Ramon Diaz-Arrastia

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Evolving treatment strategies for epilepsy
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Room F2 302, Dallas, TX 75390 9036, USA
    JAMA 287:2917-20. 2002
  2. ncbi request reprint Host genetic polymorphisms in human immunodeficiency virus-related neurologic disease
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    J Neurovirol 10:67-73. 2004
  3. ncbi request reprint Usefulness of the abbreviated injury score and the injury severity score in comparison to the Glasgow Coma Scale in predicting outcome after traumatic brain injury
    Brandon P Foreman
    University of Texas Southwestern Medical Center at Dallas, USA
    J Trauma 62:946-50. 2007
  4. ncbi request reprint Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele
    Ramon Diaz-Arrastia
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Arch Neurol 60:818-22. 2003
  5. ncbi request reprint Genetic factors in outcome after traumatic brain injury: what the human genome project can teach us about brain trauma
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Head Trauma Rehabil 21:361-74. 2006
  6. doi request reprint Posttraumatic epilepsy: the endophenotypes of a human model of epileptogenesis
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, Comprehensive Epilepsy Center, Parkland Memorial Hospital, Dallas, Texas 75390 9036, USA
    Epilepsia 50:14-20. 2009
  7. pmc Regionally selective atrophy after traumatic axonal injury
    Matthew A Warner
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Arch Neurol 67:1336-44. 2010
  8. pmc Brain-derived neurotrophic factor levels in Alzheimer's disease
    Sid E O'Bryant
    Texas Tech University Health Science Center, Department of Neurology, 3601 4th St STOP 8321, Lubbock, TX 79430, USA
    J Alzheimers Dis 17:337-41. 2009
  9. ncbi request reprint Ethnic disparities exist in trauma care
    Shahid Shafi
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 63:1138-42. 2007
  10. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010

Research Grants

  1. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
  2. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
  3. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008

Detail Information

Publications67

  1. ncbi request reprint Evolving treatment strategies for epilepsy
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Room F2 302, Dallas, TX 75390 9036, USA
    JAMA 287:2917-20. 2002
  2. ncbi request reprint Host genetic polymorphisms in human immunodeficiency virus-related neurologic disease
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    J Neurovirol 10:67-73. 2004
    ..Future studies will require much larger sample sizes and technical advances to allow screening at larger number of candidate loci...
  3. ncbi request reprint Usefulness of the abbreviated injury score and the injury severity score in comparison to the Glasgow Coma Scale in predicting outcome after traumatic brain injury
    Brandon P Foreman
    University of Texas Southwestern Medical Center at Dallas, USA
    J Trauma 62:946-50. 2007
    ..We aimed to analyze the usefulness of the head abbreviated injury score (AIS), the injury severity score (ISS), and the Glasgow Coma Scale (GCS) as measures of injury severity and predictors of outcome after traumatic brain injury (TBI)...
  4. ncbi request reprint Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele
    Ramon Diaz-Arrastia
    Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Arch Neurol 60:818-22. 2003
    ..Inheritance of the apolipoprotein E (APOE) epsilon4 allele is associated with increased risk of Alzheimer disease, progression to disability in multiple sclerosis, and poor outcome after traumatic brain injury...
  5. ncbi request reprint Genetic factors in outcome after traumatic brain injury: what the human genome project can teach us about brain trauma
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Head Trauma Rehabil 21:361-74. 2006
    ..We conclude that although genetic advances have implications for prognosis, their biggest contribution will be to elucidate the pathophysiology of TBI, potentially leading to new treatments...
  6. doi request reprint Posttraumatic epilepsy: the endophenotypes of a human model of epileptogenesis
    Ramon Diaz-Arrastia
    Department of Neurology, University of Texas Southwestern Medical Center, Comprehensive Epilepsy Center, Parkland Memorial Hospital, Dallas, Texas 75390 9036, USA
    Epilepsia 50:14-20. 2009
    ..It is likely that better understanding of the subtypes of epilepsy resulting from brain trauma will be required to successfully identify antiepileptogenic therapies...
