J de Vellis
Affiliation: University of California
- The MRRC at the University of California (UCLA), Los Angeles, CAJ de Vellis
Department of Neurobiology, Brain Research Institute, Mental Research Center, UCLA, Los Angeles, CA 90024 1759, USA
Int J Dev Neurosci 20:287-8. 2002
- Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null miceNaibedya Chattopadhyay
Department of Medicine and Membrane Biology Program, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Neurosci Res 86:2159-67. 2008..We conclude that the CaR may be a novel regulator of oligodendroglial development and function...
- Preparation of mixed glial cultures from postnatal rat brainJean de Vellis
Intellectual and Developmental Disabilities Research Center, University of California, Los Angeles, CA, USA
Methods Mol Biol 814:49-59. 2012..The findings have largely been validated and extended in animal models over the last 3 decades. Since this method has been cited in more than 2,500 research papers, the data obtained across laboratories can be compared more readily...
- Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injuryS F Tzeng
Department of Neurobiology, Mental Retardation Research Center, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
J Neurosci Res 66:1161-72. 2001..In conclusion, Id genes are upregulated in a time-dependent manner in astrocytes, oligodendrocytes, and neural progenitor subpopulations after SCI, suggesting that they play major roles in cellular responses following SCI...
- Culture system for rodent and human oligodendrocyte specification, lineage progression, and maturationAraceli Espinosa-Jeffrey
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Curr Protoc Stem Cell Biol . 2009....
- Voluntary exercise increases oligodendrogenesis in spinal cordW Krityakiarana
Intellectual and Developmental Disability Research Center, Semel Institute for Neuroscience and Human Behavior Department of Neurobiology, David Geffen, School of Medicine at UCLA, Los Angeles, California 90095, USA
Int J Neurosci 120:280-90. 2010..These results suggest that voluntary exercise positively influences oligodendrogenesis in the intact spinal cord, emphasizing the beneficial effects of voluntary exercise as a possible co-treatment for spinal cord injury...
- Transferrin is an early marker of hepatic differentiation, and its expression correlates with the postnatal development of oligodendrocytes in miceR Cassia
Department of Neurobiology, University of California, Los Angeles, USA
J Neurosci Res 50:421-32. 1997..The expression of the reporter gene during development was analyzed...
- Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cellsM A Kahn
Department of Neurobiology, UCLA School of Medicine, USA
Glia 26:153-65. 1999..These data will support an in vivo NT-3-dependent mechanism for the normal development of CNS glial cells...
- Combination of growth factors enhances remyelination in a cuprizone-induced demyelination mouse modelShalini Kumar
Department of Neurobiology, Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, 635 Charles E Young Drive South, Los Angeles, CA 90095 7332, USA
Neurochem Res 32:783-97. 2007..Remyelination in response to GF was confirmed by electron microscopy. In conclusion, this combination of GF is a promising tool to consider for remyelination strategies...
- Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpressionA Espinosa-Jeffrey
IDDRCsp, Semel Institute for Neuroscience, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Neurosci Res 88:1682-94. 2010..When the interventions were administered prior to hindlimb paralysis, He4e mice were able to walk up to 1 year of age without paralysis...
- The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowthC A Ghiani
Mental Retardation Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 7332, USA
Mol Psychiatry 15:115, 204-15. 2010....
- Transferrin regulates transcription of the MBP gene and its action synergizes with IGF-1 to enhance myelinogenesis in the md ratA Espinosa-Jeffrey
Mental Retardation Research Center, Neuropsychiatric Institute, UCLA, Los Angeles, Calif 90024 1759, USA
Dev Neurosci 24:227-41. 2002..Thus, transferrin selectively regulates MBP at the transcriptional level and together with IGF-1 synergizes to increase both the maturation and myelinogenic properties of md and normal OL...
- Remyelination of the adult demyelinated mouse brain by grafted oligodendrocyte progenitors and the effect of B-104 cograftsA Espinosa de los Monteros
Mental Retardation Research Center, Neuropsychiatric Institute, Departments of Neurobiology and Psychiatry, UCLA School of Medicine, Los Angeles, CA, USA
Neurochem Res 26:673-82. 2001..Those grafted with progenitor CG4 cells or cografts displayed a clear increase in remyelination. This data provides a new direction for the development of cell replacement therapies in demyelinating diseases...
- Thioredoxin peroxidase (natural killer enhancing factor) regulation of activator protein-1 function in endothelial cellsH Shau
Division of Surgical Oncology, UCLA School of Medicine 90095, USA
Biochem Biophys Res Commun 249:683-6. 1998..These results are consistent with the role of TxP-1 as an antioxidant and the previous reports that TNF-induced reactive oxygen species were responsible for AP-1 activation...
- Dietary iron and the integrity of the developing rat brain: a study with the artificially-reared rat pupA E de los Monteros
Mental Retardation Research Center, Neuropsychiatry Institute, UCLA School of Medicine, Los Angeles, CA 90095 1759, USA
Cell Mol Biol (Noisy-le-grand) 46:501-15. 2000..However, the iron status profoundly influences the development of myelination in that the process is delayed in iron deficiency...
