L Eckmann

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Defence molecules in intestinal innate immunity against bacterial infections
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Gastroenterol 21:147-51. 2005
  2. ncbi request reprint Small bowel infections
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Gastroenterol 18:197-202. 2002
  3. doi request reprint IgG "detoxes" the intestinal mucosa
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA Electronic address
    Cell Host Microbe 17:538-9. 2015
  4. ncbi request reprint Cytokines in host defense against Salmonella
    L Eckmann
    Department of Medicine 0623D, Laboratory of Mucosal Immunology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    Microbes Infect 3:1191-200. 2001
  5. ncbi request reprint Microbes and microbial toxins: paradigms for microbial-mucosal interactions I. Pathophysiological aspects of enteric infections with the lumen-dwelling protozoan pathogen Giardia lamblia
    L Eckmann
    Departments of Medicine and Pathology, University of California, San Diego, La Jolla, California 92093, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1-6. 2001
  6. ncbi request reprint Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella
    L Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 275:14084-94. 2000
  7. ncbi request reprint Mucosal defences against Giardia
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Parasite Immunol 25:259-70. 2003
  8. ncbi request reprint Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia
    L Eckmann
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 164:1478-87. 2000
  9. pmc Opposing functions of IKKbeta during acute and chronic intestinal inflammation
    Lars Eckmann
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:15058-63. 2008
  10. ncbi request reprint NOD2 and Crohn's disease: loss or gain of function?
    Lars Eckmann
    Department of Medicine, UCSD School of Medicine, La Jolla, California 92093, USA
    Immunity 22:661-7. 2005

Research Grants

Detail Information

Publications77

  1. ncbi request reprint Defence molecules in intestinal innate immunity against bacterial infections
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Gastroenterol 21:147-51. 2005
    ..Antimicrobial proteins are key effector molecules of innate immunity. The review discusses recent progress in understanding the function of these host defence molecules in intestinal physiology...
  2. ncbi request reprint Small bowel infections
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Gastroenterol 18:197-202. 2002
    ..coli, rotavirus, Giardia lamblia, and Cryptosporidium parvum. This review focuses on recent insights into the pathogenesis of infections with these pathogens and host defenses against them...
  3. doi request reprint IgG "detoxes" the intestinal mucosa
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA Electronic address
    Cell Host Microbe 17:538-9. 2015
    ....
  4. ncbi request reprint Cytokines in host defense against Salmonella
    L Eckmann
    Department of Medicine 0623D, Laboratory of Mucosal Immunology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    Microbes Infect 3:1191-200. 2001
    ..In animal models, protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12, IL-18 and IL-15, whereas IL-4 and IL-10 inhibit host defenses against Salmonella...
  5. ncbi request reprint Microbes and microbial toxins: paradigms for microbial-mucosal interactions I. Pathophysiological aspects of enteric infections with the lumen-dwelling protozoan pathogen Giardia lamblia
    L Eckmann
    Departments of Medicine and Pathology, University of California, San Diego, La Jolla, California 92093, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1-6. 2001
    ....
  6. ncbi request reprint Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella
    L Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 275:14084-94. 2000
    ..The results also show that evaluation of mRNA expression profiles by cDNA array analysis is a powerful approach to characterizing and understanding host-pathogen interactions...
  7. ncbi request reprint Mucosal defences against Giardia
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Parasite Immunol 25:259-70. 2003
    ..Elucidation of the key anti-giardial effector mechanisms will be important for selecting the best adjuvants in the rational development of vaccination strategies against Giardia...
  8. ncbi request reprint Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia
    L Eckmann
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 164:1478-87. 2000
    ..These studies define NO and arginine as central components in a novel cross-talk between a luminal pathogen and host intestinal epithelium...
  9. pmc Opposing functions of IKKbeta during acute and chronic intestinal inflammation
    Lars Eckmann
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:15058-63. 2008
    ..Our findings caution against the therapeutic use of IKKbeta/NF-kappaB inhibitors in acute inflammatory settings dominated by cell loss and ulceration...
  10. ncbi request reprint NOD2 and Crohn's disease: loss or gain of function?
    Lars Eckmann
    Department of Medicine, UCSD School of Medicine, La Jolla, California 92093, USA
    Immunity 22:661-7. 2005
    ..This review focuses on recent insights into the functions of normal and variant NOD2 proteins and the pathogenetic mechanisms underlying NOD2-associated inflammatory diseases...
