Edward C Dempsey

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Protein kinase C isozymes and the regulation of diverse cell responses
    E C Dempsey
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L429-38. 2000
  2. ncbi request reprint Lung disease and PKCs
    Edward C Dempsey
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pharmacol Res 55:545-59. 2007
  3. pmc Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism
    Vijaya Karoor
    Department of Medicine, University of Colorado Denver, Denver, CO, USA
    Cancer Prev Res (Phila) 5:1061-71. 2012
  4. ncbi request reprint Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes
    M Das
    Cardiovascular Pulmonary and Developmental Biology Research Laboratories, Department of Basic Science and Oral Research, School of Dentistry, University of Colorado Health Sciences Center, CO 80262, USA
    Am J Respir Cell Mol Biol 22:15-25. 2000
  5. pmc Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism
    Vijaya Karoor
    Cardiovascular Pulmonary Research Laboratory, RC 2 Room 8118, University of Colorado Anschutz Medical Campus, 12700 E 19th Ave, RC 2, Aurora, CO 80045, USA
    Hypertension 61:921-30. 2013
  6. ncbi request reprint Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern
    Marilee J Wick
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Denver, RC 2, Box B 133, 12700 E 19th Ave, Aurora, CO, 80045, USA
    Transgenic Res 25:773-784. 2016
  7. ncbi request reprint Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
    Joseph T Crossno
    Pulmonary and Critical Care Services, Veterans Affairs Medical Center, Denver, USA
    Am J Physiol Lung Cell Mol Physiol 292:L885-97. 2007
  8. pmc Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors
    Vijaya Karoor
    Denver Veterans Affairs Medical Center, University of Colorado Cancer Center, Pulmonary 111A, 1055 Clermont Street, Denver, CO 80220, USA
    Cancer Prev Res (Phila) 3:1141-7. 2010
  9. pmc Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease
    Marilee J Wick
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Respir Crit Care Med 183:330-40. 2011
  10. ncbi request reprint Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension
    D Case
    Cardiovascular Pulmonary Research Laboratory, Division of Cardiology and Department of Medicine, University of Colorado Health Science Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L154-64. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Protein kinase C isozymes and the regulation of diverse cell responses
    E C Dempsey
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Lung Cell Mol Physiol 279:L429-38. 2000
    ..More specific approaches for studying PKC isozymes and their role in cell responses have been developed. Strengths and weaknesses of different experimental strategies are reviewed. Future directions for investigation are identified...
  2. ncbi request reprint Lung disease and PKCs
    Edward C Dempsey
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pharmacol Res 55:545-59. 2007
    ..Key isotypes of PKC involved in lung pathophysiology are summarized and current and evolving therapeutic approaches to target them are identified...
  3. pmc Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism
    Vijaya Karoor
    Department of Medicine, University of Colorado Denver, Denver, CO, USA
    Cancer Prev Res (Phila) 5:1061-71. 2012
    ....
  4. ncbi request reprint Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes
    M Das
    Cardiovascular Pulmonary and Developmental Biology Research Laboratories, Department of Basic Science and Oral Research, School of Dentistry, University of Colorado Health Sciences Center, CO 80262, USA
    Am J Respir Cell Mol Biol 22:15-25. 2000
    ....
  5. pmc Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism
    Vijaya Karoor
    Cardiovascular Pulmonary Research Laboratory, RC 2 Room 8118, University of Colorado Anschutz Medical Campus, 12700 E 19th Ave, RC 2, Aurora, CO 80045, USA
    Hypertension 61:921-30. 2013
    ..Strategies that increase lung NEP activity/expression or target key downstream effectors, like Src, PTEN, or PDGFR, may be of therapeutic benefit in pulmonary vascular disease...
  6. ncbi request reprint Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern
    Marilee J Wick
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Denver, RC 2, Box B 133, 12700 E 19th Ave, Aurora, CO, 80045, USA
    Transgenic Res 25:773-784. 2016
    ..These studies help to characterize our complex transgenic model of NEP overexpression and further demonstrate NEP's protective effects against plasma extravasation...
  7. ncbi request reprint Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling
    Joseph T Crossno
    Pulmonary and Critical Care Services, Veterans Affairs Medical Center, Denver, USA
    Am J Physiol Lung Cell Mol Physiol 292:L885-97. 2007
    ..However, this agent fails to block the development of PH, apparently because of its inability to repress sustained Rho kinase-mediated arterial vasoconstriction...
