Benjamin Djulbegovic

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Impact of quality of evidence on the strength of recommendations: an empirical study
    Benjamin Djulbegovic
    Center for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute, Florida, USA
    BMC Health Serv Res 9:120. 2009
  2. doi request reprint Quality of evidence is a key determinant for making a strong GRADE guidelines recommendation
    Benjamin Djulbegovic
    Division of Evidence Based Medicine, Department of Internal Medicine, USF Health Program for Comparative Effectiveness Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA Moffitt Cancer Center and Tampa General Hospital, Tampa, FL, USA Electronic address
    J Clin Epidemiol 68:727-32. 2015
  3. pmc How do physicians decide to treat: an empirical evaluation of the threshold model
    Benjamin Djulbegovic
    Department of Internal Medicine, Division of Evidence Based Medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    BMC Med Inform Decis Mak 14:47. 2014
  4. pmc Treatment success in cancer: industry compared to publicly sponsored randomized controlled trials
    Benjamin Djulbegovic
    Center for Evidence based medicine and Health Outcomes Research, Tampa, Florida, USA
    PLoS ONE 8:e58711. 2013
  5. pmc When is it rational to participate in a clinical trial? A game theory approach incorporating trust, regret and guilt
    Benjamin Djulbegovic
    Center for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute and Department of Internal Medicine, University of South Florida, Tampa, FL, USA
    BMC Med Res Methodol 12:85. 2012
  6. pmc Dual processing model of medical decision-making
    Benjamin Djulbegovic
    Center for Evidence based medicine and Health Outcomes Research, Tampa, FL, USA
    BMC Med Inform Decis Mak 12:94. 2012
  7. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
  8. pmc The Australian 'FORM' approach to guideline development: the quest for the perfect system
    Philipp Dahm
    Department of Urology and Prostate Disease Center, University of Florida, College of Medicine, Gainesville, FL, USA
    BMC Med Res Methodol 11:17. 2011
  9. ncbi request reprint Epistemologic inquiries in evidence-based medicine
    Benjamin Djulbegovic
    Center for Evidence Based Medicine and Health Outcomes Research and the Clinical Translational Science Institute at the University of South Florida, Tampa, Florida 33612, USA
    Cancer Control 16:158-68. 2009
  10. pmc The paradox of equipoise: the principle that drives and limits therapeutic discoveries in clinical research
    Benjamin Djulbegovic
    Center for Evidence Based Medicine and Health Outcomes Research and the Clinical Translational Science Institute, The University of South Florida, Tampa, Florida 33612, USA
    Cancer Control 16:342-7. 2009

Detail Information

Publications84

  1. pmc Impact of quality of evidence on the strength of recommendations: an empirical study
    Benjamin Djulbegovic
    Center for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute, Florida, USA
    BMC Health Serv Res 9:120. 2009
    ..Surprisingly, and despite the widespread penetration of EBM in health care, there has been no empirical research to date investigating the impact of quality of evidence on the strength of recommendations made by guidelines panels...
  2. doi request reprint Quality of evidence is a key determinant for making a strong GRADE guidelines recommendation
    Benjamin Djulbegovic
    Division of Evidence Based Medicine, Department of Internal Medicine, USF Health Program for Comparative Effectiveness Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA Moffitt Cancer Center and Tampa General Hospital, Tampa, FL, USA Electronic address
    J Clin Epidemiol 68:727-32. 2015
    ..The objective of the study was to assess the association between Grading of Recommendations Assessment, Development and Evaluation (GRADE) factors and the strength of recommendations...
  3. pmc How do physicians decide to treat: an empirical evaluation of the threshold model
    Benjamin Djulbegovic
    Department of Internal Medicine, Division of Evidence Based Medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    BMC Med Inform Decis Mak 14:47. 2014
    ....
  4. pmc Treatment success in cancer: industry compared to publicly sponsored randomized controlled trials
    Benjamin Djulbegovic
    Center for Evidence based medicine and Health Outcomes Research, Tampa, Florida, USA
    PLoS ONE 8:e58711. 2013
    ..To assess if commercially sponsored trials are associated with higher success rates than publicly-sponsored trials...
