Donald B DeFranco

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line
    Madalina Stanciu
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 277:4010-7. 2002
  2. ncbi request reprint Navigating steroid hormone receptors through the nuclear compartment
    Donald B DeFranco
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 16:1449-55. 2002
  3. ncbi request reprint Alternative effects of the ubiquitin-proteasome pathway on glucocorticoid receptor down-regulation and transactivation are mediated by CHIP, an E3 ligase
    Xinjia Wang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 19:1474-82. 2005
  4. ncbi request reprint Opposing roles for ERK1/2 in neuronal oxidative toxicity: distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress
    Yue Luo
    Center for Neuroscience and Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 281:16436-42. 2006
  5. pmc Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death
    Yeung Ho
    Department of Neuroscience, University of Pittsburgh School of Medicine, 7041 BST 3, 3501 Fifth Ave, Pittsburgh, PA 15261, USA
    Mol Pharmacol 74:1141-51. 2008
  6. ncbi request reprint Hypothermia and ERK activation after cardiac arrest
    Brian J D'Cruz
    Department of Emergency Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Brain Res 1064:108-18. 2005
  7. pmc Oxidative neuronal injury. The dark side of ERK1/2
    Charleen T Chu
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Room A 516 UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Eur J Biochem 271:2060-6. 2004
  8. pmc Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats
    Yasuhito Funahashi
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Prostate 75:381-9. 2015
  9. ncbi request reprint Glucocorticoid receptors in hippocampal neurons that do not engage proteasomes escape from hormone-dependent down-regulation but maintain transactivation activity
    Xinjia Wang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 16:1987-98. 2002
  10. pmc Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi
    John Caltagarone
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neuropathol Exp Neurol 69:356-71. 2010

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line
    Madalina Stanciu
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 277:4010-7. 2002
    ..Thus, persistent nuclear retention of activated ERK-1/2 may be a critical factor in eliciting proapoptotic effects in neuronal cells subjected to oxidative stress or proteasome inhibition...
  2. ncbi request reprint Navigating steroid hormone receptors through the nuclear compartment
    Donald B DeFranco
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 16:1449-55. 2002
    ..As highlighted in this review, there may be interrelationships between seemingly distinct pathways of receptor trafficking and processing within the nucleus that impact receptor action at regulated promoters...
  3. ncbi request reprint Alternative effects of the ubiquitin-proteasome pathway on glucocorticoid receptor down-regulation and transactivation are mediated by CHIP, an E3 ligase
    Xinjia Wang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 19:1474-82. 2005
    ..Thus, the divergent response of a single transactivator (i.e. GR) to the UPP can be dictated by CHIP, an E3 ligase that also functions as a proteasome-targeting factor...
  4. ncbi request reprint Opposing roles for ERK1/2 in neuronal oxidative toxicity: distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress
    Yue Luo
    Center for Neuroscience and Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 281:16436-42. 2006
    ..Thus, ERK1/2 appears to play dual roles in HT22 cells acting as part of a cellular adaptive response during the initial phases of glutamate-induced oxidative stress and contributing to toxicity during later stages of stress...
  5. pmc Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death
    Yeung Ho
    Department of Neuroscience, University of Pittsburgh School of Medicine, 7041 BST 3, 3501 Fifth Ave, Pittsburgh, PA 15261, USA
    Mol Pharmacol 74:1141-51. 2008
    ..Thus, the elevation of intracellular zinc within neurons subjected to oxidative stress can trigger a robust positive feedback loop operating through activated ERK1/2 that rapidly sets into motion a zinc-dependent pathway of cell death...
  6. ncbi request reprint Hypothermia and ERK activation after cardiac arrest
    Brian J D'Cruz
    Department of Emergency Medicine, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Brain Res 1064:108-18. 2005
    ..These results suggest that hypothermia-induced improvement in outcomes does not require ERK activation...
  7. pmc Oxidative neuronal injury. The dark side of ERK1/2
    Charleen T Chu
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Room A 516 UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Eur J Biochem 271:2060-6. 2004
    ....
  8. pmc Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats
    Yasuhito Funahashi
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Prostate 75:381-9. 2015
    ..Prostatic inflammation is reportedly associated with the development of prostatic hyperplasia. We investigated the effects of prostatic inflammation on expression levels of androgen-responsive genes and growth factors in the rat prostate...
  9. ncbi request reprint Glucocorticoid receptors in hippocampal neurons that do not engage proteasomes escape from hormone-dependent down-regulation but maintain transactivation activity
    Xinjia Wang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Endocrinol 16:1987-98. 2002
    ..Our results suggest that appropriate maturation of proteasomal degradative or targeting activities may be required, particularly in hippocampal neurons, for hormone-dependent down-regulation of GR...
  10. pmc Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi
    John Caltagarone
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neuropathol Exp Neurol 69:356-71. 2010
    ..These data indicate that these important scaffolding proteins that link various intracellular signaling pathways to the extracellular matrix are modified and have altered subcellular distribution in AD...
