Terrence S Furey
Affiliation: University of North Carolina
- ChIP-seq and beyond: new and improved methodologies to detect and characterize protein-DNA interactionsTerrence S Furey
Department of Genetics, Carolina Center for Genome Sciences, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 120 Mason Farm Road, CB 7264, Chapel Hill, North Carolina 27599, USA
Nat Rev Genet 13:840-52. 2012..In this Review, I describe the latest advances in methods to detect and functionally characterize DNA-bound proteins...
- Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responsesJeremy M Simon
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
Eur J Immunol 46:1912-25. 2016..This supports a model in which IL-10-deficiency leads to chromatin alterations that contribute to a loss of IM tolerance to bacteria, which is a primary initiating event in chronic intestinal inflammation. ..
- Molecular classification of Crohn's disease reveals two clinically relevant subtypesMatthew Weiser
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Gut . 2016..We sought to better understand the cellular and molecular mechanisms that guide this heterogeneity, and characterise the cellular processes associated with disease phenotypes...
- Novel distal eQTL analysis demonstrates effect of population genetic architecture on detecting and interpreting associationsMatthew Weiser
Curriculum in Bioinformatics and Computational Biology, Departments of Genetics and Biology, Carolina Center for Genome Sciences, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599
Genetics 198:879-93. 2014..Furthermore, the unique genetic history of each population appears to influence the detection of genes with local and distal eQTL. ..
- Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defectsJeremy M Simon
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA
Genome Res 24:241-50. 2014..Detecting the functional consequences of specific mutations in chromatin regulatory proteins in primary human samples could ultimately inform the therapeutic application of an emerging class of chromatin-targeted compounds. ..
- Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblastsStephanie M Cohen
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
BMC Genomics 7:301. 2006..This was accomplished by first creating a cosmid library containing DNA enriched in sequences that replicate early in the S phase of normal human fibroblasts. Clone ends were then sequenced and aligned to the human genome...