Elaine Faustman

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Contribution of PCB exposure from fish consumption to total dioxin-like dietary exposure
    Nancy Judd
    Department of Environmental Health and Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA 98105, USA
    Regul Toxicol Pharmacol 40:125-35. 2004
  2. pmc Comparative analysis of state fish consumption advisories targeting sensitive populations
    Alison C Scherer
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98105, USA
    Environ Health Perspect 116:1598-606. 2008
  3. pmc Chronologically matched toenail-Hg to hair-Hg ratio: temporal analysis within the Japanese community (U.S.)
    Thomas Hinners
    National Exposure Research Laboratory, U S Environmental Protection Agency, Las Vegas, NV, USA
    Environ Health 11:81. 2012
  4. pmc Single blood-Hg samples can result in exposure misclassification: temporal monitoring within the Japanese community (United States)
    Ami Tsuchiya
    Washington State Department of Health, Olympia, WA, USA
    Environ Health 11:37. 2012
  5. pmc Linking the oceans to public health: current efforts and future directions
    Hauke L Kite-Powell
    Marine Policy Center, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, USA
    Environ Health 7:S6. 2008
  6. ncbi request reprint Comparative risk and policy analysis in environmental health
    E Y Wong
    Institute for Risk Analysis and Risk Communication and Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Risk Anal 23:1337-49. 2003
  7. pmc Mechanisms underlying Children's susceptibility to environmental toxicants
    E M Faustman
    Center for Child Environmental Health Risks Research, University of Washington, Seattle, Washington 98105 6099, USA
    Environ Health Perspect 108:13-21. 2000
  8. pmc Investigations of methylmercury-induced alterations in neurogenesis
    Elaine M Faustman
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Environ Health Perspect 110:859-64. 2002
  9. pmc A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast
    Xiaozhong Yu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 114:356-77. 2010
  10. pmc Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity: Lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates
    Xiaozhong Yu
    Institute for Risk Analysis and Risk Communication, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105 6099, USA
    Toxicol Appl Pharmacol 239:325-36. 2009