  5. pmc When is it rational to participate in a clinical trial? A game theory approach incorporating trust, regret and guilt
    Benjamin Djulbegovic
    Center for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute and Department of Internal Medicine, University of South Florida, Tampa, FL, USA
    BMC Med Res Methodol 12:85. 2012
    ..This tension creates a key dilemma: when is it rational, from the perspective of the trial patients and researchers (as societal representatives of future patients), to enroll in RCTs?..
  6. pmc Dual processing model of medical decision-making
    Benjamin Djulbegovic
    Center for Evidence based medicine and Health Outcomes Research, Tampa, FL, USA
    BMC Med Inform Decis Mak 12:94. 2012
    ..Here we postulate such a model and apply it to a common clinical situation: whether treatment should be administered to the patient who may or may not have a disease...
  7. pmc Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)
    Matthias Briel
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Trials 10:49. 2009
    ..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit...
  8. pmc The Australian 'FORM' approach to guideline development: the quest for the perfect system
    Philipp Dahm
    Department of Urology and Prostate Disease Center, University of Florida, College of Medicine, Gainesville, FL, USA
    BMC Med Res Methodol 11:17. 2011
    ..The Australian National Health and Medical Research Council has developed and pilot-tested a new framework for guideline development, the FORM approach, the role of which has yet to be further defined...
  9. ncbi request reprint Epistemologic inquiries in evidence-based medicine
    Benjamin Djulbegovic
    Center for Evidence Based Medicine and Health Outcomes Research and the Clinical Translational Science Institute at the University of South Florida, Tampa, Florida 33612, USA
    Cancer Control 16:158-68. 2009
    ..Undertaking epistemological inquiry is important because the adoption of a particular epistemological view defines how science is conducted...
  10. pmc The paradox of equipoise: the principle that drives and limits therapeutic discoveries in clinical research
    Benjamin Djulbegovic
    Center for Evidence Based Medicine and Health Outcomes Research and the Clinical Translational Science Institute, The University of South Florida, Tampa, Florida 33612, USA
    Cancer Control 16:342-7. 2009
    ..This guarantee is provided by the acknowledgment of uncertainty (equipoise), which removes ethical dilemmas and makes it easier for patients to enroll in clinical trials...
  11. ncbi request reprint Management of venous Thromboembolism in cancer: a brief review of risk-benefit approaches and guidelines' recommendations
    Benjamin Djulbegovic
    Medicine and Oncology, University of South Florida, Tampa, FL 33612, USA
    J Support Oncol 8:84-91. 2010
    ..Hence, there is an urgent need to develop a clinical decision-support system that can help integrate benefits and risks as well as take into account patients' preferences and values in managing VTE...
  12. pmc Uncertainty and equipoise: at interplay between epistemology, decision making and ethics
    Benjamin Djulbegovic
    Center and Division for Evidence based Medicine and Health Outcome Research, Clinical Translational Science Institute, University of South Florida, Tampa, Florida, USA
    Am J Med Sci 342:282-9. 2011
    ..Ultimately, our choices can only become wiser if we understand a close and intertwined relationship between irreducible uncertainty, inevitable errors and unavoidable injustice...
  13. pmc Optimism bias leads to inconclusive results-an empirical study
    Benjamin Djulbegovic
    Department of Medicine, Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL 33612, USA
    J Clin Epidemiol 64:583-93. 2011
    ..We assessed the impact of optimism bias on a proportion of trials that did not answer their research question successfully and explored whether poor accrual or optimism bias is responsible for inconclusive results...
  14. doi request reprint Bisphosphonates in multiple myeloma: a network meta-analysis
    Rahul Mhaskar
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 5:CD003188. 2012
    ..This is an update of a Cochrane review first published in 2002 and previously updated in 2010...
  15. pmc Are experimental treatments for cancer in children superior to established treatments? Observational study of randomised controlled trials by the Children's Oncology Group
    Ambuj Kumar
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    BMJ 331:1295. 2005
    ....
