N D Denslow

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Gene expression fingerprints of largemouth bass (Micropterus salmoides) exposed to pulp and paper mill effluents
    Nancy D Denslow
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA
    Mutat Res 552:19-34. 2004
  2. ncbi request reprint Multiple responses in gene expression in fish treated with estrogen
    N D Denslow
    Department of Biochemistry and Molecular Biology, University of Florida, PO Box 100156 HC, 32610, Gainesville, FL, USA
    Comp Biochem Physiol B Biochem Mol Biol 129:277-82. 2001
  3. ncbi request reprint Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation
    N D Denslow
    Department of Biochemistry, University of Florida, Gainesville, Florida 32610, USA
    Gen Comp Endocrinol 121:250-60. 2001
  4. ncbi request reprint Analysis of gene expression profiles in largemouth bass exposed to 17-beta-estradiol and to anthropogenic contaminants that behave as estrogens
    P Larkin
    Department of Biochemistry and Molecular Biology, Center for Biotechnology, University of Florida, PO Box 100156 HC, 1600 Archer Road, MSB Building, Room MG 42, Gainesville, FL 32610, USA
    Ecotoxicology 12:463-8. 2003
  5. ncbi request reprint An evaluation of biomarkers of reproductive function and potential contaminant effects in Florida largemouth bass ( Micropterus salmoidesfloridanus) sampled from the St. Johns River
    Maria S Sepúlveda
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Sci Total Environ 289:133-44. 2002
  6. pmc Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides)
    Jason L Blum
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32611, USA
    Aquat Toxicol 86:459-69. 2008
  7. pmc Dietary exposure of largemouth bass to OCPs changes expression of genes important for reproduction
    Natalia Garcia-Reyero
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, USA
    Aquat Toxicol 78:358-69. 2006
  8. doi request reprint Evaluation of water quality threats to the endangered Okaloosa darter (Etheostoma okaloosae) in East Turkey Creek on Eglin Air Force Base
    R E Weil
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, USA
    Aquat Toxicol 110:177-86. 2012
  9. ncbi request reprint Assessment of reproductive effects in largemouth bass (Micropterus salmoides) exposed to bleached/unbleached kraft mill effluents
    M S Sepulveda
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Arch Environ Contam Toxicol 41:475-82. 2001
  10. ncbi request reprint Effects of pulp and paper mill effluents on reproductive success of largemouth bass
    Maria S Sepúlveda
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Environ Toxicol Chem 22:205-13. 2003

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Gene expression fingerprints of largemouth bass (Micropterus salmoides) exposed to pulp and paper mill effluents
    Nancy D Denslow
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA
    Mutat Res 552:19-34. 2004
    ..These antiestrogenic changes are in agreement with previous studies in bass exposed to these effluents, and could result in decreased reproductive success in affected populations...
  2. ncbi request reprint Multiple responses in gene expression in fish treated with estrogen
    N D Denslow
    Department of Biochemistry and Molecular Biology, University of Florida, PO Box 100156 HC, 32610, Gainesville, FL, USA
    Comp Biochem Physiol B Biochem Mol Biol 129:277-82. 2001
    ..While physiological changes caused by estradiol treatment are not totally explained by changes at the mRNA level, those changes can nevertheless be used as fingerprints to characterize an in vivo estrogenic response...
  3. ncbi request reprint Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation
    N D Denslow
    Department of Biochemistry, University of Florida, Gainesville, Florida 32610, USA
    Gen Comp Endocrinol 121:250-60. 2001
    ....
  4. ncbi request reprint Analysis of gene expression profiles in largemouth bass exposed to 17-beta-estradiol and to anthropogenic contaminants that behave as estrogens
    P Larkin
    Department of Biochemistry and Molecular Biology, Center for Biotechnology, University of Florida, PO Box 100156 HC, 1600 Archer Road, MSB Building, Room MG 42, Gainesville, FL 32610, USA
    Ecotoxicology 12:463-8. 2003
    ..The results of these experiments demonstrate distinct gene expression patterns in LMB exposed to these compounds...
  5. ncbi request reprint An evaluation of biomarkers of reproductive function and potential contaminant effects in Florida largemouth bass ( Micropterus salmoidesfloridanus) sampled from the St. Johns River
    Maria S Sepúlveda
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Sci Total Environ 289:133-44. 2002
    ..It is clear that additional studies are needed to evaluate the potential impact of these reproductive changes in populations of Florida largemouth bass inhabiting the St. Johns River...
