Jian Q Feng

Summary

Affiliation: University of Missouri-Kansas City
Country: USA

Publications

  1. ncbi request reprint Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo
    J Q Feng
    School of Dentistry, Dept of Oral Biology, University of Missouri Kansas City, 64108, USA
    J Dent Res 81:6-10. 2002
  2. ncbi request reprint The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development
    J Q Feng
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th Street, Kansas City, MO 64108, USA
    J Dent Res 82:776-80. 2003
  3. pmc Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th Street, Kansas City, MO 64108, USA
    Dev Biol 303:191-201. 2007
  4. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
  5. ncbi request reprint Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion
    Jiwang Zhang
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Stem Cells 24:2826-39. 2006
  6. ncbi request reprint Differential regulation of dentin matrix protein 1 expression during odontogenesis
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Cells Tissues Organs 181:241-7. 2005
  7. pmc Pathogenic role of Fgf23 in Dmp1-null mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 295:E254-61. 2008
  8. pmc E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation
    Keqin Zhang
    Department of Oral Biology, School of Dentistry, University of Missouri at Kansas City, 630 East 25th Street, Kansas City, MO 64108 2784, USA
    Mol Cell Biol 26:4539-52. 2006
  9. pmc Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th St, Kansas City, MI 64108, USA
    J Biol Chem 280:6197-203. 2005
  10. ncbi request reprint Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas, City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:19141-8. 2004

