Genomes and Genes
Esther E Dupont-Versteegden
Affiliation: University of Kentucky
- Apoptosis in skeletal muscle and its relevance to atrophyEsther E Dupont-Versteegden
University of Arkansas for Medical Sciences, Department of Geriatrics, Little Rock, AR 72205, United States
World J Gastroenterol 12:7463-6. 2006..It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required for different causes of skeletal muscle loss...
- Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profilingEsther E Dupont-Versteegden
Department of Rehabilitation Sciences, Division of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA
Am J Physiol Regul Integr Comp Physiol 295:R1263-73. 2008..We conclude that a cold-shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass and that RBM3 may be a therapeutic target to prevent muscle loss...
- Effect of flywheel-based resistance exercise on processes contributing to muscle atrophy during unloading in adult ratsEsther E Dupont-Versteegden
Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham 807, Little Rock, Arkansas 72205, USA
J Appl Physiol (1985) 101:202-12. 2006..Identifying specific exercise parameters that affect these latter processes may be useful in designing effective exercise strategies in the elderly or during spaceflight...
- Aged Muscle Demonstrates Fiber-Type Adaptations in Response to Mechanical Overload, in the Absence of Myofiber Hypertrophy, Independent of Satellite Cell AbundanceJonah D Lee
Department of Rehabilitation Sciences, College of Health Sciences and Center for Muscle Biology, University of Kentucky, Lexington Department of Molecular and Integrative Physiology, Medical School, University of Michigan, Ann Arbor
J Gerontol A Biol Sci Med Sci . 2015..Overload induced a fiber-type composition improvement, independent of satellite cells, suggesting that aged muscle is very responsive to exercise-induced enhancement in oxidative capacity, even with an impaired hypertrophic response...
- Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophyChristopher S Fry
1900 S Limestone, CTW 105, University of Kentucky, Lexington, KY 40536, USA
FASEB J 28:1654-65. 2014..These results provide evidence that satellite cells regulate the muscle environment during growth...
- Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathwayEsther E Dupont-Versteegden
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Am J Physiol Cell Physiol 282:C1387-95. 2002..Therefore, results suggest that calcineurin may be playing opposing roles during skeletal muscle atrophy and under muscle mass-maintaining conditions...
- Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonucleiEsther E Dupont-Versteegden
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Am J Physiol Regul Integr Comp Physiol 291:R1730-40. 2006....
- Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a rapamycin-sensitive pathwayJames D Fluckey
Nutrition, Metabolism and Exercise Laboratory, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
Am J Physiol Endocrinol Metab 287:E1070-5. 2004..These results demonstrate that the capacity for an augmented anabolic response to resistance exercise is maintained after 4 days of HS and is independent of a rapamycin-sensitive pathway...
- Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopeniaChristopher S Fry
1 Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, Kentucky, USA 2 Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA
Nat Med 21:76-80. 2015....
- Cell death-resistance of differentiated myotubes is associated with enhanced anti-apoptotic mechanisms compared to myoblastsRijin Xiao
Division of Physical Therapy, Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, 900 S Limestone, Lexington, KY 40536 0200, USA
Apoptosis 16:221-34. 2011..These results show that resistance to apoptosis in myotubes is increased despite high levels of pro-apoptotic signaling mechanisms, and we suggest that this protective effect is mediated by enhanced anti-caspase mechanisms...
- Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophyJohn J McCarthy
Department of Physiology, College Health Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
Physiol Genomics 39:219-26. 2009..These results further expand the role of miRs in adult skeletal muscle and are consistent with a model in which the MyomiR network regulates slow myosin expression during muscle atrophy...
- Exercise-induced gene expression in soleus muscle is dependent on time after spinal cord injury in ratsEsther E Dupont-Versteegden
Department of Geriatrics, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, Arkansas 72205, USA
Muscle Nerve 29:73-81. 2004..Furthermore, the data suggest that the lumbar spinal cord undergoes time-dependent changes that temporarily impede the ability of the muscle to respond to exercise...
- Apoptosis in muscle atrophy: relevance to sarcopeniaEsther E Dupont-Versteegden
Department of Geriatrics, Institute on Aging, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
Exp Gerontol 40:473-81. 2005..The functional relevance of the increase in apoptosis with respect to the loss of muscle fibers and muscle cross-sectional area with aging remains to be determined and interventions to decrease apoptosis in muscle need to be evaluated...
