Xiang Fang

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Atorvastatin reduces lipopolysaccharide-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells
    ShangJie Wu
    Division of Cardiovascular Disease, Department of Internal Medicine, The Second Xiangya Hospital, Center Southern University, Changsha, Hunan, China
    Respir Res 6:27. 2005
  2. ncbi request reprint Soluble epoxide hydrolase: a novel target for the treatment of hypertension
    Xiang Fang
    Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Recent Pat Cardiovasc Drug Discov 1:67-72. 2006
  3. ncbi request reprint Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels
    Xiang Fang
    Dept of Biochemistry, 4 403 BSB, Univ of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 287:H2412-20. 2004
  4. pmc Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors
    Xiang Fang
    Department of Biochemistry, 4 403 BSB, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Pharmacol Exp Ther 314:260-70. 2005
  5. ncbi request reprint Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells
    Xiang Fang
    Department of Biochemistry, University of Iowa College of Medicine, 4 403 BSB, Iowa City, IA 52242, USA
    Prostaglandins Other Lipid Mediat 71:33-42. 2003
  6. ncbi request reprint The oxygen radical scavenger pyrrolidine dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells
    Xiang Fang
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Microvasc Res 64:405-13. 2002
  7. ncbi request reprint Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide
    Xiang Fang
    Department of Biochemistry, University of Iowa, Iowa City 52242, USA
    Am J Physiol Heart Circ Physiol 283:H2306-14. 2002
  8. ncbi request reprint 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha
    Xiang Fang
    Dept of Biochemistry, Univ of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 290:H55-63. 2006
  9. ncbi request reprint Induction of cyclooxygenase-2 by overexpression of the human catalase gene in cerebral microvascular endothelial cells
    X Fang
    Department of Biochemistry University of Iowa, Iowa City, Iowa, USA
    J Neurochem 75:614-23. 2000
  10. ncbi request reprint Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells
    X Fang
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 34:1242-6. 1999

