DAN ALAN DIXON
Affiliation: University of South Carolina
- The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligaseSandhya Sanduja
Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, SC 29203, USA
Aging (Albany NY) 1:803-17. 2009..These findings demonstrate the ability of TTP to act as a tumor suppressor by inhibiting the E6-AP pathway and indicate TTP loss to be a critical event during HPV-mediated carcinogenesis...
- The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2Lisa E Young
Department of Biological Sciences and Center for Colon Cancer Research, University of South Carolina, Columbia, SC 29208, USA
Mol Cancer Res 10:167-80. 2012..Along with insight into altered ARE-mediated mRNA decay observed in colorectal cancer, these findings provide a new explanation for tumor-derived loss of miR-16...
- Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signalingDan A Dixon
Department of Biological Sciences and South Carolina Cancer Center, University of South Carolina, Columbia, South Carolina 29203, USA
J Clin Invest 116:2727-38. 2006..These checkpoints may be altered in disease and therefore useful as targets for antiinflammatory intervention...
- The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesisLisa E Young
Department of Biological Sciences and Cancer Research Center, University of South Carolina, Columbia, South Carolina 29203, USA
Gastroenterology 136:1669-79. 2009..We examined the functions of HuR and TTP during colon tumorigenesis and their ability to regulate cyclooxygenase (COX-2), a mediator of prostaglandin synthesis that increases in the colon tumor microenvironment...
- Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesisGuang Peng
Department of Pathology and Microbiology, School of Medicine, The University of South Carolina, and South Carolina Cancer Center, Columbia, South Carolina 29203, USA
Mol Carcinog 45:309-19. 2006..In conclusion, these data suggest that inhibition of COX-2 is a mechanism for the anti-proliferative effect of green tea and emphasizes the role that dietary factors have as anti-cancer agents...
- Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cellsZongxian Cao
Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 9300, USA
Cell Signal 19:1542-53. 2007....
- Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cellsAlexandra Thiel
Department of Pathology, Helsinki University Central Hospital, and Molecular and Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland
J Biol Chem 281:4564-9. 2006..Our data show that inhibition of GSK-3beta stimulates COX-2 expression in gastric cancer cells, which seems to be primarily facilitated via an increase in mRNA stability and to a lesser extent through enhanced transcription...
- Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregatesAndrew S Weyrich
Department of Internal Medicine, Human Molecular Biology and Genetics, Bldg 533, Room 4220, University of Utah, Salt Lake City, UT 84112, USA
Circulation 111:633-42. 2005..Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems...
- Dysregulated post-transcriptional control of COX-2 gene expression in cancerDan A Dixon
Surgical Oncology Research Laboratory, Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
Curr Pharm Des 10:635-46. 2004....
- Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1Dan A Dixon
Surgical Oncology Research Laboratory, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
J Exp Med 198:475-81. 2003..These findings implicate that TIA-1 functions as a translational silencer of COX-2 expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia...
- Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuRKotha Subbaramaiah
Department of Medicine Division of Gastroenterology and Hepatology, New York Presbyterian Hospital, New York, New York 10021, USA
J Biol Chem 278:37637-47. 2003..To the best of our knowledge, this is the first evidence that taxanes can promote stabilization of mRNA in addition to modulating gene transcription...
- Regulation of COX-2 expression in human cancersDan A Dixon
Surgical Oncology Research Laboratory, Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, Tenn, USA
Prog Exp Tumor Res 37:52-71. 2003
- Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding siteHitoshi Sawaoka
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
J Biol Chem 278:13928-35. 2003..However, the truncated transcript escaped tristetraprolin binding and downregulation...
- Change in protein phenotype without a nucleus: translational control in plateletsAndrew S Weyrich
Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
Semin Thromb Hemost 30:491-8. 2004..We highlight the molecular machinery and pathways used by platelets to translate mRNA into protein and offer insight into how these synthesized products may regulate thrombotic and inflammatory events...
- Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-betaSheng Ru Shiou
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2730, USA
J Biol Chem 281:33971-81. 2006....
- Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transitionCindy L Kanies
Department of Surgery, Vanderbilt University Medical Center, D 4316 Medical Center North, Nashville, TN 37232 2730, USA
Mol Cancer Res 6:1124-36. 2008....
- Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cellsOlivier Boutaud
Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
Adv Exp Med Biol 525:157-60. 2003