Samuel R Dominguez

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Pediatric neurological complications of 2009 pandemic influenza A (H1N1)
    Sita Kedia
    Department of Child Neurology, The Children s Hospital, University of Colorado School of Medicine, Aurora, USA
    Arch Neurol 68:455-62. 2011
  2. pmc Human coronavirus HKU1 infection of primary human type II alveolar epithelial cells: cytopathic effects and innate immune response
    Samuel R Dominguez
    Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 8:e70129. 2013
  3. pmc Genomic analysis of 16 Colorado human NL63 coronaviruses identifies a new genotype, high sequence diversity in the N-terminal domain of the spike gene and evidence of recombination
    Samuel R Dominguez
    Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 E 19th Ave, Room P18 9403B, Aurora, CO 80045, USA
    J Gen Virol 93:2387-98. 2012
  4. doi request reprint Advances in the treatment of Kawasaki disease
    Samuel R Dominguez
    Department of Pediatrics, Section of Infectious Diseases, Children s Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Curr Opin Pediatr 25:103-9. 2013
  5. pmc Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado
    Samuel R Dominguez
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    J Med Virol 81:1597-604. 2009
  6. pmc Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses
    Kevin Messacar
    Children s Hospital Colorado, Section of Infectious Diseases, Aurora, CO 80045, United States
    J Clin Virol 56:41-5. 2013
  7. ncbi request reprint Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome
    Samuel R Dominguez
    Department of Pediatrics, The Children s Hospital, University of Colorado Health Science Center, Denver, CO, USA
    J Infect Dis 194:1697-701. 2006
  8. pmc Multiplex MassTag-PCR for respiratory pathogens in pediatric nasopharyngeal washes negative by conventional diagnostic testing shows a high prevalence of viruses belonging to a newly recognized rhinovirus clade
    Samuel R Dominguez
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Clin Virol 43:219-22. 2008
  9. pmc Isolation, propagation, genome analysis and epidemiology of HKU1 betacoronaviruses
    Samuel R Dominguez
    Departments of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 E 19th Ave, Room P18 9403B, Aurora, CO 80045, USA
    J Gen Virol 95:836-48. 2014
  10. pmc Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1
    Zhaohui Qian
    MOH Key Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Science, Beijing, China Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    J Virol 89:8816-27. 2015

