Kai Fu

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Recent advances in the molecular diagnosis of diffuse large B-cell lymphoma
    Kai Fu
    Nebraska Medical Center, Department of Pathology and Microbiology, Omaha, NE 68198 3135, USA
    Expert Rev Mol Diagn 5:397-408. 2005
  2. pmc Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling
    Kai Fu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 106:4315-21. 2005
  3. doi request reprint SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model
    Kai Fu
    Department of Pharmacology, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    Arterioscler Thromb Vasc Biol 28:665-71. 2008
  4. doi request reprint Gene arrays in lymphoma: Where will they fit in?
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Curr Hematol Malig Rep 1:129-36. 2006
  5. pmc Cell of origin fails to predict survival in patients with diffuse large B-cell lymphoma treated with autologous hematopoietic stem cell transplantation
    Keni Gu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hematol Oncol 30:143-9. 2012
  6. pmc Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP
    Xin Huang
    Xin Huang, Bin Meng, Wenfeng Cao, and Kai Fu, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Chengfeng Bi, West China Hospital, West China School of Medicine of Sichuan University, Chengdu, China Xin Huang, Bin Meng, Javeed Iqbal, Anamarija M Perry, Wenfeng Cao, Lynette M Smith, Chengfeng Bi, Chunsun Jiang, Timothy C Greiner, Dennis D Weisenburger, James O Armitage, Julie M Vose, Timothy W McKeithan, Wing C Chan, and Kai Fu, University of Nebraska Medical Center, Omaha, NE B Belinda Ding and B Hilda Ye, Albert Einstein College of Medicine, Bronx, NY Lisa Rimsza, University of Arizona, Tucson, AZ Andreas Rosenwald, University of Wurzburg, Department of Physiology and Biophysics
    J Clin Oncol 31:4520-8. 2013
  7. pmc Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab
    Paul N Meyer
    University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Oncol 29:200-7. 2011
  8. doi request reprint A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy
    William W L Choi
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Clin Cancer Res 15:5494-502. 2009
  9. doi request reprint Genomic signatures in B-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?
    Javeed Iqbal
    Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA Electronic address
    Blood Rev 30:73-88. 2016
  10. pmc A new biologic prognostic model based on immunohistochemistry predicts survival in patients with diffuse large B-cell lymphoma
    Anamarija M Perry
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 120:2290-6. 2012

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Recent advances in the molecular diagnosis of diffuse large B-cell lymphoma
    Kai Fu
    Nebraska Medical Center, Department of Pathology and Microbiology, Omaha, NE 68198 3135, USA
    Expert Rev Mol Diagn 5:397-408. 2005
    ..The future development of this field and its applications in the clinical arena will also be discussed...
  2. pmc Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling
    Kai Fu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 106:4315-21. 2005
    ..In conclusion, cases of cyclin D1-negative MCL do exist and are part of the spectrum of MCL. Up-regulation of cyclin D2 or D3 may substitute for cyclin D1 in the pathogenesis of MCL...
  3. doi request reprint SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model
    Kai Fu
    Department of Pharmacology, Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA
    Arterioscler Thromb Vasc Biol 28:665-71. 2008
    ..TGF-beta plays a significant role in vascular injury-induced stenosis. This study evaluates the efficacy of a novel, small molecule inhibitor of ALK5/ALK4 kinase, in the rat carotid injury model of vascular fibrosis...
  4. doi request reprint Gene arrays in lymphoma: Where will they fit in?
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Curr Hematol Malig Rep 1:129-36. 2006
    ..Future treatments are likely to be founded on effective, individualized, and mechanism-based therapies with the least toxicity...
  5. pmc Cell of origin fails to predict survival in patients with diffuse large B-cell lymphoma treated with autologous hematopoietic stem cell transplantation
    Keni Gu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hematol Oncol 30:143-9. 2012
    ..However, no significant differences were found in the 5-year overall or event-free survivals using any of these approaches. In conclusion, cell of origin fails to predict survival of DLBCL patients treated with AHSCT...
  6. pmc Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-CHOP
    Xin Huang
    Xin Huang, Bin Meng, Wenfeng Cao, and Kai Fu, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Chengfeng Bi, West China Hospital, West China School of Medicine of Sichuan University, Chengdu, China Xin Huang, Bin Meng, Javeed Iqbal, Anamarija M Perry, Wenfeng Cao, Lynette M Smith, Chengfeng Bi, Chunsun Jiang, Timothy C Greiner, Dennis D Weisenburger, James O Armitage, Julie M Vose, Timothy W McKeithan, Wing C Chan, and Kai Fu, University of Nebraska Medical Center, Omaha, NE B Belinda Ding and B Hilda Ye, Albert Einstein College of Medicine, Bronx, NY Lisa Rimsza, University of Arizona, Tucson, AZ Andreas Rosenwald, University of Wurzburg, Department of Physiology and Biophysics
    J Clin Oncol 31:4520-8. 2013
    ..In this study, we investigated whether STAT3 activation can risk stratify patients with DLBCL...
