Paul A Dayton

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Molecular ultrasound imaging using microbubble contrast agents
    Paul A Dayton
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Front Biosci 12:5124-42. 2007
  2. ncbi request reprint The magnitude of radiation force on ultrasound contrast agents
    Paul A Dayton
    Department of Biomedical Engineering, University of California, Davis 95616, USA
    J Acoust Soc Am 112:2183-92. 2002
  3. pmc Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy
    Paul A Dayton
    University of California, Davis, CA, USA
    Mol Imaging 5:160-74. 2006
  4. pmc Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells
    Paul A Dayton
    Department of Biomedical Engineering, UC Davis, CA 95616, USA
    Mol Imaging 3:125-34. 2004
  5. doi request reprint Imaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents
    Susanne M Stieger
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, USA
    Contrast Media Mol Imaging 3:9-18. 2008
  6. ncbi request reprint Targeted imaging using ultrasound contrast agents. Progess and opportunities for clinical and research applications
    Susannah H Bloch
    Department of Biomedical Engineering, University of California, Davis 95616, USA
    IEEE Eng Med Biol Mag 23:18-29. 2004
  7. pmc Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction
    Mark A Borden
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:1992-2002. 2005
  8. pmc Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging
    Esra Talu
    Department of Chemical Engineering, University of California, Davis, USA
    Mol Imaging 6:384-92. 2007
  9. pmc Flow-focusing regimes for accelerated production of monodisperse drug-loadable microbubbles toward clinical-scale applications
    Roger Shih
    Department of Biomedical Engineering, University of California Irvine, 3406 Engineering Hall, Irvine, CA 92697, USA
    Lab Chip 13:4816-26. 2013
  10. pmc On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging
    Kanaka Hettiarachchi
    Department of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697, USA
    Lab Chip 7:463-8. 2007

