S A Fraser
Affiliation: University of Nevada
- Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model systemS A Fraser
Cell and Molecular Biology Program, University of Nevada, Reno 89557 0046, USA
Biochem Cell Biol 76:881-7. 1998..These observations open the possibilities that membrane-bound calreticulin prevents hydrophobic entry of perforin into membranes and (or) prevents perforin from assembling into polyperforin pores...
- Perforin lytic activity is controlled by calreticulinS A Fraser
Cell and Molecular Biology Program, School of Medicine and College of Agriculture, University of Nevada, Reno, NV 89557, USA
J Immunol 164:4150-5. 2000..We propose a novel model in which calreticulin stabilizes membranes to prevent polyperforin pore formation...