  7. pmc Regionally selective atrophy after traumatic axonal injury
    Matthew A Warner
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Arch Neurol 67:1336-44. 2010
    ..To determine the spatial distribution of cortical and subcortical volume loss in patients with diffuse traumatic axonal injury and to assess the relationship between regional atrophy and functional outcome...
  8. pmc Brain-derived neurotrophic factor levels in Alzheimer's disease
    Sid E O'Bryant
    Texas Tech University Health Science Center, Department of Neurology, 3601 4th St STOP 8321, Lubbock, TX 79430, USA
    J Alzheimers Dis 17:337-41. 2009
    ..It is likely that the most accurate approach to identifying biomarkers of AD will be through an algorithmic approach that combines multiple markers reflective of various pathways...
  9. ncbi request reprint Ethnic disparities exist in trauma care
    Shahid Shafi
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 63:1138-42. 2007
    ..Ethnic disparities in access to health care have been documented in other diseases, but have not been studied in trauma care. We hypothesized that access to rehabilitation after TBI is influenced by race or ethnicity...
  10. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  11. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  12. pmc Assessing spatial relationships between axonal integrity, regional brain volumes, and neuropsychological outcomes after traumatic axonal injury
    Matthew A Warner
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    J Neurotrauma 27:2121-30. 2010
    ..Our results suggest that TAI may be a primary mechanism of post-traumatic atrophy, and provide support for regional morphometry as a biomarker for cognitive outcome after injury...
  13. doi request reprint Effects of platelet and plasma transfusion on outcome in traumatic brain injury patients with moderate bleeding diatheses
    Catherine O Anglin
    Department of Neurology, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Texas, USA
    J Neurosurg 118:676-86. 2013
    ....
  14. pmc Distinctive disruption patterns of white matter tracts in Alzheimer's disease with full diffusion tensor characterization
    Hao Huang
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8542, USA
    Neurobiol Aging 33:2029-45. 2012
    ..High correlation between FA, MD, and RD measurements from limbic tracts and cortical atrophy suggests the disruption of the limbic tract group is caused by the neuronal damage...
  15. pmc Serum brain-derived neurotrophic factor levels are specifically associated with memory performance among Alzheimer's disease cases
    Sid E O'Bryant
    Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Dement Geriatr Cogn Disord 31:31-6. 2011
    ..Our purpose was to study the link between serum brain-derived neurotrophic factor (BDNF) levels and neuropsychological functioning through the Texas Alzheimer's Research Consortium cohort...
  16. ncbi request reprint Functional outcome scales in traumatic brain injury: a comparison of the Glasgow Outcome Scale (Extended) and the Functional Status Examination
    Anne M Hudak
    Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9055, USA
    J Neurotrauma 22:1319-26. 2005
    ..The majority of the variance in outcome is not accounted for by currently available measures of injury severity...
  17. doi request reprint Detection of β-amyloid oligomers as a predictor of neurological outcome after brain injury
    Joshua Wayne Gatson
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9160, USA
    J Neurosurg 118:1336-42. 2013
    ..In this study, the authors hypothesized that the levels of toxic high-molecular-weight β-amyloid oligomers are increased in the brain and are detectable within the CSF of TBI patients with poor neurological outcomes...
  18. ncbi request reprint Ethnic differences in rehabilitation placement and outcome after TBI
    Carlos Marquez de la Plata
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Head Trauma Rehabil 22:113-21. 2007
    ..To determine whether race/ethnicity and proficiency with the English language influence access to rehabilitation services, and ultimately outcome after traumatic brain injury (TBI)...
  19. pmc Regional changes of cortical mean diffusivities with aging after correction of partial volume effects
    Tina Jeon
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8542, USA
    Neuroimage 62:1705-16. 2012
    ..The established comprehensive unbiased cortical MD profiles of young, elderly healthy subjects and AD patients at the lobe, gyral and voxel level may serve as clinical references for cortical microstructure...