  8. pmc Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors
    Vijaya Karoor
    Denver Veterans Affairs Medical Center, University of Colorado Cancer Center, Pulmonary 111A, 1055 Clermont Street, Denver, CO 80220, USA
    Cancer Prev Res (Phila) 3:1141-7. 2010
    ..Further investigation of the chemopreventive effect of vandetanib and other VEGF signaling inhibitors is needed...
  9. pmc Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease
    Marilee J Wick
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Respir Crit Care Med 183:330-40. 2011
    ..Therefore, in humans with smoke- and hypoxia-induced vascular remodeling, as in chronic obstructive pulmonary disease (COPD), pulmonary activity/expression of NEP may likewise be decreased...
  10. ncbi request reprint Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension
    D Case
    Cardiovascular Pulmonary Research Laboratory, Division of Cardiology and Department of Medicine, University of Colorado Health Science Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 292:L154-64. 2007
    ..These results suggest that Gal-1 influences the contractile response to hypoxia and subsequent remodeling during hypoxia-induced PH, which influences disease progression...
  11. ncbi request reprint Divergent contractile and structural responses of the murine protein kinase C-epsilon null pulmonary circulation to chronic hypoxia
    Cassana M Littler
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:620S-621S. 2005
  12. ncbi request reprint Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia
    C M Littler
    Cardiovascular Pulmonary Research Laboratory, B 133, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1083-93. 2005
    ..Blunting of Hx-induced eNOS and iNOS expression may contribute to the increased vascular tone. PKC-epsilon appears to be an important signaling intermediate in the hypoxic regulation of each NOS isoform...
  13. ncbi request reprint Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia
    M Das
    Cardiovascular Pulmonary and Developmental Lung Biology Research Laboratories, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Physiol Lung Cell Mol Physiol 282:L976-86. 2002
    ..We conclude that the bovine PA adventitia comprises numerous phenotypically and biochemically distinct fibroblast subpopulations and that select subpopulations expand in response to chronic hypoxia...
  14. ncbi request reprint Hypoxia-induced pulmonary vascular remodeling: contribution of the adventitial fibroblasts
    K R Stenmark
    Cardiovascular Pulmonary, Developmental Biology Research Laboratories, Denver, USA
    Physiol Res 49:503-17. 2000
    ....
  15. ncbi request reprint Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction
    Cassana M Littler
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Heart Circ Physiol 284:H1321-31. 2003
    ..Instead, the absence of PKC-epsilon allows increased expression of K(V) channels (like Kv3.1b) to occur in PASMC, which likely contributes to decreased HPV...
  16. ncbi request reprint Role of rho in the increased migration of pulmonary artery smooth muscle cells observed in the neprilysin knockout mouse
    Vijaya Karoor
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, CO, USA
    Chest 128:582S-583S. 2005
  17. ncbi request reprint cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration
    D J Klemm
    Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, Denver, Colorado 80220, USA
    J Biol Chem 276:46132-41. 2001
    ..Our data suggest a unique mode of cellular phenotype determination at the level of the nuclear content of CREB...
  18. pmc A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer
    Karen Kelly
    Pulmonary 111A, Denver VA Medical Center, 1055 Clermont Street, Denver, CO 80220, USA
    Cancer Prev Res (Phila) 2:440-9. 2009
    ..Agents advancing to phase III randomized trials should produce greater histologic changes. The addition of alpha tocopherol did not affect toxicity...
  19. ncbi request reprint Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities
    M G Frid
    Developmental Lung Biology Research, University of Colorado Health Sciences Center, Denver 80262, USA
    Circ Res 81:940-52. 1997
    ....
  20. ncbi request reprint Neonatal lung side population cells demonstrate endothelial potential and are altered in response to hyperoxia-induced lung simplification
    D Irwin
    Department of Medicine, Cardiovascular Pulmonary Research Section, University of Colorado Health Sciences Center, Denver, USA
    Am J Physiol Lung Cell Mol Physiol 293:L941-51. 2007
    ..The hyperoxia-induced changes in lung SP cells may limit their ability to effectively contribute to tissue morphogenesis during room air recovery...