Genomes and Genes
Dawn Belt Davis
Affiliation: University of Wisconsin
- FoxM1 is up-regulated by obesity and stimulates beta-cell proliferationDawn Belt Davis
Department of Medicine, University of Wisconsin, Madison, WI, USA
Mol Endocrinol 24:1822-34. 2010..Our data suggest that beta-cell proliferation occurs in adult obese humans in an attempt to expand beta-cell mass to compensate for insulin resistance, and that the FoxM1 transcriptional program plays a key role in this process...
- Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survivalJeremy A Lavine
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
Endocrinology 151:3577-88. 2010..In summary, CCK is up-regulated by islet cells during obesity and functions as a paracrine or autocrine factor to increase beta-cell survival and expand beta-cell mass to compensate for obesity-induced insulin resistance...
- A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibilityMark P Keller
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53076, USA
Genome Res 18:706-16. 2008....
- Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell lineKimberly A Krautkramer
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin, Madison, Wisconsin
Am J Physiol Endocrinol Metab 305:E600-10. 2013..Therefore, Tcf19 is necessary for both proliferation and survival and is a novel regulator of these pathways...
- Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet functionJeremy A Lavine
Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Mol Endocrinol 22:2716-28. 2008..CCK triggers beta-cell proliferation without disrupting islet function, up-regulates a distinct set of cell cycle regulators in islets, and signals independently of the CCK receptors...