  11. pmc Sensor molecules in intestinal innate immunity against bacterial infections
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Curr Opin Gastroenterol 22:95-101. 2006
    ..This review highlights new insights into the functions of these sensors in intestinal physiology...
  12. ncbi request reprint Animal models of inflammatory bowel disease: lessons from enteric infections
    Lars Eckmann
    University of California San Diego, Department of Medicine 0665, 9500 Gilman Drive, La Jolla, CA 92093 0665, USA
    Ann N Y Acad Sci 1072:28-38. 2006
    ..Furthermore, such models help to determine the physiologic consequences of neutralizing specific mediators and signaling pathways implicated in inflammation on antimicrobial host defense...
  13. doi request reprint NF-κB and mucosal homeostasis
    Lars Eckmann
    Department of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0063, USA
    Curr Top Microbiol Immunol 349:145-58. 2011
    ..This review focuses on the protective and homeostatic functions of NF-κB, and the importance of NF-κB in determining host-microbe interactions in the intestinal tract...
  14. ncbi request reprint Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells
    S K Yang
    Department of Medicine, University of California at San Diego, La Jolla, USA
    Gastroenterology 113:1214-23. 1997
    ..To further explore this role, the regulated expression of twelve C-X-C, C-C, and C-chemokines by human colon epithelial cells was characterized...
  15. ncbi request reprint Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity
    A Izadpanah
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623, USA
    Am J Physiol Gastrointest Liver Physiol 280:G710-9. 2001
    ..The constitutive and regulated expression of MIP-3alpha by human intestinal epithelium is consistent with a role for epithelial cell-produced MIP-3alpha in modulating mucosal adaptive immune responses...
  16. ncbi request reprint Production of MDC/CCL22 by human intestinal epithelial cells
    M C Berin
    Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1217-26. 2001
    ..These studies demonstrate the constitutive and regulated production by intestinal epithelial cells of a chemokine known to function in the trafficking of T cells that produce anti-inflammatory cytokines...
  17. pmc Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production
    L Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Clin Invest 100:296-309. 1997
    ..These studies define a novel autocrine/paracrine function of mediators produced by intestinal epithelial cells in the rapid induction of increased fluid secretion in response to intestinal infection with invasive bacteria...
  18. ncbi request reprint Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts
    M C Berin
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Am J Respir Cell Mol Biol 24:382-9. 2001
    ....
  19. pmc Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis
    S J Rasmussen
    Francis I Proctor Foundation, University of California, San Francisco 94143, USA
    J Clin Invest 99:77-87. 1997
    ..These findings suggest a novel pathophysiologic concept wherein the acute host response to Chlamydia at mucosal surfaces is primarily initiated and sustained by epithelial cells, the first and major targets of chlamydial infection...
  20. ncbi request reprint Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    ..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion...
  21. ncbi request reprint Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells
    M B Dwinell
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Gastroenterology 120:49-59. 2001
    ..IP-10, Mig, and I-TAC are 3 CXC chemokines that are known to act as CD4(+) T-cell chemoattractants...
  22. pmc Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function
    T F Meehan
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA
    Mucosal Immunol 7:134-42. 2014
    ..These results demonstrate that CD100-mediated signals are critical for effective activation of γδ IEL to produce growth factors, including KGF-1, that are required for healing of the colon epithelium during colitis. ..
  23. ncbi request reprint Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion
    D L Rowell
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Am J Physiol 273:G322-32. 1997
    ..Together, these studies suggest that hepatocytes can both initiate and amplify acute inflammatory responses in the liver through the regulated expression and secretion of a specific array of proinflammatory cytokines...
  24. pmc Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium
    Koji Hase
    Laboratory of Mucosal Immunology Histology Shared Resources, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Infect Immun 70:953-63. 2002
    ....
  25. ncbi request reprint Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium
    Christian Maaser
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Gastroenterology 122:667-80. 2002
    ..MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators important for regulating mucosal immune and inflammatory responses, we sought to determine if these cells produce MIF...
  26. pmc IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    Sergei Grivennikov
    Laboratory of Gene Regulation and Signal Transduction, UCSD School of Medicine, University of California San Diego, La Jolla, CA 92093 0723, USA
    Cancer Cell 15:103-13. 2009
    ..Thus, the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs...