  20. pmc Brain morphometry changes and depressive symptoms after traumatic brain injury
    Anne Hudak
    Dept of Physical Medicine and Rehabilitation, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9055, USA
    Psychiatry Res 191:160-5. 2011
    ..Regions associated with depressive symptoms in this pilot study were similar to those implicated in study of spontaneous depression...
  21. doi request reprint Racial disparities in long-term functional outcome after traumatic brain injury
    Shahid Shafi
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
    J Trauma 63:1263-8; discussion 1268-70. 2007
    ..We hypothesized that access to acute rehabilitation and long-term functional outcomes among traumatic brain injury (TBI) patients are influenced by patient race and ethnicity...
  22. pmc A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8849, USA
    J Affect Disord 150:551-8. 2013
    ..We examined whether phenytoin attenuated the effects of hydrocortisone on declarative memory. Functional magnetic resonance imaging (fMRI) assessed task-related hippocampal activation...
  23. ncbi request reprint Magnetic resonance imaging of diffuse axonal injury: quantitative assessment of white matter lesion volume
    Carlos Marquez de la Plata
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    J Neurotrauma 24:591-8. 2007
    ..Patients with greater DAI volume have poorer functional outcomes. These methods may be useful in stratifying injury severity and for the assessment of DAI-directed therapies...
  24. pmc Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease
    Uma S Yezhuvath
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neurobiol Aging 33:75-82. 2012
    ..004). Our data suggest that early AD subjects have evidence of significant forebrain vascular contractility deficits. The localization, while differing from CBF findings, appears to be spatially similar to PIB amyloid imaging findings...
  25. ncbi request reprint Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injury
    Anne M Hudak
    Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Head Trauma Rehabil 19:290-5. 2004
    ..However, as such therapy is frequently ineffective, we studied the usefulness of prolonged video electroencephalogram (VEEG) monitoring in the clinical management of paroxysmal behaviors in TBI survivors...
  26. pmc A serum protein-based algorithm for the detection of Alzheimer disease
    Sid E O'Bryant
    Texas Tech University Health Science Center, Department of Neurology, Lubbock, TX 79430, USA
    Arch Neurol 67:1077-81. 2010
    ..To develop an algorithm that separates patients with Alzheimer disease (AD) from controls...
  27. doi request reprint Variations in Inpatient Rehabilitation Functional Outcomes Across Centers in the Traumatic Brain Injury Model Systems Study and the Influence of Demographics and Injury Severity on Patient Outcomes
    Marie N Dahdah
    Baylor Institute for Rehabilitation, Dallas, TX North Texas Traumatic Brain Injury Model Systems Center, Dallas, TX Center for Medical Psychology, Baylor Regional Medical Center of Plano, Plano, TX
    Arch Phys Med Rehabil 97:1821-1831. 2016
    ..To compare patient functional outcomes across Traumatic Brain Injury Model Systems (TBIMS) rehabilitation centers using an enhanced statistical model and to determine factors that influence those outcomes...
  28. pmc Decreased C-reactive protein levels in Alzheimer disease
    Sid E O'Bryant
    Department of Neurology, F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Geriatr Psychiatry Neurol 23:49-53. 2010
    ..However, for a subgroup of patients with AD, elevated CRP continues to predict increased dementia severity suggestive of a possible proinflammatory endophenotype in AD...
  29. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  30. ncbi request reprint Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease
    John D Rogers
    Yarmen Center for Parkinson s Disease, Department of Neurology, Beth Israel Medical Center, New York, NY, USA
    Arch Neurol 60:59-64. 2003
    ..Since S-adenosylhomocysteine is rapidly converted to homocysteine, levodopa therapy may put patients at increased risk for vascular disease by raising homocysteine levels...
  31. pmc Subtypes of post-traumatic epilepsy: clinical, electrophysiological, and imaging features
    Puneet K Gupta
    1 Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas
    J Neurotrauma 31:1439-43. 2014
    ..These results have implications for the design of clinical trials of antiepileptogenic therapies for PTE...
