Wei Ding

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis
    Wei Ding
    Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, and Department of Pediatric Surgery, University of Southern California Keck School of Medicine and School of Dentistry, 90027, USA
    Am J Physiol Lung Cell Mol Physiol 287:L52-9. 2004
  2. ncbi request reprint Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells
    Wei Ding
    Developmental Biology Program, Childrens Hospital Los Angeles Saban Research Institute, Los Angeles, CA 90027, USA
    J Cell Physiol 212:796-806. 2007
  3. pmc Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha
    Wei Ding
    Developmental Biology Program, Saban Research Institute Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS 35, Los Angeles, CA 90027, USA
    Biochem Biophys Res Commun 375:460-4. 2008
  4. ncbi request reprint Functional analysis of the human Sprouty2 gene promoter
    Wei Ding
    Childrens Hospital Los Angeles Research Institute, Department of Pediatric Surgery, USC Keck School of Medicine, Los Angeles, CA 90027, USA
    Gene 322:175-85. 2003
  5. ncbi request reprint Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression
    Asra Mirza
    Tumor Biology Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 4 4600, Kenilworth, NJ 07033, USA
    Oncogene 22:3645-54. 2003
  6. ncbi request reprint Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target
    Qun Wu
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 280:12935-43. 2005
  7. ncbi request reprint [A histone deacetylase inhibitor and tumor suppressing gene p53 induction synergistically induce apoptosis of cancer cells]
    Wei Ding
    Hokkaido Igaku Zasshi 79:727-34. 2004
  8. pmc EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation
    Wei Ding
    Departments of Cell and Developmental Biology and Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:13433-8. 2008
  9. pmc Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner
    Lei Li
    State Key Laboratory of Bioorganic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Rd, Shanghai, 200032, China
    J Bacteriol 190:251-63. 2008
  10. ncbi request reprint Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome
    Xiang Ma
    Laboratory of Reproductive Medicine, Nanjing Medical University, and The Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, People s Republic of China
    Mol Hum Reprod 13:527-35. 2007

Collaborators

  • David Warburton
  • Saverio Bellusci
  • Wei Shi
  • Parviz Minoo
  • NORA C HEISTERKAMP
  • L Zhang
  • Lei M Li
  • JOHN ENGELHARDT
  • Susheela Tridandapani
  • KENNETH COGGESHALL
  • Er Qing Wei
  • Ping Qiu
  • Ziyi Li
  • Allan M Weissman
  • Zhi min He
  • Qunyan Jin
  • Kathleen M Mulder
  • Hua Hu
  • Wei Ping Zhang
  • Qun Wu
  • Asra Mirza
  • Qian Tang
  • Xiang Ma
  • Guangming Liu
  • Wen He Zhao
  • Zhi Wei Zhang
  • Liping Xie
  • Rossana Trotta
  • Hong Tian Yao
  • Zhong Chen
  • W Robert Bishop
  • Terri McClanahan
  • Suxing Liu
  • Paul Kirschmeier
  • Constance Grill
  • Ziying Yan
  • Guofeng Gao
  • Cory M Staub
  • Ferdous Gheyas
  • Luquan Wang
  • Wenli Zhao
  • Da Cheng Zhou
  • Bjorn Albrecht
  • Lu Fan
  • Jia Yin Liu
  • Zheng Hou
  • Yan Meng
  • Wei Wang
  • Yun dong Mao
  • Min Wang
  • Xin Liu
  • Yan Hui Yu
  • Li Song Teng
  • Zhaodian Chen
  • Zhi Min Ma
  • Yongfeng Jin
  • Jian Ming Sheng
  • Bing Luo
  • Shi Fu Wang
  • Xiangyi Zheng
  • Fu Sheng Wu
  • Zhu Chu Chen
  • Min Zhou
  • Jie Qin
  • Jian Min Zhang
  • Hsiaoyin Mao
  • Iris Wei
  • Lin Luo
  • Andrea Basso
  • Jing Wen
  • Qiu Fu Ge
  • Eric Gustafson
  • Brian Becknell
  • William E Carson
  • Marco Hernandez
  • Jeffrey Allard
  • Tish Van Arsdale
  • Michael A Caligiuri
  • Jianhua Yu
  • Gao Chen
  • Robin Parihar
  • Yulong Zhang
  • Simon Godwin
  • Ronald J Doll
  • Ke Da Chen
  • Wen Wen Sheng
  • Keith Munson
  • Richard Peluso
  • Priya Dayananth
  • Roman Zak

