Hermann B Frieboes

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity
    Christopher G England
    Department of Bioengineering, Lutz Hall 419, University of Louisville, Louisville, KY 40292, USA
    Curr Drug Targets 16:1057-87. 2015
  2. pmc An integrated computational/experimental model of lymphoma growth
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS Comput Biol 9:e1003008. 2013
  3. pmc A computational model for predicting nanoparticle accumulation in tumor vasculature
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, USA
    PLoS ONE 8:e56876. 2013
  4. pmc Physical oncology: a bench-to-bedside quantitative and predictive approach
    Hermann B Frieboes
    Department of Bioengineering and James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40208, USA
    Cancer Res 71:298-302. 2011
  5. pmc An interdisciplinary computational/experimental approach to evaluate drug-loaded gold nanoparticle tumor cytotoxicity
    Louis T Curtis
    Department of Bioengineering, University of Louisville, KY, USA
    Nanomedicine (Lond) 11:197-216. 2016
  6. pmc Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States of America James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States of America
    PLoS ONE 10:e0129172. 2015
  7. pmc Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer
    Lee B Sims
    Department of Bioengineering, University of Louisville, 505 S Hancock, CTRB 623, Louisville, KY, 40208, USA
    J Nanobiotechnology 14:33. 2016
  8. pmc Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles
    Louis T Curtis
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 10:e0144888. 2015
  9. pmc Evaluation of uptake and distribution of gold nanoparticles in solid tumors
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40292, USA
    Eur Phys J Plus 130:. 2015
  10. pmc Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography
    Shanice V Hudson
    Department of Medicine, University of Louisville, Kentucky
    Cancer Res 74:6271-9. 2014

Collaborators

  • Vittorio Cristini
  • Min Wu
  • Lacey R McNally
  • Paolo Decuzzi
  • Jun Yan
  • Christopher G England
  • Louis T Curtis
  • Andre M Gobin
  • Jill M Steinbach-Rankins
  • Lee B Sims
  • Michael E Halwes
  • John Lowengrub
  • Justin S Huang
  • Guandong Zhang
  • Shanice V Hudson
  • Victor Van Berkel
  • James J Lee
  • Younsoo Bae
  • Piotr Rychahou
  • Kurtis T James
  • Ashani Kuttan
  • Chin F Ng
  • M Clarke Miller
  • John O Trent
  • Brian P Ceresa
  • Wenyuan Yin
  • Sabrin Albeituni
  • Jamie Rush
  • Anil Khanal
  • Xinghua Sun
  • Justin Huang
  • Dhruvinkumar N Patel
  • Thomas Priest