  6. pmc Effects of the pesticide methoxychlor on gene expression in the liver and testes of the male largemouth bass (Micropterus salmoides)
    Jason L Blum
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32611, USA
    Aquat Toxicol 86:459-69. 2008
    ....
  7. pmc Dietary exposure of largemouth bass to OCPs changes expression of genes important for reproduction
    Natalia Garcia-Reyero
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, USA
    Aquat Toxicol 78:358-69. 2006
    ..Both pesticides targeted expression of genes involved in all three modes of action, suggesting that they each have multiple modes of action...
  8. doi request reprint Evaluation of water quality threats to the endangered Okaloosa darter (Etheostoma okaloosae) in East Turkey Creek on Eglin Air Force Base
    R E Weil
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, USA
    Aquat Toxicol 110:177-86. 2012
    ....
  9. ncbi request reprint Assessment of reproductive effects in largemouth bass (Micropterus salmoides) exposed to bleached/unbleached kraft mill effluents
    M S Sepulveda
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Arch Environ Contam Toxicol 41:475-82. 2001
    ..Johns River. The chemical(s) responsible for such changes as well as their mode(s) of action remain unknown at this time...
  10. ncbi request reprint Effects of pulp and paper mill effluents on reproductive success of largemouth bass
    Maria S Sepúlveda
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Environ Toxicol Chem 22:205-13. 2003
    ..These changes could have resulted from alterations in egg quality because of failure of parental reproductive systems, from acute embryo toxicity after translocation of contaminants from the mother to the developing embryo, or from both...
  11. ncbi request reprint Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry
    William E Haskins
    Center of Neuroproteomics and Biomarkers Research, Department of Neuroscience, University of Florida, Gainesville, Florida 32610, USA
    J Neurotrauma 22:629-44. 2005
    ..e., TBI) without a priori knowledge of the molecules involved...
  12. pmc Genomic and proteomic responses to environmentally relevant exposures to dieldrin: indicators of neurodegeneration?
    Christopher J Martyniuk
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida 32611, USA
    Toxicol Sci 117:190-9. 2010
    ..This study demonstrates that a subchronic exposure to dieldrin alters the abundance of messenger RNAs and proteins in the hypothalamus that are associated with cell metabolism, cell stability and integrity, stress, and DNA repair...
  13. ncbi request reprint Estrogen-induced vitellogenin mRNA and protein in sheepshead minnow (Cyprinodon variegatus)
    C J Bowman
    Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32610, USA
    Gen Comp Endocrinol 120:300-13. 2000
    ..Constant aqueous exposure to E(2) (2000 ng/L) or EE(2) (1000 ng/L) may thus be more effective than a single large-dose injection (5 mg/kg) to stimulate Vtg gene activation and synthesis...
  14. ncbi request reprint Gene expression analysis of largemouth bass exposed to estradiol, nonylphenol, and p,p'-DDE
    P Larkin
    Department of Biochemistry, PO Box 100156 HC, 1600 Archer Road, MSB Building, Room MG 42, Gainesville, FL 32610, USA
    Comp Biochem Physiol B Biochem Mol Biol 133:543-57. 2002
    ..This study further suggests that gene arrays have the potential to map out the gene activation pathways of hormonally active compounds...
  15. ncbi request reprint Epstein-Barr virus nuclear antigen-1 (EBNA-1) associated oligoclonal bands in patients with multiple sclerosis
    K H Rand
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Florida, JHMHC, Box 199275, Gainesville, FL 32610 0275, USA
    J Neurol Sci 173:32-9. 2000
    ..In one patient with EBNA-1 specific OCBs, EBNA-1 and a peptide 'equivalent', p62, were able to absorb a component of the total IgG. Our results suggest that in a subset of MS patients, EBNA-1 may be a major target of selected OCBs...
  16. ncbi request reprint Enhancement of phosphoprotein analysis using a fluorescent affinity tag and mass spectrometry
    Stanley M Stevens
    University of Florida, Protein Chemistry Core Facility, ICBR, Gainesville, FL 32610 0156, USA
    Rapid Commun Mass Spectrom 19:2157-62. 2005
    ..Initial results demonstrated low femtomole detection limits after fluorescence image analysis of FAT-labeled proteins or peptides...