  7. pmc Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab
    Paul N Meyer
    University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    J Clin Oncol 29:200-7. 2011
    ..Various immunohistochemical algorithms have been developed to replicate these microarray results and/or stratify patients according to survival. This study compares some of those algorithms and also proposes some modifications...
  8. doi request reprint A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy
    William W L Choi
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3135, USA
    Clin Cancer Res 15:5494-502. 2009
    ..Since then, new antibodies specific to germinal center B-cells have been developed, which might improve the performance of an immunostain algorithm...
  9. doi request reprint Genomic signatures in B-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?
    Javeed Iqbal
    Departments of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA Electronic address
    Blood Rev 30:73-88. 2016
    ..In the next era of genomic medicine, we anticipate that a clinically and biologically relevant molecular profile of each tumor will be obtained at diagnosis to guide therapy. ..
  10. pmc A new biologic prognostic model based on immunohistochemistry predicts survival in patients with diffuse large B-cell lymphoma
    Anamarija M Perry
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 120:2290-6. 2012
    ..This new biologic prognostic model could be used with the International Prognostic Index to stratify patients for novel or risk-adapted therapies...
  11. doi request reprint Genomic signatures in T-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?
    Javeed Iqbal
    Department of Pathology and Microbiology, Center for Lymphoma and Leukemia Research, University of Nebraska Medical Center, Omaha, NE, USA Electronic address
    Blood Rev 30:89-100. 2016
    ..In this review, we highlight recent advances in the molecular diagnosis and prognosis of PTCL using these genome-wide techniques. ..
  12. doi request reprint CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma
    Zdravko Mitrovic
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Br J Haematol 162:87-92. 2013
    ..The dismal outcome of CD43(+) cases in the non-GCB subgroup may be explained, at least in part, by a less favourable microenvironment...
  13. pmc Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma
    Alyssa Bouska
    Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
    Blood 123:1681-90. 2014
    ..2-24.1 or 6q13-15, predicted overall survival. Abnormalities associated with transformation of the disease likely impair immune surveillance, activate the nuclear factor-κB pathway, and deregulate p53 and B-cell transcription factors. ..
  14. doi request reprint B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and burkitt lymphoma: study of 39 cases
    Anamarija M Perry
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Br J Haematol 162:40-9. 2013
    ..This B-cell lymphoma is a morphologically-recognizable entity with a spectrum of genetic abnormalities. New and better treatments are needed for this aggressive lymphoma...
  15. pmc Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling
    Karen E Deffenbacher
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198 3135, USA
    Blood 119:3757-66. 2012
    ..Elucidation of the underlying target genes may provide insight into factors that modulate outcome and could provide potential novel therapeutic targets with less toxicity for pediatric patients with B-cell non-Hodgkin lymphoma...
  16. doi request reprint The stromal cell marker SPARC predicts for survival in patients with diffuse large B-cell lymphoma treated with rituximab
    Paul N Meyer
    Dept of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198, USA
    Am J Clin Pathol 135:54-61. 2011
    ..More aggressive chemotherapy protocols should be considered for patients with ABC DLBCL without SPARC+ stromal cells. CD68 expression by cells in the microenvironment did not predict survival...
  17. doi request reprint Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks
    Radha M Golla
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Hematol Oncol 30:175-9. 2012
    ..These results suggest that PARPi may enhance the therapeutic efficacy of DNA damaging agents on MCL through TP53-independent mechanisms without requiring the inhibition of either ATM or BRCA2...
  18. doi request reprint Isolated MYC cytogenetic abnormalities in diffuse large B-cell lymphoma do not predict an adverse clinical outcome
    Gabriel C Caponetti
    a Department of Pathology, Creighton University Medical Center, Omaha, NE, USA
    Leuk Lymphoma 56:3082-9. 2015
    ..However, patients with double/triple-hit DLBCL have a very poor outcome and should be treated with aggressive or novel therapies. ..
  19. pmc Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Blood 119:4939-48. 2012
    ..The other clusters showed enrichment of stroma-associated miRNAs, and also had higher expression of stroma-associated genes. Our clinical outcome analysis in the present study suggested that miRNAs can serve as prognosticators...
