Susan K Fried

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Leucing weight with a futile cycle
    Susan K Fried
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine and GRECC, Baltimore VA Medical Center, Baltimore, MD 21201, USA
    Cell Metab 6:155-6. 2007
  2. ncbi request reprint Sugars, hypertriglyceridemia, and cardiovascular disease
    Susan K Fried
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA
    Am J Clin Nutr 78:873S-880S. 2003
  3. pmc Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:1178-85. 2008
  4. ncbi request reprint Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase
    Maria E Trujillo
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, Howard Hall 428, Baltimore, MD 21201, USA
    J Clin Endocrinol Metab 91:1484-90. 2006
  5. pmc Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e287. 2006
  6. ncbi request reprint Acute and chronic regulation of leptin synthesis, storage, and secretion by insulin and dexamethasone in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, School of Medicine, University of Maryland, 660 West Redwood St, Baltimore, MD 21201, USA
    Am J Physiol Endocrinol Metab 292:E858-64. 2007
  7. pmc Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women
    Susan K Fried
    Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA
    J Lipid Res 51:1193-200. 2010
  8. ncbi request reprint Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Maryland 21201, USA
    J Biol Chem 282:72-80. 2007
  9. ncbi request reprint Omentin plasma levels and gene expression are decreased in obesity
    Celia M de Souza Batista
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 56:1655-61. 2007
  10. pmc Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion
    Mi Jeong Lee
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA
    Am J Physiol Endocrinol Metab 296:E1230-8. 2009

