Jonathan H Fox
Affiliation: University of Wyoming
- Iron accumulates in Huntington's disease neurons: protection by deferoxamineJianfang Chen
Department of Veterinary Sciences and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming, United States of America
PLoS ONE 8:e77023. 2013..These findings, together with protection by deferoxamine, support a potentiating role of neuronal iron accumulation in HD. ..
- The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's diseaseJonathan H Fox
MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Charlestown, MA, USA
Mol Neurodegener 5:26. 2010..In this study, we evaluated the mTOR kinase inhibitor and macroautophagy promoting drug everolimus in the R6/2 mouse model of HD...
- Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble proteinJonathan H Fox
Department of Veterinary Science and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming 82070, USA
J Biol Chem 286:18320-30. 2011..These findings show that inhibiting formation of oxidation-dependent huntingtin oligomers, or promoting their dissolution, may have protective effects in HD by decreasing the burden of soluble mutant huntingtin...
- Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse modelZhen Lu
Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA Neuroscience Graduate Program, University of Wyoming, Laramie, WY 82070, USA
Neurobiol Dis 71:34-42. 2014..Modification of selenium metabolism results in beneficial effects in mouse HD and thus may represent a therapeutic strategy. ..
- Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's diseaseKiersten L Berggren
Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Road, Laramie, WY 82070, USA Electronic address
Redox Biol 4:363-74. 2015..Findings indicate that elevated neonatal iron intake potentiates mouse HD and promotes oxidative stress and energetic dysfunction in brain. Neonatal-infant dietary iron intake level may be an environmental modifier of human HD. ..