  17. ncbi request reprint A multidimensional differential proteomic platform using dual-phase ion-exchange chromatography-polyacrylamide gel electrophoresis/reversed-phase liquid chromatography tandem mass spectrometry
    Andrew K Ottens
    Center for Neuroproteomics and Biomarker Research, University of Florida, Gainesville, Florida 32610, USA
    Anal Chem 77:4836-45. 2005
    ..When combined with RPLC-MSMS for protein identification, an additional quantification step is performed for internal validation, confirming a 2-fold or greater change in 89% of identified differential targets...
  18. ncbi request reprint Neuroproteomics in neurotrauma
    Andrew K Ottens
    Center of Neuroproteomics and Biomarkers Research, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Mass Spectrom Rev 25:380-408. 2006
    ..Ultimately, knowledge attained through neuroproteomics could lead to clinical diagnostics and therapeutics to lessen the burden of neurotrauma on society...
  19. pmc Fish 'n' chips: the use of microarrays for aquatic toxicology
    Nancy D Denslow
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, USA
    Mol Biosyst 3:172-7. 2007
    ....
  20. pmc Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry
    Andrew K Ottens
    Department of Psychiatry, Centers for Neuroproteomics and Biomarker Research and Traumatic Brain Injury Studies at the McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610 0256, USA
    J Neurochem 104:1404-14. 2008
    ..3 kDa fragment. Ultimately, the novel methodology described here can be used to study MBP dynamics and other similar proteolytic events of relevance to brain injury and other CNS processes...
  21. pmc Exposure to p,p'-DDE or dieldrin during the reproductive season alters hepatic CYP expression in largemouth bass (Micropterus salmoides)
    David S Barber
    Center for Environmental and Human Toxicology, Department of Physiological Sciences, PO Box 100885, University of Florida, Gainesville, FL 32611, United States
    Aquat Toxicol 81:27-35. 2007
    ..This work demonstrates that there are significant changes in CYP expression that occur during LMB reproduction which can be modified by exposure to OCPs...
  22. doi request reprint Towards functional genomics in fish using quantitative proteomics
    Christopher J Martyniuk
    Center for Environmental and Human Toxicology, Department of Physiological Sciences, University of Florida, P O Box 110885, Gainesville, FL 32611 0885, USA
    Gen Comp Endocrinol 164:135-41. 2009
    ..The challenge remains to integrate molecular datasets in such a manner as to be able to consider temporal effects and complex regulation at the level of the genome and proteome...
  23. ncbi request reprint Temporal gene induction patterns in sheepshead minnows exposed to 17beta-estradiol
    Iris Knoebl
    Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32610, USA
    J Exp Zool A Comp Exp Biol 305:707-19. 2006
    ....
  24. ncbi request reprint Novel differential neuroproteomics analysis of traumatic brain injury in rats
    Firas H Kobeissy
    Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute of the University of Florida, Gainesville, USA
    Mol Cell Proteomics 5:1887-98. 2006
    ..Results from this work provide insight into mechanisms of traumatic brain injury and yield putative biochemical markers to potentially facilitate patient management by monitoring the severity, progression, and treatment of injury...
  25. pmc Effects of acute dieldrin exposure on neurotransmitters and global gene transcription in largemouth bass (Micropterus salmoides) hypothalamus
    Christopher J Martyniuk
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA
    Neurotoxicology 31:356-66. 2010
    ....
  26. ncbi request reprint Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiol
    Tara Sabo-Attwood
    Interdisciplinary Program in Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA
    Mol Cell Endocrinol 218:107-18. 2004
    ..These results combined suggest that the ERs themselves are not regulated in the same manner by E2, and furthermore, do not contribute equally to the transcriptional regulation of genes involved in fish reproduction such as Vtg...
  27. ncbi request reprint Expression profiling of estrogenic compounds using a sheepshead minnow cDNA macroarray
    Patrick Larkin
    Department of Biochemistry and Molecular Biology and Center for Biotechnology, University of Florida, Gainesville, Florida, USA
    EHP Toxicogenomics 111:29-36. 2003
    ..We show that our estrogen-responsive cDNA macroarray can detect dose-dependent changes in gene expression patterns in fish treated with EE2...
