Toshihiko Ezashi

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. doi request reprint Pluripotent Stem Cells from Domesticated Mammals
    Toshihiko Ezashi
    Division of Animal Sciences and Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211 email
    Annu Rev Anim Biosci 4:223-53. 2016
  2. pmc Differential regulation of NAB corepressor genes in Schwann cells
    Rajini Srinivasan
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI, USA
    BMC Mol Biol 8:117. 2007
  3. doi request reprint The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Reprod 79:115-24. 2008
  4. pmc Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells
    Suzanne D Westfall
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211 7310, USA
    Stem Cells Dev 17:869-81. 2008
  5. pmc Generation of colonies of induced trophoblast cells during standard reprogramming of porcine fibroblasts to induced pluripotent stem cells
    Toshihiko Ezashi
    Bond Life Sciences Center and Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA
    Biol Reprod 85:779-87. 2011
  6. ncbi request reprint Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri Columbia, 920 East Campus Drive, Columbia, Missouri 65211 5300, USA
    Endocrinology 145:4452-60. 2004
  7. pmc Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line
    Padmalaya Das
    Christopher S Bond Life Sciences Center, University of Missouri Columbia, 1201 East Rollins Street, Columbia, MO 65211 7310, USA
    Mol Endocrinol 22:331-43. 2008
  8. pmc Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4
    Mitsuyoshi Amita
    Division of Animal Sciences, and Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 110:E1212-21. 2013
  9. doi request reprint The promise of stem cell research in pigs and other ungulate species
    Bhanu Prakash V L Telugu
    Division of Animal Sciences, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA
    Stem Cell Rev 6:31-41. 2010
  10. pmc Squelching of ETS2 transactivation by POU5F1 silences the human chorionic gonadotropin CGA subunit gene in human choriocarcinoma and embryonic stem cells
    Rangan Gupta
    Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA
    Mol Endocrinol 26:859-72. 2012