Research Grants

  1. TARGETED ULTRASOUND IMAGING OF TUMORS
    Paul Dayton; Fiscal Year: 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Molecular ultrasound imaging using microbubble contrast agents
    Paul A Dayton
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Front Biosci 12:5124-42. 2007
    ..Due to the widespread availability of ultrasound and ease of use, molecular ultrasound imaging is likely to emerge as a powerful diagnostic technique...
  2. ncbi request reprint The magnitude of radiation force on ultrasound contrast agents
    Paul A Dayton
    Department of Biomedical Engineering, University of California, Davis 95616, USA
    J Acoust Soc Am 112:2183-92. 2002
    ..5 m/s. Therefore, radiation force should be considered during an ultrasonic examination because of the possibility of influencing the position and flow velocity of the contrast agents with the interrogating acoustic beam...
  3. pmc Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy
    Paul A Dayton
    University of California, Davis, CA, USA
    Mol Imaging 5:160-74. 2006
    ..In a flowing system, acoustic manipulation of targeted droplets increases droplet retention. Additionally, we demonstrate the feasibility of US-enhanced particle internalization and therapeutic delivery...
  4. pmc Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells
    Paul A Dayton
    Department of Biomedical Engineering, UC Davis, CA 95616, USA
    Mol Imaging 3:125-34. 2004
    ....
  5. doi request reprint Imaging of angiogenesis using Cadence contrast pulse sequencing and targeted contrast agents
    Susanne M Stieger
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California, USA
    Contrast Media Mol Imaging 3:9-18. 2008
    ..The aim of this study was to evaluate the potential of a low-power multipulse imaging sequence, Cadence(TM) contrast pulse sequencing (CPS), combined with targeted contrast agents to quantify angiogenesis...
  6. ncbi request reprint Targeted imaging using ultrasound contrast agents. Progess and opportunities for clinical and research applications
    Susannah H Bloch
    Department of Biomedical Engineering, University of California, Davis 95616, USA
    IEEE Eng Med Biol Mag 23:18-29. 2004
  7. pmc Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction
    Mark A Borden
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:1992-2002. 2005
    ..We briefly discuss the implications of these results for therapeutic and diagnostic applications involving lipid-coated microbubbles as ultrasound contrast agents and drug/gene delivery vehicles...
  8. pmc Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging
    Esra Talu
    Department of Chemical Engineering, University of California, Davis, USA
    Mol Imaging 6:384-92. 2007
    ..The production of a functionalized, lipid-encapsulated, microbubble contrast agent with a monodisperse population is demonstrated, and we evaluate parameters that influence the size distribution and demonstrate initial acoustic testing...
  9. pmc Flow-focusing regimes for accelerated production of monodisperse drug-loadable microbubbles toward clinical-scale applications
    Roger Shih
    Department of Biomedical Engineering, University of California Irvine, 3406 Engineering Hall, Irvine, CA 92697, USA
    Lab Chip 13:4816-26. 2013
    ..This analysis and characterization of high-speed dual-layer bubble generation will enable more-predictive production control, at rates practical for in vivo or clinical use. ..
  10. pmc On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging
    Kanaka Hettiarachchi
    Department of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697, USA
    Lab Chip 7:463-8. 2007
    ....
  11. ncbi request reprint A method for radiation-force localized drug delivery using gas-filled lipospheres
    Michaelann J Shortencarier
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:822-31. 2004
    ..We also demonstrate dye transfer from flowing AALs, both in a mimetic vessel and in excised rat cecum. We believe that this method could be successfully used for drug delivery in vivo...
  12. pmc Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating
    Linsey C Phillips
    Department of Biomedical Engineering, University of North Carolina at Chapel Hill, 109 Mason Farm Road, 304 Taylor Hall, CB 7575, Chapel Hill, North Carolina 27599, USA
    J Acoust Soc Am 134:1473-82. 2013
    ..This perfluorocarbon nanodroplet has the potential to reduce the time to ablate tumors by one-third during focused ultrasound surgery while also safely enhancing thermal deposition at the target site. ..
  13. pmc A stimulus-responsive contrast agent for ultrasound molecular imaging
    Mark A Borden
    Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Biomaterials 29:597-606. 2008
    ..These results show, for the first time, the molecular mechanism for reduced immunogenicity for the buried-ligand architecture and feasibility of targeting with this motif using a physiological ligand-receptor pair...
  14. ncbi request reprint Ultrasound-driven microbubble oscillation and translation within small phantom vessels
    Hairong Zheng
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Ultrasound Med Biol 33:1978-87. 2007
    ..This study has implications for contrast-assisted ultrasound applications, aiding the manipulation of targeted microbubbles and for further theoretical understanding of the complex bubble dynamics within constrained vessel...
  15. ncbi request reprint Direct observations of ultrasound microbubble contrast agent interaction with the microvessel wall
    Charles F Caskey
    Biomedical Engineering, University of California, Davis, Davis, California 95616, USA
    J Acoust Soc Am 122:1191-200. 2007
    ..Also, contact with the endothelium was observed during asymmetrical collapse, not during expansion. These results will be used to improve the design of drug delivery techniques using microbubbles...
  16. pmc Maintaining monodispersity in a microbubble population formed by flow-focusing
    Esra Talu
    Department of Chemical Engineering and Materials Science, University of California, Davis, Davis, California 95616, USA
    Langmuir 24:1745-9. 2008
    ..These long-lived mondisperse microbubbles should be of interest in ultrasound contrast agents, microfabrication, food, and research applications...
  17. pmc Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy
    Kanaka Hettiarachchi
    Department of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697, USA
    Biotechnol Prog 25:938-45. 2009
    ..Preliminary acoustic studies of these monodisperse gas lipospheres reveal a highly uniform echo correlation of greater than 95%. The potential exists for localized drug concentration and release with ultrasound energy...
  18. pmc Ultrasound radiation force modulates ligand availability on targeted contrast agents
    Mark A Borden
    University of California, Davis, CA, USA
    Mol Imaging 5:139-47. 2006
    ..This technique can be combined with any ligand-receptor pair to optimize targeted adhesion for ultrasonic molecular imaging...
  19. pmc Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles
    Aaron F H Lum
    University of California Davis, Department of Biomedical Engineering, 451 East Health Sciences Drive, Davis, CA 95616, USA