Research Grants

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Contribution of PCB exposure from fish consumption to total dioxin-like dietary exposure
    Nancy Judd
    Department of Environmental Health and Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA 98105, USA
    Regul Toxicol Pharmacol 40:125-35. 2004
    ..PCB TEQ risk for average consumers of commercial fish is expected to be far less, but is highly uncertain, since there is a dearth of congener specific PCB data for commercial fish and seafood...
  2. pmc Comparative analysis of state fish consumption advisories targeting sensitive populations
    Alison C Scherer
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98105, USA
    Environ Health Perspect 116:1598-606. 2008
    ..Hence, formulating advice for sensitive populations poses challenges. We conducted a comparative analysis of advisory Web sites issued by states to assess health messages that sensitive populations might access...
  3. pmc Chronologically matched toenail-Hg to hair-Hg ratio: temporal analysis within the Japanese community (U.S.)
    Thomas Hinners
    National Exposure Research Laboratory, U S Environmental Protection Agency, Las Vegas, NV, USA
    Environ Health 11:81. 2012
    ..There is a need to correlate this marker with more established biomarkers that presently underlie existing dose-response relationships in order to compare these relationships across studies...
  4. pmc Single blood-Hg samples can result in exposure misclassification: temporal monitoring within the Japanese community (United States)
    Ami Tsuchiya
    Washington State Department of Health, Olympia, WA, USA
    Environ Health 11:37. 2012
    ....
  5. pmc Linking the oceans to public health: current efforts and future directions
    Hauke L Kite-Powell
    Marine Policy Center, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, USA
    Environ Health 7:S6. 2008
    ....
  6. ncbi request reprint Comparative risk and policy analysis in environmental health
    E Y Wong
    Institute for Risk Analysis and Risk Communication and Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Risk Anal 23:1337-49. 2003
    ..Through this analysis, we hope to generate discussions regarding the data requirements, analytical approaches, and assumptions required for general models to be used in comparative risk and policy analysis...
  7. pmc Mechanisms underlying Children's susceptibility to environmental toxicants
    E M Faustman
    Center for Child Environmental Health Risks Research, University of Washington, Seattle, Washington 98105 6099, USA
    Environ Health Perspect 108:13-21. 2000
    ..The final section discusses the importance of putting these considerations of children's susceptibility into an overall framework for ascertaining relevancy for human risk assessment...
  8. pmc Investigations of methylmercury-induced alterations in neurogenesis
    Elaine M Faustman
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Environ Health Perspect 110:859-64. 2002
    ....
  9. pmc A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast
    Xiaozhong Yu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 114:356-77. 2010
    ..This study suggests that these pathways play a critical role in the development of adverse effects associated with metal exposures...
  10. pmc Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity: Lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates
    Xiaozhong Yu
    Institute for Risk Analysis and Risk Communication, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105 6099, USA
    Toxicol Appl Pharmacol 239:325-36. 2009
    ....
  11. doi request reprint Children's inhalation exposure to methamidophos from sprayed potato fields in Washington State: exploring the use of probabilistic modeling of meteorological data in exposure assessment
    Jaya Ramaprasad
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195 7234, USA
    J Expo Sci Environ Epidemiol 19:613-23. 2009
    ..However, this study did not consider any pathway of exposure other than inhalation (e.g. diet, dermal, etc.) and the risk assessment should be evaluated in that context...
  12. pmc Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures
    Xiaozhong Yu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 104:385-96. 2008
    ..Taken together, our studies further characterize Cd-induced in vitro testicular toxicity and highlight the potential role of the UPS in this response...
  13. pmc Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways
    Xiaozhong Yu
    Institute for Risk Analysis and Risk Communication, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 233:389-403. 2008
    ....
  14. pmc Domoic acid: neurobehavioral consequences of exposure to a prevalent marine biotoxin
    Kimberly S Grant
    Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA 98195, USA
    Neurotoxicol Teratol 32:132-41. 2010
    ..Long-term studies will be necessary to accurately track the expression of DA-related injury, in health and behavior, over the lifespan...
  15. pmc Longitudinal mercury monitoring within the Japanese and Korean communities (United States): implications for exposure determination and public health protection
    Ami Tsuchiya
    Department of Environmental and Occupational Health Services, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 117:1760-6. 2009
    ..Fish consumption guidance based on these data may be incomplete, as recommendations are unlikely to consider impact from factors such as intraindividual variability, seasonal differences in consumption behavior, and species consumed...
  16. pmc Domoic acid as a developmental neurotoxin
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicology 31:409-23. 2010
    ..Given the potential higher susceptibility of the young to DomA neurotoxicity, additional studies investigating exposure to, and effects of this neurotoxin during brain development are warranted...
  17. doi request reprint The application of genetic information for regulatory standard setting under the clean air act: a decision-analytic approach
    Alison C Cullen
    Daniel J Evans School of Public Affairs, University of Washington, Seattle, WA 98195 3055, USA
    Risk Anal 28:877-90. 2008
    ..As future studies explore more fully the relationship between exposure, genetic makeup, and disease status, the opportunity for genetic information and disease status to play pivotal roles in regulation can only increase...
  18. ncbi request reprint Developmental toxicity: web resources for evaluating risk in humans
    Janine E Polifka
    Department of Pediatrics, TERIS Project, University of Washington, PO Box 357920, Seattle, WA 98195 7920, USA
    Toxicology 173:35-65. 2002
    ....
  19. pmc Policy implications of genetic information on regulation under the Clean Air Act: the case of particulate matter and asthmatics
    C Bradley Kramer
    Center for the Study and Improvement of Regulation, School of Public Health, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 114:313-9. 2006
    ..We conclude with recommendations on how to integrate these approaches for the improvement of regulatory health science and the prerequisites for inclusion of genetic information in decision making...
  20. pmc Framing scientific analyses for risk management of environmental hazards by communities: case studies with seafood safety issues
    Nancy L Judd
    Department of Environmental and Occupational Health Services, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 113:1502-8. 2005
    ..These examples present a spectrum of options for increasing community involvement in framing analyses and highlight the need for increased support of such activities...
  21. pmc Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos
    Estefania G Moreira
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Toxicol Appl Pharmacol 245:310-25. 2010