  16. doi request reprint Sequence of novel agents in multiple myeloma: an instrumental variable analysis
    Rachid Baz
    Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Leuk Res 37:1077-82. 2013
    ..These findings were confirmed with instrumental variable analyses. Finally, use of bortezomib first was associated with improved survival for patients with baseline renal insufficiency. ..
  17. ncbi request reprint External validation of a web-based prognostic tool for predicting survival for patients in hospice care
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, Morsani College of Medicine, University of South Florida, 3515 E Fletcher Avenue, MDT1200, Mail Code MDC27, Tampa, Florida 33612, USA
    J Palliat Care 29:140-6. 2013
    ..If it is to be useful to patients and clinicians, Prognostat needs to explicitly report patient risk scores and estimates of baseline survival...
  18. doi request reprint Towards a classification model to identify hospice candidates in terminally ill patients
    Eleazar Gil-Herrera
    Department of Industrial and Management System Engineering, University of South Florida, Tampa, FL 33620, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:1278-81. 2012
    ..Retrospective data from 9105 patients is used to demonstrate the design and implementation details of the classification model...
  19. doi request reprint Optimal information size in trial sequential analysis of time-to-event outcomes reveals potentially inconclusive results because of the risk of random error
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, Department of Internal Medicine, Clinical and Translational Science Institute, Morsani College of Medicine, University of South Florida, 3515 East Fletcher Avenue, MDC 27, Tampa, FL 33612, USA
    J Clin Epidemiol 66:654-9. 2013
    ..We conducted a TSA for time-to-event outcomes and applied the method to determine the risk of random error in MAs for treatments of multiple myeloma...
  20. doi request reprint Role of high-dose chemotherapy and autologous hematopoietic cell transplantation in primary systemic amyloidosis: a systematic review
    Rahul Mhaskar
    Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Biol Blood Marrow Transplant 15:893-902. 2009
    ..But the quality of our evidence is low, indicating a need for well-designed and adequately powered RCTs to better address the role of AHCT in AL amyloidosis...
  21. ncbi request reprint Erythropoietin use in oncology: a summary of the evidence and practice guidelines comparing efforts of the Cochrane Review group and Blue Cross/Blue Shield to set up the ASCO/ASH guidelines
    Benjamin Djulbegovic
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Best Pract Res Clin Haematol 18:455-66. 2005
    ..In this paper, the findings from the guidelines set by ASH/ASCO that were culled from systematic reviews by BCBSA TEC and the Cochrane Review are compared and contrasted...
  22. doi request reprint Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
    Charles L Bennett
    VA Chicago Healthcare System, Department of Medicine, Northwestern University Feinberg School of Medicine, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    JAMA 299:914-24. 2008
    ..Although systematic overviews of trials have identified venous thromboembolism (VTE) risks, none have identified mortality risks with ESAs...
  23. doi request reprint Tandem versus single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysis
    Ambuj Kumar
    Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA
    J Natl Cancer Inst 101:100-6. 2009
    ..We performed a systematic review and meta-analysis to synthesize the existing evidence related to the effectiveness of tandem vs single AHCT in patients with MM...
  24. doi request reprint Defining optimum treatment of patients with pancreatic adenocarcinoma using regret-based decision curve analysis
    Jonathan M Hernandez
    Department of Surgery, Division of General Surgery, University of South Florida, Tampa, FL Center for Evidence Based Medicine, University of South Florida, Tampa, FL Department of Internal Medicine, Division of Evidence Based Medicine, Tampa, FL Department of Hematology and Health Outcomes and Behavior, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL
    Ann Surg 259:1208-14. 2014
    ..To use regret decision theory methodology to assess three treatment strategies in pancreatic adenocarcinoma...
  25. doi request reprint Gemtuzumab ozogamicin for treatment of newly diagnosed acute myeloid leukaemia: a systematic review and meta-analysis
    Mohamed A Kharfan-Dabaja
    Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center, Tampa, FL, USA Department of Oncologic Sciences, H Lee Moffitt Cancer Center University of South Florida College of Medicine, Tampa, FL, USA
    Br J Haematol 163:315-25. 2013
    ..Addition of GO to conventional chemotherapy as induction therapy may improve relapse-free and event-free survival, but does not impact overall survival and significantly increases early mortality in AML. ..
