Luis A Fernandez

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Superior long-term results of simultaneous pancreas-kidney transplantation from pediatric donors
    Luis A Fernandez
    Division of Transplantation, Department of Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792 7375, USA
    Am J Transplant 4:2093-101. 2004
  2. ncbi request reprint Validation of large particle flow cytometry for the analysis and sorting of intact pancreatic islets
    Luis A Fernandez
    Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 3236, USA
    Transplantation 80:729-37. 2005
  3. pmc Donation after cardiac death: the University of Wisconsin experience with liver transplantation
    David P Foley
    Department of Surgery, Division of Transplantation, University of Florida, Gainesville, FL, USA
    Ann Surg 242:724-31. 2005
  4. pmc Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center
    David P Foley
    Division of Organ Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, 53792, USA
    Ann Surg 253:817-25. 2011
  5. pmc Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibodies in moderately sensitized renal transplant recipients
    Marissa M Brokhof
    1 Department of Pharmacy, University of Wisconsin, Madison, WI 2 Department of Surgery, University of Wisconsin, Madison, WI 3 Department of Medicine, University of Wisconsin, Madison, WI 4 Departments of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 5 Address correspondence to Arjang Djamali, M D, M S, F A S N, 5142 MFCB 1685 Highland Avenue, Madison, WI 53705
    Transplantation 97:612-7. 2014
  6. pmc Increased C4d in post-reperfusion biopsies and increased donor specific antibodies at one-week post transplant are risk factors for acute rejection in mild to moderately sensitized kidney transplant recipients
    Arjang Djamali
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 51703, USA
    Kidney Int 83:1185-92. 2013
  7. ncbi request reprint Immune status assay (ISA): a noninvasive procedure for studying allograft rejection
    Luis A Fernandez
    Division of Transplantation, Department of Surgery, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792 7375, USA
    Transpl Immunol 13:147-54. 2004
  8. pmc Simultaneous pancreas-kidney transplantation from donation after cardiac death: successful long-term outcomes
    Luis A Fernandez
    Division of Transplantation, University of Wisconsin Medical School, Madison, WI 53792 7375, USA
    Ann Surg 242:716-23. 2005
  9. pmc Donation after cardiac death: a 29-year experience
    Janet M Bellingham
    Division of Organ Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    Surgery 150:692-702. 2011
  10. pmc Complications associated with liver transplantation in the obese recipient
    John C LaMattina
    Division of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Transplant 26:910-8. 2012

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Superior long-term results of simultaneous pancreas-kidney transplantation from pediatric donors
    Luis A Fernandez
    Division of Transplantation, Department of Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792 7375, USA
    Am J Transplant 4:2093-101. 2004
    ..15; pancreas 75% vs. 76%, p = 0.10, respectively). Pediatric donors represent a valuable source of organs, providing excellent short- and long-term outcomes. Wide utilization of pediatric organs will substantially increase the donor pool...
  2. ncbi request reprint Validation of large particle flow cytometry for the analysis and sorting of intact pancreatic islets
    Luis A Fernandez
    Department of Surgery, University of Wisconsin Madison, Madison, WI 53792 3236, USA
    Transplantation 80:729-37. 2005
    ..We evaluated Complex Object Parametric Analyzer and Sorter (COPAS) large particle flow cytometry for the determination of islet equivalent counts and purities of islet preparations...
  3. pmc Donation after cardiac death: the University of Wisconsin experience with liver transplantation
    David P Foley
    Department of Surgery, Division of Transplantation, University of Florida, Gainesville, FL, USA
    Ann Surg 242:724-31. 2005
    ..To determine whether the outcomes of liver transplantation (LTx) from donation after cardiac death (DCD) donors are equivalent to those from donation after brain death (DBD) donors...
  4. pmc Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center
    David P Foley
    Division of Organ Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, 53792, USA
    Ann Surg 253:817-25. 2011
    ..This study evaluates the long-term outcomes, biliary complication rates, and risk factors for biliary complications after liver transplantation from "donation after cardiac death" (DCD) donors...
