Susan Fisher

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia
    Susan J Fisher
    Department of Stomatology, University of California San Francisco, San Francisco, California, USA
    Reprod Biol Endocrinol 2:53. 2004
  2. ncbi request reprint EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation
    Kristy Red-Horse
    Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA
    Development 132:4097-106. 2005
  3. doi request reprint Why is placentation abnormal in preeclampsia?
    Susan J Fisher
    Division of Maternal Fetal Medicine, Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Department of Anatomy, University of California, San Francisco, San Francisco, CA Electronic address
    Am J Obstet Gynecol 213:S115-22. 2015
  4. pmc Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha
    P M Drake
    Department of Biochemistry and Biophysics, University of California at San Francisco, CA 94143, USA
    J Exp Med 193:1199-212. 2001
  5. pmc Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis
    S Fisher
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143, USA
    J Virol 74:6808-20. 2000
  6. ncbi request reprint When is seeing believing? The use of color Doppler ultrasound to diagnose placenta accreta in the first trimester of pregnancy
    S J Fisher
    Department of Stomatology, University of Clifornia, San Francisco, 94143 0512, USA
    Ultrasound Obstet Gynecol 19:540-2. 2002
  7. ncbi request reprint Viral and bacterial pathogens at the maternal-fetal interface
    Susan McDonagh
    Department of Stomatology, University of California, San Francisco, San Francisco, California 94143 0512, USA
    J Infect Dis 190:826-34. 2004
  8. pmc Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro
    Takako Yamamoto-Tabata
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 78:2831-40. 2004
  9. pmc Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity
    Lenore Pereira
    Departments of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 77:13301-14. 2003
  10. ncbi request reprint Reciprocal chemokine receptor and ligand expression in the human placenta: implications for cytotrophoblast differentiation
    Penelope M Drake
    Department of Stomatology, University of California San Francisco, San Francisco, California, USA
    Dev Dyn 229:877-85. 2004

