Affiliation: University of California
- Claudins and alveolar epithelial barrier function in the lungJames A Frank
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, USA
Ann N Y Acad Sci 1257:175-83. 2012..This review considers recent advances in the understanding of the role of claudins in the breakdown of the alveolar epithelial barrier in disease and in epithelial repair...
- Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockadeJ A Frank
Cardiovascular Research Institute, University of California, San Francisco VA Medical Center, 4150 Clement St, Box 111D, San Francisco, CA 94121, USA
Thorax 63:147-53. 2008..A study was undertaken to determine if IL-1 signalling is a necessary early event in the pathogenesis of experimental ventilator-induced lung injury...
- Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungsJames A Frank
Department of Medicine, University of California, San Francisco, California, USA
Am J Physiol Lung Cell Mol Physiol 293:L52-9. 2007..Also, although additional studies are needed, a biological marker of alveolar epithelial injury may be useful clinically in predicting preserved AFC...
- Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studiesJames A Frank
Division of Pulmonary and Critical Care Medicine, University of California San Francisco, 4150 Clement Street, Mail Stop 111D, San Francisco, CA 94121, USA
Chest 130:1906-14. 2006..This analysis suggests that measurement of some of these biological markers may be of value in diagnosing VALI and in understanding its pathogenesis...
- Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injuryJames A Frank
University of California San Francisco, Departmnet of Medicine, San Francisco CA 94121, USA
Am J Physiol Lung Cell Mol Physiol 291:L1191-8. 2006..These data demonstrate that injurious mechanical ventilation rapidly activates alveolar macrophages and that alveolar macrophages play an important role in the initial pathogenesis of VILI...
- Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanismJames Frank
Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
J Biol Chem 278:43939-50. 2003..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity...
- Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cellsMichael J Lafemina
Univ of California, San Francisco, NCIRE VAMC, 94121, USA
Am J Physiol Lung Cell Mol Physiol 299:L724-34. 2010..In addition, these data demonstrate the complete claudin expression profile for AT1 and AT2 cells and indicate that claudins-3, -4, and -18 are the primary claudins expressed in these cell types...
- Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injuryJames A Frank
Cardiovascular Research Institute, University of California, San Francisco, USA
Crit Care Med 33:181-8; discussion 254-5. 2005..The primary objective of this study was to determine the effect of one type of recruitment maneuver--sustained inflation--on alveolar epithelial and lung endothelial injury in experimental acute lung injury...
- Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusionJan Hirsch
Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
Crit Care Med 36:1846-54. 2008..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...
- Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanismsMichael T Ganter
Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
Circ Res 102:804-12. 2008..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI...
- High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearanceJames A Frank
Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 284:L791-8. 2003..Because air space edema fluid inactivates surfactant and reduces ventilated lung volume, the reduction of cAMP-dependent AFC by reactive nitrogen species may be an important mechanism of clinical ventilator-associated lung injury...
- Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteomeJan Hirsch
Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
Am J Respir Crit Care Med 175:1006-13. 2007..Mechanical ventilation with high tidal volumes leads to increased permeability, generation of inflammatory mediators, and damage to alveolar epithelial cells (ATII)...
- Science review: mechanisms of ventilator-induced injuryJames A Frank
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, Cardiovascular Research Institute, San Francisco, California, USA
Crit Care 7:233-41. 2003..The objective of the present article is to review the potential cellular mechanisms of lung injury attributable to mechanical ventilation in patients with ARDS and acute lung injury...
- Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier functionGeorge Su
Lung Biology Center, Division of Pulmonary and Critical Care Medicine, Laboratory of Surgical Research, Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Am J Respir Cell Mol Biol 36:377-86. 2007..These results identify integrin alphavbeta5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI...
- Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injuryDaniel F McAuley
Cardiovascular Research Institute, University of California, San Francisco, CA, USA
Crit Care Med 32:1470-6. 2004....
- Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungsJames A Frank
Cardiovascular Research Institute and the Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0130, USA
Am J Respir Crit Care Med 165:242-9. 2002..The additional decrease in pulmonary edema with a tidal volume of 3 ml/kg is partly accounted for by greater protection of the alveolar epithelium...
- Progress toward a systems biology approach to acute lung injuryJames A Frank
Am J Physiol Lung Cell Mol Physiol 293:L290-1. 2007
- Leukotrienes in acute lung injury: a potential therapeutic target?James A Frank
Am J Respir Crit Care Med 172:261-2. 2005
- VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURYJames Frank; Fiscal Year: 2006..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..