  20. doi request reprint Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling
    Ji Yuan
    Department of Pathology and Microbiology Department of Biostatistics, College of Public Health Department of Hematology Oncology, University of Nebraska Medical Center, Omaha, NE Metabolism Branch Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD Department of Pathology, City of Hope National Medical Center, Duarte, CA Department of Pathology, University of Arizona, Tucson, AZ Department of Clinical Pathology, Oregon Health and Science University, Portland, OR Department of Molecular Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH Institute of Pathology, Comprehensive Cancer Center Mainfranken, University of Wurzburg, Würzburg Department of Clinical Pathology, Robert Bosch Krankenhaus, Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany British Columbia Cancer Agency, Centre for Lymphoid Cancer, University of British Columbia, Vancouver, BC, Canada Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Am J Surg Pathol 39:1322-30. 2015
    ..In conclusion, PMBL can present as a nonmediastinal tumor without evidence of mediastinal involvement, and GEP offers a more precise diagnosis of PMBL. ..
  21. doi request reprint Lymphoma diagnosis at an academic centre: rate of revision and impact on patient care
    Joslin M Bowen
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Br J Haematol 166:202-8. 2014
    ..Mandatory review of outside pathology material prior to treatment of patients for lymphoma will identify a significant number of misclassified cases with a major change in therapy. ..
  22. pmc Quantitative proteomics reveals that miR-155 regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma
    Xin Huang
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Am J Pathol 181:26-33. 2012
    ..Taken together, our results reveal a novel target involved in miR-155 biological characteristics and provide a molecular link between the overexpression of miR-155 and the activation of PI3K-AKT in DLBCL...
  23. doi request reprint Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent parallel clonal evolution
    Francesco D'Amore
    Department of Pathology and Microbiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Clin Cancer Res 14:7180-7. 2008
    ....
  24. ncbi request reprint Clinical implication of genome-wide profiling in diffuse large B-cell lymphoma and other subtypes of B-cell lymphoma
    Javeed Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Indian J Cancer 44:72-86. 2007
    ..In this review, important discoveries made by genome-wide GEP in understanding the biology of lymphoma and additionally the diagnostic and prognostic value of microarrays are discussed...
  25. doi request reprint Differences in the cytogenetic alteration profiles of diffuse large B-cell lymphoma among Chinese and American patients
    Yan Chen
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Genet 206:183-90. 2013
    ..Non-GCB-DLBCL in both the Chinese and American patients was characterized by recurrent gains of 3/3q and 18/18q. The incidences of both BCL6 rearrangement and t(14;18) were similar in Chinese and American non-GCB-DLBCL cases. ..
  26. pmc Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma
    Timothy C Greiner
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Proc Natl Acad Sci U S A 103:2352-7. 2006
    ..This information on molecular phenotypes may provide new areas of investigation for ATM function or may be exploited by designing specific therapies for MCL cases with p53 aberrations...
  27. doi request reprint Recurrent chromosomal alterations in molecularly classified AIDS-related lymphomas: an integrated analysis of DNA copy number and gene expression
    Karen E Deffenbacher
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    J Acquir Immune Defic Syndr 54:18-26. 2010
    ..1 locus and showed gene silencing or truncated transcript in 9 of 16 cases. These data demonstrate the ability to molecularly classify B-ARL lymphomas by gene expression and identified DNA copy number alterations targeted in B-ARL...
  28. pmc IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma
    Chao Wang
    Shandong University School of Medicine, Jinan, People s Republic of China China Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE Department of Pathology, City of Hope National Medical Center, Duarte, CA
    Blood 126:1741-52. 2015
    ..Integrative analysis of gene expression and promoter methylation revealed recurrently hypermethylated genes involved in T-cell receptor signaling and T-cell differentiation that likely contribute to lymphomagenesis in AITL. ..
  29. ncbi request reprint Leukemic diffuse large B-cell lymphoma in a patient with myeloproliferative disorder
    Vijaya Raj Bhatt
    From the Department of Internal Medicine, Division of Hematology Oncology Department of Pathology and Microbiology and Human Genetics Laboratory, Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, Nebraska
    J Natl Compr Canc Netw 13:281-7. 2015
    ..Additionally, this case serves as a reminder that the use of novel therapies should be adopted after a thorough assessment of long-term risks, including those associated with abrupt withdrawal. ..