  32. pmc Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment
    Jie Liu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Alzheimers Dement 10:162-70. 2014
    ..To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI)...
  33. pmc Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects
    Karen M Rodrigue
    Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    JAMA Neurol 70:600-6. 2013
    ..Identifying risk factors for increased β-amyloid (Aβ) deposition is important for targeting individuals most at risk for developing Alzheimer disease and informing clinical practice concerning prevention and early detection...
  34. pmc Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcome
    Kan Ding
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    J Neurotrauma 25:1433-40. 2008
    ..Our findings suggest that axonal pathology measured as white matter lesions following TBI can be identified using MRI, and may be a useful measure for DAI-directed therapies...
  35. pmc Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury
    Myron F Weiner
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Brain Inj 22:611-5. 2008
    ..To determine if plasma levels of 24S-hydroxycholesterol, the primary catabolite of brain cholesterol, provide a measure of axonal damage in acute brain trauma...
  36. pmc Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity
    Jinsoo Uh
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
    Neurobiol Aging 31:2038-46. 2010
    ..These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity...
  37. pmc Brain MRI, apoliprotein E genotype, and plasma homocysteine in American Indian Alzheimer disease patients and Indian controls
    Myron F Weiner
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9129, USA
    Curr Alzheimer Res 6:52-8. 2009
    ..In combined AD subjects and controls, WBV correlated with BMI and age. WMHV and WMHV/WBV correlated inversely with MMSE scores (p = 0.001, 0.002, respectively). In addition, WMHV correlated positively with % Indian heritage (p = 0.047)...
  38. ncbi request reprint A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease
    Paul S Aisen
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA
    Am J Geriatr Psychiatry 11:246-9. 2003
    ..Authors determined the impact of high-dose vitamin supplements on plasma homocysteine levels in patients with Alzheimer disease (AD)...
  39. pmc Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury
    Carlos D Marquez de la Plata
    Center for Brain Health, University of Texas at Dallas, Richardson, USA
    Arch Neurol 68:74-84. 2011
    ..To examine the functional connectivity of hippocampal and selected frontal lobe circuits in patients with traumatic axonal injury (TAI)...
  40. pmc Temporal lobe volume predicts Wada memory test performance in patients with mesial temporal sclerosis
    Kan Ding
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8508, USA Electronic address
    Epilepsy Res 120:25-30. 2016
    ..49-0.63, p=0.005-0.04). Our study suggests that volume loss in the nonsurgical temporal structures is associated with nonlateralized Wada memory results in patients with intractable TLE...
  41. doi request reprint Three approaches to investigating functional compromise to the default mode network after traumatic axonal injury
    Ana Arenivas
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Brain Imaging Behav 8:407-19. 2014
    ....
  42. pmc Clinical phenotype of dementia after traumatic brain injury
    Nasreen Sayed
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Neurotrauma 30:1117-22. 2013
    ..These findings suggest that dementia in individuals with a history of TBI may be distinct from AD...
  43. doi request reprint cPLA2α knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons
    Bao Xi Qu
    Department of Neurology, Center for Neuroscience and Regenerative Medicine, Uniformed Services University of Health Sciences, Rockville, MD 20852, USA
    Brain Res 1497:101-5. 2013
    ..These results further suggest that cPLA2α and its cleaved arachidonic acids play important roles in cortical neuronal maturation and in normal neurochemical processes...
  44. pmc Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors
    Kyle B Womack
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9129, USA
    Arch Neurol 68:329-37. 2011
    ....
  45. pmc Impact of age on long-term recovery from traumatic brain injury
    Carlos D Marquez de la Plata
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arch Phys Med Rehabil 89:896-903. 2008
    ..To determine whether older persons are at increased risk for progressive functional decline after traumatic brain injury (TBI)...
  46. ncbi request reprint Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's disease
    Padraig E O'Suilleabhain
    Department of Neurology, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Mov Disord 19:1403-8. 2004
    ..Levodopa elevates tHcy and lowers vitamin B12 concentration to modest degrees. The clinical implications, if any, have not yet been determined...