  26. ncbi request reprint Bisphosphonates in multiple myeloma
    Rahul Mhaskar
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 3:CD003188. 2010
    ..Also, with the baseline risk of 35% to 86% for SREs without treatment, we estimate that between six and 15 MM patients should be treated to prevent SRE(s) in one patient. No bisphoshphonate appears to be superior to others...
  27. doi request reprint Decision analysis of peripheral blood versus bone marrow hematopoietic stem cells for allogeneic hematopoietic cell transplantation
    Joseph Pidala
    Department of Blood and Marrow Transplantation, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612 9416, USA
    Biol Blood Marrow Transplant 15:1415-21. 2009
    ..PBSC is the optimal stem cell source in terms of both overall and quality-adjusted life expectancy, except in conditions with a very low relapse probability, in which BM provides optimal outcomes...
  28. pmc Published methodological quality of randomized controlled trials does not reflect the actual quality assessed in protocols
    Rahul Mhaskar
    Division and Center for Evidence Based Medicine and Outcomes Research, Department of Internal Medicine, Clinical and Translational Science Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Clin Epidemiol 65:602-9. 2012
    ..To assess whether the reported methodological quality of randomized controlled trials (RCTs) reflects the actual methodological quality and to evaluate the association of effect size (ES) and sample size with methodological quality...
  29. pmc Instrumental variable meta-analysis of individual patient data: application to adjust for treatment non-compliance
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    BMC Med Res Methodol 11:55. 2011
    ..Our objective is to correct for bias in non-experimental data from previously published individual patient data meta-analysis by applying IV methods..
  30. pmc Treatment success in cancer: new cancer treatment successes identified in phase 3 randomized controlled trials conducted by the National Cancer Institute-sponsored cooperative oncology groups, 1955 to 2006
    Benjamin Djulbegovic
    H Lee Moffitt Cancer Center, 12902 Magnolia Dr, MRC, Room 2067H, Tampa, FL 33612, USA
    Arch Intern Med 168:632-42. 2008
    ..We assessed how often experimental cancer treatments that undergo testing in randomized clinical trials (RCTs) result in discovery of successful new interventions...
  31. doi request reprint Thalidomide versus bortezomib based regimens as first-line therapy for patients with multiple myeloma: a systematic review
    Ambuj Kumar
    Center for Evidence based Medicine and Health Outcome Research, University of South Florida
    Am J Hematol 86:18-24. 2011
    ..53, 95% CI 0.38-0.73) favoring MPB. There is an uncertainty about definitive superiority of one type of regimen over the other. Therefore, direct head-to-head comparison between these competing regimens is warranted...
  32. ncbi request reprint Management of multiple myeloma: a systematic review and critical appraisal of published studies
    Ambuj Kumar
    Interdisciplinary Oncology Program of the H Lee Moffitt Cancer and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Lancet Oncol 4:293-304. 2003
    ..We conclude that the quality of total evidence supporting treatment recommendations in myeloma is modest at best and has an ample scope for improvement...
  33. doi request reprint Trial sequential analysis may be insufficient to draw firm conclusions regarding statistically significant treatment differences using observed intervention effects: a case study of meta-analyses of multiple myeloma trials
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    Contemp Clin Trials 34:257-61. 2013
    ..We recommend that the conclusion of significant treatment differences in cumulative MA should be weighed against acceptable thresholds regarding the type I error, power and apriori specified clinically meaningful treatment difference...
  34. doi request reprint Treatment of patients with multiple myeloma: an overview of systematic reviews
    Ambuj Kumar
    Center for Evidence based Medicine and Health Outcome Research, University of South Florida, USA
    Acta Haematol 125:8-22. 2011
    ..There is urgent need to perform research synthesis of data related to the effects of novel agents...
  35. pmc A regret theory approach to decision curve analysis: a novel method for eliciting decision makers' preferences and decision-making
    Athanasios Tsalatsanis
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    BMC Med Inform Decis Mak 10:51. 2010
    ..We use the cognitive emotion of regret to serve as a link between systems 1 and 2 and to reformulate DCA...