  11. ncbi request reprint Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells
    Marjet D Heitzer
    Department of Cell Biology and Physiology and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 66:7326-33. 2006
    ..These data provide the first demonstration of a stromal-specific AR coactivator that has an effect on an androgen-regulated growth factor that is essential for stromal/epithelial cell communication in the prostate...
  12. ncbi request reprint Hic-5/ARA55: a prostate stroma-specific AR coactivator
    Marjet D Heitzer
    Department of Pharmacology, University of Pittsburgh School of Medicine, 200 Lothrop St, Pittsburgh, PA 15261, United States
    Steroids 72:218-20. 2007
    ..Because Hic-5/ARA55's expression is also altered in PCa, it may play a role in the differential cellular signaling events that occur during tumor progression...
  13. ncbi request reprint Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons
    David J Levinthal
    Center for Neuroscience and Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Biol Chem 280:5875-83. 2005
    ..Together, these data implicate the inhibition of endogenous ERK-directed phosphatases as a mechanism that leads to aberrant ERK1/2 activation and nuclear accumulation during oxidative toxicity in neurons...
  14. doi request reprint Reduced glucocorticoid receptor protein expression in children with critical illness
    Justin A Indyk
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Horm Res Paediatr 79:169-78. 2013
    ....
  15. doi request reprint Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase
    Haibiao Gong
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 68:7386-93. 2008
    ..Because glucocorticoids and estrogens are widely prescribed drugs, our results also urge caution in avoiding glucocorticoid-estrogen interactions in patients...
  16. pmc Nongenomic glucocorticoid receptor action regulates gap junction intercellular communication and neural progenitor cell proliferation
    Ranmal Aloka Samarasinghe
    Department of Neuroscience, Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 108:16657-62. 2011
    ....
  17. ncbi request reprint Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation
    Jennifer Guerrero-Santoro
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Cell Biochem 92:810-9. 2004
    ..Thus, as suggested from previous analysis of LIM domain-containing proteins, separate but highly related LIM domains serve distinct functions...
  18. ncbi request reprint Glucocorticoid receptor physiology
    Marjet D Heitzer
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Rev Endocr Metab Disord 8:321-30. 2007
    ....
  19. pmc Altered transcription factor trafficking in oxidatively-stressed neuronal cells
    Vivek P Patel
    Department of Pathology, Division of Neuropathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Biochim Biophys Acta 1822:1773-82. 2012
    ..Oxidative disruption of microtubule-dependent nuclear transport may contribute to selective declines in transcriptional responses of aging or diseased dopaminergic cells...
  20. pmc A local paracrine and endocrine network involving TGFβ, Cox-2, ROS, and estrogen receptor β influences reactive stromal cell regulation of prostate cancer cell motility
    Melanie J Grubisha
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Mol Endocrinol 26:940-54. 2012
    ....
  21. ncbi request reprint Paxillin regulates steroid-triggered meiotic resumption in oocytes by enhancing an all-or-none positive feedback kinase loop
    Melissa Rasar
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8857, USA
    J Biol Chem 281:39455-64. 2006
    ..These experiments reveal a novel and critical function for Paxillin in meiosis and support the notion that Paxillin may be a general modulator of mitogen-activated protein kinase signaling...
  22. pmc Upregulation of androgen-responsive genes and transforming growth factor-β1 cascade genes in a rat model of non-bacterial prostatic inflammation
    Yasuhito Funahashi
    Departments of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Prostate 74:337-45. 2014
    ..Prostatic inflammation is associated with the development of prostatic hyperplasia. We investigated the effects of prostatic inflammation on expression levels of androgen-responsive genes and growth factors in the prostate...
  23. pmc Cooperativity and complementarity: synergies in non-classical and classical glucocorticoid signaling
    Ranmal A Samarasinghe
    Department of Neuroscience, University of Pittsburgh, School of Medicine, and Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Cell Cycle 11:2819-27. 2012
    ..Using NPCs as a cellular model, we speculate on the components of this non-classical pathway and the mechanisms whereby a number of cytoplasmic and nuclear signaling events may be integrated...
  24. pmc Oestrogen upregulates L-type Ca²⁺ channels via oestrogen-receptor- by a regional genomic mechanism in female rabbit hearts
    Xiaoyan Yang
    University of Pittsburgh, Department of Medicine, Cardiovascular Institute, 3550 Terrace Street, Suite S 628 Scaife Hall, Pittsburgh, PA 15261, USA
    J Physiol 590:493-508. 2012
    ..Therefore, E2 upregulates I(Ca,L) by a regional genomic mechanism involving ERα which is a known determinant of sex differences in TdP risk in LQT2...
  25. doi request reprint Coactivators and nuclear receptor transactivation
    Irene M Wolf
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Cell Biochem 104:1580-6. 2008
    ..Genetic analysis in humans and animal models are revealing the important cell and tissue-type specific actions of nuclear receptor coregulators as well and their role in human physiology and disease...