- In vitro injury model for oligodendrocytes: development, injury, and recoveryA E de los Monteros
Mental Retardation Research Center, Neuropsychiatric Institute, Department of Neurobiology UCLA School of Medicine, 760 Westwood Plaza, Room 78 177 NPI, Los Angeles, CA 90095 1759, USA
Microsc Res Tech 52:719-30. 2001..Moreover both, serum and cryoinjury induced the expression of HSP-60 that colocalized with OL and myelin markers. The expression of GFAP by injured cells but not by normal cells corroborated the state of injury of CG4 cells...
- Pituitary adenylyl cyclase-activating polypeptide stimulates DNA synthesis but delays maturation of oligodendrocyte progenitorsM Lee
Departments of Neurobiology and Psychiatry and Mental Retardation Research Center, University of California, Los Angeles, Los Angeles, California 90024-1759, USA
J Neurosci 21:3849-59. 2001..These findings indicate that PACAP may act at two stages during OL development to (1) stimulate proliferation and (2) delay maturation and/or myelinogenesis...
- Stem/progenitor cells in the postnatal inner ear of the GFP-nestin transgenic mouseIvan A Lopez
Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, 1000 Veteran Avenue, David Geffen School of Medicine, Los Angeles, CA 90095, USA
Int J Dev Neurosci 22:205-13. 2004....
- Selective specification of CNS stem cells into oligodendroglial or neuronal cell lineage: cell culture and transplant studiesAraceli Espinosa-Jeffrey
UCLA Mental Retardation Research Center and Department of Neurobiology, Los Angeles, California 90095 1759, USA
J Neurosci Res 69:810-25. 2002..As expected, NSCs are capable of giving rise to astrocytes in a medium favoring this phenotype...
- Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan diseaseShalini Kumar
Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
J Neurosci Res 87:3415-27. 2009..We also report an early expression of full-length ASPA mRNA in normal mouse brain at embryonic day 12.5, when OL progenitors first appear during development. These findings support involvement of ASPA in CNS development and function...
- Activation, proliferation and commitment of endogenous stem/progenitor cells to the oligodendrocyte lineage by TS1 in a rat model of dysmyelinationAraceli Espinosa-Jeffrey
Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior and Department of Neurobiology, University of California, Los Angeles, 90095 7332, USA
Dev Neurosci 28:488-98. 2006..This strategy offers for the first time the possibility of myelin restoration to treat myelin disorders...
- CD133+ neural stem cells in the ependyma of mammalian postnatal forebrainVolkan Coskun
Mental Retardation Research Center and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 105:1026-31. 2008..Collectively, our data indicate that, compared with GFAP expressing adult neural stem cells, CD133(+) ependymal cells represent an additional-perhaps more quiescent-stem cell population in the mammalian forebrain...
- A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesisFei He
Department of Molecular and Medical Pharmacology, Neuropsychiatric Institute, University of California Los Angeles, Los Angeles, California 90024, USA
Nat Neurosci 8:616-25. 2005..These observations suggest that autoregulation of the Jak-STAT pathway controls the onset of astrogliogenesis...
- Canavan disease: a white matter disorderShalini Kumar
Department of Neurobiology, Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095 7332, USA
Ment Retard Dev Disabil Res Rev 12:157-65. 2006....
- Does ASPA gene mutation in Canavan disease alter oligodendrocyte development? A tissue culture study of ASPA KO mice brainShalini Kumar
Mental Retardation Research Center, Department of Neurobiology and Psychiatry, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, USA
Adv Exp Med Biol 576:175-82; discussion 361-3. 2006
- Activation of inflammatory response by a combination of growth factors in cuprizone-induced demyelinated brain leads to myelin repairJuan Carlos Biancotti
Mental Retardation Research Center, Semel Institute for Neuroscience, David Geffen School of Medicine, University of California, 635 Charles E Young Drive South, Room 379, Los Angeles, CA 90095, USA
Neurochem Res 33:2615-28. 2008....
- Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptorsCristina A Ghiani
Mental Retardation Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behaviour, Department of Neurobiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Neurochem Res 32:363-76. 2007....
- Calcium modulates dopamine potentiation of N-methyl-D-aspartate responses: electrophysiological and imaging evidenceJ C Liu
Mental Retardation Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
J Neurosci Res 76:315-22. 2004..The existence of multiple mechanisms leading to a similar outcome allows a certain degree of redundancy in the consequences of DA modulation...
- Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathyJustin Zaghi
Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital Research Center, Los Angeles, CA 90095 7358, USA
Acta Neuropathol 117:111-24. 2009..In conclusion, in patients with AD, macrophages appear to shuttle Abeta from neurons to vessels where their apoptosis may release fibrillar Abeta, contributing to cerebral amyloid angiopathy...
- Mitochondrial transport in processes of cortical neurons is independent of intracellular calciumLuis Beltran-Parrazal
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Am J Physiol Cell Physiol 291:C1193-7. 2006....
- Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growthCristina A Ghiani
Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Neurobiology and Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Glia 55:966-75. 2007..Overall, these results show that exercise promotes a permissive cellular environment for axonal growth in the adult spinal cord requiring BDNF action...
- In vivo and in vitro localization of brain-derived neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organsRicardo Cristobal
Victor Goodhill Ear Center, Division of Head and Neck Surgery, University of California, Los Angeles School of Medicine, CHS, Room 62 129, 10833 Le Conte Ave, Los Angeles, CA 90095 1624, USA
Brain Res Mol Brain Res 102:83-99. 2002..The findings suggest that BDNF has a role in the maintenance of the vestibular epithelia while FGF-2 may regulate the proliferation of supporting cells...
- Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical cultureCristina A Ghiani
Mental Retardation Research Center, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
J Neurochem 97:35-43. 2006..Nicotine effects on immature cortical neurons perhaps do not require gene regulation but may be still acting on signalling pathways...
- Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell lineChang J Huang
Neuropsychiatric Institute, Mental Retardation Research Center, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA, USA
Int J Dev Neurosci 20:289-96. 2002....
- Myelination and motor coordination are increased in transferrin transgenic miceMaria Carla Saleh
Unité d Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France
J Neurosci Res 72:587-94. 2003..Our findings indicate that, besides its known iron transport function, Tf is able to influence myelination process and induce behavioral improvements in mice...
- Notch1 and Numb genes are inversely expressed as oligodendrocytes differentiateMaria I Givogri
Laboratory for Gene Therapy of Neurodegenerative Disorders, San Raffaele Telethon Institute for Gene Therapy, Milano, Italy
Dev Neurosci 25:50-64. 2003..In vitro, Numb expression showed to be inversely correlated to that of Notch1, with higher levels of Numb proteins in mature OLs, in association with myelin-like membranes...
- Expression of heat shock protein (HSP)-25 and HSP-32 in the rat spinal cord reconstructed with NeurogelStéphane Woerly
Organogel Canada Ltee, 1400 Parc Technologique Blvd, GIP 4R7, Quebec, Quebec, Canada
Neurochem Res 30:721-35. 2005..In conclusion, Neurogel reconstruction of the spine during the acute phase considerably reduces secondary damage resulting in a rapid and stable regenerative response...
- Notch signaling in astrocytes and neuroblasts of the adult subventricular zone in health and after cortical injuryMaria I Givogri
Laboratory for Gene Therapy of Neurodegenerative Disorders, San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Dev Neurosci 28:81-91. 2006..Finally, using a model of cortical stab wound, we show that the astrogliogenic response of the SVZ to injury is accompanied by activation of the Notch pathway...
- Loss of arginase I results in increased proliferation of neural stem cellsSara G Becker-Catania
Edward Hines Jr Veterans Administration Hospital, Hines, Illinois, USA
J Neurosci Res 84:735-46. 2006..The consequence of these changes may contribute to the differential phenotypes of KO vs. WT cells. It appears that AI may play an important and unanticipated role in growth and development of NSCs...
- Microglia in health and diseaseSeung U Kim
Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada
J Neurosci Res 81:302-13. 2005..It is thus timely to review current status of knowledge on biology and immunology of microglia, and consider new directions of investigation on microglia in health and disease...
- Prevention of gliotic scar formation by NeuroGel allows partial endogenous repair of transected cat spinal cordStéphane Woerly
Organogel Canada Ltee, Sainte Foy, Quebec, Canada
J Neurosci Res 75:262-72. 2004..We conclude that NeuroGel lead to functional recovery by providing a favorable substrate for regeneration of transected spinal cord, reducing glial scar formation and allowing angiogenesis...
- Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptorsP A Ferchmin
Center for Molecular and Behavioral Neuroscience, Universidad Central del Caribe, Bayamon, Puerto Rico
J Neurosci Res 82:631-41. 2005..In conclusion, these findings demonstrate that there are two different nicotinic neuroprotective mechanisms mediated by alpha4beta2...
- Growth factor-dependent actions of PACAP on oligodendrocyte progenitor proliferationVincent Lelievre
David Geffen School of Medicine, Department of Psychiatry, Semel Institute for Neuroscience and Mental Retardation Research Center, University of California, Los Angeles 90095, USA
Regul Pept 137:58-66. 2006..These studies reveal complex in vitro interactions of PACAP with other factors involved in OLP development...
- Preface: white matter disordersVittorio Gallo
Center for Neuroscience Research and MRDDRC, Children s National Medical Center, Washington, District of Columbia 200100 2970, USA
Ment Retard Dev Disabil Res Rev 12:83-4. 2006
- MOLECULAR ASPECTS OF MENTAL RETARDATIONJean de Vellis; Fiscal Year: 2006..This grant will facilitate the research training of pre- and post-doctoral fellows who wish to direct their career goals in research in mental retardation and developmental disabilities. ..
- MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIESJean de Vellis; Fiscal Year: 2008..They will assume positions in medical schools, in research institutes and hospitals, and in traditional academic departments. ..