Research Grants

Collaborators

Detail Information

Publications42

  1. pmc The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia
    Susan J Fisher
    Department of Stomatology, University of California San Francisco, San Francisco, California, USA
    Reprod Biol Endocrinol 2:53. 2004
    ..The current challenge is to build on this knowledge to design clinically useful tests for predicting, diagnosing and treating this dangerous disorder...
  2. ncbi request reprint EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation
    Kristy Red-Horse
    Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA
    Development 132:4097-106. 2005
    ..When they encounter ephrin B2 ligands expressed in uterine arterioles, migration is permitted. The net effect is preferential cytotrophoblast remodeling of arterioles, a hallmark of human placentation...
  3. doi request reprint Why is placentation abnormal in preeclampsia?
    Susan J Fisher
    Division of Maternal Fetal Medicine, Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Department of Anatomy, University of California, San Francisco, San Francisco, CA Electronic address
    Am J Obstet Gynecol 213:S115-22. 2015
    ..The next challenge is asking what the instigating causes are. There is added urgency to finding the answers, because these pathways could be valuable therapeutic targets for reversing abnormal placental function in patients. ..
  4. pmc Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha
    P M Drake
    Department of Biochemistry and Biophysics, University of California at San Francisco, CA 94143, USA
    J Exp Med 193:1199-212. 2001
    ....
  5. pmc Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis
    S Fisher
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143, USA
    J Virol 74:6808-20. 2000
    ..Furthermore, the observation that CMV infection impairs critical aspects of cytotrophoblast function offers testable hypotheses for explaining the deleterious effects of this virus on pregnancy outcome...
  6. ncbi request reprint When is seeing believing? The use of color Doppler ultrasound to diagnose placenta accreta in the first trimester of pregnancy
    S J Fisher
    Department of Stomatology, University of Clifornia, San Francisco, 94143 0512, USA
    Ultrasound Obstet Gynecol 19:540-2. 2002
  7. ncbi request reprint Viral and bacterial pathogens at the maternal-fetal interface
    Susan McDonagh
    Department of Stomatology, University of California, San Francisco, San Francisco, California 94143 0512, USA
    J Infect Dis 190:826-34. 2004
    ..Analyses of immunoglobulin G isolated from the placenta support the hypothesis that immune responses suppress CMV reactivation in the presence of pathogenic bacteria at the maternal-fetal interface...
  8. pmc Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro
    Takako Yamamoto-Tabata
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 78:2831-40. 2004
    ..Reduced MMP activity early in placental development could impair cytotrophoblast remodeling of the uterine vasculature and eventually restrict fetal growth in affected pregnancies...
  9. pmc Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity
    Lenore Pereira
    Departments of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 77:13301-14. 2003
    ..These results suggest that the outcome of cytomegalovirus infection depends on the presence of other pathogens and coordinated immune responses to viral replication at the maternal-fetal interface...
  10. ncbi request reprint Reciprocal chemokine receptor and ligand expression in the human placenta: implications for cytotrophoblast differentiation
    Penelope M Drake
    Department of Stomatology, University of California San Francisco, San Francisco, California, USA
    Dev Dyn 229:877-85. 2004
    ....
  11. pmc The placenta: transcriptional, epigenetic, and physiological integration during development
    Emin Maltepe
    Department of Pediatrics, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, 513 Parnassus Ave HSE 1401, Box 1346, San Francisco, CA 94143 1346, USA
    J Clin Invest 120:1016-25. 2010
    ..Developing an understanding of these pathways contributes to an improvement of our models for studying trophoblast biology and sheds light on the etiology of pregnancy complications and the in utero programming of adult diseases...
  12. pmc A new role for the human placenta as a hematopoietic site throughout gestation
    Alicia Barcena
    Institute for Regeneration Medicine, Human Embryonic Stem Cell Program, Department of Cell and Tissue Biology, University of California at San Francisco, California 94143, USA
    Reprod Sci 16:178-87. 2009
    ..Together, these data suggest that the human placenta is potentially an important hematopoietic organ, opening the possibility of banking placental hematopoietic stem cells along with cord blood for transplantation...
  13. pmc The human placenta is a hematopoietic organ during the embryonic and fetal periods of development
    Alicia Barcena
    Institute for Regeneration Medicine, Human Embryonic Stem Cell Program, Department of Cell and Tissue Biology, University of California, San Francisco, 513 Parnassus Avenue, HSE 1619, San Francisco, California 94143 0512, USA
    Dev Biol 327:24-33. 2009
    ..These data suggest that the human placenta is an important hematopoietic organ, raising the possibility of banking placental hematopoietic stem cells along with cord blood for transplantation...
