Mark Day

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Repression of androgen receptor transcription through the E2F1/DNMT1 axis
    Conrad David Valdez
    Department of Urology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e25187. 2011
  2. ncbi request reprint Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway
    M L Day
    Department of Surgery, Division of Urology, and the University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:8125-8. 1997
  3. ncbi request reprint E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway
    M L Day
    Department of Surgery, Section of Urology, University of Michigan and the University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:9656-64. 1999
  4. ncbi request reprint The convergence of hormone regulation and cell cycle in prostate physiology and prostate tumorigenesis
    Joanne N Davis
    Department of Urology, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0944, USA
    Mol Biotechnol 22:129-38. 2002
  5. ncbi request reprint Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway
    Michael T McCabe
    Department of Urology, Michigan Urology Center, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Cancer Res 65:3624-32. 2005
  6. pmc pRb-Independent growth arrest and transcriptional regulation of E2F target genes
    Michael T McCabe
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 0944, USA
    Neoplasia 7:141-51. 2005
  7. ncbi request reprint 5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer
    Christoph S Zorn
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Clin Cancer Res 13:2136-43. 2007
  8. ncbi request reprint Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer
    Joanne N Davis
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 66:11897-906. 2006
  9. ncbi request reprint Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer
    Michael T McCabe
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Cancer Res 66:385-92. 2006
  10. ncbi request reprint Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells
    Joanne N Davis
    Department of Urology, Michigan Urology Center, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Cancer Res 65:3633-42. 2005

Collaborators

  • Joanne N Davis
  • C T Powell
  • C G Kleer
  • Kenneth Pienta
  • Martin Sanda
  • Gerald Cunha
  • Mark A Rubin
  • Michael T McCabe
  • Rainer Kuefer
  • Jonathan Rios-Doria
  • Kathleen C Day
  • Kirk J Wojno
  • Christoph S Zorn
  • Arul M Chinnaiyan
  • Conrad David Valdez
  • Simon W Hayward
  • Neali Lucas
  • Abdo J Najy
  • Lesa A Begley
  • Juergen E Gschwend
  • Matthias D Hofer
  • Yuzhuo Wang
  • David G Johnson
  • Tristan L Layfield
  • Thomas R Berton
  • Hana M Odeh
  • Craig S Cousineau
  • James W MacDonald
  • Jill A Macoska
  • Michael S Sabel
  • Michael J Imperiale
  • Jonathan A Low
  • Sooryanarayana Varambally
  • Stephanie Daignault
  • Odinaka J Azih
  • Stephen P Ethier
  • Michael G Rashid
  • Thomas Ried
  • Mark A KuKuruga
  • Marion Von Geldern
  • Xin Zhao
  • John Phillips