  5. pmc Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibodies in moderately sensitized renal transplant recipients
    Marissa M Brokhof
    1 Department of Pharmacy, University of Wisconsin, Madison, WI 2 Department of Surgery, University of Wisconsin, Madison, WI 3 Department of Medicine, University of Wisconsin, Madison, WI 4 Departments of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 5 Address correspondence to Arjang Djamali, M D, M S, F A S N, 5142 MFCB 1685 Highland Avenue, Madison, WI 53705
    Transplantation 97:612-7. 2014
    ..Recent evidence suggests that de novo donor-specific antibodies (dnDSA) are associated with antibody-mediated rejection (ABMR) and graft failure after kidney transplantation. The effects of induction immunosuppression on dnDSA are unknown...
  6. pmc Increased C4d in post-reperfusion biopsies and increased donor specific antibodies at one-week post transplant are risk factors for acute rejection in mild to moderately sensitized kidney transplant recipients
    Arjang Djamali
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 51703, USA
    Kidney Int 83:1185-92. 2013
    ..8-fold risk of rejection. Thus, C4d staining in post-reperfusion biopsies and an early rise in donor specific antibodies after transplantation are risk factors for rejection in moderately sensitized patients...
  7. ncbi request reprint Immune status assay (ISA): a noninvasive procedure for studying allograft rejection
    Luis A Fernandez
    Division of Transplantation, Department of Surgery, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792 7375, USA
    Transpl Immunol 13:147-54. 2004
    ..We report here on a simple assay called immune status assay (ISA) that determines the status of the graft by simply examining the activation status of blood T cells...
  8. pmc Simultaneous pancreas-kidney transplantation from donation after cardiac death: successful long-term outcomes
    Luis A Fernandez
    Division of Transplantation, University of Wisconsin Medical School, Madison, WI 53792 7375, USA
    Ann Surg 242:716-23. 2005
    ..The outcomes of simultaneous pancreas-kidney (SPK) transplantation with donor organs procured from donation after cardiac death (DCD) are compared with transplants performed with donor organs recovered from donation after brain death (DBD)...
  9. pmc Donation after cardiac death: a 29-year experience
    Janet M Bellingham
    Division of Organ Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    Surgery 150:692-702. 2011
    ..To report the long-term outcomes of 1218 organs transplanted from donation after cardiac death (DCD) donors from January 1980 through December 2008...
  10. pmc Complications associated with liver transplantation in the obese recipient
    John C LaMattina
    Division of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Transplant 26:910-8. 2012
    ....
  11. pmc Chronic kidney disease stage progression in liver transplant recipients
    John C LaMattina
    Department of Medicine, University of Wisconsin, H4 564 CSC, 600 Highland Avenue, Madison, WI 53792, USA
    Clin J Am Soc Nephrol 6:1851-7. 2011
    ..There is little information on chronic kidney disease (CKD) stage progression rates and outcomes in liver transplant recipients. Identifying modifiable risk factors may help prevent CKD progression in liver transplant recipients...
  12. ncbi request reprint Campath-1H in renal transplantation: The University of Wisconsin experience
    Stuart J Knechtle
    Department of Surgery, University of Winsconsin Medical School, Madison 53792 7375, USA
    Surgery 136:754-60. 2004
    ....
  13. pmc Native kidney function following liver transplantation using calcineurin inhibitors: single-center analysis with 20 years of follow-up
    John C LaMattina
    Division of Transplantation, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Transplant 27:193-202. 2013
    ..As outcomes from liver transplantation continue to improve, long-term native kidney function in these recipients becomes more critical to patient survival...
  14. pmc Differential outcomes of expanded-criteria donor renal allografts according to recipient age
    Joshua D Mezrich
    Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    Clin J Am Soc Nephrol 7:1163-71. 2012
    ..This study sought to determine whether older recipients had significantly worse outcomes from receiving ECD kidneys and whether outcomes of ECD versus standard-criteria donor (SCD) kidneys differed in younger recipients...
  15. ncbi request reprint Donation after cardiac death: the University of Wisconsin experience
    Anthony M D'Alessandro
    Department of Surgery, University of Wisconsin Medical School, USA
    Ann Transplant 9:68-71. 2004
    ..The objective of this analysis was to compare the results of transplantation of livers, pancreases, kidneys, and lungs from donation after cardiac death (DCD) donors to organs transplanted from donation after brain death (DBD) donors...
  16. ncbi request reprint Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation
    Rolf N Barth
    Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, 53792 7375, USA
    Transpl Int 19:885-92. 2006
    ..Because of the higher incidence of early rejection, we recommend a modified strategy of immunosuppression including a brief course of a calcineurin inhibitor...