  47. ncbi request reprint Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations
    Padraig E O'Suilleabhain
    Department of Neurology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Arch Neurol 61:865-8. 2004
    ..An Hcy elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hcy level in patients with PD is unknown...
  48. ncbi request reprint Clinical course in Parkinson's disease with elevated homocysteine
    Padraig E O'Suilleabhain
    Department of Neurology, Southwestern Medical Center at Dallas, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
    Parkinsonism Relat Disord 12:103-7. 2006
    ..03). We conclude that hyperhomocysteinemia does not predict significantly worse progression over 2 years in early PD. The data raised the possibility of higher mortality, but the number of deaths was small...
  49. ncbi request reprint Measurement of peripheral vision reaction time identifies white matter disruption in patients with mild traumatic brain injury
    Kyle B Womack
    University of Texas Southwestern Medical Center, Neurology and Neurotherapeutics, 5323 Harry Hines Blvd, Dallas, Texas, United States, 75390 9129
    J Neurotrauma . 2016
    ..These studies suggest that the PVRT indirectly measures white matter integrity in the posterior corpus callosum, a brain region frequently damaged by mTBI...
  50. pmc Effect of alcohol on Glasgow Coma Scale in head-injured patients
    Lance Stuke
    Department of Surgery, Division of Burns, Trauma and Surgical Critical Care, University of Texas Southwestern Medical School, Dallas, TX 75390 9158, USA
    Ann Surg 245:651-5. 2007
    ..The purpose of this study was to test the hypothesis that the presence of blood alcohol has a clinically significant impact on GCS in TBI patients...
  51. pmc A comprehensive reliability assessment of quantitative diffusion tensor tractography
    Jun Yi Wang
    School of Brain and Behavioral Sciences, University of Texas at Dallas, Dallas, TX, USA
    Neuroimage 60:1127-38. 2012
    ..Increasing the number of gradient directions from 15 to 30 with equivalent scan time reduced variability whereas increasing repetition from 1 to 2 for 30-direction DTI improved the accuracy of tractography measurements...
  52. ncbi request reprint Serum biomarkers for Alzheimer's disease: proteomic discovery
    Dwight C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Biomed Pharmacother 61:383-9. 2007
    ..The identification of these peptides/proteins, and their direct measurement in patient serum, may allow the development of a simple, cost-effective test for AD...
  53. doi request reprint Prophylaxis for venous thromboembolism during rehabilitation for traumatic brain injury: a multicenter observational study
    Mary Carlile
    North Texas Traumatic Brain Injury Model System, Baylor Institute for Rehabilitation, Dallas, Texas 75246, USA
    J Trauma 68:916-23. 2010
    ..Deep venous thrombosis (DVT) is a major cause of mortality and morbidity after traumatic brain injury (TBI). There is no consensus regarding appropriate screening, prophylaxis, or treatment during acute rehabilitation...
  54. ncbi request reprint Deep venous thrombosis management following traumatic brain injury: a practice survey of the traumatic brain injury model systems
    Mary C Carlile
    Department of Physical Medicine and Rehabilitation, Baylor Institute for Rehabilitation, Dallas, TX 75246, USA
    J Head Trauma Rehabil 21:483-90. 2006
    ..To determine national patterns of screening, prophylaxis, and treatment of deep venous thrombosis (DVT) following traumatic brain injury (TBI) within the Traumatic Brain Injury Model Systems (TBIMS)...
  55. pmc C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease
    Matthew Harms
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    JAMA Neurol 70:736-41. 2013
    ..Hexanucleotide repeat expansions in the chromosome 9 open reading frame 72 (C9orf72) gene underlie a significant fraction of frontotemporal dementia and amyotrophic lateral sclerosis...
