Genomes and Genes
Affiliation: University of Utah
- Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactionsAdam Frost
Department of Biochemistry, Huntsman Cancer Institute, University of Utah, School of Medicine, Salt Lake City, 84112, USA
Cell 149:1339-52. 2012..Each discovery opens new areas of inquiry and-together-have implications for model organism-based research and the evolution of genetic systems...
- Membrane trafficking: decoding vesicle identity with contrasting chemistriesAdam Frost
Department of Biochemistry and Huntsman Cancer Institute, University of Utah, School of Medicine, Salt Lake City, UT 84112, USA
Curr Biol 21:R811-3. 2011..New work now shows that α-synuclein and ALPS motifs represent two extreme types of amphipathic helix that are tuned to detect both the curvature of transport vesicles as well as their bulk lipid content...
- Structural and functional studies of membrane remodeling machinesRaghav Kalia
Department of Biochemistry, University of Utah, School of Medicine, Salt Lake City, UT, USA Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA
Methods Cell Biol 128:165-200. 2015..This chapter describes in vitro methods for purifying, reconstituting, and visualizing membrane remodeling activities directly by electron cryomicroscopy. ..
- Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scissionSajjan Koirala
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 110:E1342-51. 2013..This result demonstrates that an adaptor protein alters the architecture of a mitochondrial dynamin GTPase polymer in a manner that could facilitate membrane constriction and severing activity...