  17. doi request reprint Alemtuzumab induction and triple maintenance immunotherapy in kidney transplantation from donors after cardiac death
    Erik Schadde
    Department of Surgery, Kansas University, Kansas City, KS, USA
    Transpl Int 21:625-36. 2008
    ..It appears however that CMV infections are increased in patients induced with alemtuzumab. We therefore conclude that induction with alemtuzumab does not confer any advantage over traditional induction agents...
  18. ncbi request reprint Influence of kidney function to the impact of acute rejection on long-term kidney transplant survival
    Philipp C Nett
    Division of Organ Transplantation, University of Wisconsin Hospital and Clinics, Madison, USA
    Transpl Int 18:385-9. 2005
    ..4-, 7.1- and 21.8-fold, but remained still significant (P = 0.023). In conclusion, the higher risk of graft loss after late AR is not fully explained by impaired graft function measured by serum creatinine...
  19. pmc A simplified approach to human islet quality assessment
    Matthew S Hanson
    Department of Surgery, University of Wisconsin Madison, WI, USA
    Transplantation 89:1178-88. 2010
    ..The objective of this study was to validate a novel set of islet quality assays and develop a simplified islet quality scoring system for both basic research and clinical applications...
  20. ncbi request reprint Donation after cardiac death: the university of wisconsin experience with renal transplantation
    Jeffrey T Cooper
    Department of Surgery, Tufts University School of Medicine, Boston, MA, USA
    Am J Transplant 4:1490-4. 2004
    ..Organ procurement organizations, transplant centers, and hospitals should work to expand the implementation of DCD policies...
  21. ncbi request reprint Liver transplantation for biliary atresia: 19-year, single-center experience
    L Thomas Chin
    Division of Organ Transplantation, Department of Surgery, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792 7375, USA
    Exp Clin Transplant 2:178-82. 2004
    ..In this study, we describe our 19-year experience with liver transplantation as the definitive treatment for congenital biliary atresia...
  22. doi request reprint Early activation of the inflammatory response in the liver of brain-dead non-human primates
    Juan Sebastian Danobeitia
    Department of Surgery, Division of Transplantation, University of Wisconsin Madison, Madison, Wisconsin 53792 3236, USA
    J Surg Res 176:639-48. 2012
    ..We characterized the early innate immune response induced by BD in the liver and peripheral blood of hemodinamically stable non-human primates (NHP)...
  23. pmc Simultaneous liver and kidney transplantation using donation after cardiac death donors: a brief report
    John C LaMattina
    Division of Transplantation, University of Wisconsin, Madison, WI, USA
    Liver Transpl 17:591-5. 2011
    ..Although long-term outcomes remain unknown, the utilization of DCD organs for SLK transplantation should be considered a valid approach to safely expanding the donor organ pool...
  24. ncbi request reprint Liver transplantation for HELLP syndrome
    Brian D Shames
    Division of Transplantation, Department of Surgery, University of Wisconsin Medical School, Madison, WI, USA
    Liver Transpl 11:224-8. 2005
    ..Patients with complicated HELLP syndrome are best managed at a center with expertise in liver transplantation...
  25. ncbi request reprint Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection
    Jose R Torrealba
    Department of Pathology, University of Wisconsin Medical School, Madison, WI 53792 7375, USA
    Transplantation 76:524-30. 2003
    ..A reliable large-animal model for renal allograft CR is needed and has not been reported in the literature yet...
  26. ncbi request reprint Flow cytometric quantification of glucose-stimulated beta-cell metabolic flux can reveal impaired islet functional potency
    Matthew S Hanson
    Department of Surgery, Division of Transplantation, University of Wisconsin Madison, Madison, WI 53792 3236, USA
    Cell Transplant 17:1337-47. 2008
    ..Single cell flow cytometry can simultaneously quantify both overall islet cell health and beta-cell glucose responsiveness as indicators of functional potency...
  27. ncbi request reprint Association of cytomegalovirus disease and acute rejection with graft loss in kidney transplantation
    Philipp C Nett
    Division of Organ Transplantation, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Transplantation 78:1036-41. 2004
    ..However, little is known about their association with graft loss when both affect the transplant recipient...
