Noelle D Dwyer

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint TGF-beta receptors PAR-ticipate in axon formation
    Noelle D Dwyer
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    Cell 142:21-3. 2010
  2. pmc Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis.
    Katrina C McNeely
    Neural Dev 12:5. 2017
  3. pmc A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype
    Noelle D Dwyer
    Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neural Dev 6:3. 2011
  4. pmc Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain
    Carlita B Favero
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 521:677-96. 2013
  5. pmc The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size
    Kerstin M Janisch
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    Development 140:4672-82. 2013
  6. pmc Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210
    Patrick Smits
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children s Hospital, Boston, MA 02115, USA
    N Engl J Med 362:206-16. 2010
  7. doi request reprint Imaging and quantitative analysis of cytokinesis in developing brains of Kinesin-6 mutant mice
    Kerstin M Janisch
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA
    Methods Cell Biol 131:233-52. 2016
  8. pmc Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse
    Jennifer L Moran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 16:436-40. 2006

Research Grants

Collaborators

Detail Information

Publications8

  1. doi request reprint TGF-beta receptors PAR-ticipate in axon formation
    Noelle D Dwyer
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    Cell 142:21-3. 2010
    ..2010) provide striking evidence that TGF-beta signaling via the Par polarity complex is required for axon formation by neocortical pyramidal neurons...
  2. pmc Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis.
    Katrina C McNeely
    Neural Dev 12:5. 2017
    ..This work advances our understanding of how neurons regulate their cytoskeleton to build their elaborate shapes. Finally, it suggests that neuronal connectivity defects may be present in some types of microcephaly...
  3. pmc A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype
    Noelle D Dwyer
    Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neural Dev 6:3. 2011
    ..The axons grow along a complex multistep pathway, making sharp turns, crossing expression boundaries, and encountering intermediate targets. However, the cellular and molecular components mediating these steps remain poorly understood...
  4. pmc Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain
    Carlita B Favero
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Comp Neurol 521:677-96. 2013
    ..Together, these findings demonstrate a sensitive requirement for the endoplasmic reticulum chaperone BiP/GRP78 during axon outgrowth and pathfinding in the developing mammalian brain...
  5. pmc The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size
    Kerstin M Janisch
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    Development 140:4672-82. 2013
    ..Thus, Kif20b is required for proper midbody organization and abscission in polarized cortical stem cells and has a crucial role in the regulation of cerebral cortex growth...
  6. pmc Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210
    Patrick Smits
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children s Hospital, Boston, MA 02115, USA
    N Engl J Med 362:206-16. 2010
    ..Establishing the genetic basis of phenotypes such as skeletal dysplasia in model organisms can provide insights into biologic processes and their role in human disease...
  7. doi request reprint Imaging and quantitative analysis of cytokinesis in developing brains of Kinesin-6 mutant mice
    Kerstin M Janisch
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA
    Methods Cell Biol 131:233-52. 2016
    ..Applying and adapting these types of analyses to other cytoskeletal proteins and mouse mutants will help advance our understanding on how the embryonic neuroepithelium generates neurons and builds the brain. ..
  8. pmc Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse
    Jennifer L Moran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genome Res 16:436-40. 2006
    ..By using this approach, we identified DNA sequence changes in two ethylnitrosourea-induced mutants...

Research Grants1

  1. Molecular Mechanisms of Thalamocortical Development
    NOELLE DWYER; Fiscal Year: 2008
    ..Combining the expertise in mouse genetics with the previous training in mouse neuroanatomy and nematode genetics will significantly add to the Candidate's potential to make a strong impact on the field. ..