Xiaohui Fang

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4
    Xiaohui Fang
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143
    J Immunol 195:875-81. 2015
  2. ncbi request reprint Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells
    Xiaohui Fang
    Cardiovascular Research Inst, Department of Medicine Physiology, Univ of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 290:L242-9. 2006
  3. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
  4. pmc Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37
    Anna Krasnodembskaya
    The Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Stem Cells 28:2229-38. 2010
  5. pmc Regulated gene expression in cultured type II cells of adult human lung
    Philip L Ballard
    Department of Pediatrics, University of California San Francisco, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L36-50. 2010
  6. ncbi request reprint Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system
    Xiaohui Fang
    Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L104-10. 2004
  7. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
  8. pmc Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
  9. pmc Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1
    Xiaohui Fang
    The Cardiovascular Research Institute, San Francisco, California, USA
    J Biol Chem 285:26211-22. 2010
  10. pmc Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    J Biol Chem 282:24109-19. 2007

Collaborators

Detail Information

Publications28

  1. doi request reprint Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4
    Xiaohui Fang
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143
    J Immunol 195:875-81. 2015
    ....
  2. ncbi request reprint Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells
    Xiaohui Fang
    Cardiovascular Research Inst, Department of Medicine Physiology, Univ of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 290:L242-9. 2006
    ..We conclude that CFTR is expressed in cultured human AT II cells and may contribute to cAMP-regulated apical-basolateral fluid transport...
  3. pmc Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16357-62. 2009
    ..In summary, treatment with allogeneic human MSCs or the conditioned medium restores normal fluid balance in an ex vivo perfused human lung injured by E. coli endotoxin...
  4. pmc Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37
    Anna Krasnodembskaya
    The Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Stem Cells 28:2229-38. 2010
    ..Human bone marrow-derived MSCs possess direct antimicrobial activity, which is mediated in part by the secretion of human cathelicidin hCAP-18/ LL-37...
  5. pmc Regulated gene expression in cultured type II cells of adult human lung
    Philip L Ballard
    Department of Pediatrics, University of California San Francisco, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L36-50. 2010
    ..Our results further define the adult human type II cell molecular phenotype and demonstrate that a subset of genes remains hormone responsive in cultured adult cells...
  6. ncbi request reprint Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system
    Xiaohui Fang
    Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L104-10. 2004
    ..In conclusion, this novel in vitro system can be used to measure net vectorial fluid transport across cultured, polarized alveolar epithelial cells...
  7. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
    ..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury...
  8. pmc Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion
    Jan Hirsch
    Anesthesia and Perioperative Care, Mass Spectrometry Facility, University of California, San Francisco, CA, USA
    Crit Care Med 36:1846-54. 2008
    ..Hepatic ischemia-reperfusion can be associated with acute lung injury. Alveolar epithelial type II cells (ATII) play an important role in maintaining lung homeostasis in acute lung injury...
  9. pmc Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1
    Xiaohui Fang
    The Cardiovascular Research Institute, San Francisco, California, USA
    J Biol Chem 285:26211-22. 2010
    ..This study provides novel evidence for a beneficial effect of MSC on alveolar epithelial permeability to protein...
  10. pmc Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells
    Jae W Lee
    Department of Anesthesiology, University of California, San Francisco, CA 94143, USA
    J Biol Chem 282:24109-19. 2007
    ....
  11. ncbi request reprint Alveolar epithelium: role in lung fluid balance and acute lung injury
    Michael A Matthay
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0624, USA
    Proc Am Thorac Soc 2:206-13. 2005
    ..Clinical trials are needed to test this potential therapeutic strategy in patients with acute lung injury...
  12. pmc Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome
    Jan Hirsch
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Respir Crit Care Med 175:1006-13. 2007
    ..Mechanical ventilation with high tidal volumes leads to increased permeability, generation of inflammatory mediators, and damage to alveolar epithelial cells (ATII)...
  13. pmc Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis
    Wei Yu
    Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 18:1693-700. 2007
    ..We conclude that epithelial differentiation and cyst formation can occur without appreciable proliferation or apoptosis...
  14. pmc Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis
    Cecilia Marmai
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0111, USA
    Am J Physiol Lung Cell Mol Physiol 301:L71-8. 2011
    ..These data suggest that alveolar type II cells can acquire features of mesenchymal cells in IPF lungs and that TGF-β can mediate this process...
  15. ncbi request reprint Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
    James Frank
    Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 278:43939-50. 2003
    ..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity...
  16. ncbi request reprint Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Exp Lung Res 30:479-93. 2004
    ..This method should be valuable for experimental lung studies in mice...
  17. pmc Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney
    Xiaohui Fang
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    J Physiol 542:63-9. 2002
    ..The results provide direct evidence against physiologically significant transport of CO2 by AQP1 in mammalian lung and kidney...
  18. ncbi request reprint Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome
    Michael A Matthay
    Critical Care Medicine, University of California, San Francisco, 505 Parnassus Avenue, Campus Box 0624, San Francisco, CA 94143 0624, USA
    Curr Treat Options Cardiovasc Med 4:139-149. 2002
    ....
  19. ncbi request reprint Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
    Daniel F McAuley
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:1470-6. 2004
    ....
  20. pmc Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome
    John T Li
    Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94110
    J Immunol 195:87-95. 2015
    ....
  21. pmc Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial
    Jennifer G Wilson
    Departments of Emergency Medicine and Anesthesia, University of California, San Francisco, CA, USA
    Lancet Respir Med 3:24-32. 2015
    ..We aimed to test the safety of a single dose of allogeneic bone marrow-derived MSCs in patients with moderate-to-severe ARDS...
  22. ncbi request reprint Protein C and thrombomodulin in human acute lung injury
    Lorraine B Ware
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 285:L514-21. 2003
    ..In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a potential therapeutic target in patients with ALI/ARDS...
  23. ncbi request reprint Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome
    Akitoshi Ishizaka
    Department of Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582 Japan
    Am J Physiol Lung Cell Mol Physiol 286:L1088-94. 2004
    ....
  24. ncbi request reprint Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury
    Xiao Su
    Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, Shanghai, P R China
    Intensive Care Med 29:2034-42. 2003
    ..This study examined whether continuous hemofiltration favorably affects cardiopulmonary variables, lung inflammation, and lung fluid balance in a canine model of oleic acid induced acute lung injury...
  25. pmc Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation
    Ling Wang
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Cell Mol Biol 36:497-503. 2007
    ..Local fibrin deposition may be a fundamental mechanism for the lung to localize and confine injury, thus limiting the risk of dissemination of injury or infection to the systemic circulation...
  26. pmc Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro
    Jieru Wang
    Department of Medicine, National Jewish and Medical Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 36:661-8. 2007
    ..The expression of the phenotypes is regulated by the culture conditions and is, in part, reversible in vitro...
  27. ncbi request reprint [The change of alveolar fluid clearance in acute lung injury rat]
    Zhiwei Chen
    Department of Pulmonary, Shanghai Chest Hospital, Shanghai 200030, China
    Zhonghua Jie He He Hu Xi Za Zhi 25:39-41. 2002
    ..To establish the animal model of lung injury caused by hydrochloric acid in rats, measure the alveolar fluid clearance (AFC) in different acidic condition...
  28. ncbi request reprint High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Heart Lung Transplant 24:1650-6. 2005
    ..The secondary objective was to better define the spectrum of histologic abnormalities in the same group of lungs...