    J Control Release 111:128-34. 2006
    ..This versatile method of delivery is shown to enable targeted deposition of nanoparticles in shear flow and could be modified to carry therapeutic agents for controlled release in targeted delivery applications...
  20. pmc Radiation-force assisted targeting facilitates ultrasonic molecular imaging
    Shukui Zhao
    Department of Biomedical Engineering, University of California Davis, USA
    Mol Imaging 3:135-48. 2004
    ....
  21. pmc Observation of contrast agent response to chirp insonation with a simultaneous optical-acoustical system
    Yang Sun
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 53:1130-7. 2006
    ..1 micros for increasing and decreasing chirp insonation, respectively (P = 0.02). The mean power in the low-frequency portion of the echoes was 8 (mV)2 and 13 (mV)2 for increasing and decreasing chirp insonation, respectively (P = 0.01)...
  22. pmc Microbubble tunneling in gel phantoms
    Charles F Caskey
    Department of Biomedical Engineering, University of California, Davis, 451 East Health Sciences Drive, Davis, California 95616, USA
    J Acoust Soc Am 125:EL183-9. 2009
    ..Combinations of ultrasonic parameters and microbubble concentrations that are relevant for diagnostic imaging and drug delivery and that lead to tunnel formation were applied and the resulting tunnel formation was quantified...
  23. ncbi request reprint Lateral phase separation in lipid-coated microbubbles
    Mark A Borden
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Langmuir 22:4291-7. 2006
    ..The overall high variation in microstructure, including the existence of anomalous three-phase coexistence, highlights the nonequilibrium (history-dependent) nature of the monolayer shell...
  24. pmc Needle size and injection rate impact microbubble contrast agent population
    Esra Talu
    Department of Chemical Engineering and Materials Science, Davis, CA, USA
    Ultrasound Med Biol 34:1182-5. 2008
    ..Our results indicate that the concentration and size distribution of microbubbles can be substantially altered in cases of rapid injection through small-gauge needles...
  25. pmc Acoustically-active microbubbles conjugated to liposomes: characterization of a proposed drug delivery vehicle
    Azadeh Kheirolomoom
    University of California, Davis, Department of Biomedical Engineering, Davis, CA 95616, USA
    J Control Release 118:275-84. 2007
    ....
  26. pmc High-speed, clinical-scale microfluidic generation of stable phase-change droplets for gas embolotherapy
    David Bardin
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    Lab Chip 11:3990-8. 2011
    ....
  27. ncbi request reprint Acoustic signatures of submicron contrast agents
    Divia N Patel
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:293-301. 2004
    ..With the experience gained in these studies, we hope to advance the development of multi-pulse or shaped-pulse techniques that are optimized for specific clinical applications...
  28. pmc High-frequency dynamics of ultrasound contrast agents
    Yang Sun
    UC Davis, Davis, CA 95616, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:1981-91. 2005
    ....
  29. pmc Ultrasound assessment of angiogenesis in a matrigel model in rats
    Susanne M Stieger
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Ultrasound Med Biol 32:673-81. 2006
    ..Ultrasound measurements of blood flow in the plugs correlated with MVD, a histologic technique used to quantify tumor angiogenesis...
  30. pmc Optical tracking of acoustic radiation force impulse-induced dynamics in a tissue-mimicking phantom
    Richard R Bouchard
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    J Acoust Soc Am 126:2733-45. 2009
    ..This tracking method provides high-frame-rate, two-dimensional tracking data and thus could prove useful in the investigation of complex ARFI-induced dynamics in controlled experimental settings...
  31. pmc Motion corrected cadence CPS ultrasound for quantifying response to vasoactive drugs in a rat kidney model
    Rachel E Pollard
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Urology 74:675-81. 2009
    ..To establish the ability of contrast-enhanced motion corrected cadence pulse sequencing (CPS) to detect changes in renal blood flow induced by vasoactive substances in rats...
  32. ncbi request reprint Effect of coupled oscillations on microbubble behavior
    John S Allen
    Department of Biomedical Engineering, University of California at Davis, One Shields Avenue, Davis, California 95616 5294, USA
    J Acoust Soc Am 114:1678-90. 2003
    ..5- and 2.2-micron radius agents at 10- and 500-micron distances under the same acoustic forcing conditions. These coupling effects on the radiated pressure and its spectral power are highlighted for contrast agent imaging applications...
  33. ncbi request reprint Targeted imaging using ultrasound
    Paul A Dayton
    Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA
    J Magn Reson Imaging 16:362-77. 2002
    ..The purpose of this review is to summarize the requirements, challenges, current progress, and future directions of targeted imaging with ultrasound...
  34. pmc Versatile horizontal force probe for mechanical tests on pipette-held cells, particles, and membrane capsules
    Chawin Ounkomol
    Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA
    Biophys J 96:1218-31. 2009
    ....
  35. pmc Long-term stability by lipid coating monodisperse microbubbles formed by a flow-focusing device
    Esra Talu
    Department of Chemical Engineering and Materials Science and Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Langmuir 22:9487-90. 2006
    ..Microbubbles coated with lipid and PEG emulsifier in a viscous solution were found to contain an extremely narrow size distribution (diameter(av) = 51 microm, standard deviation = 4 microm), which was maintained for up to several months...
  36. pmc Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets
    Cherry C Chen
    Department of Biomedical Engineering, Columbia University, New York 10027, NY, USA
    J Control Release 172:795-804. 2013
    ..Our results offered a new means of developing the FUS-induced BBB opening technology for potential extravascular targeted drug delivery in the brain, extending the potential drug delivery region beyond the cerebral vasculature. ..
  37. pmc Acoustic response from adherent targeted contrast agents
    Shukui Zhao
    J Acoust Soc Am 120:EL63-9. 2006
    ..0003). Mechanisms for the observed acoustical difference and potential techniques to utilize these differences for molecular imaging are proposed...
  38. pmc Maxwell rheological model for lipid-shelled ultrasound microbubble contrast agents
    Alexander A Doinikov
    Institute of Nuclear Problems, Belarus State University, 11 Bobruiskaya Street, Minsk 220050, Belarus
    J Acoust Soc Am 121:3331-40. 2007
    ..It is shown that the Maxwell shell model possesses specific physical features that are unavailable in the two other models...

Research Grants1

  1. TARGETED ULTRASOUND IMAGING OF TUMORS
    Paul Dayton; Fiscal Year: 2004
    ..Finally, the effect of contrast agent localization due to acoustic radiation force will be studied on targeting efficiency. ..