Gary M Freedman

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Identifying patients who may be candidates for a clinical trial of salvage accelerated partial breast irradiation after previous whole breast irradiation
    Linna Li
    Radiation Oncology, BMH Bryn Mawr, PA, USA
    Int J Breast Cancer 2012:937658. 2012
  2. pmc Differentiating lymphovascular invasion from retraction artifact on histological specimen of breast carcinoma and their implications on prognosis
    Nicholas George Zaorsky
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA
    J Breast Cancer 15:478-80. 2012
  3. doi Accelerated fractionation with a concurrent boost for early stage breast cancer
    Gary M Freedman
    University of Pennsylvania, Philadelphia, United States
    Radiother Oncol 106:15-20. 2013
  4. doi Risk stratification in ductal carcinoma in situ: the role of genomic testing
    Gary M Freedman
    Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Oncol Rep 15:7-13. 2013
  5. doi Lymphatic space invasion is not an independent predictor of outcomes in early stage breast cancer treated by breast-conserving surgery and radiation
    Gary M Freedman
    Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Breast J 18:415-9. 2012
  6. pmc Five-year local control in a phase II study of hypofractionated intensity modulated radiation therapy with an incorporated boost for early stage breast cancer
    Gary M Freedman
    Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Int J Radiat Oncol Biol Phys 84:888-93. 2012
  7. doi Hypofractionated radiation therapy in the treatment of early-stage breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Perelman Center for Advanced Medicine, TRC 4 West, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Oncol Rep 14:12-9. 2012
  8. pmc Impact of the radiation boost on outcomes after breast-conserving surgery and radiation
    Colin Murphy
    Temple University School of Medicine, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 81:69-76. 2011
  9. pmc Young age is not associated with increased local recurrence for DCIS treated by breast-conserving surgery and radiation
    Aruna Turaka
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Surg Oncol 100:25-31. 2009
  10. ncbi Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Am J Clin Oncol 29:66-70. 2006