  36. doi request reprint Rough Set Theory based prognostication of life expectancy for terminally ill patients
    Eleazar Gil-Herrera
    Department of Industrial and Management System Engineering, University of South Florida, Tampa, FL 33620, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:6438-41. 2011
    ..Preliminary results confirm the efficacy of the proposed methodology. We envision our work as a part of a comprehensive decision support system designed to assist terminally ill patients in making end-of-life care decisions...
  37. ncbi request reprint A systematic review of quality of life associated with standard chemotherapy regimens for advanced non-small cell lung cancer
    Tawee Tanvetyanon
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    J Thorac Oncol 2:1091-7. 2007
    ..We evaluated available literatures to summarize the state of current knowledge and provide suggestions for future studies...
  38. ncbi request reprint Systematic review of high dose chemotherapy and autologous haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: what is the published evidence?
    Mohamed A Kharfan-Dabaja
    Division of Blood and Marrow Transplantation, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Rsearch Institute, University of South Florida, Tampa, FL 33612, USA
    Br J Haematol 139:234-42. 2007
    ..It is uncertain whether autograft is superior to conventional therapy. The high incidence of myelodysplastic syndrome (9-12%) is particularly concerning in CLL, where median survival is 9 years...
  39. ncbi request reprint Evidence-based medicine for rare diseases: implications for data interpretation and clinical trial design
    Madhusmita Behera
    Malignant Hematology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Control 14:160-6. 2007
    ..The randomized, controlled trial (RCT) is the "gold standard" for establishing the effect of any intervention. This approach, however, is often not feasible with rare diseases such as cutaneous T-cell lymphoma...
  40. ncbi request reprint What kind of evidence do patients and practitioners need: evidence profiles based on 5 key evidence-based principles to summarize data on benefits and harms
    Benjamin Djulbegovic
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Treat Rev 32:572-6. 2006
  41. doi request reprint Uncertainty about effects is a key factor influencing institutional review boards' approval of clinical studies
    Hesborn Wao
    Division of Evidence Based Medicine and Health Outcomes Research, Department of Internal Medicine, USF Health Morsani College of Medicine, University of South Florida, Tampa Electronic address
    Ann Epidemiol 24:734-40. 2014
    ..To investigate factors, which influence institutional review boards' (IRBs') decision to approve or not approve clinical studies, a nationwide vignette-based online survey of IRB members was conducted...
  42. doi request reprint Mycophenolate mofetil versus methotrexate for prevention of graft-versus-host disease in people receiving allogeneic hematopoietic stem cell transplantation
    Mohamed Kharfan-Dabaja
    Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center, Division of Oncologic Sciences, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 7:CD010280. 2014
    ..Conflicting results regarding various clinical outcomes following allo-HCT have been observed when comparing mycophenolate mofetil-based regimens against methotrexate-based regimens for acute GVHD prophylaxis...
  43. pmc Comparative efficacy of tandem autologous versus autologous followed by allogeneic hematopoietic cell transplantation in patients with newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials
    Mohamed A Kharfan-Dabaja
    Blood and Marrow Transplantation Program, H Lee Moffitt Cancer Center University of South Florida College of Medicine, Tampa, FL, USA
    J Hematol Oncol 6:2. 2013
    ..A previously published meta-analysis has been reported; however, it suffers from serious methodological flaws...
  44. pmc Survival of patients with non-small cell lung cancer without treatment: a systematic review and meta-analysis
    Hesborn Wao
    Center for Evidence Based Medicine and Outcomes Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida Clinical and Translational Science Institute, 3515 East Fletcher Avenue, MDT 1202, Tampa, FL, 33612, USA
    Syst Rev 2:10. 2013
    ..Specifically, we estimated overall survival when no anticancer therapy is provided...
  45. pmc A flexible alternative to the Cox proportional hazards model for assessing the prognostic accuracy of hospice patient survival
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    PLoS ONE 7:e47804. 2012
    ..Researchers involved in prognosticating patient survival are encouraged to consider the Royston-Parmar model as an alternative to Cox...
