Joseph A D'Ercole

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury
    Wen Liu
    Department of Pediatrics, University of North Carolina at Chapel Hill, NC 27599 7039, USA
    BMC Neurosci 12:64. 2011
  2. pmc Expanding the mind: insulin-like growth factor I and brain development
    A Joseph D'Ercole
    Department of Pediatrics, CB 7039, University of North Carolina, Chapel Hill, North Carolina 27599 7039, USA
    Endocrinology 149:5958-62. 2008
  3. ncbi request reprint Mutant mouse models of insulin-like growth factor actions in the central nervous system
    A JOSEPH D'ERCOLE
    Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, North Carolina 27599 7220, USA
    Neuropeptides 36:209-20. 2002
  4. pmc Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice
    Ping Ye
    Division of Endocrinology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    J Neurosci Res 85:712-22. 2007
  5. pmc A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development
    William H Lagarde
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Int J Dev Neurosci 25:95-105. 2007
  6. doi request reprint Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus
    Wen Liu
    Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 87:2821-32. 2009
  7. ncbi request reprint Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci Res 80:481-90. 2005
  8. ncbi request reprint Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 78:472-84. 2004
  9. ncbi request reprint Expression of Mcl-1 in cerebellar granule neurons is regulated by IGF-I in a developmentally specific fashion
    Jihui Zhang
    Department of Pediatrics, Division of Endocrinology, CB 7039, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, United States
    Brain Res Dev Brain Res 152:255-63. 2004
  10. pmc Developmental expression of histone deacetylase 11 in the murine brain
    Hedi Liu
    Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurosci Res 86:537-43. 2008

Research Grants

  1. IGF-I Actions in Oligodendrocyte/Myelin Injury
    AUGUSTINE D ERCOLE; Fiscal Year: 2007
  2. Mechanism of IGF-I actions on oligodendroglial cells
    AUGUSTINE D ERCOLE; Fiscal Year: 2008
  3. THE HORMONAL CONTROL OF FETAL GROWTH
    AUGUSTINE D ERCOLE; Fiscal Year: 2009