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Identification of cis-DNA regions controlling Bmp4 expression during tooth morphogenesis in vivo
    J Q Feng
    School of Dentistry, Dept of Oral Biology, University of Missouri Kansas City, 64108, USA
    J Dent Res 81:6-10. 2002
    ..The determination of unique domains by controlling the expression of the Bmp4 gene suggests that different transcriptional factors regulate the Bmp4 level at different stages during tooth morphogenesis...
  2. ncbi request reprint The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development
    J Q Feng
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th Street, Kansas City, MO 64108, USA
    J Dent Res 82:776-80. 2003
    ..This suggests that DMP1 is not essential for early mouse skeletal or dental development...
  3. pmc Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th Street, Kansas City, MO 64108, USA
    Dev Biol 303:191-201. 2007
    ....
  4. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
  5. ncbi request reprint Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion
    Jiwang Zhang
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Stem Cells 24:2826-39. 2006
    ..Subsequently, PTEN, through phosphatidyl inositol 3-kinase-Akt, inhibits the activity of beta-catenin, the convergence point of the BMP and Wnt signaling pathways...
  6. ncbi request reprint Differential regulation of dentin matrix protein 1 expression during odontogenesis
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Cells Tissues Organs 181:241-7. 2005
    ....
  7. pmc Pathogenic role of Fgf23 in Dmp1-null mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 295:E254-61. 2008
    ..These data suggest that the regulation of extracellular matrix mineralization by DMP1 is coupled to renal phosphate handling and vitamin D metabolism through a DMP1-dependent regulation of FGF23 production by osteocytes...
  8. pmc E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation
    Keqin Zhang
    Department of Oral Biology, School of Dentistry, University of Missouri at Kansas City, 630 East 25th Street, Kansas City, MO 64108 2784, USA
    Mol Cell Biol 26:4539-52. 2006
    ..These data suggest that osteocytes may be able to extend their cellular processes after embedment in mineralized matrix and have implications for osteocytic modification of their microenvironment...
  9. pmc Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th St, Kansas City, MI 64108, USA
    J Biol Chem 280:6197-203. 2005
    ..In addition, blood vessel invasion is impaired in the epiphyses of Dmp1(-/-) mice. These findings show that DMP1 is essential for normal postnatal chondrogenesis and subsequent osteogenesis...
  10. ncbi request reprint Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas, City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:19141-8. 2004
    ..Taken together, these studies suggest that DMP-1 is essential for later dentinogenesis during postnatal development...
  11. pmc Studies of the DMP1 57-kDa functional domain both in vivo and in vitro
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri at Kansas City, Kansas City, MO, USA
    Cells Tissues Organs 189:175-85. 2009
    ..This suggests that the 57-kDa C-terminal fragment may be able to recapitulate the function of intact DMP1 in vivo...
  12. ncbi request reprint NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro
    Jian Q Feng
    Department of Oral Biology, School of Dentistry, University of Missouri, Kansas City, Missouri 64108, USA
    J Biol Chem 278:29130-5. 2003
    ..Therefore, in postnatal growth plate chondrocytes, expression of BMP-2 is regulated by NF-kappaB, which may play an important role in chondrogenesis...
  13. ncbi request reprint Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles
    Jianghong Zhang
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th St, Kansas City, MO 64108, USA
    Biochem Biophys Res Commun 293:1412-9. 2002
    ..Therefore we present a model to explain a mechanism controlling expression of the Bmp4 gene in different tissue types, as well as different development stages as related to hair development...
  14. ncbi request reprint Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  15. ncbi request reprint Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development
    Takuya Ogawa
    Department of Orthodontics, University of Texas Health Science Center at Houston Dental Branch, Houston, Texas 77030, USA
    J Biol Chem 281:18363-9. 2006
    ....
  16. pmc Generation of a conditional null allele for Dmp1 in mouse
    Jian Q Feng
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
    Genesis 46:87-91. 2008
    ..These homozygous Cre-recombined null mice display an identical phenotype to conventional null mice. This animal model will be useful to reveal distinct roles of DMP1 in different tissues at different ages...
  17. pmc periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype
    Hector Rios
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Mol Cell Biol 25:11131-44. 2005
    ....
  18. ncbi request reprint Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo
    Jelica Gluhak-Heinrich
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Bone Miner Res 18:807-17. 2003
    ..These results support the hypothesis that osteocytes alter their matrix microenvironment in response to mechanical loading...
  19. ncbi request reprint Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo
    Wuchen Yang
    Department of Periodontics and Cellular and Structural Biology, University of Texas, San Antonio, Texas 78229, USA
    J Biol Chem 280:20680-90. 2005
    ..Thus, the 8-kb region of the DMP1 gene is a target for mechanotransduction in osteocytes, and its cis-regulatory activity may be correlated to local strain in bone...
  20. pmc DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
    Yunfeng Ling
    Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, New York, USA
    J Bone Miner Res 20:2169-77. 2005
    ..The observed decreased mineral content in dmp1 null mice indicates a key role for dmp1 in bone mineralization. Indirect effects of DMP1 on other systems also determine the KO phenotype...
  21. ncbi request reprint Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts
    Xiao Dong Chen
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Bone Miner Res 22:1943-56. 2007
    ..We conclude that the marrow ECM facilitates expansion of mesenchymal progenitors and hypothesize that it plays an important role in the maintenance of MSC stemness...
  22. pmc Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia
    Baozhi Yuan
    Department of Medicine, University of Wisconsin, GRECC, William F Middleton Veterans Administration Hospital, Madison, Wisconsin, USA
    J Clin Invest 118:722-34. 2008
    ..These data provide evidence that aberrant Phex function in osteoblasts and/or osteocytes alone is sufficient to underlie the hyp-mouse phenotype...
  23. ncbi request reprint Critical role of calbindin-D28k in calcium homeostasis revealed by mice lacking both vitamin D receptor and calbindin-D28k
    Wei Zheng
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 279:52406-13. 2004
    ..These results directly demonstrate that CaBP-D28k plays a critical role in maintaining calcium homeostasis and skeletal mineralization and suggest that its calcemic role can be mostly compensated by CaBP-D9k...
  24. ncbi request reprint Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation
    Ke Xu
    Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, New York 10003, USA
    J Biol Chem 282:11347-55. 2007
    ..These findings provide the first evidence linking the association of COMP and GEP and identifying a previously unrecognized growth factor (i.e. GEP) in cartilage...

Research Grants3

  1. ROLES OF BMP4 & ITS REGULATION DURING TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2003
    ..Research into this relatively unexplored area will contribute to our understanding of the basic Msx1- Bmp4 signal pathway, mechanisms of tooth formation, and possible cause of autosomal dominant forms of familial tooth agenesis. ..
  2. ROLES OF BMP4 AND ITS REGULATION IN TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2004
    ..Molecular techniques include RT-PCR, in situ hybridization, DNA sequence determination, SSCP (single strand conformational polymorphism), and heteroduplex analysis. ..
  3. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2007
    ..unreadable] [unreadable]..