    ..Our approach was sensitive and reflected the diversity of responses known to be disrupted by CP and highlighted possible additional consequences of CP neurotoxicity, such as disturbance of the ubiquitin proteasome system...
  22. ncbi request reprint Essential role of extracellular matrix (ECM) overlay in establishing the functional integrity of primary neonatal rat Sertoli cell/gonocyte co-cultures: an improved in vitro model for assessment of male reproductive toxicity
    Xiaozhong Yu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 84:378-93. 2005
    ....
  23. doi request reprint Mercury exposure from fish consumption within the Japanese and Korean communities
    Ami Tsuchiya
    Department of Environmental and Occupational Health Services, University of Washington, Seattle, Washington, USA
    J Toxicol Environ Health A 71:1019-31. 2008
    ....
  24. ncbi request reprint Computational models of ethanol-induced neurodevelopmental toxicity across species: Implications for risk assessment
    Julia M Gohlke
    Institute for Risk Analysis and Risk Communication, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105 6099, USA
    Birth Defects Res B Dev Reprod Toxicol 83:1-11. 2008
    ..Our example highlights the utility of a systems-based modeling approach in risk assessment...
  25. ncbi request reprint Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells
    Jaspreet S Sidhu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    Toxicol Sci 89:475-84. 2006
    ..Together, these data support a role for perturbed cell cycle progression in As3+ mediated neurodevelopmental toxicity...
  26. ncbi request reprint Fish intake guidelines: incorporating n-3 fatty acid intake and contaminant exposure in the Korean and Japanese communities
    Ami Tsuchiya
    Department of Environmental and Occupational Health Services, Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 87:1867-75. 2008
    ..Fish consumption advisories are developed to prevent overexposure to various contaminants. Recently, discussion has centered on the need to consider the benefits of fish consumption alongside possible risks when providing guidance...
  27. ncbi request reprint p21(WAF1/CIP1) inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure
    Ma Aileen C Mendoza
    Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA
    Toxicol Appl Pharmacol 178:117-25. 2002
    ..These data suggest a role for p21 in retarding cell cycle progression, but not mitotic inhibition, following exposure to MeHg...
  28. ncbi request reprint A system-based approach to interpret dose- and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment
    Xiaozhong Yu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98105, USA
    Toxicol Sci 92:560-77. 2006
    ....
  29. pmc Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure
    Joshua F Robinson
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Reprod Toxicol 30:284-91. 2010
    ..This study provides potential insights into MeHg-induced mechanisms of developmental toxicity, alterations associated with increased MeHg sensitivity and common biological processes affected by metals in embryos undergoing neurulation...
  30. pmc Assessing the health benefits of air pollution reduction for children
    Eva Y Wong
    Institute for Risk Analysis and Risk Communication, Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Environ Health Perspect 112:226-32. 2004
    ..Key needs for environmental health policy analyses include improved information for children's health effects, additional life-stage-specific information, and improved health economics information specific for children...
  31. ncbi request reprint Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis
    Thomas A Lewandowski
    Department of Environmental Health, University of Washington, Seattle, WA 98105, USA
    Brain Res Dev Brain Res 141:117-28. 2003
    ....
  32. pmc A systems-based approach to investigate dose- and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation
    Joshua F Robinson
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Birth Defects Res B Dev Reprod Toxicol 89:188-200. 2010
    ..These detailed investigations are crucial for identifying sensitive indicators of toxicity and for risk assessment applications...
  33. pmc Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation
    Joshua F Robinson
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    Toxicol Sci 107:206-19. 2009
    ..Such observations may provide more detailed and useful mechanistic clues for identification of differences in life-stage specific teratogenic response...
  34. ncbi request reprint The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53-dependent
    Elizabeth J Gribble
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Birth Defects Res A Clin Mol Teratol 73:29-38. 2005
    ..This suggests early toxicant interference with critical molecular signaling events controlling cell behavior, i.e., proliferation...
  35. doi request reprint Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress
    Michael R Garry
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Free Radic Biol Med 44:1075-87. 2008
    ..These results suggest that adult lung fibroblasts deficient in GPx4 may have upregulated compensatory mechanisms to deal with the highly oxidized environment in which they developed...
  36. ncbi request reprint Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human
    Julia M Gohlke
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Cereb Cortex 17:2433-42. 2007
    ..These models can assist in focusing future experimental research on the differing mechanisms of rodent versus human neocortical development...
  37. pmc Nuclear waste transportation: case studies of identifying stakeholder risk information needs
    Christina H Drew
    Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, Washington, USA
    Environ Health Perspect 111:263-72. 2003
    ....
  38. ncbi request reprint A model for optimization of biomarker testing frequency to minimize disease and cost: example of beryllium sensitization testing
    Nancy L Judd
    Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA 98105 6099, USA
    Risk Anal 23:1211-20. 2003
    ..Limitations of the approach are discussed as well as options for adapting this biomarker optimization methodology to consider biomarkers of other exposure-associated diseases...
  39. pmc Para niños saludables: a community intervention trial to reduce organophosphate pesticide exposure in children of farmworkers
    Beti Thompson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Environ Health Perspect 116:687-94. 2008
    ..Exposure to organophosphate (OP) pesticides is an occupational hazard for farmworkers and affects their children through the take-home pathway...
  40. ncbi request reprint Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men
    Ulrike Luderer
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California, Irvine, California 92617, USA
    Am J Ind Med 46:614-26. 2004
    ....
  41. pmc Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, California, USA
    Environ Health Perspect 113:1419-29. 2005
    ..These centers present barriers encountered, solutions found, and considerations for future research, with the hope that the lessons learned can help inform the planning and conduct of the National Children's Study...
  42. ncbi request reprint Temporal error in biomarker-based mean exposure estimates for individuals
    Scott M Bartell
    Department of Statistics and Graduate Group in Epidemiology, University of California, Davis, California 95616, USA
    J Expo Anal Environ Epidemiol 14:173-9. 2004
    ....

Research Grants1

  1. CELL CYCLE REGULATION IN METAL DEVELOPMENTAL TOXICITY
    Elaine Faustman; Fiscal Year: 2002
    ....