Collaborators

Detail Information

Publications24

  1. pmc Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury
    Wen Liu
    Department of Pediatrics, University of North Carolina at Chapel Hill, NC 27599 7039, USA
    BMC Neurosci 12:64. 2011
    ....
  2. pmc Expanding the mind: insulin-like growth factor I and brain development
    A Joseph D'Ercole
    Department of Pediatrics, CB 7039, University of North Carolina, Chapel Hill, North Carolina 27599 7039, USA
    Endocrinology 149:5958-62. 2008
    ..Studies of the few humans with IGF-I and/or IGF1R gene mutations indicate that IGF-I serves a similar role in man...
  3. ncbi request reprint Mutant mouse models of insulin-like growth factor actions in the central nervous system
    A JOSEPH D'ERCOLE
    Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, North Carolina 27599 7220, USA
    Neuropeptides 36:209-20. 2002
    ..Evidence from experiments in these mouse models also indicates that IGF-I has a role in recovery from neural injury...
  4. pmc Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice
    Ping Ye
    Division of Endocrinology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    J Neurosci Res 85:712-22. 2007
    ..Our results indicate that IGF-I is capable of protecting myelin and oligodendrocytes from TNF-alpha-induced damage in vivo...
  5. pmc A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development
    William H Lagarde
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Int J Dev Neurosci 25:95-105. 2007
    ..This non-immortalized oligodendrocyte precursor cell line, therefore, exhibits behavior consistent with the in vivo development of oligodendrocytes and provides an excellent model for the study of developing oligodendrocytes...
  6. doi request reprint Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus
    Wen Liu
    Department of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 87:2821-32. 2009
    ....
  7. ncbi request reprint Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci Res 80:481-90. 2005
    ..These results confirm our previous suggestion that a lack of IGF-I activity contributes to apoptosis of weaver granule neurons in vivo and supports IGF-I's potential therapeutic use in neurodegenerative disease...
  8. ncbi request reprint Astrocyte-specific overexpression of insulin-like growth factor-I promotes brain overgrowth and glial fibrillary acidic protein expression
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci Res 78:472-84. 2004
    ..Our data also suggest that IGF-I's actions in CNS depend in part on the location of its expression and cellular microenvironment and that continuous presence of IGF-I expression is necessary for brain overgrowth...
  9. ncbi request reprint Expression of Mcl-1 in cerebellar granule neurons is regulated by IGF-I in a developmentally specific fashion
    Jihui Zhang
    Department of Pediatrics, Division of Endocrinology, CB 7039, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, United States
    Brain Res Dev Brain Res 152:255-63. 2004
    ..These data suggest that anti-apoptotic Mcl-1 may mediate IGF-I pro-survival actions on granule neurons during the development of cerebellar cortex. They also point out pitfalls of cDNA array analyses...
  10. pmc Developmental expression of histone deacetylase 11 in the murine brain
    Hedi Liu
    Division of Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurosci Res 86:537-43. 2008
    ..These findings support a role for HDAC11 in CNS histone deacetylation and the development of oligodendrocytes and neurons during postnatal development...
  11. ncbi request reprint Myelination is altered in insulin-like growth factor-I null mutant mice
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7220, USA
    J Neurosci 22:6041-51. 2002
    ..These data suggest that IGF-I plays a significant role in myelination during normal early development and that IGF-II can compensate in part for IGF-I actions on myelination...
  12. pmc Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells
    Hedi Liu
    Division of Endocrinology, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    Glia 57:1-12. 2009
    ..Our data strongly support a specific role for HDAC 11 in histone deacetylation and in turn the regulation of oligodendrocyte-specific protein gene expression and oligodendrocyte development...
  13. ncbi request reprint Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, 27599 7220, USA
    J Neurosci Res 83:1-6. 2006
    ..IGF-I actions, however, likely depend on cell type, developmental stage, and microenvironmental milieu...
  14. pmc beta-catenin mediates insulin-like growth factor-I actions to promote cyclin D1 mRNA expression, cell proliferation and survival in oligodendroglial cultures
    Ping Ye
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    Glia 58:1031-41. 2010
    ....
  15. pmc Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination
    Martha Zeger
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Glia 55:400-11. 2007
    ..These data also provide a fundamental basis for developing strategies with the potential to target IGF-IGF1R signaling pathways in oligodendrocyte lineage cells for the treatment of demyelinating disorders...
  16. ncbi request reprint In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system
    Gregory J Popken
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Eur J Neurosci 19:2056-68. 2004
    ..Our results demonstrate that IGF-I can both promote proliferation of neural cells in the embryonic central nervous system in vivo and inhibit their apoptosis during postnatal life...
  17. ncbi request reprint Tumor necrosis factor-alpha regulation of insulin-like growth factor-I, type 1 IGF receptor, and IGF binding protein expression in cerebellum of transgenic mice
    Ping Ye
    Division of Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Neurosci Res 71:721-31. 2003
    ..Our data indicate that TNF-alpha alters the expression of IGF-I system proteins in vivo, and suggest that altered expression of IGF-I system proteins may in part explain TNF-alpha deleterious actions on brain growth...
  18. ncbi request reprint Down-regulation of 14-3-3 eta gene expression by IGF-I in mouse cerebellum during postnatal development
    Jihui Zhang
    Department of Pediatrics, Division of Endocrinology, CB 7039, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7039, USA
    Brain Res Dev Brain Res 143:199-206. 2003
    ..e. limit Purkinje cell number, and/or (b) function as part of a distinct signaling mechanism, perhaps one that augments the capacity of Purkinje cells to promote granule cell survival...
  19. pmc Expression of insulin-like growth factor system genes during the early postnatal neurogenesis in the mouse hippocampus
    Jihui Zhang
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    J Neurosci Res 85:1618-27. 2007
    ..Our data support a role for IGF in hippocampal neurogenesis and provide evidence that IGF actions are regulated within a defined in vivo milieu...
  20. ncbi request reprint Mouse NG2+ oligodendrocyte precursors express mRNA for proteolipid protein but not its DM-20 variant: a study of laser microdissection-captured NG2+ cells
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7220, USA
    J Neurosci 23:4401-5. 2003
    ..This work also shows that LCM is a valuable tool to define and analyze gene expression in the cells of the oligodendrocyte lineage...
  21. ncbi request reprint Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination
    Ping Ye
    Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res Dev Brain Res 136:111-21. 2002
    ..Nonetheless, the finding that IGF-I stimulates brain growth less well in the absence of IRS-1 suggests that IRS-1-mediated signaling may be more central to IGF-I action in cells other than glia and oligodendrocytes...
  22. ncbi request reprint IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth
    Don W Coulter
    Division of Hematology Oncology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7220, USA
    Anticancer Res 28:1509-16. 2008
    ..Inhibition of IGF1R signaling can be accomplished by other agents, including rapamycin or temsirolimus, which target mTOR (mammalian target of rapamycin)...
  23. pmc Insulin-like growth factor-I stimulates histone H3 and H4 acetylation in the brain in vivo
    Liou Y Sun
    Department of Pediatrics, Division of Endocrinology, Campus Box 7039, 3341 MBRB, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7039, USA
    Endocrinology 147:5480-90. 2006
    ..This provides evidence that the chromatin architecture modification contributes to the action of IGF-I on gene expression in the mammalian central nerve system...
  24. ncbi request reprint Brain development
    Gregory J Popken
    Division Pediatric Endocrinology, Department of Pediatrics, University of North Carolina at Chapel Hill, NC 27599 7039, USA
    Adv Exp Med Biol 567:187-220. 2005

Research Grants3

  1. IGF-I Actions in Oligodendrocyte/Myelin Injury
    AUGUSTINE D ERCOLE; Fiscal Year: 2007
    ..abstract_text> ..
  2. Mechanism of IGF-I actions on oligodendroglial cells
    AUGUSTINE D ERCOLE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  3. THE HORMONAL CONTROL OF FETAL GROWTH
    AUGUSTINE D ERCOLE; Fiscal Year: 2009
    ..Determine the consequences of neonatal ischemia/hypoxia on DG neurogenesis in normal and IGF-I and IGF1R mutant mice. ..