Genomes and Genes
Andrew J Ewald
Affiliation: University of California
- The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epitheliumJimmie E Fata
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Dev Biol 306:193-207. 2007..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
- GATA-3 links tumor differentiation and dissemination in a luminal breast cancer modelHosein Kouros-Mehr
Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
Cancer Cell 13:141-52. 2008..Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer...
- Collective epithelial migration and cell rearrangements drive mammary branching morphogenesisAndrew J Ewald
Department of Anatomy and Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 14:570-81. 2008..Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth...
- Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epitheliumAndrew J Ewald
Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
J Cell Sci 125:2638-54. 2012..Our data suggest that reductions in polarity and adhesion during breast cancer progression might reflect partial recapitulation of a normal developmental program...
- Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopyMikala Egeblad
Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Dis Model Mech 1:155-67; discussion 165. 2008..The techniques are not limited to investigations in cancer, but could give new insights into cell behavior more broadly in development and disease...
- Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesisPengfei Lu
Department of Anatomy and Program in Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0452, USA
Dev Biol 321:77-87. 2008..Together, our data demonstrate that Fgfr2 functions in the proliferating and invading TEBs, but it is not required in the mature ducts of the pubertal mammary gland...
- p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathwayMinji Kim
Department of Anatomy, University of California, San Francisco, CA 94158, USA
J Cell Sci 128:4317-27. 2015..Lumen formation in tubules is mechanistically quite different from lumenogenesis in cysts. Thus, we demonstrate a new pathway that regulates directed cell migration and formation of a single lumen during epithelial tube morphogenesis...
- A model of intussusceptive angiogenesisMax Levin
Department of Anatomy, University of California, San Francisco, CA 94143, USA
Novartis Found Symp 283:37-42; discussion 42-5, 238-41. 2007..We have established a cell culture model of vascular pillar formation in an endothelial cell-smooth muscle cell co-culture system. Vascular pillar formation was inhibited by broad spectrum matrix metalloproteinase inhibitors...
- PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survivalSteven Song
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Nat Cell Biol 7:870-9. 2005....
- A molecular switch for the orientation of epithelial cell polarizationDavid M Bryant
Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158 2140, USA
Dev Cell 31:171-87. 2014..Thus, ECM-derived signals control the morphogenesis of epithelial tissues by controlling the collective orientation of epithelial polarization. ..
- Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesisFernando Martin-Belmonte
Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Madrid 28049, Spain
Curr Biol 18:507-13. 2008..The mechanism of lumen formation in the 3D-MDCK model can shift between hollowing and cavitation, depending on cell polarization...
- Matrix metalloproteinases and the regulation of tissue remodellingAndrea Page-McCaw
Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
Nat Rev Mol Cell Biol 8:221-33. 2007..Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated...
- Regional requirements for Dishevelled signaling during Xenopus gastrulation: separable effects on blastopore closure, mesendoderm internalization and archenteron formationAndrew J Ewald
Department of Biology and Biological Imaging Center, California Institute of Technology, Pasadena, CA 91125, USA
Development 131:6195-209. 2004....
- Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentHsiuchen Chen
Division of Biology, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
J Cell Biol 160:189-200. 2003..Therefore, mitochondrial fusion is essential for embryonic development, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population...