Affiliation: University of California
- Culture system for rodent and human oligodendrocyte specification, lineage progression, and maturationAraceli Espinosa-Jeffrey
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Curr Protoc Stem Cell Biol . 2009....
- Voluntary exercise increases oligodendrogenesis in spinal cordW Krityakiarana
Intellectual and Developmental Disability Research Center, Semel Institute for Neuroscience and Human Behavior Department of Neurobiology, David Geffen, School of Medicine at UCLA, Los Angeles, California 90095, USA
Int J Neurosci 120:280-90. 2010..These results suggest that voluntary exercise positively influences oligodendrogenesis in the intact spinal cord, emphasizing the beneficial effects of voluntary exercise as a possible co-treatment for spinal cord injury...
- White matter loss in a mouse model of periventricular leukomalacia is rescued by trophic factorsAraceli Espinosa-Jeffrey
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90095, USA
Brain Sci 3:1461-82. 2013..Furthermore, we showed that early TSC1 administration maximizes neuroprotection. ..
- Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repairAraceli Espinosa-Jeffrey
Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Intellectual and Developmental Disabilities Research Center, Los Angeles, California, United States of America
PLoS ONE 8:e76963. 2013..To our knowledge, this is the first report on the gravitational modulation of oligodendrocyte intrinsic plasticity to increase their progenies. ..
- Strategies for endogenous spinal cord repair: HPMA hydrogel to recruit migrating endogenous stem cellsAraceli Espinosa-Jeffrey
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience, University of California Los Angeles, Los Angeles, California, USA
Adv Exp Med Biol 760:25-52. 2012..Therefore, endogenous pre-existing and newly formed cells populated the gel scaffold established contact with the non injured tissue and lead to recovery of function...
- Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpressionA Espinosa-Jeffrey
IDDRCsp, Semel Institute for Neuroscience, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Neurosci Res 88:1682-94. 2010..When the interventions were administered prior to hindlimb paralysis, He4e mice were able to walk up to 1 year of age without paralysis...
- Dietary iron and the integrity of the developing rat brain: a study with the artificially-reared rat pupA E de los Monteros
Mental Retardation Research Center, Neuropsychiatry Institute, UCLA School of Medicine, Los Angeles, CA 90095 1759, USA
Cell Mol Biol (Noisy-le-grand) 46:501-15. 2000..However, the iron status profoundly influences the development of myelination in that the process is delayed in iron deficiency...
- Activation, proliferation and commitment of endogenous stem/progenitor cells to the oligodendrocyte lineage by TS1 in a rat model of dysmyelinationAraceli Espinosa-Jeffrey
Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior and Department of Neurobiology, University of California, Los Angeles, 90095 7332, USA
Dev Neurosci 28:488-98. 2006..This strategy offers for the first time the possibility of myelin restoration to treat myelin disorders...
- In vitro injury model for oligodendrocytes: development, injury, and recoveryA E de los Monteros
Mental Retardation Research Center, Neuropsychiatric Institute, Department of Neurobiology UCLA School of Medicine, 760 Westwood Plaza, Room 78 177 NPI, Los Angeles, CA 90095 1759, USA
Microsc Res Tech 52:719-30. 2001..Moreover both, serum and cryoinjury induced the expression of HSP-60 that colocalized with OL and myelin markers. The expression of GFAP by injured cells but not by normal cells corroborated the state of injury of CG4 cells...
- Remyelination of the adult demyelinated mouse brain by grafted oligodendrocyte progenitors and the effect of B-104 cograftsA Espinosa de los Monteros
Mental Retardation Research Center, Neuropsychiatric Institute, Departments of Neurobiology and Psychiatry, UCLA School of Medicine, Los Angeles, CA, USA
Neurochem Res 26:673-82. 2001..Those grafted with progenitor CG4 cells or cografts displayed a clear increase in remyelination. This data provides a new direction for the development of cell replacement therapies in demyelinating diseases...
- Selective specification of CNS stem cells into oligodendroglial or neuronal cell lineage: cell culture and transplant studiesAraceli Espinosa-Jeffrey
UCLA Mental Retardation Research Center and Department of Neurobiology, Los Angeles, California 90095 1759, USA
J Neurosci Res 69:810-25. 2002..As expected, NSCs are capable of giving rise to astrocytes in a medium favoring this phenotype...
- Transferrin regulates transcription of the MBP gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md ratA Espinosa-Jeffrey
Mental Retardation Research Center, Neuropsychiatric Institute, UCLA, Los Angeles, Calif 90024 1759, USA
Dev Neurosci 24:227-41. 2002..Thus, transferrin selectively regulates MBP at the transcriptional level and together with IGF-1 synergizes to increase both the maturation and myelinogenic properties of md and normal OL...
- Stem/progenitor cells in the postnatal inner ear of the GFP-nestin transgenic mouseIvan A Lopez
Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, 1000 Veteran Avenue, David Geffen School of Medicine, Los Angeles, CA 90095, USA
Int J Dev Neurosci 22:205-13. 2004....
- Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathyJustin Zaghi
Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital Research Center, Los Angeles, CA 90095 7358, USA
Acta Neuropathol 117:111-24. 2009..In conclusion, in patients with AD, macrophages appear to shuttle Abeta from neurons to vessels where their apoptosis may release fibrillar Abeta, contributing to cerebral amyloid angiopathy...
- Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcuminMilan Fiala
Department of Medicine, Greater Los Angeles Veterans Affairs Medical Center, and School of Medicine, University of California Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:12849-54. 2007..Thus, bisdemethoxycurcumin may correct immune defects of AD patients and provide a previously uncharacterized approach to AD immunotherapy...
- 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patientsAva Masoumi
Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095 7358, USA
J Alzheimers Dis 17:703-17. 2009..Human macrophages are a new paradigm for testing immune therapies for AD...
- Calcium modulates dopamine potentiation of N-methyl-D-aspartate responses: electrophysiological and imaging evidenceJ C Liu
Mental Retardation Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
J Neurosci Res 76:315-22. 2004..The existence of multiple mechanisms leading to a similar outcome allows a certain degree of redundancy in the consequences of DA modulation...
- Oxidative stress and the deleterious consequences to the rat cochlea after prenatal chronic mild exposure to carbon monoxide in airI A Lopez
Surgery Department Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neuroscience 151:854-67. 2008....