  56. pmc Postinjury employment as a surrogate for functional outcomes: a quality indicator for trauma systems
    Jennifer K Parks
    Department of Surgery, Division of Burns, Trauma, Surgical Critical Care Parks, Gentilello and the Department of Neurology Diaz Arrastia, The University of Texas Southwestern Medical Center, Dallas, Texas and the Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas Shafi
    Proc (Bayl Univ Med Cent) 23:355-8. 2010
    ..Once validated in other studies, postinjury employment may be used as an indicator to monitor functional outcomes in trauma registries...
  57. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  58. ncbi request reprint Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease
    Deepika Bhargava
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Geriatr Psychiatry Neurol 19:78-82. 2006
    ....
  59. doi request reprint Cerebral Vascular Injury in Traumatic Brain Injury
    Kimbra Kenney
    Center for Neuroscience and Regenerative Medicine, Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Exp Neurol 275:353-66. 2016
    ..Understanding the pathophysiology of TCVI, a relatively under-studied component of TBI, has promise for the development of novel therapies for TBI. ..
  60. doi request reprint Comparative effectiveness of traumatic brain injury rehabilitation: differential outcomes across TBI model systems centers
    Marie N Dahdah
    Baylor Institute for Rehabilitation, Baylor Health Care System, Dallas, Texas Drs Dahdah, Barisa, Dubiel, and Wilson Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, TX Ms Schmidt and Drs Barnes and Shafi North Texas Traumatic Brain Injury Model Systems Center, Dallas, Texas Drs Dahdah, Barisa, Dubiel, Wilson, Diaz Arrastia, and Shafi and Mss Dunklin, Harper, and Callender Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Dr Diaz Arrastia and Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Rockville, Maryland Dr Diaz Arrastia
    J Head Trauma Rehabil 29:451-9. 2014
    ..To measure patient functional outcomes across rehabilitation centers...
  61. doi request reprint Intracranial pressure monitoring in brain-injured patients is associated with worsening of survival
    Shahid Shafi
    Division of Burns, Department of Surgery, Trauma Critical Care, University of Texas Southwestern Medical School, Dallas, Texas, USA
    J Trauma 64:335-40. 2008
    ..However, benefits of ICP monitoring have not been documented. We hypothesized that BTF criteria for ICP monitoring in blunt TBI do not identify patients who are likely to benefit from it...
  62. pmc Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors
    Claudia Erbel-Sieler
    Departments of Biochemistry and Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:13648-53. 2004
    ..These observations raise the possibility that a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis...
  63. ncbi request reprint Development of the Texas Spanish Naming Test: a test for Spanish speakers
    Carlos Marquez de la Plata
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Clin Neuropsychol 22:288-304. 2008
    ..Results support the clinical utility of the TNT when dementia among Spanish speakers is suspected...
  64. doi request reprint Transfusions and long-term functional outcomes in traumatic brain injury
    Matthew A Warner
    Department of Neurology, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Texas, USA
    J Neurosurg 113:539-46. 2010
    ..While evidence suggests that transfusions are associated with poor hospital outcomes, no study has examined transfusions and long-term functional outcomes in this population. The preferred transfusion threshold remains controversial...
  65. ncbi request reprint Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:2751-9. 2007
    ..The link between homocysteine, PPMT, PP2A methylation, and key CNS proteins involved in AD pathogenesis provides new mechanistic insights into this disorder...
  66. pmc Arterial-cardiac baroreflex function: insights from repeated squat-stand maneuvers
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center, Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 297:R116-23. 2009
    ..Furthermore, baroreflex function can be assessed using the transfer function method during large perturbations in arterial pressure...
  67. ncbi request reprint Waiting for the patient to "sober up": Effect of alcohol intoxication on glasgow coma scale score of brain injured patients
    Jason L Sperry
    Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390 9158, USA
    J Trauma 61:1305-11. 2006
    ..Alcohol intoxication may limit the ability of the Glasgow Coma Scale (GCS) to accurately assess severity of TBI. We hypothesized that alcohol intoxication significantly depresses GCS scores of TBI patients...

Research Grants3

  1. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
  2. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  3. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008
    ..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..