  46. ncbi request reprint The importance of preservation of the ethical principle of equipoise in the design of clinical trials: relative impact of the methodological quality domains on the treatment effect in randomized controlled trials
    Benjamin Djulbegovic
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr, Tampa, FL 33612, USA
    Account Res 10:301-15. 2003
    ..We argue that an adequate control intervention can be selected if people designing a trial explicitly take into consideration the ethical principle of equipoise, also known as "the uncertainty principle."..
  47. pmc Extensions to regret-based decision curve analysis: an application to hospice referral for terminal patients
    Athanasios Tsalatsanis
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    BMC Med Inform Decis Mak 11:77. 2011
    ..Decision systems to improve the hospice referral process are sorely needed...
  48. ncbi request reprint Evidence-based oncology in cancer treatment reviews
    Benjamin Djulbegovic
    H Lee Moffitt Cancer Center, Florida, USA
    Cancer Treat Rev 29:45-50. 2003
  49. ncbi request reprint Articulating and responding to uncertainties in clinical research
    Benjamin Djulbegovic
    Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
    J Med Philos 32:79-98. 2007
    ..That is, [acknowledgement of] uncertainty determines a pattern of success in medicine and drives clinical discoveries...
  50. ncbi request reprint Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups
    Ambuj Kumar
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33612, USA
    J Clin Oncol 25:1272-6. 2007
    ..A systematic review to assess the accurate participation of elderly patients in RCTs has not been performed...
  51. pmc Bad reporting does not mean bad methods for randomised trials: observational study of randomised controlled trials performed by the Radiation Therapy Oncology Group
    Heloisa P Soares
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    BMJ 328:22-4. 2004
    ..To determine whether poor reporting of methods in randomised controlled trials reflects on poor methods...
  52. pmc Rationality, practice variation and person-centred health policy: a threshold hypothesis
    Benjamin Djulbegovic
    USF Health Comparative Effectiveness Research Core, Division of Evidence Based Medicine, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
    J Eval Clin Pract 21:1121-4. 2015
    ..In turn, this can help define a threshold model that is empirically testable. ..
  53. doi request reprint The role of iron in the management of chemotherapy-induced anemia in cancer patients receiving erythropoiesis-stimulating agents
    Rahul Mhaskar
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 2:CD009624. 2016
    ..Erythropoiesis-stimulating agents (ESAs) are commonly used to treat chemotherapy-induced anemia (CIA). However, about half of patients do not benefit...
  54. pmc Thinking Styles and Regret in Physicians
    Mia Djulbegovic
    University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 10:e0134038. 2015
    ..The relationship between regret and cognitive reasoning styles has not been well studied in physicians, and is the focus of this paper...
  55. pmc Rough set theory based prognostic classification models for hospice referral
    Eleazar Gil-Herrera
    Threshold Tuning Optimization Team Citigroup, 3800 Citibank Center, Tampa, 33610, FL, USA
    BMC Med Inform Decis Mak 15:98. 2015
    ..Accessibility refers to the ability of the model to provide traceable, interpretable results and use data that is relevant and simple to collect...
  56. pmc Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials
    Mia Djulbegovic
    Department of Urology and Prostate Disease Center, University of Florida, College of Medicine, PO Box 100247, Gainesville, Florida 32610 0247, USA
    BMJ 341:c4543. 2010
    ..To examine the evidence on the benefits and harms of screening for prostate cancer...
  57. ncbi request reprint Evidence profiles for colo-rectal cancer: benefit/harms data based on the totality of randomized evidence
    Ambuj Kumar
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Department of Interdisciplinary Oncology and Cancer Prevention and Control, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Treat Rev 32:577-80. 2006
  58. pmc When should potentially false research findings be considered acceptable?
    Benjamin Djulbegovic
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, United States of America
    PLoS Med 4:e26. 2007
    ..e., when should we accept early findings from a clinical trial indicating the benefits as true?). Obtaining absolute "truth" in research is impossible, and so society has to decide when less-than-perfect results may become acceptable...
  59. pmc A social network analysis of treatment discoveries in cancer
    Athanasios Tsalatsanis
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 6:e18060. 2011
    ..We conclude that the chances of discovering life-saving treatments are directly related to the richness of social interactions between researchers inherent in a preferential interaction model...
