Harel Dahari

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Modelling hepatitis C virus kinetics: the relationship between the infected cell loss rate and the final slope of viral decay
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Antivir Ther 14:459-64. 2009
  2. pmc Pharmacodynamics of PEG-IFN-alpha-2a in HIV/HCV co-infected patients: implications for treatment outcomes
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Hepatol 53:460-7. 2010
  3. pmc A mathematical model of hepatitis C virus dynamics in patients with high baseline viral loads or advanced liver disease
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Gastroenterology 136:1402-9. 2009
  4. pmc Modeling complex decay profiles of hepatitis B virus during antiviral therapy
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Hepatology 49:32-8. 2009
  5. pmc Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Gastroenterology 139:965-74. 2010
  6. pmc Modeling subgenomic hepatitis C virus RNA kinetics during treatment with alpha interferon
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Virol 83:6383-90. 2009
  7. pmc Agent-Based Model Forecasts Aging of the Population of People Who Inject Drugs in Metropolitan Chicago and Changing Prevalence of Hepatitis C Infections
    Alexander Gutfraind
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America The Program for Experimental and Theoretical Modeling, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America
    PLoS ONE 10:e0137993. 2015
  8. pmc Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics
    Harel Dahari
    The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Loyola University Medical Center, Maywood, IL, USA Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    Liver Int 35:289-94. 2015

Detail Information

Publications8

  1. pmc Modelling hepatitis C virus kinetics: the relationship between the infected cell loss rate and the final slope of viral decay
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Antivir Ther 14:459-64. 2009
    ..In standard models, lambda is approximately epsilondelta when the viral clearance rate c>>delta, as has been previously estimated...
  2. pmc Pharmacodynamics of PEG-IFN-alpha-2a in HIV/HCV co-infected patients: implications for treatment outcomes
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Hepatol 53:460-7. 2010
    ..We sought to estimate the pharmacokinetics and pharmacodynamics of PEG-IFN and determine whether these parameters predict treatment outcome...
  3. pmc A mathematical model of hepatitis C virus dynamics in patients with high baseline viral loads or advanced liver disease
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Gastroenterology 136:1402-9. 2009
    ....
  4. pmc Modeling complex decay profiles of hepatitis B virus during antiviral therapy
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Hepatology 49:32-8. 2009
    ..The model predicts that complex profiles such as those exhibiting a plateau or shoulder phase, as well as a class of stepwise declines, occur only in patients in whom the majority of hepatocytes are infected before therapy...
  5. pmc Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Gastroenterology 139:965-74. 2010
    ..To draw meaningful conclusions about the efficacy of HCV vaccines in chimpanzees, we performed statistical analyses of data from previously published studies from different groups...
  6. pmc Modeling subgenomic hepatitis C virus RNA kinetics during treatment with alpha interferon
    Harel Dahari
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Virol 83:6383-90. 2009
    ..As such, dissection of HCV IFN-alpha inhibition kinetics in vitro has brought us closer to understanding the mechanism(s) by which IFN-alpha may be inhibiting HCV in vivo...
  7. pmc Agent-Based Model Forecasts Aging of the Population of People Who Inject Drugs in Metropolitan Chicago and Changing Prevalence of Hepatitis C Infections
    Alexander Gutfraind
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America The Program for Experimental and Theoretical Modeling, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America
    PLoS ONE 10:e0137993. 2015
    ....
  8. pmc Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics
    Harel Dahari
    The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Loyola University Medical Center, Maywood, IL, USA Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
    Liver Int 35:289-94. 2015
    ....