Detail Information

Publications26

  1. ncbi request reprint Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis
    Wei Ding
    Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, and Department of Pediatric Surgery, University of Southern California Keck School of Medicine and School of Dentistry, 90027, USA
    Am J Physiol Lung Cell Mol Physiol 287:L52-9. 2004
    ..Homology analysis further showed that the core promoter region of the hSpry4 gene exhibits significant similarity to the 5'-flanking region of the mouse gene...
  2. ncbi request reprint Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells
    Wei Ding
    Developmental Biology Program, Childrens Hospital Los Angeles Saban Research Institute, Los Angeles, CA 90027, USA
    J Cell Physiol 212:796-806. 2007
    ..Together, the combined operation of transcriptional and post-translational mechanisms suggests that regulation of Spry2 is a crucial event and emphasizes the important role that Spry2 plays in controlling cell behaviors...
  3. pmc Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha
    Wei Ding
    Developmental Biology Program, Saban Research Institute Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS 35, Los Angeles, CA 90027, USA
    Biochem Biophys Res Commun 375:460-4. 2008
    ..To our knowledge, this study is the first that reported the association of Spry2 with TNF-alpha signaling pathway...
  4. ncbi request reprint Functional analysis of the human Sprouty2 gene promoter
    Wei Ding
    Childrens Hospital Los Angeles Research Institute, Department of Pediatric Surgery, USC Keck School of Medicine, Los Angeles, CA 90027, USA
    Gene 322:175-85. 2003
    ..To our knowledge, this is the first promoter study of any mammalian Sprouty gene. We propose that the high-level basal expression of hSpry2 is controlled by multiple transcription factors binding to its proximal promoter...
  5. ncbi request reprint Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression
    Asra Mirza
    Tumor Biology Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 4 4600, Kenilworth, NJ 07033, USA
    Oncogene 22:3645-54. 2003
    ..The approaches and genes described here should aid the understanding of global gene regulatory network of p53...
  6. ncbi request reprint Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target
    Qun Wu
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 280:12935-43. 2005
    ..Taken together, these data suggest a role for RAI3 in tumor growth and demonstrate the predictive power of integrative genomics...
  7. ncbi request reprint [A histone deacetylase inhibitor and tumor suppressing gene p53 induction synergistically induce apoptosis of cancer cells]
    Wei Ding
    Hokkaido Igaku Zasshi 79:727-34. 2004
  8. pmc EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation
    Wei Ding
    Departments of Cell and Developmental Biology and Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 105:13433-8. 2008
    ..These results identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells...
  9. pmc Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner
    Lei Li
    State Key Laboratory of Bioorganic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Rd, Shanghai, 200032, China
    J Bacteriol 190:251-63. 2008
    ....
  10. ncbi request reprint Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome
    Xiang Ma
    Laboratory of Reproductive Medicine, Nanjing Medical University, and The Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, People s Republic of China
    Mol Hum Reprod 13:527-35. 2007
    ....
  11. ncbi request reprint Requirement for the dynein light chain km23-1 in a Smad2-dependent transforming growth factor-beta signaling pathway
    Qunyan Jin
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:19122-32. 2007
    ..Collectively, our findings indicate for the first time that a dynein light chain is required for a Smad2-dependent TGFbeta signaling pathway...
  12. ncbi request reprint [Mechanism of migration in CNE2 cells promoted by EBV-LMP1]
    Zhi Wei Zhang
    Cancer Research Institute, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:470-4. 2006
    ..To investigate the mechanism of migration phenotype change induced by EBV-LMP1 in nasopharyngeal carcinoma (NPC) cell line CNE2...
  13. ncbi request reprint Role of PI3-kinase/Akt signalling pathway in renal function and cell proliferation after renal ischaemia/reperfusion injury in mice
    Liping Xie
    Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Nephrology (Carlton) 11:207-12. 2006
    ..The aim of the present study was to investigate the role of PI3K/Akt pathway in the renal ischaemia/reperfusion...