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Leucing weight with a futile cycle
    Susan K Fried
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine and GRECC, Baltimore VA Medical Center, Baltimore, MD 21201, USA
    Cell Metab 6:155-6. 2007
    ....
  2. ncbi request reprint Sugars, hypertriglyceridemia, and cardiovascular disease
    Susan K Fried
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA
    Am J Clin Nutr 78:873S-880S. 2003
    ....
  3. pmc Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:1178-85. 2008
    ..Our main objective was to compare the regulation of cortisol production within omental (Om) and abdominal subcutaneous (Abd sc) human adipose tissue...
  4. ncbi request reprint Tumor necrosis factor alpha and glucocorticoid synergistically increase leptin production in human adipose tissue: role for p38 mitogen-activated protein kinase
    Maria E Trujillo
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 West Redwood Street, Howard Hall 428, Baltimore, MD 21201, USA
    J Clin Endocrinol Metab 91:1484-90. 2006
    ..TNF increases plasma leptin in humans in vivo, but previous studies showed it decreases leptin in vitro...
  5. pmc Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e287. 2006
    ..However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood...
  6. ncbi request reprint Acute and chronic regulation of leptin synthesis, storage, and secretion by insulin and dexamethasone in human adipose tissue
    Mi Jeong Lee
    Division of Endocrinology, School of Medicine, University of Maryland, 660 West Redwood St, Baltimore, MD 21201, USA
    Am J Physiol Endocrinol Metab 292:E858-64. 2007
    ....
  7. pmc Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women
    Susan K Fried
    Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA
    J Lipid Res 51:1193-200. 2010
    ..Overall, these data are consistent with the hypothesis that decreased responsiveness of Abd adipocytes to antilipolytic effectors may contribute to higher FA availability and thereby to racial differences in insulin resistance...
  8. ncbi request reprint Feeding and insulin increase leptin translation. Importance of the leptin mRNA untranslated regions
    Mi Jeong Lee
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland at Baltimore, Maryland 21201, USA
    J Biol Chem 282:72-80. 2007
    ..Our data suggest that insulin derepresses leptin translation by a mechanism that requires both the 5'-UTR and the 3'-UTR and may contribute to the increase in leptin production with feeding...
  9. ncbi request reprint Omentin plasma levels and gene expression are decreased in obesity
    Celia M de Souza Batista
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Diabetes 56:1655-61. 2007
    ..In summary, decreased omentin levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity...
  10. pmc Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion
    Mi Jeong Lee
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA
    Am J Physiol Endocrinol Metab 296:E1230-8. 2009
    ....
  11. ncbi request reprint Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action
    Rong Ze Yang
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Endocrinol Metab 290:E1253-61. 2006
    ..05) human adipocytes. Omentin increased Akt phosphorylation in the absence and presence of insulin. In conclusion, omentin is a new adipokine that is expressed in omental adipose tissue in humans and may regulate insulin action...
  12. ncbi request reprint Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Physiol Genomics 25:450-7. 2006
    ....
  13. ncbi request reprint Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Metabolism 52:753-9. 2003
    ..We conclude that TZDs have multiple actions and that many, but perhaps not all, can be accounted for by their action on adipose tissue...
  14. ncbi request reprint Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot
    Yanxin Wang
    Department of Nutritional Science, Cook College, Rutgers University, New Brunswick, New Jersey, USA
    Obes Res 11:930-6. 2003
    ..We sought to determine the effects of severe obesity and depot [omental (Om) vs. subcutaneous (Sc)] on perilipin expression in the adipose tissue of individuals...
  15. ncbi request reprint Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy
    Julia A Johnson
    Obesity Research Center, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA
    Am J Physiol Endocrinol Metab 286:E261-71. 2004
    ....
  16. pmc Thrombospondin-1 is an adipokine associated with obesity, adipose inflammation, and insulin resistance
    Vijayalakshmi Varma
    Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th St, Little Rock, AR 72205, USA
    Diabetes 57:432-9. 2008
    ..We examined the relationship between the expression of thrombospondin (TSP)1, an antiangiogenic factor and regulator of transforming growth factor-beta activity, obesity, adipose inflammation, and insulin resistance...
  17. ncbi request reprint Inhibitory effects of grape seed extract on lipases
    Diego A Moreno
    Biotech Center, Cook College, Rutgers The State University of New Jersey, New Brunswick, New Jersey 08901 8520, USA
    Nutrition 19:876-9. 2003
    ....
  18. pmc Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone
    Aiwei Yao-Borengasser
    The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:2590-7. 2007
    ..Retinol binding protein 4 (RBP4) was recently found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance...
  19. ncbi request reprint Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet
    Katherine E Wortley
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Regul Pept 117:89-99. 2004
    ..These results suggest that, on a fat-rich diet, this leptin-CART pathway originating in the ARC inhibits excessive body fat accrual by causing a shift from lipid storage toward lipid mobilization...
  20. ncbi request reprint Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro
    Maria E Trujillo
    Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    J Clin Endocrinol Metab 89:5577-82. 2004
    ..We conclude that high local concentrations of IL-6 can modulate leptin production and lipid metabolism in human adipose tissue...
  21. pmc Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation
    Vijayalakshmi Varma
    The Central Arkansas Veterans Healthcare System, 598 151 LR, 4300 West 7th Street, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 92:666-72. 2007
    ..Visfatin (VF) is a recently described adipokine preferentially secreted by visceral adipose tissue (VAT) with insulin mimetic properties...
  22. ncbi request reprint Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms
    Matthew R Ricci
    Department of Nutritional Sciences, Rutgers Univeristy, New Brunswick, New Jersey, USA
    Am J Physiol Endocrinol Metab 288:E798-804. 2005
    ..Furthermore, the rat does not provide an ideal model to study mechanisms of cellular leptin regulation in humans...
  23. ncbi request reprint Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue
    Mi Jeong Lee
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 47:1984-93. 2006
    ..The insulin-stimulated release of leptin from a preformed intracellular leptin pool may contribute to increases in serum leptin levels after meals...
  24. ncbi request reprint Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways
    Tara M D'Eon
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 280:35983-91. 2005
    ..Thus, novel genomic and non-genomic actions of E2 promote leanness in OVX mice independently of reduced energy intake...
  25. ncbi request reprint Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates
    Wenjuan Shi Jobgen
    Texas A and M University, College Station, TX 77843, USA
    J Nutr Biochem 17:571-88. 2006
    ....

Research Grants1

  1. Integrative approaches to understanding obesity
    SUSAN FRIED; Fiscal Year: 2004
    ..The conference will be structured to maximize discussion and to highlight work by new investigators through short talk and poster discussions formats. ..