Collaborators

Detail Information

Publications34

  1. pmc Identifying patients who may be candidates for a clinical trial of salvage accelerated partial breast irradiation after previous whole breast irradiation
    Linna Li
    Radiation Oncology, BMH Bryn Mawr, PA, USA
    Int J Breast Cancer 2012:937658. 2012
    ..0001). Conclusions. Clinical stage at presentation strongly correlated with pathologic stage at mastectomy. More than 70% of recurrences were favorable and may be appropriate candidates for salvage APBI trials...
  2. pmc Differentiating lymphovascular invasion from retraction artifact on histological specimen of breast carcinoma and their implications on prognosis
    Nicholas George Zaorsky
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA
    J Breast Cancer 15:478-80. 2012
    ....
  3. doi Accelerated fractionation with a concurrent boost for early stage breast cancer
    Gary M Freedman
    University of Pennsylvania, Philadelphia, United States
    Radiother Oncol 106:15-20. 2013
    ..Results from these current trials could improve the acceptance and broaden the applicability of hypofractionation treatment courses for the treatment of patients with early stage breast cancer...
  4. doi Risk stratification in ductal carcinoma in situ: the role of genomic testing
    Gary M Freedman
    Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Oncol Rep 15:7-13. 2013
    ..Whether this method of risk stratification will prove more accurate than clinical, radiological and pathologic risk stratification, or identify patients with little to no clinical benefit from radiation, remains to be seen...
  5. doi Lymphatic space invasion is not an independent predictor of outcomes in early stage breast cancer treated by breast-conserving surgery and radiation
    Gary M Freedman
    Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Breast J 18:415-9. 2012
    ....
  6. pmc Five-year local control in a phase II study of hypofractionated intensity modulated radiation therapy with an incorporated boost for early stage breast cancer
    Gary M Freedman
    Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Int J Radiat Oncol Biol Phys 84:888-93. 2012
    ..We report the 5-year results of a phase II study of intensity modulated radiation therapy (IMRT), hypofractionation, and incorporated boost that shortened treatment time to 4 weeks...
  7. doi Hypofractionated radiation therapy in the treatment of early-stage breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Perelman Center for Advanced Medicine, TRC 4 West, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Oncol Rep 14:12-9. 2012
    ..But results from current trials could make hypofractionation more widely accepted for patients with early-stage breast cancer...
  8. pmc Impact of the radiation boost on outcomes after breast-conserving surgery and radiation
    Colin Murphy
    Temple University School of Medicine, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 81:69-76. 2011
    ..We examined the impact of radiation tumor bed boost parameters in early-stage breast cancer on local control and cosmetic outcomes...
  9. pmc Young age is not associated with increased local recurrence for DCIS treated by breast-conserving surgery and radiation
    Aruna Turaka
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Surg Oncol 100:25-31. 2009
    ..We report local recurrence (LR) after breast-conserving surgery and radiation (BCS + RT) for ductal carcinoma in situ (DCIS) to determine outcomes for patients aged <or=40 years compared with older women...
  10. ncbi Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Am J Clin Oncol 29:66-70. 2006
    ..Our hypothesis is that measures to decrease dose inhomogeneity within the breast and skin with IMRT will improve acute skin toxicity...
  11. ncbi Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:2000-9. 2007
    ..Resection offers the only reasonable probability for cure, but at the cost of perioperative morbidity and potential mortality. Clinical decision making remains difficult...
  12. doi Five-year results of whole breast intensity modulated radiation therapy for the treatment of early stage breast cancer: the Fox Chase Cancer Center experience
    Lanea M M Keller
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 84:881-7. 2012
    ..To report the 5-year outcomes using whole-breast intensity-modulated radiation therapy (IMRT) for the treatment of early-stage-breast cancer at the Fox Chase Cancer Center...
  13. ncbi Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 68:347-53. 2007
    ..This is an inconvenience to many women, and for some a barrier for breast conservation. We present the acute toxicity of a 4-week course of hypofractionated radiation...
  14. ncbi Parity confers better prognosis in older women with early-stage breast cancer treated with breast-conserving therapy
    Penny R Anderson
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Clin Breast Cancer 5:225-31. 2004
    ..Parity can be considered a prognostic factor in elderly patients with early-stage breast cancer, and therefore may be used as a tool for identifying patients who may benefit from a more aggressive treatment approach...
  15. doi History of smoking is associated with younger age at diagnosis of breast cancer
    Mathew C Abramowitz
    Department of Radiation Oncology, University of Miami, Miller School of Medicine, Miami, Florida, USA
    Breast J 16:344-9. 2010
    ..Further efforts to clarify potential reasons for any racial differences and lower utilization of breast conservation with smoking are warranted...
  16. pmc Locoregional recurrence of triple-negative breast cancer after breast-conserving surgery and radiation
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Cancer 115:946-51. 2009
    ..The results of radiation on the local control of triple receptor-negative breast cancer (negative estrogen [ER], progesterone [PR], and HER-2/neu receptors) was studied...
  17. doi Does axillary boost increase lymphedema compared with supraclavicular radiation alone after breast conservation?
    Shelly B Hayes
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 72:1449-55. 2008
    ..To determine independent predictors of lymphedema (LE) after breast radiotherapy and to quantify added risks of LE from regional node irradiation (RNI)...
  18. pmc Breast intensity-modulated radiation therapy reduces time spent with acute dermatitis for women of all breast sizes during radiation
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 74:689-94. 2009
    ..To study the time spent with radiation-induced dermatitis during a course of radiation therapy for breast cancer in women treated with conventional or intensity-modulated radiation therapy (IMRT)...