  30. pmc t(14;18)-negative follicular lymphomas are associated with a high frequency of BCL6 rearrangement at the alternative breakpoint region
    Keni Gu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Mod Pathol 22:1251-7. 2009
    ..Therefore, it is important to perform FISH analysis with ABR to determine possible involvement of BCL6 rearrangement in follicular lymphoma, especially in t(14;18)-negative cases...
  31. pmc Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mTOR kinase inhibitors in aggressive B-cell lymphomas
    Chengfeng Bi
    University of Nebraska Medical Center, Omaha, USA
    Haematologica . 2017
    ..Taken together, this study provides mechanistic insight in TORKi cytotoxicity and identified a potential way to optimize its efficacy in clinical treatment of aggressive B-cell lymphoma...
  32. pmc ISPTM: an iterative search algorithm for systematic identification of post-translational modifications from complex proteome mixtures
    Xin Huang
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States
    J Proteome Res 12:3831-42. 2013
    ..In summary, ISPTM is a new and powerful tool for unbiased identification of many different PTMs with high confidence from complex proteome mixtures. ..
  33. doi request reprint Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma
    Kai Fu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 7680, USA
    J Clin Oncol 26:4587-94. 2008
    ..However, with the addition of rituximab to standard chemotherapy, the prognostic significance of this subclassification of DLBCL is unclear...
  34. ncbi request reprint General Biomarker Recommendations for Lymphoma
    Lisa Rimsza
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ LR, Department of Pathology and Laboratory Medicine, University of North Carolina Medical School, Chapel Hill, NC YF, Center for Cancer Research, National Cancer Institute, Bethesda, MD LMS, Department of Medicine, Weill Cornell Medical College, New York, NY AM, Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada RG, Clinical Cancer Research Unit, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada MC, Coordinating Center for Clinical Trials, National Cancer Institute, Bethesda, MD LB, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE KF, Department of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, Cleveland, OH ED, Department of Pathology, City of Hope Medical Center, Duarte, CA JWCC, Biometrics Research Branch, National Cancer Institute, Bethesda, MD LM, Department of Medicine, University of Leeds
    J Natl Cancer Inst 108:. 2016
    ....
  35. doi request reprint Flow Cytometric Characteristics of Extrathymic Thymocytes in Adenoid Tissue: A Case Report and Comparison to Normal Thymus and Thymoma
    Ji Yuan
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
    Cytometry B Clin Cytom . 2017
    ..Normal thymocyte precursors in secondary lymphoid organs have previously been described. It is important to recognize normal thymocyte precursors by flow cytometry to differentiate them from T-cell lymphoblastic leukemia...
  36. doi request reprint EZH2 mutations in follicular lymphoma from different ethnic groups and associated gene expression alterations
    Shuangping Guo
    Authors Affiliations Department of Pathology, Xi Jing Hospital, The Fourth Military Medical University, Xi an, Shaan Xi Province Department of Pathology, Queen Elizabeth Hospital, Hong Kong Department of Pathology, Shandong University School of Medicine, Jinan, Shandong Province Department of Pathology, Tianjin Cancer Hospital Department of Pathology, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NebraskaAuthors Affiliations Department of Pathology, Xi Jing Hospital, The Fourth Military Medical University, Xi an, Shaan Xi Province Department of Pathology, Queen Elizabeth Hospital, Hong Kong Department of Pathology, Shandong University School of Medicine, Jinan, Shandong Province Department of Pathology, Tianjin Cancer Hospital Department of Pathology, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska
    Clin Cancer Res 20:3078-86. 2014
    ..However, the frequency of EZH2 mutation in Chinese follicular lymphomas and the potential targets affected by this mutation are unknown...
  37. doi request reprint Needle-core biopsy in the pathologic diagnosis of malignant lymphoma showing high reproducibility among pathologists
    Qinglong Hu
    Department of Pathology, Alegent Creighton Health, Omaha, NE, USA
    Am J Clin Pathol 140:238-47. 2013
    ..To evaluate the role of needle-core biopsy in the pathologic diagnosis of lymphoma...
  38. pmc The miR-17-92 microRNA cluster is regulated by multiple mechanisms in B-cell malignancies
    Ming Ji
    School of Life Science, Nanjing University, Nanjing, China Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska
    Am J Pathol 179:1645-56. 2011
    ..Because the miR-17-92 cluster acts as an important oncogene in several cancers and targets genes important in regulating cell proliferation and survival, further studies of its transcriptional control are warranted...