  27. ncbi request reprint Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens
    Mitsutoshi Iimura
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
    J Immunol 174:4901-7. 2005
    ..Moreover, Cnlp+/+ mice were protected from oral infections with C. rodentium inocula that infected the majority of Cnlp-/- mice. These results establish cathelicidin as an important component of innate antimicrobial defense in the colon...
  28. pmc A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion
    H C Jung
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623
    J Clin Invest 95:55-65. 1995
    ....
  29. pmc How bile acids confer gut mucosal protection against bacteria
    Alan F Hofmann
    Department of Medicine, Division of Gastroenterology, University of California at San Diego, La Jolla, CA 92093 0813, USA
    Proc Natl Acad Sci U S A 103:4333-4. 2006
  30. ncbi request reprint Innate immune defenses in the intestinal tract
    Sara M Dann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0063, USA
    Curr Opin Gastroenterol 23:115-20. 2007
    ..Innate intestinal defenses are important for protection against ingested and commensal microbes. This review highlights recent new insights into innate immune effectors in the intestine...
  31. ncbi request reprint Regulated production of the chemokine CCL28 in human colon epithelium
    Hiroyuki Ogawa
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1062-9. 2004
    ..These findings indicate that CCL28 functions as an "inflammatory" chemokine in human colon epithelium and suggest the notion that CCL28 may act to counterregulate colonic inflammation...
  32. pmc Toll-like receptor 9-induced type I IFN protects mice from experimental colitis
    Kyoko Katakura
    Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
    J Clin Invest 115:695-702. 2005
    ..They also underscore the important protective role of type I IFN in intestinal homeostasis and suggest that strategies to modulate innate immunity may be of therapeutic value for the treatment of intestinal inflammatory conditions...
  33. ncbi request reprint Intestinal mucosal responses to microbial infection
    Lars Eckmann
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Springer Semin Immunopathol 27:181-96. 2005
    ....
  34. doi request reprint Nuclear factor-kappa B in intestinal protection and destruction
    Martina E Spehlmann
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
    Curr Opin Gastroenterol 25:92-9. 2009
    ..This review highlights new insights into the functions of NF-kappaB in normal homeostasis and specific disease processes in the intestinal tract...
  35. pmc Central importance of immunoglobulin A in host defense against Giardia spp
    T Dianne Langford
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Infect Immun 70:11-8. 2002
    ..Moreover, B-cell-dependent but IgA-independent and B-cell-independent antigiardial host defenses exist but are less important for controlling infection...
  36. pmc Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetin
    Tineke Lauwaet
    Department of Pathology, University of California at San Diego, 214 Dickinson Street, San Diego, CA 92103 8416, USA
    J Antimicrob Chemother 65:531-4. 2010
    ..Attachment to the small intestinal mucosa is crucial for initiating and maintaining Giardia infection. We tested the effect of isoflavones on Giardia attachment...
  37. ncbi request reprint Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    Jongdae Lee
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0663, USA
    Nat Cell Biol 8:1327-36. 2006
    ..Our data provide a case for organ-specific innate immunity in which TLR expression in polarized IECs has uniquely evolved to maintain colonic homeostasis and regulate tolerance and inflammation...
  38. pmc Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion
    S P Cole
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Infect Immun 65:843-6. 1997
    ..Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells...
  39. ncbi request reprint Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury
    Sungwon Chae
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Immunol 177:1214-20. 2006
    ..difficile toxin A exposure that is mediated, at least in part, through promoting epithelial cell survival by abrogating epithelial cell apoptosis...
  40. pmc Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
    Kazumichi Abe
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:17022-7. 2007
    ..These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation...
  41. pmc CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen
    Martina E Spehlmann
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 183:3332-43. 2009
    ..Thus, CXCR2-dependent processes, particularly mucosal neutrophil influx, not only contribute to host defense against C. rodentium, but provide protection against infection-associated diarrhea...
  42. doi request reprint STAT3 and its activators in intestinal defense and mucosal homeostasis
    Petr Hruz
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0063, USA
    Curr Opin Gastroenterol 26:109-15. 2010
    ..The review discusses recent findings on two cytokines, IL-22 and IL-6, and their common signaling pathway, which bridge innate and adaptive immunity in the intestinal tract...
  43. ncbi request reprint Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia
    Barbara J Davids
    Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92103, USA
    J Immunol 177:6281-90. 2006
    ..These results, together with prior data on pIgR-mediated immune neutralization of luminal cholera toxin, suggest that pIgR is essential in intestinal defense against pathogenic microbes with high-level and persistent luminal presence...