  19. ncbi Identifying breast cancer patients most likely to benefit from aromatase inhibitor therapy after adjuvant radiation and tamoxifen
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cancer 107:2552-8. 2006
    ..The purpose of the current study was to examine patient selection for an aromatase inhibitor in breast cancer patients who were free from adverse events 5 years after treatment with tamoxifen...
  20. pmc Health states of women after conservative surgery and radiation for breast cancer
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 121:519-26. 2010
    ..These health states are comparable to the adult female U.S. population. These data will provide valuable patient utility information for informing decision analyses investigating new treatments in women with breast cancer...
  21. pmc Risk of positive nonsentinel nodes in women with 1-2 positive sentinel nodes related to age and molecular subtype approximated by receptor status
    Gary M Freedman
    Department of Radiation Oncology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA
    Breast J 20:358-63. 2014
    ..Several high risk groups with >15% risk for having ≥4 positive nodes were identified. Further data is needed to confirm that ACOSOG Z0011 results are equally applicable to all molecular phenotypes...
  22. pmc Presence of lobular carcinoma in situ does not increase local recurrence in patients treated with breast-conserving therapy
    Robin M Ciocca
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Ann Surg Oncol 15:2263-71. 2008
    ..We hypothesized that, if LCIS were a precursor, its presence in the lumpectomy specimen, particularly at the margin, could increase local recurrence (LR) after breast-conserving therapy (BCT)...
  23. ncbi Pattern of local recurrence after conservative surgery and whole-breast irradiation
    Gary M Freedman
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 61:1328-36. 2005
    ..We analyzed the long-term risk of recurrence by area of the breast after whole-breast irradiation...
  24. ncbi Phase I trial of preoperative hypofractionated intensity-modulated radiotherapy with incorporated boost and oral capecitabine in locally advanced rectal cancer
    Gary M Freedman
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 67:1389-93. 2007
    ..To determine the safety and efficacy of preoperative hypofractionated radiotherapy using intensity-modulated radiotherapy (IMRT) and an incorporated boost with concurrent capecitabine in patients with locally advanced rectal cancer...
  25. ncbi Importance of physical examination in the absence of a mammographic abnormality for the detection of early-stage breast cancer
    Hasmik Diratzouian
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Clin Breast Cancer 6:330-3. 2005
    ..A recent trial called into question the efficacy of breast self-examination. We studied the characteristics and outcome of women in whom physical examination (PE) was their sole method of breast cancer detection...
  26. ncbi Re-excision of margins before breast radiation-diagnostic or therapeutic?
    Derek B Chism
    Department of Radiation Oncology, North Shore Medical Center, Peabody, MA, USA
    Int J Radiat Oncol Biol Phys 65:1416-21. 2006
    ..To identify factors in breast cancer patients that predict the pathologic results of re-excision for close or positive margins and to determine the effect on local control...
  27. ncbi Multi-institutional review of repeat irradiation of chest wall and breast for recurrent breast cancer
    Andrew O Wahl
    Department of Radiation Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Int J Radiat Oncol Biol Phys 70:477-84. 2008
    ..To review the toxicity and clinical outcomes for patients who underwent repeat chest wall or breast irradiation (RT) after local recurrence...
  28. doi Effect of bra use during radiation therapy for large-breasted women: Acute toxicity and treated heart and lung volumes
    Lanea M M Keller
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania Electronic address
    Pract Radiat Oncol 3:9-15. 2013
    ..We report our experience using a bra during radiation in large-breasted women and its effect on acute toxicity and heart and lung dosimetry...
  29. doi Five year results of US intergroup/RTOG 9704 with postoperative CA 19-9 ≤90 U/mL and comparison to the CONKO-001 trial
    Adam C Berger
    Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 84:e291-7. 2012
    ..This report analyzes 5-year survival by serum level of tumor marker CA 19-9 of ≤90 vs >90 U/mL and compares results to the those of the CONKO-001 trial...
  30. ncbi Low complication rates are achievable after postmastectomy breast reconstruction and radiation therapy
    Penny R Anderson
    Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Int J Radiat Oncol Biol Phys 59:1080-7. 2004
    ..To report our institution's experience of complications and cosmetic results among patients who underwent modified radical mastectomy followed by reconstruction and radiation therapy (RT)...
  31. pmc Symptomatic cardiac toxicity is predicted by dosimetric and patient factors rather than changes in 18F-FDG PET determination of myocardial activity after chemoradiotherapy for esophageal cancer
    Andre Konski
    Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Radiother Oncol 104:72-7. 2012
    ..To determine factors associated with symptomatic cardiac toxicity in patients with esophageal cancer treated with chemoradiotherapy...
  32. ncbi Resection of isolated pelvic recurrences after colorectal surgery: long-term results and predictors of improved clinical outcome
    Leonard R Henry
    Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Ann Surg Oncol 14:1081-91. 2007
    ..Resection offers the only reasonable probability for cure, but at the cost of marked perioperative morbidity and potential mortality. Clinical decision making remains difficult...
  33. ncbi Routine mammography is associated with earlier stage disease and greater eligibility for breast conservation in breast carcinoma patients age 40 years and older
    Gary M Freedman
    Department of Radiation Oncology, the Breast Evaluation Center, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer 98:918-25. 2003
    ..The current study analyzed the impact of mammography in the staging and treatment of breast carcinoma...
  34. ncbi MRI-based treatment planning for radiotherapy: dosimetric verification for prostate IMRT
    Lili Chen
    Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    Int J Radiat Oncol Biol Phys 60:636-47. 2004
    ..Furthermore, it will reduce treatment cost by avoiding redundant CT scans and save patient, staff, and machine time. The purpose of this study is to investigate the dosimetric accuracy of MRI-based treatment planning for prostate IMRT...