  28. ncbi request reprint Estradiol-induced gene expression in largemouth bass (Micropterus salmoides)
    Christopher J Bowman
    Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA
    Mol Cell Endocrinol 196:67-77. 2002
    ..Taken together these studies indicate that the acute molecular response to E(2) involves a complex network of responses over time...
  29. ncbi request reprint Differential gene expression analysis in fish exposed to endocrine disrupting compounds
    P Larkin
    Department of Biochemistry and Molecular Biology and Center for Biotechnology University of Florida, P O Box 100156 HC, Gainesville, FL 32610, USA
    Comp Biochem Physiol B Biochem Mol Biol 136:149-61. 2003
    ....
  30. pmc Gene expression responses in male fathead minnows exposed to binary mixtures of an estrogen and antiestrogen
    Natalia Garcia-Reyero
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA
    BMC Genomics 10:308. 2009
    ..We analyzed gene expression changes in the gonad, as well as hormone and vitellogenin plasma levels...
  31. ncbi request reprint Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol
    Tara Sabo-Attwood
    Department of Pharmacology and Therapeutics, University of Florida, PO Box 110885, Gainesville, Florida 32611, USA
    J Mol Endocrinol 39:223-37. 2007
    ..Results from these studies collectively reveal the differential response of fish ER isotypes in response to xenoestrogens...
  32. ncbi request reprint Exposure to copper nanoparticles causes gill injury and acute lethality in zebrafish (Danio rerio)
    Robert J Griffitt
    Physiological Sciences, University of Florida, Building 471 Mowry Road, Gainesville, Florida 32611, USA
    Environ Sci Technol 41:8178-86. 2007
    ....
  33. ncbi request reprint Use of cDNA macroarrays and gene profiling for detection of effects of environmental toxicants
    Jason L Blum
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, USA
    Methods Mol Biol 410:43-53. 2008
    ..In all, gene macroarrays are a relatively easy way to generate large amounts of data in a short amount of time...
  34. ncbi request reprint Use of suppressive subtractive hybridization and cDNA arrays to discover patterns of altered gene expression in the liver of dihydrotestosterone and 11-ketotestosterone exposed adult male largemouth bass (Micropterus salmoides)
    Jason L Blum
    Interdisciplinary Program for Biomedical Research, Department of Pharmacology, University of Florida, Gainesville, FL 32610, USA
    Mar Environ Res 58:565-9. 2004
    ..Determining which genes are responsive to natural androgens will help to identify biochemical pathways that are impacted...
  35. ncbi request reprint Induction of zona radiata and vitellogenin genes in estradiol and nonylphenol exposed male sheepshead minnows (Cyprinodon variegatus)
    Iris Knoebl
    Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32610, USA
    Mar Environ Res 58:547-51. 2004
    ..Both E(2) and NP elicited a dose-response increase in all of the mRNAs tested. Exposure to both chemicals resulted in VTG2 expression at about a 10-fold lower level than VTG1, and ZRP2 expression at a lower level than ZRP3...
  36. doi request reprint Aquatic contaminants alter genes involved in neurotransmitter synthesis and gonadotropin release in largemouth bass
    Christopher J Martyniuk
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA
    Aquat Toxicol 95:1-9. 2009
    ..This study demonstrates that brain transcripts important for neurotransmitter synthesis neuroendocrine function are potential targets for emerging and prevalent aquatic contaminants...
  37. doi request reprint Quantitative proteomic profiles of androgen receptor signaling in the liver of fathead minnows (Pimephales promelas)
    Christopher J Martyniuk
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida 32611, USA
    J Proteome Res 8:2186-200. 2009
    ..We demonstrate the utility of proteomic profiling for use on a model species with value to ecotoxicology but having limited genomic information...
  38. ncbi request reprint Expression signatures for a model androgen and antiandrogen in the fathead minnow (Pimephales promelas) ovary
    Natalia Garcia-Reyero
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida 32611, USA
    Environ Sci Technol 43:2614-9. 2009
    ....
  39. ncbi request reprint Interaction of bovine mitochondrial ribosomes with Escherichia coli initiation factor 3 (IF3)
    N D Denslow
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville 32601 0245
    Biochemistry 27:3521-7. 1988
    ..Furthermore, bacterial IF3 inhibits the Mg2+-dependent association of mitochondrial ribosomal subunits, suggesting that the bacterial IF3 binds to mitochondrial small subunits in a functional way...