  14. ncbi request reprint Human pregnancy: the role of chemokine networks at the fetal-maternal interface
    Kristy Red-Horse
    Department of Pathology, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0512, USA
    Expert Rev Mol Med 6:1-14. 2004
    ..Thus, as in other systems, at the fetal-maternal interface chemokines might regulate multiple functions...
  15. ncbi request reprint Abnormal placentation and the syndrome of preeclampsia
    Michael T McMaster
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA
    Semin Nephrol 24:540-7. 2004
    ..It is likely that this new paradigm will improve both diagnosis and treatment of this life-threatening pregnancy complication...
  16. ncbi request reprint A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta
    Akraporn Prakobphol
    Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA
    Dev Biol 298:107-17. 2006
    ..This type of adhesion may also facilitate CTB exit from cell columns, a prerequisite for uterine invasion...
  17. ncbi request reprint Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype
    Jingly F Weier
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143 0720, USA
    Dev Biol 279:420-32. 2005
    ..Thus, aneuploidy appears to be an important component of normal placentation, perhaps limiting the proliferative and invasive potential of cytotrophoblasts within the uterus...
  18. ncbi request reprint The human placenta remodels the uterus by using a combination of molecules that govern vasculogenesis or leukocyte extravasation
    Yan Zhou
    Department of Stomatology, University of California, San Francisco, California 94143 0512, USA
    Ann N Y Acad Sci 995:73-83. 2003
    ....
  19. pmc Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface
    Kristy Red-Horse
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Clin Invest 114:744-54. 2004
    ..The challenge is to turn this information into clinically useful tests for monitoring placental function and, hence, pregnancy outcome...
  20. ncbi request reprint Chemokine expression and function at the human maternal-fetal interface
    Penelope M Drake
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143 0512, USA
    Rev Endocr Metab Disord 3:159-65. 2002
  21. ncbi request reprint Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor
    Yan Zhou
    Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA
    Cell Tissue Res 329:559-69. 2007
    ..Our results suggest that the maternal-fetal interface from cases of PTL without inflammation can be used for comparative purposes, e.g., as age-matched controls, in studies of the effects of PE on cells in this region...
  22. pmc Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning
    Bernard Lo
    Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Cell Stem Cell 6:16-20. 2010
    ..Professional standards and laws that ban human reproductive cloning by somatic cell nuclear transfer should be revised to also forbid it by other methods, such as iPSCs via tetraploid complementation...
  23. doi request reprint Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo
    Tamara Zdravkovic
    Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143 0512, USA
    Reprod Toxicol 26:86-93. 2008
    ..Together these results offer new explanations in terms of embryo toxicity for the large negative impact of cigarette smoke exposure on a woman's reproductive capacity...
  24. pmc Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation
    Kristy Red-Horse
    Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California, USA
    J Clin Invest 116:2643-52. 2006
    ....
  25. ncbi request reprint Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall
    Tamara Zdravkovic
    Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA
    Reprod Toxicol 22:69-76. 2006
    ....
  26. ncbi request reprint Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta
    Emin Maltepe
    Department of Pediatrics and Molecular Medicine Program, University of California, Parnassus Avenue, San Francisco, CA 94143, USA
    Development 132:3393-403. 2005
    ..Thus, the HIFs play important roles in modulating the developmental plasticity of stem cells by integrating physiological, transcriptional and epigenetic inputs...
  27. pmc Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
    Yan Zhou
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    Am J Pathol 160:1405-23. 2002
    ..Together, the results of this study showed that VEGF family members regulate cytotrophoblast survival and that expression of a subset of family members is dysregulated in severe forms of preeclampsia...
  28. ncbi request reprint Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies
    Robert N Taylor
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    Am J Obstet Gynecol 188:177-82. 2003
    ....
  29. ncbi request reprint Disruption of oxygen-regulated responses underlies pathological changes in the placentas of women who smoke or who are passively exposed to smoke during pregnancy
    Olga Genbacev
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    Reprod Toxicol 17:509-18. 2003
    ..Together, these findings explain, in part, how smoking damages the placenta by altering expression of key mediators of placental development...
  30. pmc Chapter 12. Placental remodeling of the uterine vasculature
    Nathan M Hunkapiller
    Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, USA
    Methods Enzymol 445:281-302. 2008