  44. pmc Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium
    Christian Maaser
    Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Immunology 112:437-45. 2004
    ....
  45. ncbi request reprint IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    Florian R Greten
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
    Cell 118:285-96. 2004
    ..In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer...
  46. pmc D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways
    L Eckmann
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 94:14456-60. 1997
    ..Thus, elevation of Ins(1,4,5,6)P4 in Salmonella-infected epithelia may promote Cl- flux by antagonizing EGF inhibition mediated through PtdIns3K and PtdInsP3...
  47. pmc Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha
    L Eckmann
    Department of Medicine, University of California, San Diego, La Jolla 93093, USA
    J Clin Invest 96:1269-79. 1995
    ..These studies define novel mechanisms through which acute inflammation can be initiated in the host in response to a cytolytic pathogen, such as E. histolytica...
  48. ncbi request reprint Analysis of host responses to microbial infection using gene expression profiling
    M F Kagnoff
    University of California, San Diego, Laboratory of Mucosal Immunology, 9500 Gilman Drive, La Jolla, California 92093 0623, USA
    Curr Opin Microbiol 4:246-50. 2001
    ....
  49. pmc Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia
    Carlos A Valdez
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Med Chem 52:4038-53. 2009
    ..These studies show the potential of combining systematic synthetic approaches with biological and electrochemical evaluations in developing improved 5-NI drugs...
  50. pmc Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiation
    Lillian J Choi
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:12504-11. 2010
    ....
  51. pmc GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen
    Yoshihiro Hirata
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0623, USA
    Cell Host Microbe 7:151-63. 2010
    ..Thus, GM-CSF produced in the intestinal mucosa acts to enhance host protection against an enteric bacterial pathogen through regulating recruitment and survival of DCs...
  52. pmc IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium
    Laurence J Egan
    Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:2452-7. 2004
    ..Selective preactivation of NF-kappaB through IKKbeta in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy...
  53. pmc Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies
    Christian Maaser
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 72:3315-24. 2004
    ..These results indicate that host defense against C. rodentium depends on B cells and IgG antibodies but does not require production or transepithelial transport of IgA or secreted IgM...
  54. pmc Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp
    Yolanda S Andersen
    Department of Medicine 0665, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0665, USA
    Infect Immun 74:2473-6. 2006
    ..Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance...
  55. ncbi request reprint Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD
    Lone S Bertelsen
    Department of Medicine, Division of Gastroenterology, UCSD Medical Center 8414, 200 W Arbor Dr, San Diego, CA 92103 8414, USA
    Am J Physiol Cell Physiol 287:C939-48. 2004
    ..We conclude that the Salmonella bacterial effector protein SigD may play critical roles in the pathogenesis of disease caused by this microorganism...
  56. pmc Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2
    Lone S Bertelsen
    Division of Gastroenterology, Department of Medicine, UCSD School of Medicine, Medical Center, 200 W Arbor Street, San Diego, CA 92103 8414, USA
    Infect Immun 71:2102-9. 2003
    ..In summary, Salmonella infection rapidly increases Cox-2 expression in human intestinal tissue, accounting for increased epithelial ion transport characteristic of infectious diarrhea...
  57. ncbi request reprint Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells
    Charles C Yang
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Am J Physiol Cell Physiol 288:C321-8. 2005
    ....
  58. pmc Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity
    Petr Hruz
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Curr Opin Gastroenterol 24:108-14. 2008
    ..The present review discusses the physiological functions of selected caspase recruitment domain (CARD)-containing sensor and adaptor proteins and their role in the pathogenesis of intestinal diseases...
  59. pmc Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis
    J Fierer
    Medical and Pathology Services, VA San Diego Healthcare System, University of California, San Diego, San Diego, California, USA
    Infect Immun 66:4397-402. 1998
    ..immitis, but IL-10 has a larger effect and is the cytokine that is consistently associated with susceptibility in all strains of inbred mice...
  60. ncbi request reprint Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity
    S Resta-Lenert
    Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
    Am J Physiol Cell Physiol 281:C1837-49. 2001
    ..However, these effects may not all be equally important in determining Cl(-) secretion in response to physiologically relevant secretagogues...