Collaborators

Detail Information

Publications28

  1. pmc Pediatric neurological complications of 2009 pandemic influenza A (H1N1)
    Sita Kedia
    Department of Child Neurology, The Children s Hospital, University of Colorado School of Medicine, Aurora, USA
    Arch Neurol 68:455-62. 2011
    ..To analyze the spectrum of neurological manifestations in children hospitalized with pandemic influenza A H1N1 virus of 2009 (pH1N1)...
  2. pmc Human coronavirus HKU1 infection of primary human type II alveolar epithelial cells: cytopathic effects and innate immune response
    Samuel R Dominguez
    Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 8:e70129. 2013
    ..Furthermore, these studies demonstrate that human alveolar cells can be used to isolate and study novel human respiratory viruses that cause lower respiratory tract disease. ..
  3. pmc Genomic analysis of 16 Colorado human NL63 coronaviruses identifies a new genotype, high sequence diversity in the N-terminal domain of the spike gene and evidence of recombination
    Samuel R Dominguez
    Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 E 19th Ave, Room P18 9403B, Aurora, CO 80045, USA
    J Gen Virol 93:2387-98. 2012
    ..Ten different amino acid sequences were found in the NTD of the spike protein among these NL63 strains and the 75 partial published sequences of NTDs from strains found at different times throughout the world...
  4. doi request reprint Advances in the treatment of Kawasaki disease
    Samuel R Dominguez
    Department of Pediatrics, Section of Infectious Diseases, Children s Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Curr Opin Pediatr 25:103-9. 2013
    ..Although there is no conclusive body of evidence defining the best second and third-line therapies for Kawasaki patients, there have been several recent studies published describing the results of these therapies...
  5. pmc Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado
    Samuel R Dominguez
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    J Med Virol 81:1597-604. 2009
    ..Our data raise the possibility that HCoV may play a role in gastrointestinal and CNS disease. Additional studies are needed to investigate the potential roles of HCoVs in these diseases...
  6. pmc Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses
    Kevin Messacar
    Children s Hospital Colorado, Section of Infectious Diseases, Aurora, CO 80045, United States
    J Clin Virol 56:41-5. 2013
    ..The relative impact of human rhino/enteroviruses (HRV/EV) compared to influenza viruses on hospitalized children is unknown...
  7. ncbi request reprint Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome
    Samuel R Dominguez
    Department of Pediatrics, The Children s Hospital, University of Colorado Health Science Center, Denver, CO, USA
    J Infect Dis 194:1697-701. 2006
    ..These data suggest that, although HCoV-NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV-NL63 was not greater in patients with KS than in control subjects...
  8. pmc Multiplex MassTag-PCR for respiratory pathogens in pediatric nasopharyngeal washes negative by conventional diagnostic testing shows a high prevalence of viruses belonging to a newly recognized rhinovirus clade
    Samuel R Dominguez
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Clin Virol 43:219-22. 2008
    ..Respiratory infections are the most common infectious diseases in humans worldwide and are a leading cause of death in children less than 5 years of age...
  9. pmc Isolation, propagation, genome analysis and epidemiology of HKU1 betacoronaviruses
    Samuel R Dominguez
    Departments of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 E 19th Ave, Room P18 9403B, Aurora, CO 80045, USA
    J Gen Virol 95:836-48. 2014
    ..Elucidating the function of and mechanisms responsible for the formation of these varying tandem repeats will increase our understanding of the replication process and pathogenicity of HKU1 and potentially of other coronaviruses. ..
  10. pmc Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1
    Zhaohui Qian
    MOH Key Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Science, Beijing, China Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    J Virol 89:8816-27. 2015
    ..Thus, two β-CoVs in group A, HKU1 and murine CoV, have evolved to use different regions of their spike glycoproteins to recognize their respective receptor proteins...
  11. pmc Alphacoronaviruses in New World bats: prevalence, persistence, phylogeny, and potential for interaction with humans
    Christina Osborne
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 6:e19156. 2011
    ..Further CoV surveillance studies in bats throughout the Americas are warranted...
  12. pmc Detection of group 1 coronaviruses in bats in North America
    Samuel R Dominguez
    University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Emerg Infect Dis 13:1295-300. 2007
    ..Because of the potential for bat coronaviruses to cause disease in humans and animals, further surveillance and characterization of bat coronaviruses in North America are needed...
  13. pmc Potential clinical impact of the film array meningitis encephalitis panel in children with suspected central nervous system infections
    Kevin Messacar
    University of Colorado Children s Hospital Colorado Department of Pediatrics, Section of Infectious Diseases, Aurora, CO, USA University of Colorado Children s Hospital Colorado Department of Pediatrics, Section of Hospital Medicine, Aurora, CO, USA Electronic address
    Diagn Microbiol Infect Dis 86:118-20. 2016
    ..The panel had comparable diagnostic yield (96% agreement) and improved time-to-diagnosis by 10.3 hours with potential for more judicious antimicrobial use, particularly acyclovir. ..
  14. pmc Enterovirus D68 in Critically Ill Children: A Comparison With Pandemic H1N1 Influenza
    Suchitra Rao
    1Department of Pediatrics Hospital Medicine and Infectious Diseases, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO 2Department of Pediatrics Hospital Medicine, University of Colorado School of Medicine Adult and Child Center for Health Outcomes Research and Delivery Science, Aurora, CO 3Department of Pediatrics, University of Colorado School of Medicine, and Children s Hospital Colorado, Aurora, CO 4University of Colorado School of Medicine, Aurora, CO 5Department of Pediatrics Critical Care, University of Maryland School of Medicine, Baltimore, MD 6Department of Pediatrics Infectious Diseases, University of Colorado School of Medicine, and Children s Hospital Colorado, Aurora, CO 7Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 8Department of Pediatrics Critical Care, University of Colorado School of Medicine, and Children s Hospital Colorado, Aurora, CO 9Department of Microbiology Virology, Children s Hospital Colorado, Aurora, CO
