Wu
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China
    Org Lett 10:1533-6. 2008
    ....
  14. doi request reprint A chiron approach to the total synthesis of (+)-aculeatin D
    Zhi Bin Zhen
    State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China
    J Org Chem 73:7310-6. 2008
    ..An unexplained deprotonation at a benzyl protecting group by a thermodynamically more stable dithiane carbanion in the literature was also addressed...
  15. ncbi request reprint [Effects of cimetidine on the biological behaviors of human gastric cancer cells]
    Cheng Gang Jiang
    Department of Oncology, First Hospital of China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 86:1813-6. 2006
    ..To investigate the effects of cimetidine on the proliferation, apoptosis, adhesion, and invasion of human gastric cancer cells...