Collaborators

Detail Information

Publications29

  1. pmc Atorvastatin reduces lipopolysaccharide-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells
    ShangJie Wu
    Division of Cardiovascular Disease, Department of Internal Medicine, The Second Xiangya Hospital, Center Southern University, Changsha, Hunan, China
    Respir Res 6:27. 2005
    ..To explore the effects of atorvastatin on expression of cyclooxygenase-2 (COX-2) in human pulmonary epithelial cells (A549)...
  2. ncbi request reprint Soluble epoxide hydrolase: a novel target for the treatment of hypertension
    Xiang Fang
    Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Recent Pat Cardiovasc Drug Discov 1:67-72. 2006
    ..Potent selective sEH inhibitors have been developed, and these sEH inhibitors have potential to become a novel class of anti-hypertensive drug...
  3. ncbi request reprint Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels
    Xiang Fang
    Dept of Biochemistry, 4 403 BSB, Univ of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 287:H2412-20. 2004
    ..These findings in intact human blood vessels indicate that conversion to DHET is the predominant pathway for 11,12- and 14,15-EET metabolism and that sEH inhibition can modulate EET metabolism in vascular tissue...
  4. pmc Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors
    Xiang Fang
    Department of Biochemistry, 4 403 BSB, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Pharmacol Exp Ther 314:260-70. 2005
    ..Further development of these compounds could lead to a class of agents with hypotensive and lipid-lowering properties that may be valuable for the prevention and treatment of cardiovascular disease...
  5. ncbi request reprint Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells
    Xiang Fang
    Department of Biochemistry, University of Iowa College of Medicine, 4 403 BSB, Iowa City, IA 52242, USA
    Prostaglandins Other Lipid Mediat 71:33-42. 2003
    ....
  6. ncbi request reprint The oxygen radical scavenger pyrrolidine dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells
    Xiang Fang
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Microvasc Res 64:405-13. 2002
    ..These results suggest that endogenous oxygen radicals may blunt COX-2 induced by IL-1beta through an effect on translation...
  7. ncbi request reprint Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide
    Xiang Fang
    Department of Biochemistry, University of Iowa, Iowa City 52242, USA
    Am J Physiol Heart Circ Physiol 283:H2306-14. 2002
    ..These findings implicate beta-oxidation as a major pathway of 14,15-EET metabolism in HCEC and provide the first evidence that EET-derived chain-shortened epoxy fatty acids are biologically active...
  8. ncbi request reprint 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha
    Xiang Fang
    Dept of Biochemistry, Univ of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 290:H55-63. 2006
    ..These findings suggest that 14,15-DHET, produced from 14,15-EET by the action of SEH, may function as an endogenous activator of PPARalpha...
  9. ncbi request reprint Induction of cyclooxygenase-2 by overexpression of the human catalase gene in cerebral microvascular endothelial cells
    X Fang
    Department of Biochemistry University of Iowa, Iowa City, Iowa, USA
    J Neurochem 75:614-23. 2000
    ..Therefore, peroxide may have regulatory effect on COX-2 function in the cerebral microcirculation...
  10. ncbi request reprint Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells
    X Fang
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 34:1242-6. 1999
    ..This 14,15-EET-induced increase in [Ca(i)(2+)] can produce vasoconstriction and therefore may act to modulate EET-induced vasorelaxation...
  11. ncbi request reprint 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma
    Xiang Fang
    Department of Biochemistry, 4 403 BSB, University of Iowa Carver College of Medicine, Iowa City, IA 52242, United States
    Prostaglandins Other Lipid Mediat 82:175-84. 2007
    ..87+/-0.12 microM) and PPARgamma (Kd=1.7+/-0.5 microM). These findings suggest that 20-COOH-AA, a relatively stable metabolite of 20-HETE, might function as an endogenous dual activator of PPARalpha and PPARgamma...
  12. ncbi request reprint Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production
    Shawn D Harmon
    Department of Biochemistry, Carver College of Medicine, 4 403 BSB, University of Iowa, Iowa City, IA 52242, USA
    Prostaglandins Leukot Essent Fatty Acids 75:169-77. 2006
    ..These findings suggest that some functional effects of omega-3 fatty acid supplementation may be due to inhibition of 20-HETE formation or the conversion of EPA to the corresponding omega-oxidized product...
  13. ncbi request reprint Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4
    Xixuan H Collins
    Department of Biochemistry, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:33157-64. 2005
    ..Although ADH4 and ADH3 are expressed in MSMC and MEC, the inhibition produced by N-heptylformamide suggests that ADH4 is primarily responsible for 20-COOH-AA formation in the cerebral microvasculature...
  14. ncbi request reprint 20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells
    Terry L Kaduce
    Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:2648-56. 2004
    ..These results suggest that the incorporation of 20-HETE and its subsequent conversion to 20-COOH-AA in the endothelium may be important in modulating coronary vascular function...
  15. ncbi request reprint Metabolism of anandamide in cerebral microvascular endothelial cells
    Ping Chen
    Department of Biochemistry, University of Iowa College of Medicine, 4 403 BSB, Iowa City, IA 52242, USA
    Prostaglandins Other Lipid Mediat 73:59-72. 2004
    ....
  16. ncbi request reprint Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function
    Arthur A Spector
    Department of Biochemistry, 4 403 Bowen Science Building, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Prog Lipid Res 43:55-90. 2004
    ..Because of the diversity of biochemical and functional responses produced by EETs, it is doubtful that a single mechanism or signal transduction pathway can account for all of their actions...
  17. ncbi request reprint Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium
    Ping Chen
    Department of Biochemistry, 4 403 BSB, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Microvasc Res 69:28-35. 2005
    ..These results indicate that AEA increased COX-2 expression at the transcriptional level through, at least in part, a cannabinoid receptor-1-mediated mechanism in cerebral microvascular endothelium...
  18. ncbi request reprint Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids
    N L Weintraub
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Circ Res 81:258-67. 1997
    ....
  19. ncbi request reprint Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids
    N L Weintraub
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol 277:H2098-108. 1999
    ..These data suggest that epoxide hydrolases may play a role in regulating EET incorporation into phospholipids, thereby modulating endothelial function in the coronary vasculature...
  20. ncbi request reprint Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells
    M R Brown
    Department of Surgery, University of Iowa College of Medicine, Iowa City 52242, USA
    Circ Res 85:524-33. 1999
    ..Our results suggest that endogenously produced H(2)O(2) importantly modulates survival and proliferation of vascular smooth muscle cells...
  21. ncbi request reprint Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling
    Francis J Miller
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA
    Arterioscler Thromb Vasc Biol 22:560-5. 2002
    ..Thus, oxidative stress is markedly increased in AAA, in part through the activation of NAD(P)H oxidase, and may contribute to the disease pathogenesis...
  22. ncbi request reprint Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition
    X Fang
    Department of Biochemistry, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 276:14867-74. 2001
    ..The modulation of EET metabolism by DCU provides novel insight into the mechanisms by which pharmacological or molecular inhibition of sEH effectively treats hypertension...
  23. ncbi request reprint Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells
    Cha Xiang Guan
    Department of Physiology, Central South University Xiangya Medical School, Changsha, Hunan 410078, China
    Peptides 28:1667-73. 2007
    ..These results suggest that intracellular signaling molecules such as PKA, PKC, ERK, and calmodulin play important role in VIP-mediated wound healing of HBEC...
  24. ncbi request reprint 20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase
    Xiang Fang
    Dept of Medicine, Harbor Hospital Center, 3001 S Hanover St, Baltimore MD 21225, USA
    Am J Physiol Heart Circ Physiol 291:H2301-7. 2006
    ..Whereas the conversion of 20-HETE to 20-OH-PGE(2) and production of endogenous prostaglandins probably are primarily responsible for vasodilation, the production of 20-COOH-AA also may contribute to this process...
  25. ncbi request reprint Involvement of PKC, p38 MAPK and AP-2 in IL-1beta-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells
    Ping Chen
    Department of Respiratory Medicine, The Second Affilitated Hospital, Central South University, Xiangya Medical School, Changsha, Hunan, China
    Respirology 11:18-23. 2006
    ..The aim of this study was to identify the signal molecules involved in IL-1beta-induced expression of cyclooxygenase (COX)-2 in human pulmonary epithelial (A549) cells...
  26. pmc The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase
    Yi Liu
    Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 102:16747-52. 2005
    ..Blocking PPARgamma by GW9662 abolished the EET/AUDA-mediated antiinflammatory effect, which indicates that PPARgamma is an effector of EETs...
  27. ncbi request reprint Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis
    Si Wan Kim
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 277:8202-8. 2002
    ..The significance of the XKaiso-p120(ctn) interaction has yet to be determined, but it may include transducing information from cadherin-mediated cell-cell contacts to transcriptional processes within the nucleus...
  28. doi request reprint Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells
    Hong Peng
    Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Peptides 29:419-24. 2008
    ..These findings indicate that ET-1 plays important roles in regulating COX-2 expression and production of IL-8 in A549 cells. ET-1 mediated production of IL-8 is likely through a COX-2-dependent mechanism...
  29. ncbi request reprint Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells
    Jon P Lyons
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Exp Cell Res 298:369-87. 2004
    ....