  40. pmc Environmentally relevant exposure to 17alpha-ethinylestradiol affects the telencephalic proteome of male fathead minnows
    Christopher J Martyniuk
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA
    Aquat Toxicol 98:344-53. 2010
    ....
  41. pmc Seasonal relationship between gonadotropin, growth hormone, and estrogen receptor mRNA expression in the pituitary gland of largemouth bass
    Christopher J Martyniuk
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA
    Gen Comp Endocrinol 163:306-17. 2009
    ....
  42. pmc Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells
    Jason L Blum
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville FL 32611, USA
    J Steroid Biochem Mol Biol 108:55-63. 2008
    ....
  43. ncbi request reprint Reproductive seasonality of the female Florida gar, Lepisosteus platyrhincus
    Edward F Orlando
    University of Florida, Department of Zoology, 223 Bartram Hall, Gainesville, FL 32611, USA
    Gen Comp Endocrinol 151:318-24. 2007
    ..Moreover, it increases our understanding of basic reproductive biology of semitropical fishes in general, and nonteleost, bony fishes in particular...
  44. ncbi request reprint Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease
    M Levine
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, Oklahoma, 73190, USA
    Microb Pathog 30:179-92. 2001
    ..Thus, lysine decarboxylases such as p80 inhibit growth by removing lysine from mammalian cell culture media. A new role for lysine decarboxylase activity in the microbial aetiology of periodontal disease is discussed...
  45. ncbi request reprint Integration of isoelectric focusing with multi-channel gel electrophoresis by using microfluidic pseudo-valves
    Champak Das
    Department of Mechanical and Aerospace Engineering, University of Florida, PO Box 116250, Gainesville, FL 32611, USA
    Lab Chip 7:1806-12. 2007
    ..The total separation time is less than 10 minutes for IEF and PAGE, an improvement of 2 orders of magnitude over the conventional 2D slab gel electrophoresis...
  46. pmc Site-specific impacts on gene expression and behavior in fathead minnows (Pimephales promelas) exposed in situ to streams adjacent to sewage treatment plants
    Natalia Garcia-Reyero
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA
    BMC Bioinformatics 10:S11. 2009
    ..The present study was designed to obtain additional information for well-characterized sites adjacent to sewage treatment plants in MN that are thought to be impacted by endocrine disruptors...
  47. ncbi request reprint A comparison of the estrogenic potencies of estradiol, ethynylestradiol, diethylstilbestrol, nonylphenol and methoxychlor in vivo and in vitro
    Leroy C Folmar
    US Environmental Protection Agency, 1 Sabine Island Drive, Gulf Breeze, FL 32561, USA
    Aquat Toxicol 60:101-10. 2002
    ....
  48. pmc Relationship between reproductive success and male plasma vitellogenin concentrations in cunner, Tautogolabrus adspersus
    Lesley J Mills
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Atlantic Ecology Division, Narragansett, Rhode Island 02882, USA
    Environ Health Perspect 111:93-100. 2003
    ..Male plasma vitellogenin expression may serve as an indicator of reduced female reproductive function caused by estrogen exposure...
  49. ncbi request reprint Vitellogenin-derived yolk proteins of white perch, Morone americana: purification, characterization, and vitellogenin-receptor binding
    Naoshi Hiramatsu
    Department of Zoology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695 7617, USA
    Biol Reprod 67:655-67. 2002
    ..Lipovitellin was less effective than vitellogenin in this regard, suggesting that the remaining yolk protein domains of vitellogenin may interact with its lipovitellin domain to facilitate binding of vitellogenin to its receptor...
  50. ncbi request reprint A graphical systems model to facilitate hypothesis-driven ecotoxicogenomics research on the teleost brain-pituitary-gonadal axis
    Daniel L Villeneuve
    Mid Continent Ecology Division, U S EPA, USA
    Environ Sci Technol 41:321-30. 2007
    ..Furthermore, microarray results helped identify additional elements (genes/ proteins) that could be included in the model to potentially increase its predictive capacity. With proper recognition of..