    Pediatr Crit Care Med 17:1023-1031. 2016
    ..The clinical characteristics associated with severe illness from enterovirus D68 during this outbreak compared with those associated with the 2009 H1N1 influenza virus outbreak are unknown...
  15. pmc Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation
    Zhaohui Qian
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    PLoS ONE 8:e76469. 2013
    ....
  16. doi request reprint Kawasaki disease in a pediatric intensive care unit: a case-control study
    Samuel R Dominguez
    Department of Pediatrics, University of Colorado Denver School of Medicine, Denver, Colorado, USA
    Pediatrics 122:e786-90. 2008
    ..We conducted a case-control study to ascertain the clinical presentations, risk factors, and clinical outcomes of children who had Kawasaki disease and were admitted to the ICU of our children's hospital...
  17. doi request reprint Kawasaki disease and the pediatric gastroenterologist: a diagnostic challenge
    Mohammed Eladawy
    Ain Shams University Department of Pediatrics, University of Colorado School of Medicine and Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Gastroenterol Nutr 56:297-9. 2013
    ..In the present study, we report a series of patients with KD in whom a gastroenterology consult was obtained before consideration of the diagnosis of KD...
  18. doi request reprint Preventing coronary artery abnormalities: a need for earlier diagnosis and treatment of Kawasaki disease
    Samuel R Dominguez
    Department of Pediatrics, University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO 80045
    Pediatr Infect Dis J 31:1217-20. 2012
    ..The aim of this study was to explore the timing of coronary artery (CA) abnormalities in light of the expanding clinical spectrum of Kawasaki disease (KD)...
  19. doi request reprint Procalcitonin (PCT) and Kawasaki Disease: Does PCT Correlate With IVIG-Resistant Disease, Admission to the Intensive Care Unit, or Development of Coronary Artery Lesions?
    Samuel R Dominguez
    Department of Pediatrics, Section of Infectious Diseases
    J Pediatric Infect Dis Soc 5:297-302. 2016
    ..We hypothesized that PCT might be useful in predicting coronary artery lesions (CALs) and intravenous immunoglobulin (IVIG) resistance...
  20. pmc Acute flaccid myelitis: A clinical review of US cases 2012-2015
    Kevin Messacar
    Department of Pediatrics, Section of Hospital Medicine, Children s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO
    Ann Neurol 80:326-38. 2016
    ..Epidemiological evidence and biological plausibility support an association between enterovirus D68 and the recent increase in acute flaccid myelitis cases in the United States. Ann Neurol 2016;80:326-338. ..
  21. doi request reprint 2014 outbreak of enterovirus D68 in North America
    Kevin Messacar
    Pediatric Hospital Medicine and Infectious Diseases, University of Colorado Children s Hospital Colorado, Aurora, Colorado
    J Med Virol 88:739-45. 2016
    ..The 2014 outbreak of EV-D68 in North America demonstrates the public health importance of this emerging pathogen...
  22. doi request reprint A cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA
    Kevin Messacar
    Departments of Pediatric Infectious Diseases, Children s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA Hospital Medicine, Children s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA
    Lancet 385:1662-71. 2015
    ..We aimed to assess a cluster of children with acute flaccid paralysis and cranial nerve dysfunction geographically and temporally associated with an outbreak of enterovirus-D68 respiratory disease...
  23. pmc Hospitalized children with 2009 pandemic influenza A (H1N1): comparison to seasonal influenza and risk factors for admission to the ICU
    Dayanand Bagdure
    Department of Pediatric Critical Care, The Children s Hospital, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 5:e15173. 2010
    ..Limited data are available describing the clinical presentation and risk factors for admission to the intensive care unit for children with 2009 H1N1 infection...
  24. doi request reprint Epidemiology and clinical characteristics of infants with human parechovirus or human herpes virus-6 detected in cerebrospinal fluid tested for enterovirus or herpes simplex virus
    Kevin Messacar
    Department of Pediatrics, Section of Hospital Medicine and Infectious Diseases, Aurora, Colorado Department of Pathology and Laboratory Medicine, Aurora, Colorado
    J Med Virol 87:829-35. 2015
    ..The clinical and fiscal impact of testing infants for HPeV and HHV-6 needs to be determined...
  25. pmc The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia
    Kathryn V Holmes
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA
    MBio 4:e00548-12. 2013
    ....
  26. doi request reprint Epidemiology and Molecular Characteristics of Mycoplasma pneumoniae During an Outbreak of M. pneumoniae-Associated Stevens-Johnson Syndrome
    Louise K Francois Watkins
    1Epidemic Intelligence Service Centers for Disease Control and Prevention, Atlanta, Georgia, USA 2University of Colorado School of Medicine, Aurora, Colorado, USA 3Centers for Disease Control and Prevention, Atlanta, Georgia, USA 4Children s Hospital Colorado, Aurora, Colorado, USA 5Colorado Department of Public Health and Environment, Denver, CO, USA
    Pediatr Infect Dis J . 2017
    ..We describe the epidemiologic and molecular characteristics of M. pneumoniae among SJS case-patients and surrounding community members during the outbreak...
  27. doi request reprint Viral gastroenteritis in children in Colorado 2006-2009
    Christina M Osborne
    University of Colorado School of Medicine, Aurora, Colorado, 80045
    J Med Virol 87:931-9. 2015
    ..Immunocompromised patients can be infected with multiple viruses and shed viruses in their stools for prolonged periods. This data support the superiority of RT-PCR compared to EM for diagnosis of viral gastroenteritis...