    ..Finally, we conclude with methods devised by our group and others to explore the complex heterotypic cell-cell interactions that occur as CTBs invade blood vessels in vivo in the nude mouse...
  31. pmc Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2
    Virginia D Winn
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94143, USA
    Endocrinology 150:452-62. 2009
    ..The functional significance of these novel observations may provide new insights into the pathogenesis of PE, and assaying the circulating levels of these proteins could have clinical utility for predicting and/or diagnosing PE...
  32. ncbi request reprint Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation
    Ana Krtolica
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94143, USA
    Stem Cells 25:2215-23. 2007
    ..Our findings have numerous implications with regard to strategies for deriving, propagating, and differentiating hESC...
  33. ncbi request reprint Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders
    Olga Genbacev
    Department of Cell and Tissue Biology, Program in Human Stem Cell Biology, and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, California 94143 0512, USA
    Fertil Steril 83:1517-29. 2005
    ..Because the embryo develops in close contact with extraembryonic membranes, we hypothesized that placental mesenchyme might replicate the stem cell niche in situ...
  34. ncbi request reprint Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C
    Yan Zhou
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143, USA
    Dev Biol 263:114-25. 2003
    ....
  35. ncbi request reprint Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface
    Olga D Genbacev
    Departments of Stomatology, Anatomy, and Pharmaceutical Chemistry, University of California, San Francisco, CA 94143, USA
    Science 299:405-8. 2003
    ..These results suggest that trophoblast L-selectin mediates interactions with the uterus and that this adhesion mechanism may be critical to establishing human pregnancy...
  36. ncbi request reprint Highly glycosylated human salivary molecules present oligosaccharides that mediate adhesion of leukocytes and Helicobacter pylori
    Akraporn Prakobphol
    Departments of Stomatology, University of California, San Francisco, California 94143, USA
    Biochemistry 44:2216-24. 2005
    ..Our findings suggest novel strategies, based on the relevant carbohydrate structures, for promoting or inhibiting these processes...
  37. ncbi request reprint Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway
    Alexi Wright
    University of Pennsylvania Medical School, Philadelphia, PA, USA
    Am J Med Genet A 130:354-64. 2004
    ..Furthermore, our data may explain why a significant number of these pregnancies end in spontaneous abortion while others survive to term...
  38. ncbi request reprint Modification of the standard Trizol-based technique improves the integrity of RNA isolated from RNase-rich placental tissue
    Ronit Haimov-Kochman
    Clin Chem 52:159-60. 2006
  39. ncbi request reprint MUC1 is a scaffold for selectin ligands in the human uterus
    Daniel D Carson
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Front Biosci 11:2903-8. 2006
    ..Consequently, MUC1 represents a potential ligand for selectins expressed by human blastocysts...
  40. pmc Listeriosis in the pregnant guinea pig: a model of vertical transmission
    Anna I Bakardjiev
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    Infect Immun 72:489-97. 2004
    ..Further understanding of vertical transmission of L. monocytogenes will help in designing more effective means of treatment and disease prevention...
  41. ncbi request reprint Functional and placental expression analysis of the human NRF3 transcription factor
    Benoît Chénais
    Lady Davis Institute for Medical Research, University of Montreal, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Mol Endocrinol 19:125-37. 2005
    ..Our functional studies suggest that human NRF3 is a potent transcriptional activator. Finally, our expression and induction analyses hint at a possible role of Nrf3 in placental gene expression and development...
  42. ncbi request reprint Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term
    Virginia D Winn
    Reproductive Science, University of Colorado Health Sciences Center, 12800 East 19th Avenue, P O Box 6511, Aurora, CO 80045, USA
    Endocrinology 148:1059-79. 2007
    ....

Research Grants5

  1. A NOVEL VASCULOGENESIS PROGRAM IN CYTOTROPHOBLASTS
    Susan Fisher; Fiscal Year: 2003
    ..Whether these mechanisms could inhibit tumor-induced angiogenesis, and consequently tumor growth, is another intriguing possibility. ..
  2. Trophoblast Selectins and Their Uterine Mucin Ligands
    Susan Fisher; Fiscal Year: 2006
    ..abstract_text> ..
  3. Cataloguing the Human Salivary Proteome
    Susan Fisher; Fiscal Year: 2007
    ..We envision that the data from this project will have important relevance to on-going efforts to improve oral health. ..
  4. MOLECULAR MECHANISMS--BACTERIAL ADHERENCE TO CEMENTUM
    Susan Fisher; Fiscal Year: 2008
    ..This greatly simplifies the design of artificial salivary molecules that mimic the natural bacterial receptor activity of this fluid, as well as competitive inhibitors of plaque formation. ..
  5. Neuronal Guidance Mechanisms in Placental Development
    Susan Fisher; Fiscal Year: 2009
    ..In doing so, we will gain important insights into the etiology of PE, GTDs and, perhaps, other types of tumors. ..