  51. ncbi request reprint Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol
    Michael J Hemmer
    US Environmental Protection Agency, Gulf Ecology Division, 1 Sabine Island Drive, Gulf Breeze, FL 32561, USA
    Aquat Toxicol 58:99-112. 2002
    ....
  52. ncbi request reprint Environmental contaminants and biomarker responses in fish from the Columbia River and its tributaries: spatial and temporal trends
    Jo Ellen Hinck
    U S Geological Survey, Columbia Environmental Research Center, 4200 New Haven Rd, Columbia, MO 65201, USA
    Sci Total Environ 366:549-78. 2006
    ..Results from our study and other investigations indicate that continued monitoring in the CRB is warranted to identify consistently degraded sites and those with emerging problems...
  53. ncbi request reprint Chemical contaminants, health indicators, and reproductive biomarker responses in fish from the Colorado River and its tributaries
    Jo Ellen Hinck
    U S Geological Survey USGS, Columbia Environmental Research Center CERC, Columbia, MO 65201, USA
    Sci Total Environ 378:376-402. 2007
    ..Anomalous reproductive biomarkers including low GSI and gonadal abnormalities (calcifications, edema, and parasites) observed in fish downstream of Phoenix are likely related to the poor water-quality of the Gila River in this area...
  54. ncbi request reprint Environmental contaminants and biomarker responses in fish from the Rio Grande and its U.S. tributaries: spatial and temporal trends
    Christopher J Schmitt
    U S Geological Survey USGS, Columbia Environmental Research Center CERC, 4200 New Haven Rd, Columbia, MO 65201, USA
    Sci Total Environ 350:161-93. 2005
    ....
  55. ncbi request reprint Chemical contaminants, health indicators, and reproductive biomarker responses in fish from rivers in the Southeastern United States
    Jo Ellen Hinck
    U S Geological Survey USGS, Columbia Environmental Research Center CERC, 4200 New Haven Rd, Columbia, MO 65201, USA
    Sci Total Environ 390:538-57. 2008
    ..Comparatively high vitellogenin concentrations (>0.35 mg/mL) in male fish from the MRB, SRB, and PRB indicate exposure to estrogenic or anti-androgenic chemicals...
  56. ncbi request reprint Array technology as a tool to monitor exposure of fish to xenoestrogens
    Patrick Larkin
    Department of Biochemistry and Molecular Biology and Center for Biotechnology, Gainesville, FL 32610 USA
    Mar Environ Res 54:395-9. 2002
    ..The results of these experiments demonstrate a characteristic expression pattern of estrogen responsive genes in sheepshead minnows exposed to 17 beta-estradiol (E2)...
  57. ncbi request reprint Effects of cyclic hypoxia on gene expression and reproduction in a grass shrimp, Palaemonetes pugio
    Nancy J Brown-Peterson
    Department of Coastal Sciences, The University of Southern Mississippi, 703 East Beach Dr, Ocean Springs, Mississippi 39564, USA
    Biol Bull 214:6-16. 2008
    ..Demographic analysis showed a lower estimated rate of population growth in grass shrimp exposed to both continuous and short-term cyclic hypoxia, suggesting population-level impacts on grass shrimp...
  58. pmc Toxicogenomics in regulatory ecotoxicology
    Gerald T Ankley
    U S EPA
    Environ Sci Technol 40:4055-65. 2006
  59. doi request reprint Perturbation of gene expression and steroidogenesis with in vitro exposure of fathead minnow ovaries to ketoconazole
    Edward J Perkins
    Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS 39180, USA
    Mar Environ Res 66:113-5. 2008
    ....
  60. ncbi request reprint Development and validation of a 2,000-gene microarray for the fathead minnow (Pimephales promelas)
    Patrick Larkin
    EcoArray, 12085 Research Drive, Alachua, Florida 32615, USA
    Environ Toxicol Chem 26:1497-506. 2007
    ..Our studies indicate the feasibility and utility of microarrays as a basis for understanding biological responses to chemical exposure in a model ecotoxicology test species...
  61. doi request reprint Chemical cleavage of proteins in solution
    Dan L Crimmins
    Washington University School of Medicine, St Louis, Missouri, USA
    Curr Protoc Protein Sci . 2005
    ..Because the above loci are at relatively low abundance in most proteins, digestion with these agents will yield relatively long peptides...