Detail Information

Publications20

  1. pmc Repression of androgen receptor transcription through the E2F1/DNMT1 axis
    Conrad David Valdez
    Department of Urology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e25187. 2011
    ..Taken together, our results suggest that DNMT1 operates either as a functional intermediary or in cooperation with E2F1 inhibiting AR gene expression in a methylation independent manner...
  2. ncbi request reprint Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway
    M L Day
    Department of Surgery, Division of Urology, and the University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:8125-8. 1997
    ..We present evidence that the Rb-dependent apoptotic pathway functions in vivo in the apoptosis of the prostate glandular epithelium following castration...
  3. ncbi request reprint E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway
    M L Day
    Department of Surgery, Section of Urology, University of Michigan and the University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 274:9656-64. 1999
    ..These data also indicate that Rb can initiate a fatal growth signal conflict in non-aggregated, cycling cells when the protein is hypophosphorylated as these epithelial cells enter S phase...
  4. ncbi request reprint The convergence of hormone regulation and cell cycle in prostate physiology and prostate tumorigenesis
    Joanne N Davis
    Department of Urology, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0944, USA
    Mol Biotechnol 22:129-38. 2002
    ..This article is then intended to summarize the functional convergence of androgen regulation and cell cycle in normal prostate physiology and prostate tumorigenesis...
  5. ncbi request reprint Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway
    Michael T McCabe
    Department of Urology, Michigan Urology Center, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Cancer Res 65:3624-32. 2005
    ..These findings show a link between inactivation of the pRb pathway and induction of DNA hypermethylation of CpG island-containing genes in tumorigenesis...
  6. pmc pRb-Independent growth arrest and transcriptional regulation of E2F target genes
    Michael T McCabe
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 0944, USA
    Neoplasia 7:141-51. 2005
    ..These findings demonstrate that pRb is not strictly required for the vast majority of transcriptional alterations associated with growth arrest...
  7. ncbi request reprint 5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer
    Christoph S Zorn
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Clin Cancer Res 13:2136-43. 2007
    ..The purpose of this study was to determine the effect of 5-aza on preexisting TRAMP prostate cancers and prevention of androgen-independent prostate cancer...
  8. ncbi request reprint Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer
    Joanne N Davis
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 66:11897-906. 2006
    ..Taken together, these results show that elevated E2F1, through its ability to repress AR transcription, may contribute to the progression of hormone-independent prostate cancer...
  9. ncbi request reprint Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer
    Michael T McCabe
    Department of Urology, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Cancer Res 66:385-92. 2006
    ..Taken together, these data suggest that Dnmt1 is rapidly activated by pRb pathway inactivation, and that DNA methyltransferase activity is required for malignant transformation and tumorigenesis...
  10. ncbi request reprint Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells
    Joanne N Davis
    Department of Urology, Michigan Urology Center, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Cancer Res 65:3633-42. 2005
    ..This study reports a novel finding describing that deregulation of the Rb/E2F complex results in increased COX-2 expression and activity...
  11. ncbi request reprint The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells
    Jonathan Rios-Doria
    Department of Urology, University of Michigan, Ann Arbor 48109, USA
    J Biol Chem 278:1372-9. 2003
    ..These findings demonstrate a novel mechanism by which E-cadherin is functionally inactivated through calpain-mediated proteolysis and suggests that E-cadherin is targeted by calpain during the tumorigenic progression of prostate cancer...
  12. doi request reprint The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression
    Neali Lucas
    Department of Urology, University of Michigan, Ann Arbor, MI 48109 5944, USA
    J Cell Biochem 106:967-74. 2009
    ..Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression...
  13. doi request reprint ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction
    Abdo J Najy
    Department of Urology, Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109 0944, USA
    Cancer Res 68:1092-9. 2008
    ..Taken together, these data strongly support a functional role for ADAM15 in prostate tumor cell interaction with vascular endothelium and the metastatic progression of human prostate cancer...
  14. ncbi request reprint CXCL12 activates a robust transcriptional response in human prostate epithelial cells
    Lesa A Begley
    Department of Urology and the Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center zDrive, Ann Arbor, MI 48109, USA
    J Biol Chem 282:26767-74. 2007
    ..Thus, CXCL12 may play a major role in the etiology of benign proliferative disease in the context of an aging tissue microenvironment...
  15. ncbi request reprint Truncated E-cadherin potentiates cell death in prostate epithelial cells
    Jonathan Rios-Doria
    Department of Urology, University of Michigan, Ann Arbor, Michigan, USA
    Prostate 63:259-68. 2005
    ..We postulated that the E-cad(100) fragment may play a role in abrogating survival of LNCaP cells following induction of apoptosis...
  16. pmc ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease
    Rainer Kuefer
    Department of Urology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 0944, USA
    Neoplasia 8:319-29. 2006
    ..These results suggest that ADAM15 is generally overexpressed in adenocarcinoma and is highly associated with metastatic progression of prostate and breast cancers...
  17. ncbi request reprint The role of an 80 kDa fragment of E-cadherin in the metastatic progression of prostate cancer
    Rainer Kuefer
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0944, USA
    Clin Cancer Res 9:6447-52. 2003
    ..The purpose of this study was to evaluate an 80 kDa proteolytic fragment of E-cadherin as a potential biomarker for prostate cancer progression and to identify putative proteases that are responsible for the cleavage of E-cadherin...
  18. ncbi request reprint Cleavage of beta-catenin by calpain in prostate and mammary tumor cells
    Jonathan Rios-Doria
    Cellular and Molecular Biology Graduate Program, Department of Urology, Michigan Urology Center, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 64:7237-40. 2004
    ....
  19. ncbi request reprint Rescue and isolation of Rb-deficient prostate epithelium by tissue recombination
    Simon W Hayward
    Department of Urologic Surgery, Department of Cancer Biology, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Methods Mol Biol 218:17-33. 2003
    ....
  20. ncbi request reprint Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis
    Kathleen C Day
    Department of Urology, Flow Cytometry Core, University of Michigan Comprehensive Cancer Center, The University of Michigan, Ann Arbor 48109, USA
    J Biol Chem 277:44475-84. 2002
    ..Additionally, the development of this technology will allow similar studies in other tissues and cell populations rescued from Rb-/- fetuses...

Research Grants3

  1. HORMONE REGULATED INVOLUTION SIGNALED THROUGH E CADHERIN
    Mark Day; Fiscal Year: 2003
    ..abstract_text> ..
  2. Role of Retinoblastoma in Prostate Homeostasis
    Mark Day; Fiscal Year: 2006
    ..Lastly, we will determine the role of Rb and E2F1 in the regulation of AR transcription and determine if PrERb-/- cells and grafts exhibit heightened androgen sensitivity and AR activity. [unreadable] [unreadable] [unreadable]..
  3. Rb/E2F in Hormone Signaling of Prostate Epithelium
    Mark Day; Fiscal Year: 2006
    ..Lastly we will determine if the apoptotic mitochondrial/caspase-9 pathway is attenuated in the Rb-/- cells and tissue recombinants. ..