TERRY DU CLOS
Affiliation: University of New Mexico
- Function of C-reactive proteinT W Du Clos
The VA Medical Center and the University of New Mexico School of Medicine, Department of Medicine, Albuquerque, USA
Ann Med 32:274-8. 2000..Thus, CRP is though to act as a surveillance molecule for altered self and certain pathogens. This recognition provides early defense and leads to a proinflammatory signal and activation of the humoural, adaptive immune system...
- Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptorsTerry W Du Clos
Department of Veterans Affairs Medical Center and the University of New Mexico School of Medicine, Albuquerque, New Mexico 87108, USA
Curr Opin Organ Transplant 16:15-20. 2011..Understanding the role of pentraxins in inflammation has been advanced by the recent identification and structural analysis of their receptor interactions...
- C-reactive protein: an activator of innate immunity and a modulator of adaptive immunityTerry W Du Clos
Department of Veterans Affairs Medical Center Research Service 151, 1501 San Pedro S E, Albuquerque, NM 87108, USA
Immunol Res 30:261-77. 2004..A general description of the proposed function of CRP is provided as a framework for future investigation...
- The role of C-reactive protein in the resolution of bacterial infectionT W Du Clos
Department of Veterans Affairs Medical Center, University of New Mexico, Albuquerque, New Mexico 87108, USA
Curr Opin Infect Dis 14:289-93. 2001..The recent identification of the interaction of C-reactive protein with Fc gamma receptors will lead to an enhanced understanding of C-reactive protein and its role in both the innate and acquired immune systems...
- Chromatin clearance in C57Bl/10 mice: interaction with heparan sulphate proteoglycans and receptors on Kupffer cellsT W Du Clos
Department of Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
Clin Exp Immunol 117:403-11. 1999..These data suggest that chromatin clearance is mediated by charge interactions with cell surface HSPG and by DNA receptors. Clearance and degradation of chromatin require functional macrophages in the liver and spleen...
- Limited Wegener's granulomatosis presenting with complete heart blockN O Ghaussy
Division of Rheumatology, Department of Internal Medicine, University of New Mexico Health Sciences Center, Veterans Administration Hospital, Albuquerque, NM 87131, USA
Scand J Rheumatol 33:115-8. 2004..In addition, a gallium-scan fused with a myocardial perfusion scan and cardiac magnetic resonance imaging (MRI) suggested focal inflammation near the atrioventricular (AV) node...
- Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma RsC Mold
Department of Molecular Genetics and Microbiology, Veterans Affairs Medical Center, and Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
J Immunol 166:1200-5. 2001..The use of FcgammaR by the pentraxins links innate and adaptive immunity and may have important consequences for processing, presentation, and clearance of the self-Ags to which these proteins bind...
- Regulation of complement activation by C-reactive proteinC Mold
Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque 87131, USA
Immunopharmacology 42:23-30. 1999..Complement activation by CRP may help limit the inflammatory response by providing opsonization with minimal generation of C5a and C5b-9...
- Definition of a C-reactive protein binding determinant on histonesT W Du Clos
Veterans Administration Medical Center, Albuquerque, New Mexico 87108
J Biol Chem 266:2167-71. 1991..Thus we have defined the first reported CRP binding determinant on a protein...
- C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specificM P Stein
Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87108, USA
J Clin Invest 105:369-76. 2000..This counterbalance may affect the contribution of FcgammaRIIA alleles to host defense and autoimmunity...
- C-reactive protein binding to murine leukocytes requires Fc gamma receptorsM P Stein
Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
J Immunol 164:1514-20. 2000..These findings may have important implications in understanding the physiological function of CRP...
- C-reactive protein reacts with the U1 small nuclear ribonucleoproteinT W Du Clos
Department of Medicine, VA Medical Center, Albuquerque, New Mexico 87108
J Immunol 143:2553-9. 1989..Considering the ability of CRP to inhibit antibody responses to its ligands and its ability to activate C and promote phagocytosis it is suggested that CRP may play a role in the regulation of autoantibody responses to nuclear Ag...
- C-REACTIVE PROTEIN--RECETORS, LIGANDS AND AUTOIMMUNITYTERRY DU CLOS; Fiscal Year: 1999..Functional studies will delineate the ability of CRP to stimulate signal transduction and opsonic activities through each of the two receptors. ..