David A D'Argenio
Affiliation: University of Washington
- Autolysis and autoaggregation in Pseudomonas aeruginosa colony morphology mutantsDavid A D'Argenio
Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
J Bacteriol 184:6481-9. 2002..The fact that PQS levels correlated with autolysis suggests a fine balance in natural populations of P. aeruginosa between survival of the many and persistence of the few...
- Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patientsDavid A D'Argenio
Department of Microbiology, University of Washington, Seattle, WA, USA
Mol Microbiol 64:512-33. 2007..Loss of LasR function may represent a marker of an early stage in chronic infection of the CF airway with clinical implications for antibiotic resistance and disease progression...
- Aminoglycoside antibiotics induce bacterial biofilm formationLucas R Hoffman
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Nature 436:1171-5. 2005..Our results demonstrate that biofilm formation can be a specific, defensive reaction to the presence of antibiotics, and indicate that the molecular basis of this response includes alterations in the level of c-di-GMP...
- Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patientsHillary S Hayden
Genome Center, University of Washington, Seattle, WA 98195, USA
Genomics 91:530-7. 2008..aeruginosa and validates a technology that complements emerging, short-read sequencing methods that are better suited to characterizing single-nucleotide polymorphisms than structural variation...
- Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosaLucas R Hoffman
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 103:19890-5. 2006....
- Cyclic di-GMP as a bacterial second messengerDavid A D'Argenio
Department of Microbiology, University of Washington, Seattle, WA 98195, USA
Microbiology 150:2497-502. 2004..Genetic evidence suggests that the GGDEF domain acts as a nucleotide cyclase for c-di-GMP synthesis while the EAL domain is a good candidate for the opposing activity, a phosphodiesterase for c-di-GMP degradation...
- Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strainsLaurence Rohmer
Department of Genome Sciences, University of Washington, Campus Box 357710, 1705 NE Pacific Street Seattle, Washington 98195, USA
Genome Biol 8:R102. 2007....
- Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patientsEric E Smith
Genome Center, Program in Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 103:8487-92. 2006..aeruginosa strains present in advanced CF infections differ systematically from those of "wild-type" P. aeruginosa and that these differences may offer new opportunities for treatment of this chronic disease...