  60. doi request reprint Multiple myeloma: detecting the effects of new treatments
    Benjamin Djulbegovic
    Division of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Lancet 371:1642-4. 2008
  61. ncbi request reprint A systematic review and lessons learned from early lung cancer detection trials using low-dose computed tomography of the chest
    Gerold Bepler
    Thoracic Oncology Program, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa 33612, USA
    Cancer Control 10:306-14. 2003
    ..Computed tomography (CT) screening of the chest has shown promise for early detection of lung cancer, but evidence for a reduction in lung cancer mortality by CT screening is not available...
  62. ncbi request reprint At what degree of belief in a research hypothesis is a trial in humans justified?
    Benjamin Djulbegovic
    Interdisciplinary Oncology Programme, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa 33612, USA
    J Eval Clin Pract 8:269-76. 2002
    ..The purpose of this study is to determine the degree of uncertainty in a research hypothesis before it can empirically be tested in an RCT...
  63. ncbi request reprint Effect of Age on Clinical Outcomes in Phase 1 Trial Participants
    Amit Mahipal
    Clinical Research Unit, Moffitt Cancer Center, Tampa, FL 33612, USA
    Cancer Control 22:235-41. 2015
    ..Most persons with cancer living in the United States are older than 65 years of age; however, in general, elderly persons are under-represented in clinical trials and outcomes data are lacking...
  64. pmc Dual Processing Model for Medical Decision-Making: An Extension to Diagnostic Testing
    Athanasios Tsalatsanis
    comparative effectiveness research, University of South Florida, Tampa, FL, United States of America Department of Internal Medicine, University of South Florida, Tampa, FL, United States of America
    PLoS ONE 10:e0134800. 2015
    ..These findings could explain variations in the treatment and diagnostic patterns documented in today's clinical practice. ..
  65. doi request reprint Platelet transfusion: a systematic review of the clinical evidence
    Ambuj Kumar
    Division of Evidence Based Medicine, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida
    Transfusion 55:1116-27; quiz 1115. 2015
    ..Significant uncertainty exists regarding the appropriate use of PLT transfusion and the optimal threshold for transfusion in various settings. We formulated 12 key questions to assess the role of PLT transfusion...
  66. doi request reprint Colony-stimulating factors for chemotherapy-induced febrile neutropenia
    Rahul Mhaskar
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 10:CD003039. 2014
    ..Clinical trials have addressed the question of whether the addition of a CSF to antibiotics could improve outcomes in individuals diagnosed with febrile neutropenia. However, the results of these trials are conflicting...
  67. pmc Benchmarks for detecting 'breakthroughs' in clinical trials: empirical assessment of the probability of large treatment effects using kernel density estimation
    Branko Miladinovic
    Division and Center for Evidence Based Medicine and Outcomes Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
    BMJ Open 4:e005249. 2014
    ..To understand how often 'breakthroughs,' that is, treatments that significantly improve health outcomes, can be developed...
  68. pmc Concordance between decision analysis and matching systematic review of randomized controlled trials in assessment of treatment comparisons: a systematic review
    Rahul S Mhaskar
    Department of Internal Medicine, Division of Evidence Based Medicine and Outcomes Research, Morsani College of Medicine, University of South Florida, Tampa, FL, USA
    BMC Med Inform Decis Mak 14:57. 2014
    ..It is unknown how often the results of DA and matching SR of RCTs are in concordance. We assessed whether the results of DA are in concordance with SR of RCTs matched on patient population, intervention, control, and outcomes...
  69. pmc Evolution of treatment regimens in multiple myeloma: a social network analysis
    Helen Mahony
    Department of Internal Medicine, Division of Evidence Based Medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 9:e104555. 2014
    ..However, the reasoning behind treatment selection in RCTs is often unclear. Here, we focus on a cohort of RCTs in multiple myeloma (MM) to understand the patterns of competing treatment selections...
  70. doi request reprint Value of repeat head computed tomography after traumatic brain injury: systematic review and meta-analysis
    Tea Reljic
    1 Center for Evidence Based Medicine and Health Outcomes Research, University of South Florida, Tampa, Florida
    J Neurotrauma 31:78-98. 2014
    ..The evidence suggests that repeat CT in patients with TBI results in a change in management for only a minority of patients. Better designed studies are needed to address the issue of the value of repeat CT in the management of TBI...