  61. ncbi request reprint Prolonged interferon-gamma exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivo
    Lone S Bertelsen
    Division of Gastroenterology, Department of Medicine, University of California San Diego School of Medicine, San Diego, California 92103 8414, USA
    Am J Physiol Gastrointest Liver Physiol 286:G157-65. 2004
    ..These findings demonstrate the implications of elevated IFN-gamma levels in human small intestine and validate the human intestinal xenograft as a model to study chronic effects of physiologically relevant stimuli...
  62. ncbi request reprint Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori
    Koji Hase
    Department of Medicine, University of California at San Diego, La Jolla, 92093, USA
    Gastroenterology 125:1613-25. 2003
    ....
  63. ncbi request reprint Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayers
    Laurence J Egan
    Laboratory of Mucosal Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    Am J Physiol Cell Physiol 285:C1028-35. 2003
    ....
  64. ncbi request reprint Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells
    Günther Paesold
    Department of Medicine 0623D, University of California at San Diego, La Jolla, CA 92093 0623, USA
    Cell Microbiol 4:771-81. 2002
    ..In addition to their influence on intracellular proliferation of Salmonella, genes in those loci determine the ultimate fate of infected epithelial cells with respect to caspase 3 activation and undergoing death by apoptosis...
  65. pmc IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens
    Sara M Dann
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 180:6816-26. 2008
    ..Thus, IL-6 is an important regulator of host defense against C. rodentium by protecting the mucosa against ulcerations which can act as a microbial niche for the bacteria...
  66. pmc Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model
    Samuel G Melendez-Lopez
    Department of Pathology, University of California, San Diego, San Diego, California 92103 8416, USA
    Eukaryot Cell 6:1130-6. 2007
    ..The resultant dramatic inhibition of invasion by both inhibitors in this human colonic model of amebiasis strongly suggests a significant role of secreted amebic proteinases, such as EhCP1, in the pathogenesis of amebiasis...
  67. pmc Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2
    Hiroshi Nishihara
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 100:8921-6. 2003
    ....
  68. pmc Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia
    Noa Tejman-Yarden
    University of California, San Diego, Department of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Antimicrob Agents Chemother 55:4643-51. 2011
    ..However, the data also caution that some forms of Mz resistance do not markedly interfere with in vivo infectivity...
  69. ncbi request reprint Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    J Infect Dis 185:196-203. 2002
    ..These data indicate that the GBS beta-h/c contributes to invasion and immune activation of lung epithelial cells and may represent a multifunctional virulence factor in the early pulmonary stages of GBS infection...
  70. pmc NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation
    Petr Hruz
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:12873-8. 2009
    ....
  71. pmc A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    Li Chung Hsu
    Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:7803-8. 2008
    ..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion...
  72. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...
  73. ncbi request reprint Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    Colby Zaph
    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 446:552-6. 2007
    ..These results indicate that the balance of IKK-beta-dependent gene expression in the intestinal epithelium is crucial in intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation...
  74. ncbi request reprint The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis
    Thomas W Spahn
    Department of Medicine, Munster University Hospital, Munster, Germany
    Gastroenterology 127:1463-73. 2004
    ..We studied the role of lymphotoxin alpha 1 beta 2 /lymphotoxin-beta receptor signaling in Citrobacter rodentium -induced colitis...
  75. pmc Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice
    Ulrich Meinzer
    INSERM, U843, Universite Paris 7, Hopital Robert Debre, Paris, France
    PLoS ONE 3:e2769. 2008
    ..This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice...
  76. pmc Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells
    Emma Ringqvist
    Department of Cell and Molecular Biology, BMC, Uppsala University, Uppsala, Sweden
    Mol Biochem Parasitol 159:85-91. 2008
    ..These results indicate that contact of Giardia with epithelial cells triggers metabolic enzyme release, which might facilitate effective colonization of the human small intestine...
  77. ncbi request reprint An important role for polymeric Ig receptor-mediated transport of IgA in protection against Streptococcus pneumoniae nasopharyngeal carriage
    Keer Sun
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 173:4576-81. 2004
    ..The results demonstrate the critical role of secretory IgA in protection against pneumococcal nasal colonization and suggest that directed targeting to mucosal tissues will be needed for effective vaccination in humans...

Research Grants3

  1. HOST DEFENSES AGAINST PATHOGENIC E. coli
    Lars Eckmann; Fiscal Year: 2007
    ..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
  2. MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    Lars Eckmann; Fiscal Year: 2008
    ..abstract_text> ..
  3. MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    Lars Eckmann; Fiscal Year: 2010
    ..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..