  28. doi request reprint Results of pediatric living donor compared to deceased donor liver transplantation in the PELD/MELD era: Experience from two centers on two different continents
    Yucel Yankol
    Department of Surgery Division of Transplantation, University of Wisconsin, Madison, WI, USA
    Pediatr Transplant 20:72-82. 2016
    ..3% and 53.3%, p = 0.002 and p = 0.028, respectively). Regardless of PELD/MELD score, status, age group, and recipient weight, LDLT provides excellent patient and graft survival with a lower incidence of rejection compared to DDLT. ..
  29. doi request reprint Donor Pretreatment With IL-1 Receptor Antagonist Attenuates Inflammation and Improves Functional Potency in Islets From Brain-Dead Nonhuman Primates
    Juan S Danobeitia
    Department of Surgery Division of Transplantation, University of Wisconsin Madison, Madison, WI, USA
    Cell Transplant 24:1863-77. 2015
    ..These results suggest that early immunomodulation targeting inflammation in the BD donor may represent an effective therapeutic strategy to improve islet quality and function prior to transplantation...
  30. pmc FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation
    Dawn Belt Davis
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Mol Endocrinol 24:1822-34. 2010
    ..Our data suggest that beta-cell proliferation occurs in adult obese humans in an attempt to expand beta-cell mass to compensate for insulin resistance, and that the FoxM1 transcriptional program plays a key role in this process...
  31. doi request reprint Can 'extreme' pancreas donors expand the donor pool?
    Nikole A Neidlinger
    University of Wisconsin Department of Surgery, Division of Organ Transplantation, Clinical Science Center, Madison, Wisconsin 53792 7375, USA
    Curr Opin Organ Transplant 13:67-71. 2008
    ..The present review investigates donor qualities that impact pancreas and islet transplantation, with a focus on donors that have been historically underutilized, including those of extreme age, extreme size, and donors after cardiac death...
  32. doi request reprint When Do DCD Donors Die?: Outcomes and Implications of DCD at a High-volume, Single-center OPO in the United States
    Joseph R Scalea
    Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, WI University of Wisconsin Organ and Tissue Donation UWOTD, Madison, WI
    Ann Surg 263:211-6. 2016
    ..The objective of this study was to determine the fate of patients who attempted to donate organs after circulatory death (DCD) using a standardized DCD protocol...
  33. ncbi request reprint Biliary Complications After Liver Transplantation From Donation After Cardiac Death Donors: An Analysis of Risk Factors and Long-term Outcomes From a Single Center
    David P Foley
    From the Division of Organ Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison
    Ann Surg 253:817-25. 2011
    ..This study evaluates the long-term outcomes, biliary complication rates, and risk factors for biliary complications after liver transplantation from "donation after cardiac death" (DCD) donors...
  34. ncbi request reprint Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model
    Luis A Fernandez
    Department of Surgery, Division of Transplantation, Laboratory of Transplant Immunology, University of Wisconsin Madison, WI, USA
    Transplantation 74:1609-17. 2002
    ..Piceatannol blocks Syk and ZAP-70, tyrosine kinases involved in immune cell activation. We examined whether piceatannol prolongs kidney allograft survival in the stringent ACI-to-Lewis rat model...
  35. pmc Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets
    Michael J MacDonald
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 286:18383-96. 2011
    ....
  36. pmc Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipient
    Micah R Chan
    Department of Medicine, Section of Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI, USA
    Am J Kidney Dis 53:321-6. 2009
    ..This report reemphasizes the importance of screening patients with atypical hemolytic uremic syndrome for mutations in these genes before renal transplantation and shows the challenges in the management of these patients...
  37. ncbi request reprint A significant role for histocompatibility in human islet transplantation
    T Mohanakumar
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 82:180-7. 2006
    ..The purpose of this study was to determine the role of pretransplant sensitization to human leukocyte antigen (HLA) in islet transplantation...

Research Grants2

  1. Donation After Cardiac Death for Isolated Pancreatic Is*
    Luis Fernandez; Fiscal Year: 2006
    ..In addition, the development of rapid, accurate, and predictive tests of islet viability and function post isolation will contribute to significant improvements in post transplant success. ..
  2. Multi-Parametric Characterization of Human Islets: Predictor of Islet Quality, Po
    Luis Fernandez; Fiscal Year: 2008
    ..abstract_text> ..