  39. pmc PCR-based generation of shRNA libraries from cDNAs
    Cheng Du
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 0766, USA
    BMC Biotechnol 6:28. 2006
    ..The high cost of chemical synthesis and the low efficiency of the enzymatic approach have hampered the widespread use of screening with shRNA libraries...
  40. ncbi request reprint Molecular diagnostics on lymphoid malignancies
    Wing C Chan
    Department of Pathology Microbiology, University of Nebraska Medical Center, Omaha 68198 3135, USA
    Arch Pathol Lab Med 128:1379-84. 2004
    ....
  41. pmc Podoplanin (d2-40): a new immunohistochemical marker for reactive follicular dendritic cells and follicular dendritic cell sarcomas
    Qingmei Xie
    Department of Pathology, Creighton University Medical Center, Omaha, NE, USA
    Int J Clin Exp Pathol 1:276-84. 2008
    ..In addition, our results suggest that podoplanin (D2-40) can be used to support the diagnosis of FDC sarcoma...
  42. pmc Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness
    Mohammad Saeid Jami
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    BMC Cancer 14:194. 2014
    ..In the present study, we examined the functional significance of KIAA1199 expression in breast cancer growth, motility and invasiveness...
  43. pmc The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells
    Lin Zhang
    Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Mol Cell Biol 35:1350-62. 2015
    ..Together, our results identify YAP to be a novel regulator in prostate cancer cell motility, invasion, and castration-resistant growth and as a potential therapeutic target for metastatic castration-resistant prostate cancer (CRPC). ..
  44. doi request reprint Relationship between Rosai-Dorfman disease and IgG4-related disease: study of 32 cases
    Liping Liu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Am J Clin Pathol 140:395-402. 2013
    ..To assess the association between Rosai-Dorfman disease (RDD) and IgG4-related disease (IgG4-RD)...
  45. doi request reprint Racial patterns of extranodal natural killer/T-cell lymphoma, nasal type, in California: a population-based study
    Weiyun Z Ai
    Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Br J Haematol 156:626-32. 2012
    ..In conclusion, ENKTL is more common and clinically more similar among Hispanics and APIs than non-Hispanic whites with poor outcome in all racial groups...
  46. pmc Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis
    Xin Ming Liu
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Pharm Res 25:2910-9. 2008
    ..To develop a pH-sensitive dexamethasone (Dex)-containing N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugate with well-defined structure for the improved treatment of rheumatoid arthritis (RA)...
  47. ncbi request reprint CD23 expression in mantle cell lymphoma: clinicopathologic features of 18 cases
    Ellen Schlette
    Dept of Hematopathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 72, Houston, TX 77030, USA
    Am J Clin Pathol 120:760-6. 2003
    ..The frequency of CD23 expression by MCL is method-dependent, being typically dim and most commonly detected by flow cytometry. In this small study group, bone marrow and leukemic involvement were relatively common...
  48. pmc Gene- and cell-type-specific effects of signal transduction cascades on metal-regulated gene transcription appear to be independent of changes in the phosphorylation of metal-response-element-binding transcription factor-1
    Huimin Jiang
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7421, USA
    Biochem J 382:33-41. 2004
    ..Instead, protein kinases may exert their interdependent effects on metal-induced gene expression by acting on cofactors that interact with MTF-1...
  49. ncbi request reprint Full clinical recovery after topical acyclovir treatment of Epstein-Barr virus associated cutaneous B-cell lymphoma in patient with mycosis fungoides
    M Sitki Copur
    Saint Francis Cancer Center, 2116 W Faidley Ave, Grand Island, NE 68802 9804, USA
    Croat Med J 46:458-62. 2005
    ....
  50. ncbi request reprint Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006
    ..We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma...
  51. ncbi request reprint A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus
    Stefan Gesk
    Blood 108:1109-10. 2006
  52. ncbi request reprint Mantle cell lymphoma with plasma cell differentiation
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Am J Surg Pathol 30:954-61. 2006
    ..These findings indicate that the clonal PC differentiation may occur within GCs in some cases of MCL...
  53. ncbi request reprint Clonal CD8+ lymphocytic proliferation associated with Epstein-Barr virus infection mimicking T-cell leukemia
    Qinglong Hu
    Leuk Lymphoma 48:1651-3. 2007
  54. ncbi request reprint Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features
    Olga Balague
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 31:1310-22. 2007
    ..The distinctive features of these patients suggest that these lesions represent a specific phenomenon in PTCL...
  55. pmc Comprehensive analysis of GST-pi expression in B-cell lymphomas: Correlation with histological subtypes and survival
    Catherine Thieblemont
    Leuk Lymphoma 49:1403-6. 2008