  26. ncbi request reprint Transient phosphatidylinositol 3-kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal-regulated kinase activation
    David J Levinthal
    Center for Neuroscience and Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:11206-13. 2004
    ..The PI3K pathway, therefore, may serve opposing roles during the progression of oxidative stress in neurons, acting at distinct kinetic phases to either promote or limit a slowly developing program of cell death...
  27. ncbi request reprint Small molecule activators of the heat shock response and neuroprotection from stroke
    Donald B DeFranco
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Curr Atheroscler Rep 6:295-300. 2004
    ....
  28. pmc TNF-alpha and glucocorticoid receptor interaction in L6 muscle cells: a cooperative downregulation of myosin heavy chain
    Bassem H Dekelbab
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Steroids 72:705-12. 2007
    ..Thus, the selective perseverance of GR function in the presence of increased levels of glucocorticoids and TNF-alpha during sepsis or other inflammatory states may exacerbate muscle protein breakdown...
  29. pmc Differential subcellular localization of the glucocorticoid receptor in distinct neural stem and progenitor populations of the mouse telencephalon in vivo
    Maria A Tsiarli
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Brain Res 1523:10-27. 2013
    ..5 and primarily occupies the nucleus. Moreover, our study suggests that the subcellular localization of the receptor may be subjected to region and neurodevelopmental stage-specific regulation...
  30. pmc A comparison of Zn2+- and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition
    Michael J Devinney
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cell Calcium 45:447-55. 2009
    ....
  31. ncbi request reprint Regional changes in glial cell line-derived neurotrophic factor after cardiac arrest and hypothermia in rats
    Katherine M Schmidt
    Department of Emergency Medicine, University of Pittsburgh, 230 McKee Place, Suite 400, Pittsburgh, PA 15213, USA
    Neurosci Lett 368:135-9. 2004
    ..These results suggest that temperature after resuscitation produces regionally specific changes of GNDF levels in brain...
  32. pmc Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-Reductase Inhibition in Prostate Epithelial Cells
    Teresa T Liu
    From the Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260
    J Biol Chem 291:14747-60. 2016
    ....
  33. pmc Local endocrine, paracrine and redox signaling networks impact estrogen and androgen crosstalk in the prostate cancer microenvironment
    Melanie J Grubisha
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 3051 Fifth Avenue, Pittsburgh, PA 15260, USA
    Steroids 78:538-41. 2013
    ....
  34. ncbi request reprint Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement
    William B Pratt
    Department of Pharmacology, University of Michigan Medical School, 1301 Med Sci Res Building III, Ann Arbor, MI 48109 0632, USA
    Cell Signal 16:857-72. 2004
    ..We review evidence that dynamic assembly of heterocomplexes with hsp90 is required for movement to these foci and for the dynamic exchange of transcription factors between chromatin and the nucleoplasm...
  35. ncbi request reprint Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein
    Haibing Jiang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hum Mol Genet 12:1-12. 2003
    ..Thus, selected substrates may be directed to the ubiquitin/proteasome-dependent protein degradation pathway in response to polyQ-expanded htt within the nucleus...
  36. ncbi request reprint The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines
    Masaaki Kasai
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 63:4927-35. 2003
    ..e., COOH-terminal LIM domain) and by the dominant-negative activity of its NH(2)-terminal domain. Thus, highly related group 3 LIM domain proteins may use distinct mechanisms to modulate steroid hormone receptor transactivation...
  37. pmc Proteasomal inhibition enhances glucocorticoid receptor transactivation and alters its subnuclear trafficking
    Bonnie J Deroo
    Chromatin and Gene Expression Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Cell Biol 22:4113-23. 2002
    ..Proteasomes may therefore impact steroid receptor action at multiple levels and exert distinct effects on individual receptor types...
  38. ncbi request reprint Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation
    Brian J D'Cruz
    Department of Emergency Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 22:843-51. 2002
    ..Increased activation of BDNF signaling is a possible mechanism by which mild hypothermia is able to reduce the neuronal damage typically occurring after cardiac arrest...
  39. pmc Molecular chaperones function as steroid receptor nuclear mobility factors
    Cem Elbi
    Laboratory of Receptor Biology and Gene Expression, Building 41, Room B602, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 5055, USA
    Proc Natl Acad Sci U S A 101:2876-81. 2004
    ..Thus, our results provide a description of soluble nuclear mobility factors and furthermore demonstrate a previously unrecognized role for molecular chaperones in the regulation of steroid receptor function within the nucleus...
  40. ncbi request reprint Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin
    Haibing Jiang
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurobiol Dis 23:543-51. 2006
    ..CBP overexpression rescued both acetylated histone levels and cell toxicity. These data suggest that CBP dysfunction and altered gene transcription contribute to mutant htt-induced neurotoxicity...
  41. pmc Intracellular zinc release, 12-lipoxygenase activation and MAPK dependent neuronal and oligodendroglial death
    Yumin Zhang
    Department of Anatomy, Physiology and Genetics and Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Mol Med 13:350-5. 2007
    ..In this review, we describe how the activation of 12-lipoxygenase and mitogen-activated protein kinase (MAPK) contribute to the toxicity of liberated zinc to neurons and oligodendrocytes...