Affiliation: University of Chicago
- Role of hormones in pilosebaceous unit developmentD Deplewski
Department of Medicine and Pediatrics, The University of Chicago Pritzker School of Medicine, Illinois 60637 1470, USA
Endocr Rev 21:363-92. 2000..Improved understanding of the multiplicity of factors involved in normal PSU growth and differentiation will be necessary to provide optimal treatment approaches for these disorders...
- Unique mode of lipogenic activation in rat preputial sebocytesDianne Deplewski
Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Avenue MC 5053, Chicago, IL 60637 1470, USA
J Nutr Metab 2011:163631. 2011..This suggests that substrates provided by lipoproteins are targeted to sebocytes and affect their own disposition via PPAR activation...
- Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiationD Deplewski
The University of Chicago, Pritzker School of Medicine, Department of Medicine, Illinois 60637 1470, USA
Endocrinology 140:4089-94. 1999..These data are consistent with the concept that increases in GH and IGF production contribute in complementary ways to the increase in sebum production during puberty and in acromegaly...
- Limited cooperation between peroxisome proliferator-activated receptors and retinoid X receptor agonists in sebocyte growth and developmentM J Kim
Department of Pediatrics, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
Mol Genet Metab 74:362-9. 2001..Furthermore, since there is no enhancement of the growth-promoting effects of RXR agonist and cPGI2 when they are combined, this effect also does not appear to be mediated by PPAR-RXR interaction...
- Peroxisome proliferator-activated receptors and skin developmentR L Rosenfield
Department of Pediatrics, The University of Chicago Pritzker School of Medicine, Chicago, Ill, USA
Horm Res 54:269-74. 2000..In addition, they may play roles in keratinocyte growth and differentiation and the inhibition of skin inflammation by diverse mechanisms not necessarily related to fat metabolism...
- Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndromeElizabeth E Littlejohn
University of Chicago, Pritzker School of Medicine, Department of Pediatrics, Section of Pediatric Endocrinology, 5841 S Maryland Avenue, IL 60637, USA
J Pediatr Endocrinol Metab 20:41-51. 2007..We report that intractable early childhood obesity may be associated with severe insulin resistance syndromes (pseudo-Cushing's syndrome and pseudo-acromegaly) and precede polycystic ovary syndrome (PCOS)...
- Role of PPAR Gamma Amino-Terminus in the AdipocyteDianne Deplewski; Fiscal Year: 2007..3) To use transgenic techniques to develop mice with a Ser112Ala mutation in PPARgamma2. The degree of obesity and insulin sensitivity will be further studied in these mice. ..