- Enhanced survival of skeletal muscle myoblasts in response to overexpression of cold shock protein RBM3Amy L Ferry
Department of Rehabilitation Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
Am J Physiol Cell Physiol 301:C392-402. 2011....
- Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowthThomas Chaillou
Center for Muscle Biology, University of Kentucky, Lexington, Kentucky Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky
J Appl Physiol (1985) 118:86-97. 2015..These findings suggest conserved regulatory mechanisms involved in the adaptation of skeletal muscle to increased mechanical loading. ..
- Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophyJanna R Jackson
Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, 40536 0200, USA
Am J Physiol Cell Physiol 303:C854-61. 2012..These results provide convincing evidence that satellite cells are not required for muscle regrowth following atrophy and that, instead, the myonuclear domain size changes as myofibers adapt...
- Satellite cell regulation of muscle mass is altered at old ageJason C Gallegly
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Appl Physiol 97:1082-90. 2004..These data indicate that altered satellite cell function with age contributes to the impaired response of soleus muscle to an intervention that attenuates muscle atrophy in young animals during imposed disuse...
- Hindlimb unloading in adult rats using an alternative tail harness designMicheal Knox
University of Arkansas for Medical Sciences, Little Rock, AR, USA
Aviat Space Environ Med 75:692-6. 2004..However, using current methodologies, maintenance of adult rats in hindlimb unloading for long periods is challenging. Therefore, our goal was to develop a technique allowing long-term hindlimb unloading in adult rats...
- Age-related changes of cell death pathways in rat extraocular muscleColleen A McMullen
Department of Physiology, University of Kentucky, 800 Rose St, MS508, Lexington, KY 40536 0298, USA
Exp Gerontol 44:420-5. 2009..Based on these data, we suggest that the decrease in autophagy with age leads to the accumulation of damaged organelles, particularly mitochondria, which results in the decrease in function observed in EOM with age...
- Aging alters the skeletal response to disuse in the ratDaniel S Perrien
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham St, Slot 505, Little Rock, AR 72205, USA
Am J Physiol Regul Integr Comp Physiol 292:R988-96. 2007....
- Effective fiber hypertrophy in satellite cell-depleted skeletal muscleJohn J McCarthy
Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
Development 138:3657-66. 2011..These results provide convincing evidence that skeletal muscle fibers are capable of mounting a robust hypertrophic response to mechanical overload that is not dependent on satellite cells...
- Age-related differences in apoptosis with disuse atrophy in soleus muscleChristiaan Leeuwenburgh
Biochemistry of Aging Laboratory and Department of Aging and Geriatric Research, University of Florida, Gainesville, USA
Am J Physiol Regul Integr Comp Physiol 288:R1288-96. 2005..Apoptosis in skeletal muscle is partly mediated by the subsarcolemmal mitochondria through EndoG translocation to the nucleus in response to HS...
- Altered activity of signaling pathways in diaphragm and tibialis anterior muscle of dystrophic miceJoshua M Lang
Muscle Biology Laboratory, School of Kinesiology, University of Illinois, Chicago, Illinois 60608, USA
Exp Biol Med (Maywood) 229:503-11. 2004..The specificity of these responses, particularly in the diaphragm, provides insight for potential targets for blunting the progression of the muscular dystrophy phenotype...
- Insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP kinase pathwayJames D Fluckey
Muscle Biology Laboratory, Dept of Health and Kinesiology, Mail Stop 4243, Texas A and M University, College Station, TX 77845, USA
Am J Physiol Endocrinol Metab 290:E1205-11. 2006..Together, these results suggest that the insulin-facilitated increase of muscle protein synthesis after resistance exercise requires multiple signaling pathways...
- Impaired Regulation of Muscle size with AgingESTHER DUPONT VERSTEEGDEN; Fiscal Year: 2002..Also, potential regulatory pathways and molecules involved in control of muscle size will be determined. ..
- INTEGRATED STUDY OF MUSCULOSKELETAL LOSS AND RESTORATIONEsther E Dupont Versteegden; Fiscal Year: 2010..Identifying these common pathways influencing muscle and bone integrity could lead to putative targets for pharmacologic or therapeutic interventions. ..