Detail Information

Publications18

  1. ncbi A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity
    Christopher G England
    Department of Bioengineering, Lutz Hall 419, University of Louisville, Louisville, KY 40292, USA
    Curr Drug Targets 16:1057-87. 2015
    ..To this end, nanotherapeutic options currently in clinical trials offer hope to help address some of these critical issues. ..
  2. pmc An integrated computational/experimental model of lymphoma growth
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS Comput Biol 9:e1003008. 2013
    ..We conclude that computational modeling tightly integrated with experimental data gives insight into the dynamics of Non-Hodgkin's lymphoma and provides a platform to generate confirmable predictions of tumor growth...
  3. pmc A computational model for predicting nanoparticle accumulation in tumor vasculature
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, USA
    PLoS ONE 8:e56876. 2013
    ..The computational tool described here can effectively select an optimal NP formulation presenting high accumulation doses and uniform spatial intra-tumor distributions as a function of the development stage of the malignancy...
  4. pmc Physical oncology: a bench-to-bedside quantitative and predictive approach
    Hermann B Frieboes
    Department of Bioengineering and James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40208, USA
    Cancer Res 71:298-302. 2011
    ....
  5. pmc An interdisciplinary computational/experimental approach to evaluate drug-loaded gold nanoparticle tumor cytotoxicity
    Louis T Curtis
    Department of Bioengineering, University of Louisville, KY, USA
    Nanomedicine (Lond) 11:197-216. 2016
    ..We develop an interdisciplinary approach modeling diffusive transport of drug-loaded gold nanoparticles in heterogeneously-vascularized tumors...
  6. pmc Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States of America James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States of America
    PLoS ONE 10:e0129172. 2015
    ..06 in the spleen, and 0.20 ± 0.04 in the tumor. Hyperspectral imaging of histology sections enables analysis of phosphatidylcholine-coated gold-based nanoparticles in pancreatic tumors with the goal to improve nanotherapeutic efficacy...
  7. pmc Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer
    Lee B Sims
    Department of Bioengineering, University of Louisville, 505 S Hancock, CTRB 623, Louisville, KY, 40208, USA
    J Nanobiotechnology 14:33. 2016
    ..To circumvent these challenges, NP surfaces can be modified to facilitate tumor interstitial transport and cellular uptake...
  8. pmc Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles
    Louis T Curtis
    Department of Bioengineering, University of Louisville, Louisville, Kentucky, United States of America
    PLoS ONE 10:e0144888. 2015
    ..This model system enables evaluation of efficacy for vascular-targeted drug-loaded NPs as a function of critical NP, drug, and tumor parameters. ..
  9. pmc Evaluation of uptake and distribution of gold nanoparticles in solid tumors
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40292, USA
    Eur Phys J Plus 130:. 2015
    ..We also examine the potential role of novel layered gold nanoparticles designed to address some of these critical issues, assessing their uptake and transport in cancerous tissue...
  10. pmc Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography
    Shanice V Hudson
    Department of Medicine, University of Louisville, Kentucky
    Cancer Res 74:6271-9. 2014
    ..These studies demonstrate the utility of MSOT to obtain volumetric images of ligand probe biodistribution in vivo to detect orthotopic pancreatic tumor lesions through active targeting of the EGF receptor...
  11. pmc Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville, Louisville, KY, 40202, United States of America James Graham Brown Cancer Center, University of Louisville, Louisville, KY, 40202, United States of America Department of Pathology, University of New Mexico, Albuquerque, NM, 87131, United States of America
    PLoS ONE 10:e0129433. 2015
    ..Lastly, tissue blood volume fraction was determined to be the most sensitive model parameter and a primary contributor to drug resistance. ..
  12. doi A Computational/Experimental Assessment of Antitumor Activity of Polymer Nanoassemblies for pH-Controlled Drug Delivery to Primary and Metastatic Tumors
    Louis T Curtis
    Department of Bioengineering, University of Louisville, Lutz Hall 419, Louisville, Kentucky, 40208, USA
    Pharm Res 33:2552-64. 2016
    ..However, therapeutic benefits of pH-controlled drug delivery remain elusive due to complex interactions between the drug carriers, tumor cells with varying drug sensitivity, and the tumor microenvironment...
  13. doi Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans
    Michael E Halwes
    Department of Bioengineering, University of Louisville, Louisville, KY, USA
    Eur J Pharm Sci 93:410-8. 2016
    ..These observations may have important ramifications if a specific time frame is required for efficacy, or if a minimum/maximum concentration is needed in the mucus, epithelium, or stroma based on combined efficacy and safety data. ..
  14. ncbi The Tumor Microenvironment as a Barrier to Cancer Nanotherapy
    Louis T Curtis
    Department of Bioengineering, University of Louisville, Lutz Hall 419, Louisville, KY, 40292, USA
    Adv Exp Med Biol 936:165-190. 2016
    ..We conclude that an even tighter interdisciplinary effort between biological, material, and physical scientists is needed in order to eventually overcome the tumor microenvironment barrier to successful nanotherapy...
  15. pmc Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles
    Christopher G England
    Dept of Pharmacology and Toxicology, University of Louisville, KY, USA James Graham Brown Cancer Center, University of Louisville, KY, USA
    Eur J Pharm Biopharm 92:120-9. 2015
    ....
  16. pmc Enhanced penetration into 3D cell culture using two and three layered gold nanoparticles
    Christopher G England
    Department of Pharmacology and Toxicology, University of Louisville, KY, USA
    Int J Nanomedicine 8:3603-17. 2013
    ..This multilayer formulation may help overcome transport barriers presented by tumor vasculature, and could be further investigated in vivo as a platform for targeted cancer therapies. ..
  17. doi Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy
    Hermann B Frieboes
    Department of Bioengineering, University of Louisville Louisville, KY, USA
    JOP 15:189-97. 2014
    ..We hypothesize that treating metastatic cells with chloroquine, an inhibitor of autophagy, in hypoxia will decrease cell viability and induce cell death...
  18. pmc Predictive modeling of in vivo response to gemcitabine in pancreatic cancer
    James J Lee
    School of Medicine, University of Louisville, Louisville, Kentucky, United States of America
    PLoS Comput Biol 9:e1003231. 2013
    ....