  71. pmc New treatments compared to established treatments in randomized trials
    Benjamin Djulbegovic
    USF Clinical Translational Science Institute, Dpts of Medicine, Hematology and Health Outcome Research, USF and H LeeMoffitt Cancer Center, USF Health Clinical Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 10:MR000024. 2012
    ..We investigated how often new, experimental treatments evaluated in randomized controlled trials (RCTs) are superior to established treatments...
  72. ncbi request reprint Why evidence based oncology management
    Ambuj Kumar
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Oncol Manag 11:13-6. 2002
  73. doi request reprint Designing patient-centric applications for chronic disease management
    Athanasios Tsalatsanis
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL 33612, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3146-9. 2011
    ..We also outline preliminary results regarding a self-management application currently under development targeting young adults suffering from type 1 diabetes...
  74. ncbi request reprint Allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia (ALL) in first complete remission
    Joseph Pidala
    Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center, Division of Oncologic Sciences, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 10:CD008818. 2011
    ....
  75. ncbi request reprint Evidence-based oncology section - aims and scope
    Benjamin Djulbegovic
    H Moffit Cancer Centre, Florida, USA
    Cancer Treat Rev 29:51-3. 2003
  76. ncbi request reprint Evidence and decision making. Commentary on M.R. Tonelli (2006), Integrating evidence into clinical practice: an alternative approach to evidence-based approaches. Journal of Evaluation in Clinical Practice 12, 248-256
    Benjamin Djulbegovic
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Department of Interdisciplinary Oncology, Tampa, FL, USA
    J Eval Clin Pract 12:257-9. 2006
  77. ncbi request reprint Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
    Melissa Alsina
    Experimental Therapeutics Program, H Lee Moffitt Cancer Center and Research Institute and Department of Oncology, University of South Florida, Tampa, FL 33612, USA
    Blood 103:3271-7. 2004
    ..We conclude that tipifarnib is tolerable, can induce disease stabilization, and can inhibit farnesylation and oncogenic/tumor survival pathways...
  78. doi request reprint Optimal type I and type II error pairs when the available sample size is fixed
    John P A Ioannidis
    Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Epidemiol 66:903-910.e2. 2013
    ..To model how to select the optimal pair of type I and type II errors that maximize study value when there are constrains on the available study sample size...
  79. ncbi request reprint Screening mammography at 40-49 years: regret or no regret?
    Benjamin Djulbegovic
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Department of Interdisciplinary Oncology, Tampa, FL 33612, USA
    Lancet 368:2035-7. 2006
  80. pmc Erythropoietin, uncertainty principle and cancer related anaemia
    Otavio Clark
    Interdisciplinary Oncology Program H, Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL, USA
    BMC Cancer 2:23. 2002
    ..We also wanted to demonstrate that cumulative meta-analysis (CMA) can be used to resolve uncertainty regarding clinical questions...
  81. doi request reprint Efficacy of rituximab in the setting of steroid-refractory chronic graft-versus-host disease: a systematic review and meta-analysis
    Mohamed A Kharfan-Dabaja
    Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, Florida, USA
    Biol Blood Marrow Transplant 15:1005-13. 2009
    ....
  82. pmc Quality and methods of developing practice guidelines
    Hugh Cruse
    H Lee Moffitt Cancer Center and Research Institute, The University of South Florida, Tampa, FL, USA
    BMC Health Serv Res 2:1. 2002
    ..It is not known whether there are differences in the quality and recommendations between evidence-based (EB) and consensus-based (CB) guidelines. We used breast cancer guidelines as a case study to assess for these differences...
  83. ncbi request reprint Nonmyeloablative allogeneic stem-cell transplantation for hematologic malignancies: a systematic review
    Benjamin Djulbegovic
    Malignant Hematology Program, H Lee Moffitt Cancer Center Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Control 10:17-41. 2003
    ..They hypothesize that NM-allo-SCT is equally efficacious to standard allo-SCT but produces less regimen-related toxicity...