Collaborators

Detail Information

Publications22

  1. doi request reprint Pluripotent Stem Cells from Domesticated Mammals
    Toshihiko Ezashi
    Division of Animal Sciences and Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211 email
    Annu Rev Anim Biosci 4:223-53. 2016
    ..Finally, we discuss the future utility of these cells for biomedical and agricultural purposes. ..
  2. pmc Differential regulation of NAB corepressor genes in Schwann cells
    Rajini Srinivasan
    Department of Comparative Biosciences, University of Wisconsin Madison, Madison, WI, USA
    BMC Mol Biol 8:117. 2007
    ..NAB corepressors have also been implicated in macrophage development, cardiac hypertrophy, prostate carcinogenesis, and feedback regulation involved in hindbrain development...
  3. doi request reprint The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Reprod 79:115-24. 2008
    ..Together, these results suggest that DLX3 has a central role in controlling IFNT gene expression by associating with ETS2 on the IFNT promoter...
  4. pmc Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells
    Suzanne D Westfall
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211 7310, USA
    Stem Cells Dev 17:869-81. 2008
    ..The data are consistent with the hypothesis that 4% O(2) favors the molecular mechanisms required for the maintenance of pluripotency...
  5. pmc Generation of colonies of induced trophoblast cells during standard reprogramming of porcine fibroblasts to induced pluripotent stem cells
    Toshihiko Ezashi
    Bond Life Sciences Center and Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA
    Biol Reprod 85:779-87. 2011
    ..In conclusion, reprogramming of porcine fibroblasts to iPS cells generates, as a by-product, colonies composed of self-renewing populations of TR cells, possibly containing TR stem cells...
  6. ncbi request reprint Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri Columbia, 920 East Campus Drive, Columbia, Missouri 65211 5300, USA
    Endocrinology 145:4452-60. 2004
    ..These data emphasize the importance of a complex Ets-2 enhancer for expression of IFNT and suggest a means whereby the mother can exert control over conceptus IFN-tau production...
  7. pmc Combinatorial roles of protein kinase A, Ets2, and 3',5'-cyclic-adenosine monophosphate response element-binding protein-binding protein/p300 in the transcriptional control of interferon-tau expression in a trophoblast cell line
    Padmalaya Das
    Christopher S Bond Life Sciences Center, University of Missouri Columbia, 1201 East Rollins Street, Columbia, MO 65211 7310, USA
    Mol Endocrinol 22:331-43. 2008
    ..The up-regulation of IFNT in the elongating bovine conceptus is likely due to the combinatorial effects of PKA, Ets2, and CBP/p300 and triggered via growth factors released from maternal endometrium...
  8. pmc Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4
    Mitsuyoshi Amita
    Division of Animal Sciences, and Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 110:E1212-21. 2013
    ..The experiments demonstrate that the in vitro BMP4/hESC model is valid for studying the emergence and differentiation of trophoblasts...
  9. doi request reprint The promise of stem cell research in pigs and other ungulate species
    Bhanu Prakash V L Telugu
    Division of Animal Sciences, Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, USA
    Stem Cell Rev 6:31-41. 2010
    ....
  10. pmc Squelching of ETS2 transactivation by POU5F1 silences the human chorionic gonadotropin CGA subunit gene in human choriocarcinoma and embryonic stem cells
    Rangan Gupta
    Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA
    Mol Endocrinol 26:859-72. 2012
    ..Hence, a squelching mechanism underpins the transcriptional silencing of CGA by POU5F1 and could have general relevance to how pluripotency is maintained and how the trophoblast lineage emerges from pluripotent precursor cells...
  11. pmc Effects of fgf2 and oxygen in the bmp4-driven differentiation of trophoblast from human embryonic stem cells
    Padmalaya Das
    Department of Animal Sciences, University of Missouri Columbia, Christopher S Bond Life Sciences Center, 65211, USA
    Stem Cell Res 1:61-74. 2007
    ..In conclusion, BMP4 induced conversion of hESC exclusively towards trophoblast; FGF2 slowed differentiation, while O(2) accelerated this process and promoted syncytiotrophoblast formation...
  12. pmc Leukemia inhibitory factor (LIF)-dependent, pluripotent stem cells established from inner cell mass of porcine embryos
    Bhanu Prakash V L Telugu
    Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211 7310, USA
    J Biol Chem 286:28948-53. 2011
    ....
  13. pmc Interferons and the maternal-conceptus dialog in mammals
    R Michael Roberts
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Semin Cell Dev Biol 19:170-7. 2008
    ..Conceivably, disparate signaling mechanisms trigger common downstream events necessary to secure a successful pregnancy...
  14. pmc Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas
    Shinichiro Yabe
    Department of Obstetrics, Gynecology, and Women s Health, University of Missouri, Columbia, MO 65211
    Proc Natl Acad Sci U S A 113:E2598-607. 2016
    ..We propose that the STB generated from human ESCs represents the primitive syncytium encountered in early pregnancy soon after the human trophoblast invades into the uterine wall...
  15. pmc Model systems for studying trophoblast differentiation from human pluripotent stem cells
    Toshihiko Ezashi
    Division of Animal Sciences and Bond Life Sciences Center, University of Missouri Columbia, 65211, USA
    Cell Tissue Res 349:809-24. 2012
    ....
  16. doi request reprint Porcine induced pluripotent stem cells analogous to naïve and primed embryonic stem cells of the mouse
    Bhanu Prakash V L Telugu
    Division of Animal Sciences, University of Missouri, Columbia, MO, USA
    Int J Dev Biol 54:1703-11. 2010
    ..They exhibit high telomerase activity, a short cell cycle interval, and a normal karyotype, and are able to generate teratomas. Currently, the competence of these lines for contributing to germ-line chimeras is being tested...
  17. pmc Abnormal oxidative stress responses in fibroblasts from preeclampsia infants
    Penghua Yang
    Division of Animal Sciences, University of Missouri, Columbia, Missouri, United States of America Bond Life Sciences Center, University of Missouri, Columbia, Missouri, United States of America College of Life Science, Yangtze University, Jingzhou, Hubei, China
    PLoS ONE 9:e103110. 2014
    ..Contrary to expectations, the oxidative stress responses of these non-placental cells from PE infants were more severe than those from controls...
  18. pmc Derivation of induced pluripotent stem cells from pig somatic cells
    Toshihiko Ezashi
    Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 106:10993-8. 2009
    ..Such cell lines derived from individual animals could provide a means for testing the safety and efficacy of stem cell-derived tissue grafts when returned to the same pigs at a later age...
  19. pmc Trophoblast gene expression: transcription factors in the specification of early trophoblast
    R Michael Roberts
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Reprod Biol Endocrinol 2:47. 2004
    ....
  20. ncbi request reprint Induced pluripotent stem cells from swine (Sus scrofa): why they may prove to be important
    R Michael Roberts
    Division of Animal Sciences, University of Missouri, Columbia, MO, USA
    Cell Cycle 8:3078-81. 2009
    ....
  21. pmc Low O2 tensions and the prevention of differentiation of hES cells
    Toshihiko Ezashi
    Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 102:4783-8. 2005
    ..In addition, hES cell growth under hypoxia provided enhanced formation of embryoid bodies. Hypoxic culture would appear to be necessary to maintain full pluripotency of hES cells...
  22. ncbi request reprint A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene
    Debjani Ghosh
    Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211 5300, USA
    Mol Endocrinol 17:11-26. 2003
    ..The data are consistent with the hypothesis that Ets-2 has a general and possibly essential role in controlling the activity of genes associated with trophectoderm differentiation...