  14. ncbi request reprint c-Fos is required for TGFbeta1 production and the associated paracrine migratory effects of human colon carcinoma cells
    Guangming Liu
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Mol Carcinog 45:582-93. 2006
    ..Thus, c-Fos may have utility as a target for blocking tumor cell-secreted TGFbeta1, thereby suppressing the migratory behavior associated with the malignant phenotype of HCCCs...
  15. pmc Apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action
    Wen He Zhao
    Department of Oncological Surgery, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
    World J Gastroenterol 12:1356-61. 2006
    ..To study the apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action...
  16. ncbi request reprint Requirement of km23 for TGFbeta-mediated growth inhibition and induction of fibronectin expression
    Qunyan Jin
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Cell Signal 17:1363-72. 2005
    ..Thus, our results demonstrate that km23 is required for TGFbeta induction of fibronectin expression and is necessary, but not sufficient, for TGFbeta-mediated growth inhibition...
  17. ncbi request reprint Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors
    Hua Hu
    Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    Acta Pharmacol Sin 26:685-90. 2005
    ..To determine the distribution of cysteinyl leukotriene receptor 2 (CysLT2), one of the cysteinyl leukotriene receptors, in human brains with traumatic injury and tumors...
  18. ncbi request reprint Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo
    Da Cheng Zhou
    Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, Bronx, NY 10467, USA
    Blood 99:1356-63. 2002
    ....
  19. ncbi request reprint Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation
    Rossana Trotta
    Department of Molecular Virology, Immunology, and Medical Genetics, Colelge of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Blood 105:3011-8. 2005
    ....
  20. ncbi request reprint Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors
    Wei Ping Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, 353, Yan An Road, Hangzhou 310031, PR China
    Neurosci Lett 363:247-51. 2004
    ..CysLT(1) was also detected in astrocytoma, ganglioglioma and metastatic adenocarcinoma, and the expression in the neuron- and glial-appearing cells around brain tumors increased robustly...
  21. pmc Analysis of the ERK1,2 transcriptome in mammary epithelial cells
    Constance Grill
    Biological Research Oncology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Biochem J 381:635-44. 2004
    ..Our results suggest that, in addition to anti-proliferative properties, MEK1,2 inhibitors may be anti-angiogenic and possess therapeutic utility in the treatment of PHRP-positive tumours...
  22. pmc Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the apical surfaces of human airway epithelia
    Ziying Yan
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Virol 78:2863-74. 2004
    ..Findings from this study provide new insights into how modulation of proteasome function can be effectively used to augment rAAV transduction in airway epithelia for gene therapy of cystic fibrosis...
  23. ncbi request reprint Developmental capacity of ferret embryos by nuclear transfer using G0/G1-phase fetal fibroblasts
    Ziyi Li
    Departments of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Biol Reprod 68:2297-303. 2003
    ....
  24. pmc A novel transforming growth factor-beta receptor-interacting protein that is also a light chain of the motor protein dynein
    Qian Tang
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Mol Biol Cell 13:4484-96. 2002
    ..Furthermore, our results suggest that TGFbeta pathway components may use a motor protein light chain as a receptor for the recruitment and transport of specific cargo along microtublules...
  25. ncbi request reprint Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II
    Wenli Zhao
    Division of Cancer Pathobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, Hokkaido 060 0815, Japan
    Cancer Immunol Immunother 51:381-8. 2002
    ....
  26. pmc Activation of nuclear factor of activated T cells by human T-lymphotropic virus type 1 accessory protein p12(I)
    Bjorn Albrecht
    Center for Retrovirus Research and Department of Veterinary Biosciences, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    J Virol 76:3493-501. 2002
    ..We propose a novel mechanism by which HTLV-1, a virus associated with lymphoproliferative disease, dysregulates common T-cell activation pathways critical for the virus to establish persistent infection...